A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

Science

Volumn 314, Issue 5804, 2006, Pages 1461-1463

  Duerr, Richard H ^a,b   Taylor, Kent D ^c   Brant, Steven R ^d,e   Rioux, John D ^f,g   Silverberg, Mark S ^h   Daly, Mark J ^g,i   Steinhart, A Hillary ^h   Abraham, Clara ^j   Regueiro, Miguel ^a   Griffiths, Anne ^k   Dassopoulos, Themistocles ^d   Bitton, Alain ^l   Yang, Huiying ^c   Targan, Stephan ^c   Datta, Lisa Wu ^d   Kistner, Emily O ^j   Schumm, L Philip ^j   Lee, Annette T ^m   Gregersen, Peter K ^m   Barmada, M Michael ^b   Rotter, Jerome I ^c   Nicolae, Dan L ^j   Cho, Judy H ⁿ   more..

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^f MONTREAL HEART INSTITUTE   (Canada)

^g BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^h UNIVERSITY OF TORONTO   (Canada)

ⁱ MASSACHUSETTS GENERAL HOSPITAL   (United States)

^j UNIVERSITY OF CHICAGO   (United States)

^k HOSPITAL FOR SICK CHILDREN   (Canada)

^l ROYAL VICTORIA HOSPITAL   (Canada)

^m FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

ⁿ YALE UNIVERSITY   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; GENETIC ENGINEERING;

CROHN'S DISEASE; NONCODING IL23R VARIANTS; PROINFLAMMATORY CYTOKINE INTERLEUKIN-23; THERAPEUTIC TARGET;

GENES;

ARGININE; CYTOKINE; GLUTAMINE; INTERLEUKIN 23; RECEPTOR SUBUNIT;

DIARRHEAL DISEASE; DISEASE; GENETIC ANALYSIS; GENOME; GENOMICS;

ABDOMINAL PAIN; ARTICLE; CHROMOSOME 1P; CROHN DISEASE; DIARRHEA; ENTERITIS; GASTROINTESTINAL HEMORRHAGE; GENE; GENE IDENTIFICATION; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOME ANALYSIS; HUMAN; IL23R GENE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ULCERATIVE COLITIS;

EID: 33845340501     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1135245     Document Type: Article

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30. We thank the patients and their families for participating in the studies. The National Institute of Diabetes and Digestive and Kidney Diseases IBD Genetics Consortium is funded by the following grants: DK62431 (S.R.B.), DK62422 (J.H.C.), DK62420 (R.H.D.), DK62432 (J.D.R.), DK62423 (M.S.S.), DK62413 (K.D.T.), and DK62429 (J.H.C.). A.H.S. is on the Scientific Advisory Boards of Shire Pharmaceuticals, Schering (Canada), and Procter & Gamble Pharmaceuticals.