IL-27 and IFN-α signal via Stat1 and Stat3 and induce T-Bet and IL-12Rβ2 in naive T cells

Journal of Interferon and Cytokine Research

Volumn 23, Issue 9, 2003, Pages 513-522

  Hibbert, Linda ^a   Pflanz, Stefan ^a,b   De Waal Malefyt, Rene ^a   Kastelein, Robert A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b MICROMET AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CD4 ANTIGEN; CYTOKINE; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 12 RECEPTOR BETA2; INTERLEUKIN 27; STAT1 PROTEIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL LINE; CYTOKINE PRODUCTION; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; T BET GENE; T LYMPHOCYTE; TH1 CELL;

DNA-BINDING PROTEINS; HUMANS; INTERFERON-ALPHA; INTERLEUKINS; PHOSPHORYLATION; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-12; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; T-BOX DOMAIN PROTEINS; T-LYMPHOCYTES; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

ANIMALIA; MURINAE;

EID: 0141519112     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/10799900360708632     Document Type: Article

References (43)

1. O'SHEA, J., and PAUL, W.E. (2002). Regulation of Th1 differentiation: controlling the controllers. Nat. Immunol. 3, 506-508.
2. RENZ, H. (1999). Soluble interleukin-4 receptor (sIL-4R) in allergic diseases. Inflamm. Res. 48, 425-431.
3. O'GARRA, A., and ARAI, N. (2000). The molecular basis of T helper 1 and T helper 2 differentiation. Trends Cell Biol. 10, 542-550.
4. O'GARRA, A. (1998). Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 8, 275-283.
5. + T cells controls the direction of the Th cell response. Int. Immunol. 14, 1-11.
6. BANCHEREAU, J. (1994). Interleukin 4. Trends Exp. Clin. Med. 4, 514-531.
7. RENGARARJAN, J., SZABO, S.J., and GLIMCHER, L.H. (2000). Transcriptional regulation of Th1/Th2 polarization. Immunol. Today 21, 479-483.
8. KIKKAWA, E., YAMASHITA, M., KIMURA, M., OMORI, M., SUGAYA, K., SHIMIZU, C., KATSUMOTO, T., IKEKITA, M., TANIGUCHI, M., and NAKAYAMA, T. (2002). Th1/Th2 cell differentiation of developing CD4 single-positive thymocytes. Int. Immunol. 14, 943-951.
9. PAUL, W.E. (1997). Interleukin 4: signalling mechanisms and control of T cell differentiation. Ciba Found. Symp. 204, 208-216.
10. NAKANISHI, K., YOSHIMOTO, T., TSUTSUI, H., and OKAMURA, H. (2001). Interleukin-18 regulates both Th1 and Th2 responses. Annu. Rev. Immunol. 19, 423-474.
11. FREUDENBERG, M.A., MERLIN, T., KALIS, C., CHVATCHCO, Y., STUBIG, H., and GALANOS, C. (2002). Cutting edge: a murine, IL-12-independent pathway of IFN-γ induction by gram-negative bacteria based on Stat4 activation by type I IFN and IL-18 signaling. J. Immunol. 169, 1665-1668.
12. BELLADONNA, M.L., RENAULD, J.-C., BIANCHI, R., VACCA, C., FALLARINO, F., ORABONA, C., FIORETTI, M.C., GROHMANN, U., and PUCCETTI, P. (2002). IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells. J. Immunol. 168, 5448-5454.
13. NEIGHBORS, M., XU, X., BARRAT, F.J., RUULS, S.R., CHURAKOVA, T., DEBETS, R., BAZAN, J.F., KASTELEIN, R.A., ABRAMS, J.S., and O'GARRA, A. (2001). A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on interferon-γ production. J. Exp. Med. 194, 343-354.
