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Volumn 19, Issue 3-4, 2008, Pages 231-244

Physiological functions of tumor necrosis factor and the consequences of its pathologic overexpression or blockade: Mouse models

Author keywords

Anti cytokine therapy; Disease models; Knockout; Transgenic mice

Indexed keywords

CYTOKINE; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2;

EID: 44749088915     PISSN: 13596101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cytogfr.2008.04.010     Document Type: Article
Times cited : (65)

References (133)
  • 2
    • 0022371461 scopus 로고
    • Identity of tumour necrosis factor and the macrophage-secreted factor cachectin
    • Beutler B., Greenwald D., Hulmes J.D., Chang M., Pan Y.C., Mathison J., et al. Identity of tumour necrosis factor and the macrophage-secreted factor cachectin. Nature 316 (1985) 552-554
    • (1985) Nature , vol.316 , pp. 552-554
    • Beutler, B.1    Greenwald, D.2    Hulmes, J.D.3    Chang, M.4    Pan, Y.C.5    Mathison, J.6
  • 3
    • 0033213590 scopus 로고    scopus 로고
    • Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
    • Takeuchi O., Hoshino K., Kawai T., Sanjo H., Takada H., Ogawa T., et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11 (1999) 443-451
    • (1999) Immunity , vol.11 , pp. 443-451
    • Takeuchi, O.1    Hoshino, K.2    Kawai, T.3    Sanjo, H.4    Takada, H.5    Ogawa, T.6
  • 4
    • 0026717674 scopus 로고
    • The pathophysiology of tumor necrosis factors
    • Vassalli P. The pathophysiology of tumor necrosis factors. Annu Rev Immunol 10 (1992) 411-452
    • (1992) Annu Rev Immunol , vol.10 , pp. 411-452
    • Vassalli, P.1
  • 5
    • 0023491364 scopus 로고
    • Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
    • Tracey K.J., Fong Y., Hesse D.G., Manogue K.R., Lee A.T., Kuo G.C., et al. Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature 330 (1987) 662-664
    • (1987) Nature , vol.330 , pp. 662-664
    • Tracey, K.J.1    Fong, Y.2    Hesse, D.G.3    Manogue, K.R.4    Lee, A.T.5    Kuo, G.C.6
  • 6
    • 0033559125 scopus 로고    scopus 로고
    • Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin
    • Bean A.G., Roach D.R., Briscoe H., France M.P., Korner H., Sedgwick J.D., et al. Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin. J Immunol 162 (1999) 3504-3511
    • (1999) J Immunol , vol.162 , pp. 3504-3511
    • Bean, A.G.1    Roach, D.R.2    Briscoe, H.3    France, M.P.4    Korner, H.5    Sedgwick, J.D.6
  • 7
    • 0028979703 scopus 로고
    • Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice
    • Flynn J.L., Goldstein M.M., Chan J., Triebold K.J., Pfeffer K., Lowenstein C.J., et al. Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity 2 (1995) 561-572
    • (1995) Immunity , vol.2 , pp. 561-572
    • Flynn, J.L.1    Goldstein, M.M.2    Chan, J.3    Triebold, K.J.4    Pfeffer, K.5    Lowenstein, C.J.6
  • 8
    • 0026039673 scopus 로고
    • Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis
    • Keffer J., Probert L., Cazlaris H., Georgopoulos S., Kaslaris E., Kioussis D., et al. Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J 10 (1991) 4025-4031
    • (1991) EMBO J , vol.10 , pp. 4025-4031
    • Keffer, J.1    Probert, L.2    Cazlaris, H.3    Georgopoulos, S.4    Kaslaris, E.5    Kioussis, D.6
  • 9
    • 0031916192 scopus 로고    scopus 로고
    • TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination
    • Liu J., Marino M.W., Wong G., Grail D., Dunn A., Bettadapura J., et al. TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination. Nat Med 4 (1998) 78-83
    • (1998) Nat Med , vol.4 , pp. 78-83
    • Liu, J.1    Marino, M.W.2    Wong, G.3    Grail, D.4    Dunn, A.5    Bettadapura, J.6
  • 11
    • 0029989339 scopus 로고    scopus 로고
    • Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response
    • Pasparakis M., Alexopoulou L., Episkopou V., and Kollias G. Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J Exp Med 184 (1996) 1397-1411
    • (1996) J Exp Med , vol.184 , pp. 1397-1411
    • Pasparakis, M.1    Alexopoulou, L.2    Episkopou, V.3    Kollias, G.4
  • 12
    • 0031985413 scopus 로고    scopus 로고
    • TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation
    • Peschon J.J., Torrance D.S., Stocking K.L., Glaccum M.B., Otten C., Willis C.R., et al. TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J Immunol 160 (1998) 943-952
    • (1998) J Immunol , vol.160 , pp. 943-952
    • Peschon, J.J.1    Torrance, D.S.2    Stocking, K.L.3    Glaccum, M.B.4    Otten, C.5    Willis, C.R.6
  • 14
    • 17044383352 scopus 로고    scopus 로고
    • TNF pathophysiology in murine models of chronic inflammation and autoimmunity
    • Kollias G. TNF pathophysiology in murine models of chronic inflammation and autoimmunity. Semin Arthritis Rheum 34 (2005) 3-6
    • (2005) Semin Arthritis Rheum , vol.34 , pp. 3-6
    • Kollias, G.1
  • 15
    • 0035056003 scopus 로고    scopus 로고
    • Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?
    • Feldmann M., and Maini R.N. Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?. Annu Rev Immunol 19 (2001) 163-196
    • (2001) Annu Rev Immunol , vol.19 , pp. 163-196
    • Feldmann, M.1    Maini, R.N.2
  • 16
    • 0022992590 scopus 로고
    • Cachectin: the dark side of tumor necrosis factor
    • Cerami A., and Beutler B. Cachectin: the dark side of tumor necrosis factor. Cold Spring Harb Symp Quant Biol 51 Pt 1 (1986) 625-629
    • (1986) Cold Spring Harb Symp Quant Biol , vol.51 , Issue.PART 1 , pp. 625-629
    • Cerami, A.1    Beutler, B.2
  • 17
    • 0036694562 scopus 로고    scopus 로고
    • Role of TNF/TNFR in autoimmunity: specific TNF receptor blockade may be advantageous to anti-TNF treatments
    • Kollias G., and Kontoyiannis D. Role of TNF/TNFR in autoimmunity: specific TNF receptor blockade may be advantageous to anti-TNF treatments. Cytokine Growth Factor Rev. 13 (2002) 315-321
    • (2002) Cytokine Growth Factor Rev. , vol.13 , pp. 315-321
    • Kollias, G.1    Kontoyiannis, D.2
  • 18
    • 34548648099 scopus 로고    scopus 로고
    • The use of TNF-alpha blocking agents in rheumatoid arthritis: an update
    • Toussirot E., and Wendling D. The use of TNF-alpha blocking agents in rheumatoid arthritis: an update. Expert Opin Pharmacother 8 (2007) 2089-2107
    • (2007) Expert Opin Pharmacother , vol.8 , pp. 2089-2107
    • Toussirot, E.1    Wendling, D.2
  • 19
    • 0027297663 scopus 로고
    • Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection
    • Pfeffer K., Matsuyama T., Kundig T.M., Wakeham A., Kishihara K., Shahinian A., et al. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 73 (1993) 457-467
    • (1993) Cell , vol.73 , pp. 457-467
