Characterization of chemokines and chemokine receptors in two murine models of inflammatory bowel disease: IL-10-/- mice and Rag-2-/- mice reconstituted with CD4+CD45RBhigh T cells

European Journal of Immunology

Volumn 31, Issue 5, 2001, Pages 1465-1474

  Scheerens, Heleen ^a   Hessel, Edith ^a   De Waal Malefyt, Rene ^a   Leach, Michael W ^b   Rennick, Donna ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NONE

Author keywords

Cell trafficking; Chemokine; Inflammation; Inflammatory bowel disease; Quantitative PCR analysis

Indexed keywords

CD4 ANTIGEN; CD45 ANTIGEN; CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR6; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; LYMPHOTACTIN; MACROPHAGE INFLAMMATORY PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; MESSENGER RNA; MONOCLONAL ANTIBODY; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOKINE; RANTES; RECOMBINASE; THYMUS AND ACTIVATION CHEMOKINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC INFLAMMATION; COLON; CONTROLLED STUDY; ENTERITIS; GENE ACTIVATION; LYMPHOCYTE TRANSFER; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL;

ACUTE DISEASE; ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, MONOCLONAL; CELLS, CULTURED; CHEMOKINES; COLON; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; GENE DELETION; GENE EXPRESSION REGULATION; INFLAMMATORY BOWEL DISEASES; INTERLEUKIN-10; INTERLEUKIN-12; MICE; MICE, KNOCKOUT; RECEPTORS, CHEMOKINE; RNA, MESSENGER; TH1 CELLS;

EID: 0035023806     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200105)31:5<1465::AID-IMMU1465>3.0.CO;2-E     Document Type: Article

References (41)