14. ROBINSON, D.S., and O'GARRA, A. (2002). Further checkpoints in Th1 development. Immunity 16, 755-758.
15. DEBETS, R., TIMANS, J.C., CHURAKOWA, T., ZURAWSKI, S., DE WAAL MALEFYT, R., MOORE, K.W., ABRAMS, J.S., O'GARRA, A., BAZAN, J.F., and KASTELEIN, R.A. (2000). IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18. J. Immunol. 165, 4950-4956.
16. DONG, C., and FLAVELL, R.A. (2000). Control of T helper cell differentiation - in search of master genes. Sci STKE 2000, PE1.
17. KUO, C.T., and LEIDEN, J.M. (1999). Transcriptional regulation of T lymphocyte development and function. Annu. Rev. Immunol. 17, 149-187.
18. YIN, Z., CHEN, C., SZABO, S.J., GLIMCHER, L.H., RAY, A., and CRAFT, J. (2002). T-Bet expression and failure of GATA-3 cross-regulation lead to default production of IFN-gamma by gammadelta T cells. J. Immunol. 168, 1566-1571.
19. ZHENG, W.-P., and FLAVELL, R.A. (1997). The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89, 587-596.
20. SZABO, S.J., KIM, S.T., COSTA, G.L., ZHANG, X., FATHMAN, C.G., and GLIMCHER, L.H. (2000). A novel transcription factor, T-Bet, directs Th1 lineage commitment. Cell 100, 655-669.
21. SZABO, S.J., SULLIVAN, B.M., STEMMANN, C., SATOSKAR, A.R., SLECKMAN, B.P., and GLIMCHER, L.H. (2002). Distinct effects of T-Bet in Th1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 295, 338-342.
22. LIGHVANI, A.A., FRUCHT, D.M., JANKOVIC, D., YAMANE, H., ALIBERTI, J., HISSONG, B.D., NGUYEN, B.V., GADINA, M., SHER, A., PAUL, W.E., and O'SHEA, J.J. (2001). T-Bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells. Proc. Natl. Acad. Sci. USA 98, 15137-15142.
23. FINOTTO, S., NEURATH, M.F., GLICKMAN, J.N., QIN, S., LEHR, H.A., GREEN, F.H., ACKERMAN, K., HALEY, K., GALLE, P.R., SZABO, S.J., DRAZEN, J.M., DE SANCTIS, G.T., and GLIMCHER, L.H. (2002). Development of spontaneous airway changes consistent with human asthma in mice lacking T-Bet. Science 295, 336-338.
24. MULLEN, A.C., HIGH, F.A., HUTCHINS, A.S., LEE, H.W., VILLARINO, A.V., LIVINGSTON, D.M., KUNG, A.L., CEREB, N., YAO, T.P., YANG, S.Y., and REINER, S.L. (2001). Role of T-Bet in commitment of Th1 cells before IL-12-dependent selection. Science 292, 1907-1910.
25. + T cells. Nat. Immunol. 3, 549-557.
26. WEIGMANN, B., and NEURATH, M.F. (2002). T-Bet and mucosal Th1 responses in the gastrointestinal tract. Gut 51, 301-303.
27. SINIGAGLIA, F., D'AMBROSIO, D., PANINA-BORDIGNON, P., and ROGGE, L. (1999). Regulation of the IL-12/IL-12R axis: a critical step in T-helper cell differentiation and effector function. Immunol. Rev. 170, 65-72.
28. SZABO, S.J., DIGHE, A.S., GUBLER, U., and MURPHY, K.M. (1997). Regulation of the interleukin (IL)-12R b2 subunit expression in developing T helper 1 (Th1) and Th2 Cells. J. Exp. Med. 185, 817-824.
29. FARRAR, J.D., and MURPHY, K.M. (2000). Type I interferons and T helper development. Immunol. Today 21, 484-489.