    • Pfeffer, K.1    Matsuyama, T.2    Kundig, T.M.3    Wakeham, A.4    Kishihara, K.5    Shahinian, A.6
  • 20
    • 0027327619 scopus 로고
    • Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes
    • Rothe J., Lesslauer W., Lotscher H., Lang Y., Koebel P., Kontgen F., et al. Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes. Nature 364 (1993) 798-802
    • (1993) Nature , vol.364 , pp. 798-802
    • Rothe, J.1    Lesslauer, W.2    Lotscher, H.3    Lang, Y.4    Koebel, P.5    Kontgen, F.6
  • 22
    • 0027415109 scopus 로고
    • Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface
    • Browning J.L., Ngam-ek A., Lawton P., DeMarinis J., Tizard R., Chow E.P., et al. Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface. Cell 72 (1993) 847-856
    • (1993) Cell , vol.72 , pp. 847-856
    • Browning, J.L.1    Ngam-ek, A.2    Lawton, P.3    DeMarinis, J.4    Tizard, R.5    Chow, E.P.6
  • 24
    • 0028277665 scopus 로고
    • Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin
    • De Togni P., Goellner J., Ruddle N.H., Streeter P.R., Fick A., Mariathasan S., et al. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science 264 (1994) 703-707
    • (1994) Science , vol.264 , pp. 703-707
    • De Togni, P.1    Goellner, J.2    Ruddle, N.H.3    Streeter, P.R.4    Fick, A.5    Mariathasan, S.6
  • 25
    • 0031931573 scopus 로고    scopus 로고
    • Differential activities of secreted lymphotoxin-alpha3 and membrane lymphotoxin-alpha1beta2 in lymphotoxin-induced inflammation: critical role of TNF receptor 1 signaling
    • Sacca R., Cuff C.A., Lesslauer W., and Ruddle N.H. Differential activities of secreted lymphotoxin-alpha3 and membrane lymphotoxin-alpha1beta2 in lymphotoxin-induced inflammation: critical role of TNF receptor 1 signaling. J Immunol 160 (1998) 485-491
    • (1998) J Immunol , vol.160 , pp. 485-491
    • Sacca, R.1    Cuff, C.A.2    Lesslauer, W.3    Ruddle, N.H.4
  • 26
    • 0038917435 scopus 로고    scopus 로고
    • Critical points of tumor necrosis factor action in central nervous system autoimmune inflammation defined by gene targeting
    • Korner H., Riminton D.S., Strickland D.H., Lemckert F.A., Pollard J.D., and Sedgwick J.D. Critical points of tumor necrosis factor action in central nervous system autoimmune inflammation defined by gene targeting. J Exp Med 186 (1997) 1585-1590
    • (1997) J Exp Med , vol.186 , pp. 1585-1590
    • Korner, H.1    Riminton, D.S.2    Strickland, D.H.3    Lemckert, F.A.4    Pollard, J.D.5    Sedgwick, J.D.6
  • 28
    • 0031445985 scopus 로고    scopus 로고
    • Failure of germinal center formation and impairment of response to endotoxin in tumor necrosis factor alpha-deficient mice
    • Taniguchi T., Takata M., Ikeda A., Momotani E., and Sekikawa K. Failure of germinal center formation and impairment of response to endotoxin in tumor necrosis factor alpha-deficient mice. Lab Invest 77 (1997) 647-658
    • (1997) Lab Invest , vol.77 , pp. 647-658
    • Taniguchi, T.1    Takata, M.2    Ikeda, A.3    Momotani, E.4    Sekikawa, K.5
  • 29
    • 13344295091 scopus 로고    scopus 로고
    • Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-alpha double-deficient mice
    • Eugster H.P., Muller M., Karrer U., Car B.D., Schnyder B., Eng V.M., et al. Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-alpha double-deficient mice. Int Immunol 8 (1996) 23-36
    • (1996) Int Immunol , vol.8 , pp. 23-36
    • Eugster, H.P.1    Muller, M.2    Karrer, U.3    Car, B.D.4    Schnyder, B.5    Eng, V.M.6
  • 30
    • 0030454014 scopus 로고    scopus 로고
    • Abnormal organisation of the splenic marginal zone and the correlated leukocytosis in lymphotoxin-alpha and tumor necrosis factor alpha double deficient mice
    • Amiot F., Bellkaid Y., Lebastard M., Ave P., Dautry F., and Milon G. Abnormal organisation of the splenic marginal zone and the correlated leukocytosis in lymphotoxin-alpha and tumor necrosis factor alpha double deficient mice. Eur Cytokine Netw 7 (1996) 733-739
    • (1996) Eur Cytokine Netw , vol.7 , pp. 733-739
    • Amiot, F.1    Bellkaid, Y.2    Lebastard, M.3    Ave, P.4    Dautry, F.5    Milon, G.6
  • 31
    • 0042631675 scopus 로고    scopus 로고
    • Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue
    • Korner H., Cook M., Riminton D.S., Lemckert F.A., Hoek R.M., Ledermann B., et al. Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. Eur J Immunol 27 (1997) 2600-2609
    • (1997) Eur J Immunol , vol.27 , pp. 2600-2609
    • Korner, H.1    Cook, M.2    Riminton, D.S.3    Lemckert, F.A.4    Hoek, R.M.5    Ledermann, B.6
  • 32
    • 0032759847 scopus 로고    scopus 로고
    • TNF and lymphotoxin beta cooperate in the maintenance of secondary lymphoid tissue microarchitecture but not in the development of lymph nodes
    • Kuprash D.V., Alimzhanov M.B., Tumanov A.V., Anderson A.O., Pfeffer K., and Nedospasov S.A. TNF and lymphotoxin beta cooperate in the maintenance of secondary lymphoid tissue microarchitecture but not in the development of lymph nodes. J Immunol 163 (1999) 6575-6580
    • (1999) J Immunol , vol.163 , pp. 6575-6580
    • Kuprash, D.V.1    Alimzhanov, M.B.2    Tumanov, A.V.3    Anderson, A.O.4    Pfeffer, K.5    Nedospasov, S.A.6
  • 33
    • 18744387205 scopus 로고    scopus 로고
    • Redundancy in tumor necrosis factor (TNF) and lymphotoxin (LT) signaling in vivo: mice with inactivation of the entire TNF/LT locus versus single-knockout mice
    • Kuprash D.V., Alimzhanov M.B., Tumanov A.V., Grivennikov S.I., Shakhov A.N., Drutskaya L.N., et al. Redundancy in tumor necrosis factor (TNF) and lymphotoxin (LT) signaling in vivo: mice with inactivation of the entire TNF/LT locus versus single-knockout mice. Mol Cell Biol 22 (2002) 8626-8634
    • (2002) Mol Cell Biol , vol.22 , pp. 8626-8634
    • Kuprash, D.V.1    Alimzhanov, M.B.2    Tumanov, A.V.3    Grivennikov, S.I.4    Shakhov, A.N.5    Drutskaya, L.N.6
  • 34
    • 0032476621 scopus 로고    scopus 로고
    • An essential role for tumor necrosis factor in natural killer cell-mediated tumor rejection in the peritoneum
    • Smyth M.J., Kelly J.M., Baxter A.G., Korner H., and Sedgwick J.D. An essential role for tumor necrosis factor in natural killer cell-mediated tumor rejection in the peritoneum. J Exp Med 188 (1998) 1611-1619
    • (1998) J Exp Med , vol.188 , pp. 1611-1619
    • Smyth, M.J.1    Kelly, J.M.2    Baxter, A.G.3    Korner, H.4    Sedgwick, J.D.5
  • 35
    • 0032983865 scopus 로고    scopus 로고
    • Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis
    • Moore R.J., Owens D.M., Stamp G., Arnott C., Burke F., East N., et al. Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis. Nat Med 5 (1999) 828-831
    • (1999) Nat Med , vol.5 , pp. 828-831
