Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody

Inflammatory Bowel Diseases

Volumn 12, Issue 1, 2006, Pages 9-15

  Fuss, Ivan J ^a,e   Becker, Christoph ^b   Yang, Zhiqiong ^a   Groden, Catherine ^a   Hornung, Ronald L ^c   Heller, Frank ^d   Neurath, Markus F ^b   Strober, Warren ^a   Mannon, Peter J ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c SAIC FREDERICK INC   (United States)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e Laboratory of Host Defenses   (United States)

Author keywords

Inflammatory bowel diseases; Interleukin 12; Interleukin 23

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12P40 MONOCLONAL ANTIBODY; INTERLEUKIN 12P70; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 6; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ADULT; ANTIGEN PRESENTING CELL; ARTICLE; CELL STIMULATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE RELEASE; DISEASE ASSOCIATION; DOWN REGULATION; FEMALE; HUMAN; MALE; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; ANTIBODIES, MONOCLONAL; BIOPSY; CELLS, CULTURED; CROHN DISEASE; DOWN-REGULATION; FEMALE; HUMANS; INTERLEUKIN-1; INTERLEUKIN-12; INTERLEUKIN-12 SUBUNIT P40; INTERLEUKIN-23; INTERLEUKIN-23 SUBUNIT P19; INTERLEUKIN-6; INTERLEUKINS; MACROPHAGES; MALE; MIDDLE AGED; MUCOUS MEMBRANE; PROTEIN SUBUNITS; T-LYMPHOCYTES;

EID: 29744450121     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1097/01.MIB.0000194183.92671.b6     Document Type: Article

References (20)

1. Bouma G, Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol. 2003;3:521-533.
2. Langrish CL, McKenzie BS, Wilson NJ, et al. IL-12 and IL-23: master regulators of innate and adaptive immunity. Immunol Rev. 2004;202:96-105.
3. Hunter CA. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat Rev Immunol. 2005;5:521-531.
4. Langrish CL, Chen Y, Blumenschein WM, et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med. 2005;201:233-240.
5. Murphy CA, Langrish CL, Chen Y, et al. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med. 2003;198:1951-1957.
6. Schmidt C, Giese T, Ludwig B, et al. Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis. Inflamm Bowel Dis. 2005;11:16-23.
7. Mannon PJ, Fuss IJ, Mayer L, et al. Anti-interleukin-12 antibody for active Crohn's disease. N Engl J Med. 2004;351:2069-2079.
8. Fuss IJ, Neurath M, Boirivant M, et al. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of INF-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol. 1996;157:1261-1270.
9. Monteleone G, Biancone L, Marasco R, et al. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology. 1997;112:1169-1178.
10. Cario E, Podolsky DK. Intestinal epithelial TOLLerance versus inTOLLerance of commensals. Mol Immunol. 2005;42:887-893.
11. Dobrovolskaia MA, Medvedev AE, Thomas KE, et al. Induction of in vitro reprogramming by Toll-like receptor (TLR)2 and TLR4 agonists in murine macrophages: effects of TLR "homotolerance" versus "heterotolerance" on NF-kappa B signaling pathway components. J Immunol. 2003;170:508-519.
12. Hausmann M, Bataille F, Spoettl T, et al. Physiological role of macrophage inflammatory protein-3α induction during maturation of intestinal macrophages. J Immunol. 2005;175:1389-1398.
13. Fournier B, Philpott D. Recognition of Staphylococcus aureus by the innate immune system. Clin Microbiol Rev. 2005;18:521-540.
14. Monteleone G, MacDonald TT, Wathen NC. Enhancing lamina propria Th1 cell responses with interleukin 12 produces severe tissue injury. Gastroenterology. 1999;117:1069-1077.
15. Cua DJ, Sherlock J, Chen Y, et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature. 2003;421:744-748.
16. Kolis J, Linden A. Interleukin-17 family members and inflammation. Immunity. 2004;21:467-476.
17. Fossiez F, Djossou O, Chomarat P, et al. T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med. 1996;183:2593-2603.
18. Hurst SD, Muchamuel T, German DM, et al. New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25. J Immunol. 2002;169:443-453.
19. Henness S, Johnson CK, Ge Q, et al. IL-17A augments TNF-α-induced IL-6 expression in airway smooth muscle by enhancing mRNA stability. J Allergy Clin Immunol. 2004;114:958-964.
20. van den Berg A, Kuiper M, Snoek M, et al. Interleukin-17 induces hyperresponsive interleukin-8 and interleukin-6 production to tumor necrosis factor-α in structural lung cells. Am J Respir Cell Mol Biol. 2005;33:97-104.