30. WU, C.-Y., GADINA, M., WANG, K., O'SHEA, J., and SEDER, R.A., (2000). Cytokine regulation of IL-12 receptor b2 expression: differential effects on human T and NK cells. Eur. J. Immunol. 30, 1364-1374.
31. WENNER, C.A., GULER, M.L., MACATONIA, S.E., O'GARRA, A., and MURPHY, K.M. (1996). Roles of IFN-gamma and IFN-alpha in IL-12-induced T helper cell-1 development. J. Immunol. 156, 1442-1447.
32. LUND, T.C., MEDVECZKY, M.M., and MEDVECZKY, P.G. (1999). Interferon-alpha induction of Stats1-3 DNA binding and growth arrest is independent of Lck and active mitogen-activated kinase in T cells. Cell Immunol. 192, 133-139.
33. + T cells. Immunity 16, 779-790.
34. SPRECHER, C.A., GRANT, F., BAUMGARTNER, J.W., PRESNELL, S.R., SCHRADER, S.K., YAMAGIWA, T., WHITMORE, T.E., O'HARA, P.J., and FOSTER, D.F. (1998). Cloning and characterization of a novel class I cytokine receptor. Biochem. Biophys. Res. Commun. 246, 82-90.
35. FAVRE, C., WIJDENES, J., CABRILLAT, H., DJOSSOU, O., BANCHEREAU, J., and DE VRIES, J.E. (1989). Epitope mapping of recombinant human gamma interferon using monoclonal antibodies. Mol. Immunol. 26, 17-25.
36. SIEGAL, F.P., KADOWAKI, N., SHODELL, M., FITZGERALD-BOCARSLY, P.A., SHAH, K., HO, S., ANTONENKO, S., and LIU, Y.-J. (1999). The nature of the principal type 1 interferon-producing cells in human blood. Science 284, 1835-1837.
37. KADOWAKI, N., ANTONENKO, S., HO, S., RISSOAN, M.C., SOUMELIS, V., PORCELLI, S.A., LANIER, L.L., and LIN, Y.J. (2001). Distinct cytokine profiles of neonatal natural killer T cells after expansion with subsets of dendritic cells. J. Exp. Med. 193, 1221-1226.
38. SOUMELIS, V., RECHE, P.A., KANZLER, H., YUAN, W., EDWARD, G., HOMEY, B., GILLIET, M., HO, S., ANTONENKO, S., LAUERMA, A., SMITH, K., GORMAN, D., ZURAWSKI, S., ABRAMS, J., MENON, S., McCLANAHAN, T., DE WAAL-MALEFYT, R., BAZAN, F., KASTELEIN, R.A., and LIU, Y.J. (2002). Human epithelial cells trigger dendritic cell-mediated allergic inflammation by producing TSLP. Nat. Immunol. 3, 673-680.
39. THIERFELDER, W.E., VAN DEURSEN, J.M., YAMAMOTO, K., TRIPP, R.A., SARAWAR, S.R, CARSON, R.T., SANGSTER, M.Y., VIGNALI, D.A., DONHERTY, P.C., and GROSVELD, G.C. (1996). Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382, 171-174.
40. LANIER, L., O'FALLON, S., SOMOZA, C., PHILLIPS, J., LINSLEY, P., OKUMURA, K., ITO, D., and AZUMA, M. (1995). CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. J. Immunol. 154, 97-105.
41. BACON, C.M., PETRICOIN, E.F., 3rd, ORTALDO, J.R., REES, R.C., LARNER, A.C., JOHNSTON, J.A., and O'SHEA, J.J. (1995). Interleukin 12 induces tyrosine phosphorylation and activation of Stat4 in human lymphocytes. Proc. Natl. Acad. Sci. USA 92, 7307-7311.
42. YOSHIDA, H., HAMANO, S., SENALDI, G., COVEY, T., FAGGONI, R., MU, S., XIA, M., WAKEHAM, A.C., NISHINA, H., POTTER, J., SARIS, C.J., and MAK, T.W. (2001). WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection. Immunity 15, 569-578.
43. HILLIARD, B.A., MASON, N., XU, L., SUN, J., LAMHAMEDI-CHERRADI, S.-E., LIOU, H.-C., HUNTER, C., and CHEN, Y.H. (2002). Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation. J. Clin. Invest. 110, 843-850.