    • Moore, R.J.1    Owens, D.M.2    Stamp, G.3    Arnott, C.4    Burke, F.5    East, N.6
  • 36
    • 0033568358 scopus 로고    scopus 로고
    • Essential role of tumor necrosis factor alpha (TNF-alpha) in tumor promotion as revealed by TNF-alpha-deficient mice
    • Suganuma M., Okabe S., Marino M.W., Sakai A., Sueoka E., and Fujiki H. Essential role of tumor necrosis factor alpha (TNF-alpha) in tumor promotion as revealed by TNF-alpha-deficient mice. Cancer Res 59 (1999) 4516-4518
    • (1999) Cancer Res , vol.59 , pp. 4516-4518
    • Suganuma, M.1    Okabe, S.2    Marino, M.W.3    Sakai, A.4    Sueoka, E.5    Fujiki, H.6
  • 37
    • 36448978124 scopus 로고    scopus 로고
    • TNF-alpha is critical for antitumor but not antiviral T cell immunity in mice
    • Calzascia T., Pellegrini M., Hall H., Sabbagh L., Ono N., Elford A.R., et al. TNF-alpha is critical for antitumor but not antiviral T cell immunity in mice. J Clin Invest 117 (2007) 3833-3845
    • (2007) J Clin Invest , vol.117 , pp. 3833-3845
    • Calzascia, T.1    Pellegrini, M.2    Hall, H.3    Sabbagh, L.4    Ono, N.5    Elford, A.R.6
  • 38
    • 0028063303 scopus 로고
    • Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice
    • Erickson S.L., de Sauvage F.J., Kikly K., Carver-Moore K., Pitts-Meek S., Gillett N., et al. Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice. Nature 372 (1994) 560-563
    • (1994) Nature , vol.372 , pp. 560-563
    • Erickson, S.L.1    de Sauvage, F.J.2    Kikly, K.3    Carver-Moore, K.4    Pitts-Meek, S.5    Gillett, N.6
  • 39
    • 0028866022 scopus 로고
    • The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor
    • Grell M., Douni E., Wajant H., Lohden M., Clauss M., Maxeiner B., et al. The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. Cell 83 (1995) 793-802
    • (1995) Cell , vol.83 , pp. 793-802
    • Grell, M.1    Douni, E.2    Wajant, H.3    Lohden, M.4    Clauss, M.5    Maxeiner, B.6
  • 40
    • 34250864955 scopus 로고    scopus 로고
    • Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells
    • Chen X., Baumel M., Mannel D.N., Howard O.M., and Oppenheim J.J. Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells. J Immunol 179 (2007) 154-161
    • (2007) J Immunol , vol.179 , pp. 154-161
    • Chen, X.1    Baumel, M.2    Mannel, D.N.3    Howard, O.M.4    Oppenheim, J.J.5
  • 41
    • 0031974459 scopus 로고    scopus 로고
    • TNF receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1
    • Grell M., Becke F.M., Wajant H., Mannel D.N., and Scheurich P. TNF receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1. Eur J Immunol 28 (1998) 257-263
    • (1998) Eur J Immunol , vol.28 , pp. 257-263
    • Grell, M.1    Becke, F.M.2    Wajant, H.3    Mannel, D.N.4    Scheurich, P.5
  • 42
    • 0035892888 scopus 로고    scopus 로고
    • TNF type 2 receptor (p75) lowers the threshold of T cell activation
    • Kim E.Y., and Teh H.S. TNF type 2 receptor (p75) lowers the threshold of T cell activation. J Immunol 167 (2001) 6812-6820
    • (2001) J Immunol , vol.167 , pp. 6812-6820
    • Kim, E.Y.1    Teh, H.S.2
  • 43
    • 0032055981 scopus 로고    scopus 로고
    • Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis, nuclear factor-kappa B activation, and c-Jun kinase activation
    • Haridas V., Darnay B.G., Natarajan K., Heller R., and Aggarwal B.B. Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis, nuclear factor-kappa B activation, and c-Jun kinase activation. J Immunol 160 (1998) 3152-3162
    • (1998) J Immunol , vol.160 , pp. 3152-3162
    • Haridas, V.1    Darnay, B.G.2    Natarajan, K.3    Heller, R.4    Aggarwal, B.B.5
  • 44
    • 30744461133 scopus 로고    scopus 로고
    • TNF receptor type 2 (p75) functions as a costimulator for antigen-driven T cell responses in vivo
    • Kim E.Y., Priatel J.J., Teh S.J., and Teh H.S. TNF receptor type 2 (p75) functions as a costimulator for antigen-driven T cell responses in vivo. J Immunol 176 (2006) 1026-1035
    • (2006) J Immunol , vol.176 , pp. 1026-1035
    • Kim, E.Y.1    Priatel, J.J.2    Teh, S.J.3    Teh, H.S.4
  • 45
    • 0026768768 scopus 로고
    • Functional characterization of the human tumor necrosis factor receptor p75 in a transfected rat/mouse T cell hybridoma
    • Vandenabeele P., Declercq W., Vercammen D., van de C.M., Grooten J., Loetscher H., et al. Functional characterization of the human tumor necrosis factor receptor p75 in a transfected rat/mouse T cell hybridoma. J Exp Med 176 (1992) 1015-1024
    • (1992) J Exp Med , vol.176 , pp. 1015-1024
    • Vandenabeele, P.1    Declercq, W.2    Vercammen, D.3    van de, C.M.4    Grooten, J.5    Loetscher, H.6
  • 46
    • 0344496062 scopus 로고    scopus 로고
    • Ikkbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha
    • Maeda S., Chang L., Li Z.W., Luo J.L., Leffert H., and Karin M. Ikkbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha. Immunity 19 (2003) 725-737
    • (2003) Immunity , vol.19 , pp. 725-737
    • Maeda, S.1    Chang, L.2    Li, Z.W.3    Luo, J.L.4    Leffert, H.5    Karin, M.6
  • 47
    • 0035863941 scopus 로고    scopus 로고
    • TNF-alpha-induced expression of adhesion molecules in the liver is under the control of TNFR1-relevance for concanavalin A-induced hepatitis
    • Wolf D., Hallmann R., Sass G., Sixt M., Kusters S., Fregien B., et al. TNF-alpha-induced expression of adhesion molecules in the liver is under the control of TNFR1-relevance for concanavalin A-induced hepatitis. J Immunol 166 (2001) 1300-1307
    • (2001) J Immunol , vol.166 , pp. 1300-1307
    • Wolf, D.1    Hallmann, R.2    Sass, G.3    Sixt, M.4    Kusters, S.5    Fregien, B.6
  • 48
    • 0027275490 scopus 로고
    • A novel domain within the 55 kDa TNF receptor signals cell death
    • Tartaglia L.A., Ayres T.M., Wong G.H., and Goeddel D.V. A novel domain within the 55 kDa TNF receptor signals cell death. Cell 74 (1993) 845-853
    • (1993) Cell , vol.74 , pp. 845-853
    • Tartaglia, L.A.1    Ayres, T.M.2    Wong, G.H.3    Goeddel, D.V.4
  • 49
    • 0027301244 scopus 로고
    • Ligand passing: the 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor
    • Tartaglia L.A., Pennica D., and Goeddel D.V. Ligand passing: the 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor. J Biol Chem 268 (1993) 18542-18548
    • (1993) J Biol Chem , vol.268 , pp. 18542-18548
    • Tartaglia, L.A.1    Pennica, D.2    Goeddel, D.V.3
  • 50
    • 0037149542 scopus 로고    scopus 로고
    • TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
    • Li X., Yang Y., and Ashwell J.D. TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Nature 416 (2002) 345-347
    • (2002) Nature , vol.416 , pp. 345-347
    • Li, X.1    Yang, Y.2    Ashwell, J.D.3
  • 51