1. 3C motif. Nature 1997. 385: 640-644.
2. Kelner, G. S., Kennedy, J., Bacon, K. B., Kleyensteuber, S., Largaespada, D. A., Jenkins, N. A., Copeland, N. G., Bazan, J. F., Moore, K. W., Schall, T. J. and Zlotnik, A., Lymphotactin: a cytokine that represents a new class of chemokine. Science 1994. 266: 1395-1399.
3. Lewin, K. J., Riddell, R. H. and Weinstein, W. M., Inflammatory bowel diseases. Igaku-Shoin, New York. 1992.
4. Parronchi, P., Romagnani, P., Annunciato, F., Sampognaro, S., Becchio, A., Giannarini, L., Maggi, E., Pupilli, C., Tonelli, F. and Romagnani, S., Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease. Am. J. Pathol. 1997. 150: 823-831.
5. Nielsen, O. H., Koppen, T., Rudiger, N., Horn, T., Eriksen, J. and Kirman, I., Involvement of interleukin-4 and -10 in inflammatory bowel disease. Dig. Dis. and Sci. 1996. 41: 1786-1793.
6. Arai, F., Takahashi, T., Fufukawa, K., Matsushima, K. and Asakura, H., Mucosal expression of interleukin-6 and interleukin-8 messenger RNA in ulcerative colitis and in Crohn's disease. Dig. Dis. and Sci. 1998. 43: 2071-2079.
7. Mazzucchelli, L., Hauser, C., Zgraggen, K., Wagner, H., Hess, M., Laissue, J. A. and Mueller, C., Expression of interleukin-8 gene in inflammatory bowel disease is related to the histological grade of active inflammation. Am. J. Pathol. 1991. 144: 997-1007.
8. Grimm, M. C., Elsbury, S. K. O., Pavli, P. and Doe, W. F., Enhanced expression and production of monocyte chemoattractant protein-1 in inflammatory bowel disease mucosa. J. Leukoc. Biol. 1996. 59: 804-812.
9. Keates, S., Keates, A. C., Mizoguchi, E., Bhan, A. and Kelly, C. P., Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis. Am. J. Physiol. 1997. 273: G75-G82.
10. Walz, A., Schmutz, P., Mueller, C. and Schnyder-Candrian, S., Regulation and function of the CXC chemokine ENA-78 in monocytes and its role in disease. J. Leukoc. Biol. 1997. 62: 604-611.
11. Z'Graggen, K., Walz, A., Mazzucchelli, L., Strieter, R. M. and Mueller, C., The CXC chemokine ENA-78 is preferentially expressed in intestinal epithelium in inflammatory bowel disease. Gastroenterology 1997. 113: 808-816.
12. Wedemeyer, J., Lorentz, A., Goke, M., Meier, P. N., Flamming, P., Dahinden, C. A., Manns, M. P. and Bischoff, S. C., Enhanced production of monocyte chemotactic protein 3 in inflammatory bowel disease mucosa. Gut 1999. 44: 629-635.
13. Mazzucchelli, L., Hauser, C., Zgraggen, K., Wagner, H. E., Hess, M. W., Laissue, J. A. and Mueller, C. Differential in situ expression of the genes encoding the chemokines MCP-1 and RANTES in human inflammatory bowel disease. J. Pathol. 1996. 178: 201-206.
14. Grimm, M. C., Elsbury, S. K. O., Pavli, P. and Doe, W. F., Interleukin 8: cells of origin in inflammatory bowel disease. Gut 1996. 38: 90-98.
15. Annunziato, F., Cosmi, L., Galli, G., Beltrame, C., Romagnani, P., Manetti, R., Romagnani, S. and Maggi, E., Assessment of chemokine receptor expression by human Th1 and Th2 cells in vitro and in vivo. J. Leukoc. Biol. 1999. 65: 691-699.
16. Kühn, R., Lohler, J., Rennick, D., Rajewsky, K. and Müller, W., Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993. 75: 263-274.
17. Powrie, F., Leach, M. W., Mauze, S., Barcomb Caddle, L. and Coffman, R. L., Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C.B-17 scid mice. Int. Immunol. 1993. 5: 1461-1471.
18. Davidson, N. J., Leach, M. W., Fort, M. M., Thompson-Snipes, L., Kühn, R., Müller, W., Berg, D. J. and Rennick, D. M., T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin-10-deficient mice. J. Exp. Med. 1996. 184: 241-251.
19. hi CD4+ T cells. Immunity 1994. 1: 553-562.
20. Davidson, N. J., Hudak, S. A., Lesley, R. E., Menon, S., Leach, M. W. and Rennick, D. M., IL-12, but not IFN-gamma, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice. J. Immunol. 1998. 161: 3143-3149.
21. Boring, L., Gosling, J., Chensue, S. W., Kunkel, S. L., Farese, R. V., Jr., Boxmeyer, H. E. and Charo, I. F., Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J. Clin. Invest. 1997. 100: 2552-2561.
22. Sato, K., Kawasaki, H., Nagayama, H., Serizawa, R., Ikeda, J., Morimoto, C., Yasunaga, K., Yamaji, N., Tadokoro, K., Juji, T. and Takahashi, T. A., CC chemokine receptors, CCR1-and CCR3-, are potentially involved in antigen-presenting cell function of human peripherel blood monocyte-derived dendritic cells. Blood 1999. 93: 34-42.
