Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease

Gut

Volumn 38, Issue 2, 1996, Pages 216-222

  Daig, R ^a   Andus, T ^a   Aschenbrenner, E ^a   Falk, W ^a   Scholmerich J ^a   Gross, V ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Chemokines; Cytokines; In situ hybridisation; Inflammatory bowel disease; Interleukin 8; Mucosal immunology

Indexed keywords

CHEMOKINE; CYTOKINE; INTERLEUKIN 8; MESSENGER RNA;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; COLON MUCOSA; CONTROLLED STUDY; CROHN DISEASE; ENTERITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOLOGY; IN SITU HYBRIDIZATION; MALE; PRIORITY JOURNAL; ULCERATIVE COLITIS;

ADOLESCENT; ADULT; AGED; BIOPSY; CASE-CONTROL STUDIES; COLITIS, ULCERATIVE; COLON; CROHN DISEASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; HUMANS; IN SITU HYBRIDIZATION; INTERLEUKIN-8; INTESTINAL MUCOSA; MALE; MIDDLE AGED; RNA, MESSENGER;

EID: 0030067724     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.38.2.216     Document Type: Article

References (33)

1. Baggiolini M, Walz A, Kunkel SL. Neutrophil-activating peptide-1/interleukin-8, a novel cytokine that activates neutrophils. J Clin Invest 1989; 84: 1045-9.
2. Yoshimura T, Matsushima K, Tanaka S, Robinson EA, Appella E, Oppenheim JJ, et al. Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines. Proc Natl Acad Sci USA 1987; 84: 9233-7.
3. Schroeder JM, Mrowietz U, Morita E, Christophers E. Purification and partial biochemical characterization of a human monocyte-activating peptide that lacks interleukin-1 activity. J Immunol 1987; 139: 3474-83.
4. Peveri H, Walz A, Dewald B, Baggiolini M. A novel neutrophil-activating factor produced by human mononuclear phagocytes. J Exp Med 1988; 167: 1547-59.
5. Schroeder JM, Christophers E. Secretion of novel and homologous neutrophil-activating peptides by LPS-stimulated human endothelial cells. J Immunol 1989; 142: 244-51.
6. Strieter RM, Phan SH, Showell HJ, Remick DG, Lynch JP, Genord M, et al. Monokine-induced neutrophil chemotactic factor gene expression in human fibroblasts. J Biol Chem 1989; 264: 10621-6.
7. Elner VM, Strieter RM, Elner SG, Baggiolini M, Linley I, Kunkel SL. Neutrophil chemotactic factor (IL-8) gene expression by cytokine-treated retinal pigment epithelial cells. Am J Pathol 1990; 136: 745-50.
8. Schmouder RL, Strieter RM, Wiggrins RC, Chensue SW, Kunkel SL. In vitro and in vivo interleukin-8 production in human renal cortical epithelia. Kidney Int 1992; 41: 191-8.
9. Mukaida N, Shiroo M, Matsushima K. Genomic structure of the human monocyte-derived neutrophil chemotactic factor IL-8. J Immunol 1989; 143: 1366-71.
10. Eckmann L, Jung HC, Schürer-Maly C, Panja A, Morzycka-Wroblewska E, Kagnoff MF. Differential cytokine expression by human intestinal epithelial cell lines: regulated expression of interleukin-8. Gastroenterology 1993; 105: 1698-97.
11. Nguyen HC, Ohno Y, Reinecker HC, Furth EE, MacDermott RP, Rombeau JC. CaCo-2 cells synthesize and secrete increased amounts of interleukin-8 after stimulation by PMA, IL-1, and IL-1. Gastroenterology 1993; 104: A754.
12. Gross V, Andus T, Daig R, Aschenbrenner L, Falk W, Schölmerich J. Protein tyrosine kinase activation is required for induction of IL-8 by IL-1 or TNF in an intestinal epithelial cell line (HT-29). Gastroenterology 1994; 106: A694.
13. Mahida YR, Ceska M, Effenberger F, Kurlak L, Lindley I, Hawkey CJ. Enhanced synthesis of neutrophil-activating peptide-1/interleukin-8 in active ulcerative colitis. Clin Sci 1992; 82: 2173-5.
14. Izzo RS, Witkon K, Chen AI, Hadjiyane C, Weinstein MI, Pellecchia C. Neutrophil-activating peptide (interleukin-8.) in colonic mucosa from patients with Crohn's disease. Scand J Gastroenterol 1993; 28: 296-300.