    • 15644382222 scopus 로고    scopus 로고
    • Crucial role of tumor necrosis factor (TNF) receptor 2 and membrane-bound TNF in experimental cerebral malaria
    • Lucas R., Juillard P., Decoster E., Redard M., Burger D., Donati Y., et al. Crucial role of tumor necrosis factor (TNF) receptor 2 and membrane-bound TNF in experimental cerebral malaria. Eur J Immunol 27 (1997) 1719-1725
    • (1997) Eur J Immunol , vol.27 , pp. 1719-1725
    • Lucas, R.1    Juillard, P.2    Decoster, E.3    Redard, M.4    Burger, D.5    Donati, Y.6
  • 52
    • 8044257704 scopus 로고    scopus 로고
    • A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells
    • Black R.A., Rauch C.T., Kozlosky C.J., Peschon J.J., Slack J.L., Wolfson M.F., et al. A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature 385 (1997) 729-733
    • (1997) Nature , vol.385 , pp. 729-733
    • Black, R.A.1    Rauch, C.T.2    Kozlosky, C.J.3    Peschon, J.J.4    Slack, J.L.5    Wolfson, M.F.6
  • 53
    • 0032846604 scopus 로고    scopus 로고
    • Cutting edge: a dominant negative form of TNF-alpha converting enzyme inhibits proTNF and TNFRII secretion
    • Solomon K.A., Pesti N., Wu G., and Newton R.C. Cutting edge: a dominant negative form of TNF-alpha converting enzyme inhibits proTNF and TNFRII secretion. J Immunol 163 (1999) 4105-4108
    • (1999) J Immunol , vol.163 , pp. 4105-4108
    • Solomon, K.A.1    Pesti, N.2    Wu, G.3    Newton, R.C.4
  • 54
    • 19944432071 scopus 로고    scopus 로고
    • Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects
    • Grivennikov S.I., Tumanov A.V., Liepinsh D.J., Kruglov A.A., Marakusha B.I., Shakhov A.N., et al. Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects. Immunity 22 (2005) 93-104
    • (2005) Immunity , vol.22 , pp. 93-104
    • Grivennikov, S.I.1    Tumanov, A.V.2    Liepinsh, D.J.3    Kruglov, A.A.4    Marakusha, B.I.5    Shakhov, A.N.6
  • 56
    • 0025903905 scopus 로고
    • Tumor necrosis factor alpha mediates lethal activity of killed gram-negative and gram-positive bacteria in d-galactosamine-treated mice
    • Freudenberg M.A., and Galanos C. Tumor necrosis factor alpha mediates lethal activity of killed gram-negative and gram-positive bacteria in d-galactosamine-treated mice. Infect Immun 59 (1991) 2110-2115
    • (1991) Infect Immun , vol.59 , pp. 2110-2115
    • Freudenberg, M.A.1    Galanos, C.2
  • 57
    • 0023175468 scopus 로고
    • Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and d-galactosamine-treated mice
    • Lehmann V., Freudenberg M.A., and Galanos C. Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and d-galactosamine-treated mice. J Exp Med 165 (1987) 657-663
    • (1987) J Exp Med , vol.165 , pp. 657-663
    • Lehmann, V.1    Freudenberg, M.A.2    Galanos, C.3
  • 58
    • 17944381638 scopus 로고    scopus 로고
    • Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation
    • Ruuls S.R., Hoek R.M., Ngo V.N., McNeil T., Lucian L.A., Janatpour M.J., et al. Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation. Immunity 15 (2001) 533-543
    • (2001) Immunity , vol.15 , pp. 533-543
    • Ruuls, S.R.1    Hoek, R.M.2    Ngo, V.N.3    McNeil, T.4    Lucian, L.A.5    Janatpour, M.J.6
  • 59
    • 33750269857 scopus 로고    scopus 로고
    • Transmembrane TNF protects mutant mice against intracellular bacterial infections, chronic inflammation and autoimmunity
    • Alexopoulou L., Kranidioti K., Xanthoulea S., Denis M., Kotanidou A., Douni E., et al. Transmembrane TNF protects mutant mice against intracellular bacterial infections, chronic inflammation and autoimmunity. Eur J Immunol 36 (2006) 2768-2780
    • (2006) Eur J Immunol , vol.36 , pp. 2768-2780
    • Alexopoulou, L.1    Kranidioti, K.2    Xanthoulea, S.3    Denis, M.4    Kotanidou, A.5    Douni, E.6
  • 60
    • 0026596020 scopus 로고
    • T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor
    • Miethke T., Wahl C., Heeg K., Echtenacher B., Krammer P.H., and Wagner H. T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor. J Exp Med 175 (1992) 91-98
    • (1992) J Exp Med , vol.175 , pp. 91-98
    • Miethke, T.1    Wahl, C.2    Heeg, K.3    Echtenacher, B.4    Krammer, P.H.5    Wagner, H.6
  • 61
    • 0024504495 scopus 로고
    • Toxic shock syndrome-associated staphylococcal and streptococcal pyrogenic toxins are potent inducers of tumor necrosis factor production
    • Fast D.J., Schlievert P.M., and Nelson R.D. Toxic shock syndrome-associated staphylococcal and streptococcal pyrogenic toxins are potent inducers of tumor necrosis factor production. Infect Immun 57 (1989) 291-294
    • (1989) Infect Immun , vol.57 , pp. 291-294
    • Fast, D.J.1    Schlievert, P.M.2    Nelson, R.D.3
  • 62
    • 0027431885 scopus 로고
    • Distribution and kinetics of superantigen-induced cytokine gene expression in mouse spleen
    • Bette M., Schafer M.K., van Rooijen N., Weihe E., and Fleischer B. Distribution and kinetics of superantigen-induced cytokine gene expression in mouse spleen. J Exp Med 178 (1993) 1531-1539
    • (1993) J Exp Med , vol.178 , pp. 1531-1539
    • Bette, M.1    Schafer, M.K.2    van Rooijen, N.3    Weihe, E.4    Fleischer, B.5
  • 63
    • 33646941874 scopus 로고    scopus 로고
    • Differential requirements for soluble and transmembrane tumor necrosis factor in the immunological control of primary and secondary Listeria monocytogenes infection
    • Musicki K., Briscoe H., Tran S., Britton W.J., and Saunders B.M. Differential requirements for soluble and transmembrane tumor necrosis factor in the immunological control of primary and secondary Listeria monocytogenes infection. Infect Immun 74 (2006) 3180-3189
    • (2006) Infect Immun , vol.74 , pp. 3180-3189
    • Musicki, K.1    Briscoe, H.2    Tran, S.3    Britton, W.J.4    Saunders, B.M.5
  • 65
    • 34548394502 scopus 로고    scopus 로고
    • Memory CD8+ T cells mediate antibacterial immunity via CCL3 activation of TNF/ROI+ phagocytes
    • Narni-Mancinelli E., Campisi L., Bassand D., Cazareth J., Gounon P., Glaichenhaus N., et al. Memory CD8+ T cells mediate antibacterial immunity via CCL3 activation of TNF/ROI+ phagocytes. J Exp Med 204 (2007) 2075-2087
    • (2007) J Exp Med , vol.204 , pp. 2075-2087
    • Narni-Mancinelli, E.1    Campisi, L.2    Bassand, D.3    Cazareth, J.4    Gounon, P.5    Glaichenhaus, N.6
  • 66
    • 0037625155 scopus 로고    scopus 로고
    • TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection
    • Serbina N.V., Salazar-Mather T.P., Biron C.A., Kuziel W.A., and Pamer E.G. TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection. Immunity 19 (2003) 59-70
    • (2003) Immunity , vol.19 , pp. 59-70
    • Serbina, N.V.1    Salazar-Mather, T.P.2    Biron, C.A.3    Kuziel, W.A.4    Pamer, E.G.5
  • 67