23. Saboe, I., Hartnell, A., Jopling, L. A., Bel, S., Ponah, P. D., Pease, J. E., Collins, P. D. and Williams, T. J., Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways. J. Immunol. 1999. 162: 2946-2955.
24. O'Garra, A., McEvoy, L. M. and Zlotnik, A., T-cell subsets: chemokine receptors guide the way. Curr. Biol. 1998. 8: R646-649.
25. Yanagihara, S., Komura, E., Nagafune, J., Watarai, H. and Yamaguchi, Y., EBII/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation. J. Immunol. 1998. 161: 3096-3102.
26. Charo, I. F., Myers, S. J., Herman, A., Franci, C., Connolly, A. J. and Coughlin, S. R., Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc. Natl. Acad. Sci. USA 1994. 91: 2752-2756.
27. D'Ambrosio, D., Iellem, A., Bonecchi, R., Mazzeo, D., Sozzani, S., Montovani, A. and Sinigaglia, F., Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells. J. Immunol. 1998. 161: 5111-5115.
28. Campbell, J. J., Haraldson, G., Pan, J., Rottman, J., Qin, S., Ponath, P., Andrew, S. P., Warnke, R., Ruffing, N., Kassam, N., Wu, L. and Butcher, E. C., The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. Nature 1999. 400: 776-780.
29. Imai, T., Baba, M., Nishimura, M., Kakizaki, M., Takagi, S. and Yoshie, O., The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. J. Biol. Chem. 1997. 272: 15036-15042.
30. Imai, T., Chantry, D., Raport, C. J., Wood, C. L., Nishimura, M., Godiska, R., Yoshie, O. and Gray, P. W., Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. J. Biol. Chem. 1998. 271: 21514.
31. Liao, F., Rabin, R. L., Smith, C. S., Sharma, G., Nutman, T. B. and Farber, J. M., CC-Chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3α. J. Immunol. 1999. 162: 186-194.
32. Dieu, M., Vanbervliet, B., Vicari, A., Bridon, J., Oldham, W., Ait-Yahia, S., Briere, F., Zlotnik, A., Lebecque, S. and Caux, C., Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J. Exp. Med. 1998. 188: 373-386.
33. Tanaka, Y., Imai, T., Baba, M., Ishikawa, I., Uehira, M., Nomiyama, H. and Yoshie, O., Selective expression of liver and activation-regulated chemokine (LARC) in intestinal epithelium in mice and humans. Eur. J. Immunol. 1999. 29: 633-642.
34. Cook, D. N., Prosser, D. M., Forster, R., Zhang, J., Kuklin, N. A., Abbondanzo, S. J., Niu, X., Chen, S., Manfra, D. J., Wiekowski, M. T., Sullivan, L. M., Smith, S. R., Greenberg, H. B., Narula, S. K., Lipp, M. and Lira, S. A., CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue. Immunity 2000. 12: 495-503.
35. Farber, J. M., A macrophage mRNA selectively induced by γ-interferon encodes a member of the platelet factor 4 family of cytokines. Proc. Natl. Acad. Sci. USA 1990. 87: 5238-5242.
36. Bonecchi, R., Bianchi, G., Panina Bordignon, P., D'Ambrosio, D., Lang, R., Borsatti, A., Sozani, S., Allavena, P., Gray, P. A., Mantovani, A. and Sinigaglia, F., Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (This) and Th2s. J. Exp. Med. 1998. 187: 129-134.
37. Rahimpour, R., Mitchell, G., Khandaker, M. H., Kong, C., Singh, B., Xu, L., Ochi, A., Feldman, R. D., Pickering, J. G., Gill, B. M. and Kelvin, D. J., Bacterial superantigens induce down-modulation of CC chemokine responsiveness in human monocytes via an alternative chemokine ligand-independent mechanism. J. Immunol. 1999. 162: 2299-2307.
38. Sallusto, F., Schaerli, P., Loetscher, P., Schaniel, C., Lenig, D., Mackay, C. R., Qin, S. and Lanzavecchia, A., Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation. Eur. J. Immunol. 1998. 28: 2760-2769.
39. Qin, S., Rottman, J. B., Myers, P., Kassam, N., Weinblatt, M., Loetscher, M., Koch, A. E., Moser, B. and Mackay, C. R., The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. J. Clin. Invest. 1998. 101: 746-754.
40. Berg, D. J., Davidson, N., Kühn, R., Müller, W., Menon, S., Holland, G., Thompson-Snipes, L., Leach, M. W. and Rennick, D., Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4+ Th1-like response. J. Clin. Invest. 1996. 98: 1010-1020.
41. Rissoan, M. C., Soumelis, V., Kadowaki, N., Grouard, G., Briere, F., De Waal Malefyt, R. and Liu, Y. J., Reciprocal control of T helper cell and dendritic cell differentiation. Science 1999. 283: 1183-1186.