15. Gross V, Villiger PM, Zhang B, Lotz M. Retinoic acid inhibits interleukin-1-induced cytokine synthesis in human monocytes. J Leukoc Biol 1993; 54: 125-32.
16. Sartor RB. Pathogenetic and clinical relevance of cytokines in inflammatory bowel disease. Immunol Res 1991; 27: 897-906.
17. Schreiber S, Raedler A, Stenson WF, MacDermott RP. The role of the mucosal immune system in inflammatory bowel disease. Gastroenterol Clin North Am 1992; 21: 451-502.
18. Cominelli R, Nast CC, Clark BD, Schindler R, Lierena R, Eysselcin VE, et al. Interleukin-1 (IL-1) gene expression, synthesis, and effect of specific IL-1 receptor blockade in rabbits immune complex colitis. J Clin Invest 1990; 86: 972-80.
19. Brynskov J, Tvede N, Andersen CB, Vilien M. Increased concentrations of interleukin-1, interleukin-2, and soluble interleukin-2 receptor in endoscopical mucosal biopsy specimens with active inflammatory bowel disease. Gut 1992; 33: 55-8.
20. Issues K, Sartor RH, Haskill JS, Cytokine messenger RNA profiles in inflammatory bowel disease mucosa detected by polymerase chain reaction amplification, Gastroenterology 1992; 103; 1587-95.
21. Cominelli F, Nast CC, Duchini A, Lee M. Recombinant interleukin-1 receptor antagonist blocks the proinflammatory activity of endogenous interleukin-1 in rabbit immune colitis. Gastroenterology 1992; 103: 65-71.
22. Pullman WE, Elsbury S, Kobayashi M, Hapel AJ, Doe WF. Einhanced mucosal cytokine production in inflammatory bowel disease. Gastroenterology 1992; 102: 529-37.
23. Mullin GE, Lazenby AJ, Harris ML, Bayless TM, James SP. Increased interleukin-2 messenger RNA in the intestinal mucosal lesions of Crohn's disease but not ulcerative colitis. Gastroenterology 1992; 102: 1620-50.
24. Mahida YR, Kurlac L, Gallagher A, Hawkey CJ. High circulating concentrations of interleukin-6 in active Crohn's disease but not a ulcerative colitis. Gut 1991; 32: 1531-4.
25. Gross V, Andus T, Caesar I, Roth M, Schölmerich J. Evidence for continuous stimulation of interleukin-6 production in Crohn's disease. Gastroenterology 1992; 102: 514-9.
26. Mitsuyama K, Sasaki E, Toyonaga A, Ikeda H, Tsuruta O, Irie A, et al. Colonic mucosal interleukin-6 in inflammatory bowel disease. Digestion 1991; 50: 104-11.
27. Braegger CP, Nicholis S, Murch SH, Stephens S, MacDonald TT. Tumor necrosis factor-α in stool as a marker of intestinal inflammation. Lancet 1992; 339: 89-91.
28. Nixon JB, Riddell RH. Histopathology of ulcerative colitis. In: Allan RN, Keighley MRB, Alexander-Williams J, Hawkins CF, eds. Inflammatory bowel diseases. 2nd ed. Edinburgh: Churchill Livingstone, 1990: 246-62.
29. Thompson H, Histopathology of Crohn's disease. In: Allan RN, Keighley MRB, Alexander-Williams J, Hawkins CF, eds. Inflammatory bowel disease. 2nd ed. Edinburgh: Churchill Livingstone, 1990: 263-85.
30. Mitsuyama K, Toyonaga A, Sasaki E, Watanabe K, Tateishi H, Nishiyama T, et al. IL-8 as an important chemoattractant for neutrophils in ulcerative colitis and Crohn's disease. Clin Exp Immunol 1994; 96: 432-6.
31. Mazzucchelli L, Hauser C, Zgraggen K, Wagner H, Hess M, Laissue JA, et al. Expression of interleukin-8 gene in inflammatory bowel disease is related to the histological grade of active inflammation. Am J Pathol 1994; 144: 997-1007.
32. Capello M, Keshav S, Prince C, Jewell DP, Gordon S. Detection of mRNAs for macrophage products in inflammatory bowel disease by in situ hybridisation. Gut 1992; 33: 1214-9.
33. Izutani R, Loh EY, Reinecker H-C, Ohno Y, Fusunyan RD, Lichtenstein GR, et al. Increased expression of interleukin-8 mRNA in ulcerative colitis and Crohn's disease mucosa und epithelial cells. Inflammatory Bowel Diseases 1995; 1: 37-47.