    • 39549089300 scopus 로고    scopus 로고
    • Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases
    • Armaka M., Apostolaki M., Jacques P., Kontoyiannis D.L., Elewaut D., and Kollias G. Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases. J Exp Med 205 (2008) 331-337
    • (2008) J Exp Med , vol.205 , pp. 331-337
    • Armaka, M.1    Apostolaki, M.2    Jacques, P.3    Kontoyiannis, D.L.4    Elewaut, D.5    Kollias, G.6
  • 68
    • 0037442019 scopus 로고    scopus 로고
    • Parenchymal, but not leukocyte TNF receptor 2 mediates T cell-dependent hepatitis in mice
    • Schumann J., Muhlen K., Kiemer A.K., Vollmar A.M., and Tiegs G. Parenchymal, but not leukocyte TNF receptor 2 mediates T cell-dependent hepatitis in mice. J Immunol 170 (2003) 2129-2137
    • (2003) J Immunol , vol.170 , pp. 2129-2137
    • Schumann, J.1    Muhlen, K.2    Kiemer, A.K.3    Vollmar, A.M.4    Tiegs, G.5
  • 69
    • 0343505811 scopus 로고    scopus 로고
    • In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis
    • Kusters S., Tiegs G., Alexopoulou L., Pasparakis M., Douni E., Kunstle G., et al. In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis. Eur J Immunol 27 (1997) 2870-2875
    • (1997) Eur J Immunol , vol.27 , pp. 2870-2875
    • Kusters, S.1    Tiegs, G.2    Alexopoulou, L.3    Pasparakis, M.4    Douni, E.5    Kunstle, G.6
  • 70
    • 0347994956 scopus 로고    scopus 로고
    • Essential role for neutrophil recruitment to the liver in concanavalin A-induced hepatitis
    • Bonder C.S., Ajuebor M.N., Zbytnuik L.D., Kubes P., and Swain M.G. Essential role for neutrophil recruitment to the liver in concanavalin A-induced hepatitis. J Immunol 172 (2004) 45-53
    • (2004) J Immunol , vol.172 , pp. 45-53
    • Bonder, C.S.1    Ajuebor, M.N.2    Zbytnuik, L.D.3    Kubes, P.4    Swain, M.G.5
  • 71
    • 17044409102 scopus 로고    scopus 로고
    • Natural killer T cells: rapid responders controlling immunity and disease
    • Mercer J.C., Ragin M.J., and August A. Natural killer T cells: rapid responders controlling immunity and disease. Int J Biochem Cell Biol 37 (2005) 1337-1343
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 1337-1343
    • Mercer, J.C.1    Ragin, M.J.2    August, A.3
  • 72
    • 0030018413 scopus 로고    scopus 로고
    • Defective Peyer's patch organogenesis in mice lacking the 55-kDa receptor for tumor necrosis factor
    • Neumann B., Luz A., Pfeffer K., and Holzmann B. Defective Peyer's patch organogenesis in mice lacking the 55-kDa receptor for tumor necrosis factor. J Exp Med 184 (1996) 259-264
    • (1996) J Exp Med , vol.184 , pp. 259-264
    • Neumann, B.1    Luz, A.2    Pfeffer, K.3    Holzmann, B.4
  • 73
    • 0031984960 scopus 로고    scopus 로고
    • Essential role of IL-7 receptor alpha in the formation of Peyer's patch anlage
    • Adachi S., Yoshida H., Honda K., Maki K., Saijo K., Ikuta K., et al. Essential role of IL-7 receptor alpha in the formation of Peyer's patch anlage. Int Immunol 10 (1998) 1-6
    • (1998) Int Immunol , vol.10 , pp. 1-6
    • Adachi, S.1    Yoshida, H.2    Honda, K.3    Maki, K.4    Saijo, K.5    Ikuta, K.6
  • 74
    • 0346496018 scopus 로고    scopus 로고
    • An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells
    • Eberl G., Marmon S., Sunshine M.J., Rennert P.D., Choi Y., and Littman D.R. An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat Immunol 5 (2004) 64-73
    • (2004) Nat Immunol , vol.5 , pp. 64-73
    • Eberl, G.1    Marmon, S.2    Sunshine, M.J.3    Rennert, P.D.4    Choi, Y.5    Littman, D.R.6
  • 75
    • 0037978900 scopus 로고    scopus 로고
    • Organogenesis of lymphoid tissues
    • Mebius R.E. Organogenesis of lymphoid tissues. Nat Rev Immunol 3 (2003) 292-303
    • (2003) Nat Rev Immunol , vol.3 , pp. 292-303
    • Mebius, R.E.1
  • 76
    • 34248573325 scopus 로고    scopus 로고
    • Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells
    • Meier D., Bornmann C., Chappaz S., Schmutz S., Otten L.A., Ceredig R., et al. Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells. Immunity 26 (2007) 643-654
    • (2007) Immunity , vol.26 , pp. 643-654
    • Meier, D.1    Bornmann, C.2    Chappaz, S.3    Schmutz, S.4    Otten, L.A.5    Ceredig, R.6
  • 77
    • 0032956866 scopus 로고    scopus 로고
    • IL-7 receptor alpha+ CD3(-) cells in the embryonic intestine induces the organizing center of Peyer's patches
    • Yoshida H., Honda K., Shinkura R., Adachi S., Nishikawa S., Maki K., et al. IL-7 receptor alpha+ CD3(-) cells in the embryonic intestine induces the organizing center of Peyer's patches. Int Immunol 11 (1999) 643-655
    • (1999) Int Immunol , vol.11 , pp. 643-655
    • Yoshida, H.1    Honda, K.2    Shinkura, R.3    Adachi, S.4    Nishikawa, S.5    Maki, K.6
  • 78
    • 2942737209 scopus 로고    scopus 로고
    • Lymphotoxin and TNF produced by B cells are dispensable for maintenance of the follicle-associated epithelium but are required for development of lymphoid follicles in the Peyer's patches
    • Tumanov A.V., Kuprash D.V., Mach J.A., Nedospasov S.A., and Chervonsky A.V. Lymphotoxin and TNF produced by B cells are dispensable for maintenance of the follicle-associated epithelium but are required for development of lymphoid follicles in the Peyer's patches. J Immunol 173 (2004) 86-91
    • (2004) J Immunol , vol.173 , pp. 86-91
    • Tumanov, A.V.1    Kuprash, D.V.2    Mach, J.A.3    Nedospasov, S.A.4    Chervonsky, A.V.5
  • 79
    • 0033521542 scopus 로고    scopus 로고
    • Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells
    • Endres R., Alimzhanov M.B., Plitz T., Futterer A., Kosco-Vilbois M.H., Nedospasov S.A., et al. Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells. J Exp Med 189 (1999) 159-168
    • (1999) J Exp Med , vol.189 , pp. 159-168
    • Endres, R.1    Alimzhanov, M.B.2    Plitz, T.3    Futterer, A.4    Kosco-Vilbois, M.H.5    Nedospasov, S.A.6
  • 80
    • 0035164357 scopus 로고    scopus 로고
    • Complementary effects of TNF and lymphotoxin on the formation of germinal center and follicular dendritic cells
    • Wang Y., Wang J., Sun Y., Wu Q., and Fu Y.X. Complementary effects of TNF and lymphotoxin on the formation of germinal center and follicular dendritic cells. J Immunol 166 (2001) 330-337
    • (2001) J Immunol , vol.166 , pp. 330-337
    • Wang, Y.1    Wang, J.2    Sun, Y.3    Wu, Q.4    Fu, Y.X.5
  • 81
    • 18644366772 scopus 로고    scopus 로고
    • Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues
    • Tumanov A.V., Kuprash D.V., Lagarkova M.A., Grivennikov S.I., Abe K., Shakhov A.N., et al. Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues. Immunity 17 (2002) 239-250
    • (2002) Immunity , vol.17 , pp. 239-250
    • Tumanov, A.V.1    Kuprash, D.V.2    Lagarkova, M.A.3    Grivennikov, S.I.4    Abe, K.5    Shakhov, A.N.6
  • 82
    • 30444457243 scopus 로고    scopus 로고
    • FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses
    • Victoratos P., Lagnel J., Tzima S., Alimzhanov M.B., Rajewsky K., Pasparakis M., et al. FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses. Immunity 24 (2006) 65-77
    • (2006) Immunity , vol.24 , pp. 65-77
    • Victoratos, P.1    Lagnel, J.2    Tzima, S.3    Alimzhanov, M.B.4    Rajewsky, K.5    Pasparakis, M.6
  • 83
    • 0025186678 scopus 로고
    • Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages
    • Shakhov A.N., Collart M.A., Vassalli P., Nedospasov S.A., and Jongeneel C.V. Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages. J Exp Med 171 (1990) 35-47
    • (1990) J Exp Med , vol.171 , pp. 35-47
    • Shakhov, A.N.1    Collart, M.A.2    Vassalli, P.3    Nedospasov, S.A.4    Jongeneel, C.V.5
  • 84
    • 0025098538 scopus 로고
    • Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level
    • [published erratum appears in J Exp Med 1990 Mar 1; 171 3 971-2]
    • Han J., Brown T., and Beutler B. Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level. J Exp Med 171 (1990) 465-475 [published erratum appears in J Exp Med 1990 Mar 1; 171 3 971-2]
    • (1990) J Exp Med , vol.171 , pp. 465-475
    • Han, J.1    Brown, T.2    Beutler, B.3
  • 85
    • 0028983373 scopus 로고
    • Lipopolysaccharide-induced expression of TNF-alpha gene in the macrophage cell line ANA-1 is regulated at the level of transcription processivity
    • Biragyn A., and Nedospasov S.A. Lipopolysaccharide-induced expression of TNF-alpha gene in the macrophage cell line ANA-1 is regulated at the level of transcription processivity. J Immunol 155 (1995) 674-683
    • (1995) J Immunol , vol.155 , pp. 674-683
    • Biragyn, A.1    Nedospasov, S.A.2
  • 86
    • 3543079892 scopus 로고    scopus 로고
    • Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases
    • Xanthoulea S., Pasparakis M., Kousteni S., Brakebusch C., Wallach D., Bauer J., et al. Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases. J Exp Med 200 (2004) 367-376
    • (2004) J Exp Med , vol.200 , pp. 367-376
    • Xanthoulea, S.1    Pasparakis, M.2    Kousteni, S.3    Brakebusch, C.4    Wallach, D.5    Bauer, J.6
  • 87
    • 0027293509 scopus 로고
    • Wasting, ischemia, and lymphoid abnormalities in mice expressing T cell-targeted human tumor necrosis factor transgenes
    • Probert L., Keffer J., Corbella P., Cazlaris H., Patsavoudi E., Stephens S., et al. Wasting, ischemia, and lymphoid abnormalities in mice expressing T cell-targeted human tumor necrosis factor transgenes. J Immunol 151 (1993) 1894-1906
    • (1993) J Immunol , vol.151 , pp. 1894-1906
    • Probert, L.1    Keffer, J.2    Corbella, P.3    Cazlaris, H.4    Patsavoudi, E.5    Stephens, S.6
  • 89
    • 0030639621 scopus 로고    scopus 로고
    • Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice
    • Akassoglou K., Probert L., Kontogeorgos G., and Kollias G. Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice. J Immunol 158 (1997) 438-445
    • (1997) J Immunol , vol.158 , pp. 438-445
    • Akassoglou, K.1    Probert, L.2    Kontogeorgos, G.3    Kollias, G.4
  • 90
    • 0029045458 scopus 로고
    • The type I interleukin-1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF-transgenic mice
    • Probert L., Plows D., Kontogeorgos G., and Kollias G. The type I interleukin-1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF-transgenic mice. Eur J Immunol 25 (1995) 1794-1797
    • (1995) Eur J Immunol , vol.25 , pp. 1794-1797
    • Probert, L.1    Plows, D.2    Kontogeorgos, G.3    Kollias, G.4
  • 92
    • 0033103805 scopus 로고    scopus 로고
    • Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies
    • Kontoyiannis D., Pasparakis M., Pizarro T.T., Cominelli F., and Kollias G. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 10 (1999) 387-398
    • (1999) Immunity , vol.10 , pp. 387-398
    • Kontoyiannis, D.1    Pasparakis, M.2    Pizarro, T.T.3    Cominelli, F.4    Kollias, G.5
  • 95
    • 0023189866 scopus 로고
    • Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria
    • Grau G.E., Fajardo L.F., Piguet P.F., Allet B., Lambert P.H., and Vassalli P. Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria. Science 237 (1987) 1210-1212
    • (1987) Science , vol.237 , pp. 1210-1212
    • Grau, G.E.1    Fajardo, L.F.2    Piguet, P.F.3    Allet, B.4    Lambert, P.H.5    Vassalli, P.6
  • 96
    • 0028864801 scopus 로고
    • Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha
    • Probert L., Akassoglou K., Pasparakis M., Kontogeorgos G., and Kollias G. Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha. Proc Natl Acad Sci USA 92 (1995) 11294-11298
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 11294-11298
    • Probert, L.1    Akassoglou, K.2    Pasparakis, M.3    Kontogeorgos, G.4    Kollias, G.5
  • 97
    • 0032487514 scopus 로고    scopus 로고
    • A critical role of the p75 tumor necrosis factor receptor (p75TNF-R) in organ inflammation independent of TNF, lymphotoxin alpha, or the p55TNF-R
    • Douni E., and Kollias G. A critical role of the p75 tumor necrosis factor receptor (p75TNF-R) in organ inflammation independent of TNF, lymphotoxin alpha, or the p55TNF-R. J Exp Med 188 (1998) 1343-1352
    • (1998) J Exp Med , vol.188 , pp. 1343-1352
    • Douni, E.1    Kollias, G.2
  • 98
    • 0037458017 scopus 로고    scopus 로고
    • Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice
    • Akassoglou K., Douni E., Bauer J., Lassmann H., Kollias G., and Probert L. Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice. Proc Natl Acad Sci USA 100 (2003) 709-714
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 709-714
    • Akassoglou, K.1    Douni, E.2    Bauer, J.3    Lassmann, H.4    Kollias, G.5    Probert, L.6
  • 99
    • 0035960624 scopus 로고    scopus 로고
    • Onset of multiple sclerosis associated with anti-TNF therapy
    • Sicotte N.L., and Voskuhl R.R. Onset of multiple sclerosis associated with anti-TNF therapy. Neurology 57 (2001) 1885-1888
    • (2001) Neurology , vol.57 , pp. 1885-1888
    • Sicotte, N.L.1    Voskuhl, R.R.2
  • 100
    • 0035910751 scopus 로고    scopus 로고
    • Uncoupling the proinflammatory from the immunosuppressive properties of tumor necrosis factor (TNF) at the p55 TNF receptor level: implications for pathogenesis and therapy of autoimmune demyelination
    • Kassiotis G., and Kollias G. Uncoupling the proinflammatory from the immunosuppressive properties of tumor necrosis factor (TNF) at the p55 TNF receptor level: implications for pathogenesis and therapy of autoimmune demyelination. J Exp Med 193 (2001) 427-434
    • (2001) J Exp Med , vol.193 , pp. 427-434
    • Kassiotis, G.1    Kollias, G.2
  • 101
    • 0037121941 scopus 로고    scopus 로고
    • Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease
    • Kontoyiannis D., Boulougouris G., Manoloukos M., Armaka M., Apostolaki M., Pizarro T., et al. Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. J Exp Med 196 (2002) 1563-1574
    • (2002) J Exp Med , vol.196 , pp. 1563-1574
    • Kontoyiannis, D.1    Boulougouris, G.2    Manoloukos, M.3    Armaka, M.4    Apostolaki, M.5    Pizarro, T.6
  • 102
    • 0033571441 scopus 로고    scopus 로고
    • Nonlymphocyte-derived tumor necrosis factor is required for induction of colitis in recombination activating gene (RAG)2(-/-) mice upon transfer of CD4(+)CD45RB(hi) T cells
    • Corazza N., Eichenberger S., Eugster H.P., and Mueller C. Nonlymphocyte-derived tumor necrosis factor is required for induction of colitis in recombination activating gene (RAG)2(-/-) mice upon transfer of CD4(+)CD45RB(hi) T cells. J Exp Med 190 (1999) 1479-1492
    • (1999) J Exp Med , vol.190 , pp. 1479-1492
    • Corazza, N.1    Eichenberger, S.2    Eugster, H.P.3    Mueller, C.4
  • 104
    • 0038730729 scopus 로고    scopus 로고
    • Enhanced intestinal inflammation induced by dextran sulfate sodium in tumor necrosis factor-alpha deficient mice
    • Naito Y., Takagi T., Handa O., Ishikawa T., Nakagawa S., Yamaguchi T., et al. Enhanced intestinal inflammation induced by dextran sulfate sodium in tumor necrosis factor-alpha deficient mice. J Gastroenterol Hepatol 18 (2003) 560-569
    • (2003) J Gastroenterol Hepatol , vol.18 , pp. 560-569
    • Naito, Y.1    Takagi, T.2    Handa, O.3    Ishikawa, T.4    Nakagawa, S.5    Yamaguchi, T.6
  • 105
    • 34848889673 scopus 로고    scopus 로고
    • Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system
    • Garrett W.S., Lord G.M., Punit S., Lugo-Villarino G., Mazmanian S.K., Ito S., et al. Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell 131 (2007) 33-45
    • (2007) Cell , vol.131 , pp. 33-45
    • Garrett, W.S.1    Lord, G.M.2    Punit, S.3    Lugo-Villarino, G.4    Mazmanian, S.K.5    Ito, S.6
  • 106
    • 0034735842 scopus 로고    scopus 로고
    • Infliximab and methotrexate in the treatment of rheumatoid arthritis
    • Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group
    • Lipsky P.E., van der Heijde D.M., St Clair E.W., Furst D.E., Breedveld F.C., Kalden J.R., et al., Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group. Infliximab and methotrexate in the treatment of rheumatoid arthritis. N Engl J Med 343 (2000) 1594-1602
    • (2000) N Engl J Med , vol.343 , pp. 1594-1602
    • Lipsky, P.E.1    van der Heijde, D.M.2    St Clair, E.W.3    Furst, D.E.4    Breedveld, F.C.5    Kalden, J.R.6
  • 107
    • 33744479185 scopus 로고    scopus 로고
    • Long term efficacy and safety of adalimumab plus methotrexate in patients with rheumatoid arthritis: ARMADA 4 year extended study
    • Weinblatt M.E., Keystone E.C., Furst D.E., Kavanaugh A.F., Chartash E.K., and Segurado O.G. Long term efficacy and safety of adalimumab plus methotrexate in patients with rheumatoid arthritis: ARMADA 4 year extended study. Ann Rheum Dis 65 (2006) 753-759
    • (2006) Ann Rheum Dis , vol.65 , pp. 753-759
    • Weinblatt, M.E.1    Keystone, E.C.2    Furst, D.E.3    Kavanaugh, A.F.4    Chartash, E.K.5    Segurado, O.G.6
  • 108
    • 0033611472 scopus 로고    scopus 로고
    • A trial of etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate
    • Weinblatt M.E., Kremer J.M., Bankhurst A.D., Bulpitt K.J., Fleischmann R.M., Fox R.I., et al. A trial of etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate. N Engl J Med 340 (1999) 253-259
    • (1999) N Engl J Med , vol.340 , pp. 253-259
    • Weinblatt, M.E.1    Kremer, J.M.2    Bankhurst, A.D.3    Bulpitt, K.J.4    Fleischmann, R.M.5    Fox, R.I.6
  • 109
    • 23944435859 scopus 로고    scopus 로고
    • The therapeutic potential of tumor necrosis factor for autoimmune disease: a mechanistically based hypothesis
    • Kodama S., Davis M., and Faustman D.L. The therapeutic potential of tumor necrosis factor for autoimmune disease: a mechanistically based hypothesis. Cell Mol Life Sci 62 (2005) 1850-1862
    • (2005) Cell Mol Life Sci , vol.62 , pp. 1850-1862
    • Kodama, S.1    Davis, M.2    Faustman, D.L.3
  • 110
    • 0038772008 scopus 로고    scopus 로고
    • Tumor necrosis factor biology in experimental and clinical arthritis
    • Sfikakis P.P., and Kollias G. Tumor necrosis factor biology in experimental and clinical arthritis. Curr Opin Rheumatol 15 (2003) 380-386
    • (2003) Curr Opin Rheumatol , vol.15 , pp. 380-386
    • Sfikakis, P.P.1    Kollias, G.2
  • 111
    • 0027438710 scopus 로고
    • Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha
    • Elliott M.J., Maini R.N., Feldmann M., Long-Fox A., Charles P., Katsikis P., et al. Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha. Arthritis Rheum 36 (1993) 1681-1690
    • (1993) Arthritis Rheum , vol.36 , pp. 1681-1690
    • Elliott, M.J.1    Maini, R.N.2    Feldmann, M.3    Long-Fox, A.4    Charles, P.5    Katsikis, P.6
  • 112
    • 0030267786 scopus 로고    scopus 로고
    • Attenuation of collagen-induced arthritis in 55-kDa TNF receptor type 1 (TNFR1)-IgG1-treated and TNFR1-deficient mice
    • Mori L., Iselin S., De L.G., and Lesslauer W. Attenuation of collagen-induced arthritis in 55-kDa TNF receptor type 1 (TNFR1)-IgG1-treated and TNFR1-deficient mice. J Immunol 157 (1996) 3178-3182
    • (1996) J Immunol , vol.157 , pp. 3178-3182
    • Mori, L.1    Iselin, S.2    De, L.G.3    Lesslauer, W.4
  • 113
    • 34249007153 scopus 로고    scopus 로고
    • Neutralization of tumor necrosis factor (TNF) by antibody but not TNF receptor fusion molecule exacerbates chronic murine tuberculosis
    • Plessner H.L., Lin P.L., Kohno T., Louie J.S., Kirschner D., Chan J., et al. Neutralization of tumor necrosis factor (TNF) by antibody but not TNF receptor fusion molecule exacerbates chronic murine tuberculosis. J Infect Dis 195 (2007) 1643-1650
    • (2007) J Infect Dis , vol.195 , pp. 1643-1650
    • Plessner, H.L.1    Lin, P.L.2    Kohno, T.3    Louie, J.S.4    Kirschner, D.5    Chan, J.6
  • 115
    • 34548657310 scopus 로고    scopus 로고
    • Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity to infection
    • Zalevsky J., Secher T., Ezhevsky S.A., Janot L., Steed P.M., O'Brien C., et al. Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity to infection. J Immunol 179 (2007) 1872-1883
    • (2007) J Immunol , vol.179 , pp. 1872-1883
    • Zalevsky, J.1    Secher, T.2    Ezhevsky, S.A.3    Janot, L.4    Steed, P.M.5    O'Brien, C.6
  • 117
