Interleukin-11 reduces T-cell-dependent experimental liver injury in mice

Hepatology

Volumn 30, Issue 6, 1999, Pages 1441-1447

  Bozza, Mary ^a   Bliss, Judith L ^a   Maylor, Richard ^a   Erickson, Jamie ^a   Donnelly, Lori ^a   Bouchard, Page ^a   Dorner, Andrew J ^a   Trepicchio, William L ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONCANAVALIN A; INTERLEUKIN 11;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; IMMUNOMODULATION; INFLAMMATORY CELL; LIVER INJURY; LYMPHOCYTE FUNCTION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; SURVIVAL; T LYMPHOCYTE ACTIVATION;

EID: 0032742184     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510300616     Document Type: Article

References (23)

1. Trepicchio WL, Bozza M, Pedneault G, Dorner, AJ. Recombinant human IL-11 attenuates the inflammatory response through down-regulation of proinflammatory cytokine release and nitric oxide production. J Immunol 1996;157:3627.
2. Redlich CA, Gao X, Rockwell S, Kelley M, Elias, JA. IL-11 enhances survival and decreases TNF production after radiation-induced thoracic injury. J Immunol 1996;157:1705.
3. Trepicchio WL, Wang L, Bozza M, Dorner AJ. IL-11 regulates macrophage effector function through the inhibition of nuclear factor-kappaB. J Immunol 1997;159:5661.
4. Anderson KC, Morimoto C, Paul SR, Chauhan D, Williams D, Cochran M, Barut BA. Interleukin-11 promotes accessory cell-dependent B-cell differentiation in humans. Blood; 1992;80:2797.
5. Yin TG, Schendel P, Yang YC. Enhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11. J Exp Med 1992; 175:211.
6. Hill GR, Cooke KR, Teshima T, Crawford JM, Keith JC, Jr., Brinson YS, Bungard D, Ferrara JL. Interleukin-11 promotes T cell polarization and prevents acute graft-versus-host disease after allogeneic bone marrow transplantation. J Clin Invest 1998;102:115.
7. Keith JC, Jr., Albert L, Sonis ST, Pfeiffer CJ, Schaub RG. IL-11, a pleiotropic cytokine: exciting new effects of IL-11 on gastrointestinal mucosal biology. Stem Cells 1994;1:79.
8. Barton BE, Shortall J, Jackson JV. Intetleukins 6 and 11 protect mice from mortality in a staphylococcal enterotoxin-induced toxic shock model. Infect Immun 1996;64:714.
9. Leng SX, Elias JA. Interleukin-11 inhibits macrophage interleukin-12 production. J Immunol 1997;159:2161.
10. Lis H, Sharon N. Biological properties of lectin. In: Leiner JE, Sharon N, Goldstein IJ, eds. The Lectins: Properties, functions and applications in biology and medicine. London: Academic Press, Inc., 1986;256.
11. Tiegs G, Hentschel J, Wendel A. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J Clin Invest 1992;90:196.
12. Tagawa Y, Sekikawa K, Iwakura Y. Suppression of concanavalin A-induced hepatitis in IFN-gamma (-/- ) mice, but not in TNF-alpha (-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes. J Immunol 1997;159:1418.
13. Gantner F, Leist M, Lohse AW, Germann PG, Tiegs G. Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor. HEPATOLOGY 1995;21:190.
14. Mizuhura H, O'Neill E, Seki N, Ogawa T, Kusunoki C, Otsuka K, Satoh S, Niwa M, Senoh H, Fujiwara H. T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6. J Exp Med 1994;179:1529.
15. Mizuhara H, Uno M, Seki N, Yamashita M, Yamaoka M, Ogawa T, Kaneda K, Fujii T, Senoh H, Fujiwara H. Critical involvement of interferon gamma in the pathogenesis of T-cell activation-associated hepatitis and regulatory mechanisms of interleukin-6 for the manifestations of hepatitis. HEPATOLOGY 1996;23:1608.
16. Bergmeyer H-U. Methods of Enzymatic Analysis. Verlag Chemie, Weinheim FRG 1984.
17. Dorner AJ, Goldman SJ, Keith JCJ. Interleukin-11: Biological Activity and Clinical Studies. BioDrugs 1997;6:418.
18. Peterson RL, Wang L, Albert L, Keith JC, Jr., Dorner, AJ. Molecular effects of recombinant human interleukin-11 in the HLA-B27 rat model of inflammatory bowel disease. Lab Invest 1998;78:1503.
19. Tiegs G, Gantner F. Immunotoxicology of T cell-dependent experimental liver injury. Exp Toxicol Pathol 1996;48:471.
20. Tiegs G. Experimental hepatitis and role of cytokines. Acta GastroenterolBelg 1997;60:176.
21. Knolle PA, Gerken G, Loser E, Dienes H-P, Gantner F, Tiegs, G, Meyer Zum Buschenfelde K-H, Lohse AW. Role of sinusoidal endothelial cells of the liver in Concanavalin A-induced hepatic injury in mice. HEPATOLOGY 1996;24:824-829.
22. Baumann H, Schendel P. Interleukin-11 regulates the hepatic expression of the same plasma protein genes as interleukin-6. J Biol Chem 1991; 266:20424.
23. Roeb E, Graeve L, Hoffmann R, Decker K, Edwards DR, Heinrich PC. Regulation of tissue inhibitor of metalloproteinases-1 gene expression by cytokines and dexamethasone in rat hepatocyte primary cultures. HEPATOLOGY 1993;18:1437.