T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon γ expression by T cells

Journal of Experimental Medicine

Volumn 187, Issue 8, 1998, Pages 1225-1234

  Simpson, Stephen J ^a,d   Shah, Samir ^a   Comiskey, Martina ^a   De Jong, Ype P ^a   Wang, Baoping ^a   Mizoguchi, Emiko ^b   Bhan, Atul K ^b   Terhorst, Cox ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^d ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; CYTOKINE ANTIBODY; GAMMA INTERFERON; INTERLEUKIN 12; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHRONIC DISEASE; COLITIS; CONTROLLED STUDY; CROHN DISEASE; DISEASE ACTIVITY; ENTERITIS; GENE EXPRESSION; IMMUNOPATHOLOGY; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION INITIATION; ULCERATIVE COLITIS;

ANIMALS; COLITIS; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; IMMUNOTHERAPY, ADOPTIVE; INTERFERON TYPE II; INTERLEUKIN-12; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, MUTANT STRAINS; SIGNAL TRANSDUCTION; STAT4 TRANSCRIPTION FACTOR; TH1 CELLS; TRANS-ACTIVATORS; TUMOR NECROSIS FACTOR-ALPHA; WASTING SYNDROME;

EID: 0032550312     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.187.8.1225     Document Type: Article

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