A novel transcription factor, T-bet, directs Th1 lineage commitment

Cell

Volumn 100, Issue 6, 2000, Pages 655-669

  Szabo, Susanne J ^a   Kim, Sean T ^a   Costa, Gina L ^c   Zhang, Xiankui ^d   Fathman, C Garrison ^c   Glimcher, Laurie H ^a,b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 4; INTERLEUKIN 5; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; GENETIC TRANSDUCTION; HELPER CELL; INTERFERON PRODUCTION; MOUSE; NATURAL KILLER CELL; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL; TRANSACTIVATION; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS;

EID: 0034677646     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80702-3     Document Type: Article

References (64)

1. Functional diversity of helper T lymphocytes
2. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
3. Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome
4. Mutations in human cause limb and cardiac malformation in Holt-Oram syndrome
5. P-selectin glycoprotein ligand-1 (PSGL-1) on T helper 1 but not on T helper 2 ceils binds to P-selectin and supports migration into inflamed skin
6. IL-2 promoter-driven/acZ expression as a monitoring tool for IL-2 expression in primary T cells of transgenic mice
7. Lineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferen γ production from CD4+ versus CD8+ T cells
8. Interieukin-12 induces expression of interferon regulatory factor-1 via signal transducer and activator of transcription-4 in human T helper type 1 cells
9. + T cell responses: The alternative approaches
10. Generation of polarized antigen-specific CD8 effector populations: Reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles
11. GATA-3 significantly downregulates IFN-γ production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels
12. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells
13. Groucho proteins: Transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates
14. Antiproliferative effect of IFN-gamma in immune regulation. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-gamma
15. The interleukin-12/interleukin-12-receptor system: Role in normal and pathologic immune responses
16. Prolactin induces phosphorylation of Tyr694 of Stats (MGF), a prerequisite for DNA binding and induction of transcription
17. Structure of the human immune interferon gene
18. Cloning of the T gene required in mesoderm formation in the mouse
19. The proto-oncogene c-maf is responsible for tissue-specific expression of intedeukin-4
20. NFAT-driven interleukin-4 transcription potentiated by NIP45
21. Rapid retroviral delivery of tetracycline-inducible genes in a single autoregulatory cassette
22. Development of TH1 CD4+T cells through IL-12 produced by Listeria-induced macrophages
23. Immune response in mice that lack the interferon-γ receptor
24. IL-4 and IL-13 production in differentiated T helper type 2 cells is not IL-4 dependent
25. Converting an activator into a repressor
26. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
27. The transcription factor c-Maf controls the production of IL-4 but not other Th2 cytokines
28. Cell surface phenotype of a cloned line of human natural killer cells
29. High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice
30. Regulation of cytokine gane expression in T helper cell subsets
31. Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo
32. The interleukin 12 p40 gene promoter is primed by interferon γ in monocytic cells
33. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
34. Reversibility of T helper 1 and 2 populations is lost after long-term stimulation
35. Crystallographic structure of the T domain-DNA complex of the Brachyury transcription factor
36. Polarization of IL-4- and IFN-γ-producing CD4+ T cells following activation of naive CD4+ T cells
37. The IL-4 receptor: Signaling mechanisms and biologic functions
38. Cytokines induce the development of functionally heterogeneous T helper cell subsets
39. Inhibition of Th1 developmental mediated by GATA-3 through an IL-4 independent mechanism
40. The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway
41. T-box family reunion
42. Lymphocyte responses and cytokines
43. The proximal regulatory element of the interferon-g promoter mediates selective expression in T cells
44. The T-box genes Tbx4 and Tbx5 regulate limb outgrowth and identity
45. A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors
46. Lymphokine production by human T ceils in disease states
47. Acquisition of lymphokine-producing phenotype by CD4+ T cells
48. Interaction of NF-kB and NFAT with the interferon-g promoter
49. Brachyury and the T-box genes
50. The roles of nuclear factor of activated T cells and Ying-Yang 1 in activation-induced expression of the interferen-γ promoter in T cells
51. Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: Roles for NF-Y and NF-ATc
52. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling
53. Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells
54. Tbx5 and Tbx4 genes determine the wing/leg identity of limb buds
55. Multistage regulation of Th1-type immune responses by the transcription factor IRF-1
56. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
57. Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain
58. Transcriptional repression of the IL-2 gene in Th cells by ZEB
59. TCGF (IL-2)-receptor inducing factor(s). I. Regulation of IL 2 receptor on a natural killer-like cell line (YT cells)
60. Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-g production from activated B cells
61. Differentiation of the T helper phenotypes by analysis of methylation state of the IFN-γ gene
62. Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene
63. Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3
64. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells