Blocking Smad7 restores TGF-β1 signaling in chronic inflammatory bowel disease

Journal of Clinical Investigation

Volumn 108, Issue 4, 2001, Pages 601-609

  Monteleone, G ^a   Kumberova, A ^a   Croft, N M ^a   McKenzie, C ^a   Steer, H W ^a   MacDonald, T T ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; CYTOKINE ANTIBODY; SMAD PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; CHILD; CHRONIC INFLAMMATION; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; ENTERITIS; HUMAN; HUMAN TISSUE; INTESTINE MUCOSA; LAMINA PROPRIA; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; ULCERATIVE COLITIS;

EID: 0034894059     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI12821     Document Type: Article

References (30)

1. Inflammatory bowel disease: Etiology and pathogenesis
2. Transforming growth factor β: The good, the bad, and the ugly
3. Regulation of immune responses by TGF-β
4. Specificity, diversity, and regulation in TGF-β superfamily signaling
5. TGF-beta signalling from cell membrane to nucleus through SMAD proteins
6. Smads: Transcriptional activators of TGF-β responses
7. TGFβRI phosphorylation of Smad2 on Ser465 and 467 is required for Smad2/Smad4 complex formation and signalling
8. A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway
9. Direct binding of Smad3 and Smad4 to critical TG Fβ-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
10. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β
11. The Mad-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling
12. Identification of Smad7, a TGFβ-inducible antagonist of TGFβ signalling
13. A mechanism of suppression of TGF-β/SMAD signaling by NF-kB/RelA
14. Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway
15. Tumor necrosis factor alpha-producing cells in the intestinal mucosa of children with inflammatory bowel disease
16. Interleukin-2- and interferon-γ secreting T cells in normal and diseased human intestinal mucosa
17. Spontaneous release of interferon gamma by intestinal lamina propria lymphocytes in Crohn's disease. Kinetics of in vitro response to interferon gamma inducers
18. Reciprocal IFN-γ and TGF-β responses regulate the occurrence of mucosal inflammation
19. Experimental granulomatous colitis in mice is abrogated by induction of TGF - Mediated oral tolerance
20. TGF-β production regulates the development of the 2,4,6-trinitrophenol-conjugated keyhole lipet hemocyanin-induced colonic inflammation in IL-2-deficient mice
21. Oxazolone colitis: A murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4
22. + T cells
23. Expression of transforming growth factors α and β in colonic mucosa in inflammatory bowel disease
24. A distinct array of proinflammatory cytokines is expressed in human colonic epithelial cells in response to bacterial invasion
25. Organ culture of mucosal biopsies of human small intestine
26. Immune dysregulation in TGF-β1-deficient mice
27. Targeted disruption of the mouse TGF-β1 gene results in multifocal inflammatory disease
28. Abrogation of TGFβ signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease
29. Blockade of transforming growth factor β/Smad signaling in T cells by overexpression of Smad7 enhances antigen-induced inflammation and airway reactivity
30. Vascular MADs: Two novel MAD-related genes selectively inducible by flow in human vascular endothelium