Type 1 T-helper cell predominance and lnterleukin-12 expression in the gut of patients with Crohn's disease

American Journal of Pathology

Volumn 150, Issue 3, 1997, Pages 823-832

  Parronchi, Paola ^a   Romagnani, Paola ^a   Annunziato, Francesco ^a   Sampognaro, Salvatore ^a   Becchio, Aleksej ^a   Giannarini, Loretta ^a   Maggi, Enrico ^a   Pupilli, Cinzia ^a   Tonelli, Francesco ^a   Romagnani, Sergio ^a,b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b Dipartimento di Medicina Interna   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12;

ARTICLE; CROHN DISEASE; HELPER CELL; HUMAN; HUMAN TISSUE; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; PATHOGENESIS; PRIORITY JOURNAL;

CD4-POSITIVE T-LYMPHOCYTES; CLONE CELLS; COLITIS, ULCERATIVE; CROHN DISEASE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-4; INTESTINAL DISEASES; INTESTINE, LARGE; TH1 CELLS; UP-REGULATION;

EID: 0031057872     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Kirsner JB, Shorter RG: Recent developments in "non-specific" inflammatory bowel disease. N Engl J Med 1982, 306:775-837
2. Strickland RG, Husby G, Black WC, Williams RCJ: Peripheral blood and intestinal lymphocyte subpopulations in Crohn's disease. Gut 1982, 16:847-853
3. Meuwissen SGM, Feltkamp-Vroom TM, Brutel de Al Riviere A, Vom dem Borne AEC, Titgat GN: Analysis of the lymph-plasmacytic infiltrate in Crohn's disease with special reference to identification of lymphocyte sub-populations. Gut 1986, 17:770-780
4. Mueller Ch, Knoflach P, Zielinski CC: T-cell activation in Crohn's disease. Increased levels of soluble interleukin-2 receptor in serum and in supernatants of stimulated peripheral blood mononuclear cells. Gastroenterology 1990, 98:639-646
5. Mullin E, Lazenby AJ, Harris ML, Bayless TM. James SP: Increased interleukin-2 messenger RNA in the intestinal mucosa lesions of Crohn's disease but not ulcerative colitis. Gastroenterology 1992, 102:1620-1627
6. Braegger CP, Nicholis S, Murch SH, Stephens S, MacDonald TT: Tumor necrosis factor a in stool as a marker of intestinal inflammation. Lancet 1992, 339:89-91
7. Gross V, Andus T, Caesar I, Roth M, Scholmerick J: Evidence for continuous stimulation of interleukin-6 production in Crohn's disease. Gastroenterology 1992, 102:514-519
8. Beagley KW, Elson CO: Cells and cytokines in mucosal immunity and inflammation. Gastronterol Clin North Am 1992, 21:347-366
9. Raab Y, Hailegren R, Gerdin B: Enhanced intestinal synthesis of interleukin-6 is related to the disease severity and activity in ulcerative colitis. Digestion 1994, 55:44-49
10. Mazlam MZ, Hodgson HJF: Interactions between interleukin-6, interleukin-1β, plasma C-reactive protein values, and in vitro C-reactive protein generation in patients with inflammatory bowel disease. Gut 1994. 35:77-83