    • 27144479900 scopus 로고    scopus 로고
    • Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors
    • Deng G.M., Zheng L., Ka-Ming C.F., and Lenardo M. Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors. Nat Med 11 (2005) 1066-1072
    • (2005) Nat Med , vol.11 , pp. 1066-1072
    • Deng, G.M.1    Zheng, L.2    Ka-Ming, C.F.3    Lenardo, M.4
  • 118
    • 39649097890 scopus 로고    scopus 로고
    • Cutting edge: anti-tumor necrosis factor therapy in rheumatoid arthritis inhibits memory B lymphocytes via effects on lymphoid germinal centers and follicular dendritic cell networks
    • Anolik J.H., Ravikumar R., Barnard J., Owen T., Almudevar A., Milner E.C., et al. Cutting edge: anti-tumor necrosis factor therapy in rheumatoid arthritis inhibits memory B lymphocytes via effects on lymphoid germinal centers and follicular dendritic cell networks. J Immunol 180 (2008) 688-692
    • (2008) J Immunol , vol.180 , pp. 688-692
    • Anolik, J.H.1    Ravikumar, R.2    Barnard, J.3    Owen, T.4    Almudevar, A.5    Milner, E.C.6
  • 119
    • 0034651738 scopus 로고    scopus 로고
    • Virulent Mycobacterium tuberculosis strains evade apoptosis of infected alveolar macrophages
    • Keane J., Remold H.G., and Kornfeld H. Virulent Mycobacterium tuberculosis strains evade apoptosis of infected alveolar macrophages. J Immunol 164 (2000) 2016-2020
    • (2000) J Immunol , vol.164 , pp. 2016-2020
    • Keane, J.1    Remold, H.G.2    Kornfeld, H.3
  • 120
    • 0035118698 scopus 로고    scopus 로고
    • Effects of tumor necrosis factor alpha on host immune response in chronic persistent tuberculosis: possible role for limiting pathology
    • Mohan V.P., Scanga C.A., Yu K., Scott H.M., Tanaka K.E., Tsang E., et al. Effects of tumor necrosis factor alpha on host immune response in chronic persistent tuberculosis: possible role for limiting pathology. Infect Immun 69 (2001) 1847-1855
    • (2001) Infect Immun , vol.69 , pp. 1847-1855
    • Mohan, V.P.1    Scanga, C.A.2    Yu, K.3    Scott, H.M.4    Tanaka, K.E.5    Tsang, E.6
  • 121
    • 33746773036 scopus 로고    scopus 로고
    • Tumor-necrosis-factor blockers: differential effects on mycobacterial immunity
    • Saliu O.Y., Sofer C., Stein D.S., Schwander S.K., and Wallis R.S. Tumor-necrosis-factor blockers: differential effects on mycobacterial immunity. J Infect Dis 194 (2006) 486-492
    • (2006) J Infect Dis , vol.194 , pp. 486-492
    • Saliu, O.Y.1    Sofer, C.2    Stein, D.S.3    Schwander, S.K.4    Wallis, R.S.5
  • 122
    • 0033177995 scopus 로고    scopus 로고
    • Conditional gene targeting in macrophages and granulocytes using LysMcre mice
    • Clausen B.E., Burkhardt C., Reith W., Renkawitz R., and Forster I. Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res 8 (1999) 265-277
    • (1999) Transgenic Res , vol.8 , pp. 265-277
    • Clausen, B.E.1    Burkhardt, C.2    Reith, W.3    Renkawitz, R.4    Forster, I.5
  • 123
    • 18244365863 scopus 로고    scopus 로고
    • A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival
    • Lee P.P., Fitzpatrick D.R., Beard C., Jessup H.K., Lehar S., Makar K.W., et al. A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity 15 (2001) 763-774
    • (2001) Immunity , vol.15 , pp. 763-774
    • Lee, P.P.1    Fitzpatrick, D.R.2    Beard, C.3    Jessup, H.K.4    Lehar, S.5    Makar, K.W.6
  • 124
    • 0030818183 scopus 로고    scopus 로고
    • B lymphocyte-specific Cre-mediated mutagenesis in mice
    • Rickert R.C., Roes J., and Rajewsky K. B lymphocyte-specific Cre-mediated mutagenesis in mice. Nucleic Acids Res 25 (1997) 1317-1318
    • (1997) Nucleic Acids Res , vol.25 , pp. 1317-1318
    • Rickert, R.C.1    Roes, J.2    Rajewsky, K.3
  • 125
  • 126
    • 34447275920 scopus 로고    scopus 로고
    • Notch-RBP-J signaling controls the homeostasis of CD8-dendritic cells in the spleen
    • Caton M.L., Smith-Raska M.R., and Reizis B. Notch-RBP-J signaling controls the homeostasis of CD8-dendritic cells in the spleen. J Exp Med 204 (2007) 1653-1664
    • (2007) J Exp Med , vol.204 , pp. 1653-1664
    • Caton, M.L.1    Smith-Raska, M.R.2    Reizis, B.3
  • 127
    • 4043059169 scopus 로고    scopus 로고
    • Tissue-specific and inducible Cre-mediated recombination in the gut epithelium
    • el Marjou F., Janssen K.P., Chang B.H., Li M., Hindie V., Chan L., et al. Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis 39 (2004) 186-193
    • (2004) Genesis , vol.39 , pp. 186-193
    • el Marjou, F.1    Janssen, K.P.2    Chang, B.H.3    Li, M.4    Hindie, V.5    Chan, L.6
  • 128
    • 0033555398 scopus 로고    scopus 로고
    • Mice lacking mature T and B lymphocytes develop arthritic lesions after immunization with type II collagen
    • Plows D., Kontogeorgos G., and Kollias G. Mice lacking mature T and B lymphocytes develop arthritic lesions after immunization with type II collagen. J Immunol 162 (1999) 1018-1023
    • (1999) J Immunol , vol.162 , pp. 1018-1023
    • Plows, D.1    Kontogeorgos, G.2    Kollias, G.3
  • 129
    • 36949020850 scopus 로고    scopus 로고
    • Mast cells initiate early anti-Listeria host defences
    • Gekara N.O., and Weiss S. Mast cells initiate early anti-Listeria host defences. Cell Microbiol 10 (2008) 225-236
    • (2008) Cell Microbiol , vol.10 , pp. 225-236
    • Gekara, N.O.1    Weiss, S.2
  • 130
    • 0029981928 scopus 로고    scopus 로고
    • Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha
    • Malaviya R., Ikeda T., Ross E., and Abraham S.N. Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha. Nature 381 (1996) 77-80
    • (1996) Nature , vol.381 , pp. 77-80
    • Malaviya, R.1    Ikeda, T.2    Ross, E.3    Abraham, S.N.4
  • 132
    • 0029891052 scopus 로고    scopus 로고
    • Transmembrane TNF is sufficient to induce localized tissue toxicity and chronic inflammatory arthritis in transgenic mice
    • Georgopoulos S., Plows D., and Kollias G. Transmembrane TNF is sufficient to induce localized tissue toxicity and chronic inflammatory arthritis in transgenic mice. J Inflamm 46 (1996) 86-97
    • (1996) J Inflamm , vol.46 , pp. 86-97
    • Georgopoulos, S.1    Plows, D.2    Kollias, G.3
  • 133
    • 4444361558 scopus 로고    scopus 로고
    • Transmembrane tumor necrosis factor is a potent inducer of colitis even in the absence of its secreted form
    • Corazza N., Brunner T., Buri C., Rihs S., Imboden M.A., Seibold I., et al. Transmembrane tumor necrosis factor is a potent inducer of colitis even in the absence of its secreted form. Gastroenterology 127 (2004) 816-825
    • (2004) Gastroenterology , vol.127 , pp. 816-825
    • Corazza, N.1    Brunner, T.2    Buri, C.3    Rihs, S.4    Imboden, M.A.5    Seibold, I.6


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