메뉴 건너뛰기




Volumn 132, Issue 7, 2007, Pages 2359-2370

Monoclonal Anti-Interleukin 23 Reverses Active Colitis in a T Cell-Mediated Model in Mice

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 23; MONOCLONAL ANTIBODY;

EID: 34250026960     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2007.03.104     Document Type: Article
Times cited : (398)

References (42)
  • 1
    • 23344449020 scopus 로고    scopus 로고
    • Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota
    • Elson C.O., Cong Y., McCracken V.J., Dimmitt R.A., Lorenz R.G., and Weaver C.T. Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota. Immunol Rev 206 (2005) 260-276
    • (2005) Immunol Rev , vol.206 , pp. 260-276
    • Elson, C.O.1    Cong, Y.2    McCracken, V.J.3    Dimmitt, R.A.4    Lorenz, R.G.5    Weaver, C.T.6
  • 4
    • 27744533839 scopus 로고    scopus 로고
    • Cdcs1, a major colitogenic locus in mice, regulates innate and adaptive immune response to enteric bacterial antigens
    • Beckwith J., Cong Y., Sundberg J.P., Elson C.O., and Leiter E.H. Cdcs1, a major colitogenic locus in mice, regulates innate and adaptive immune response to enteric bacterial antigens. Gastroenterology 129 (2005) 1473-1484
    • (2005) Gastroenterology , vol.129 , pp. 1473-1484
    • Beckwith, J.1    Cong, Y.2    Sundberg, J.P.3    Elson, C.O.4    Leiter, E.H.5
  • 6
    • 0034663766 scopus 로고    scopus 로고
    • Colitis induced by enteric bacterial antigen-specific CD4+ T cells requires CD40-CD40 ligand interactions for a sustained increase in mucosal IL-12
    • Cong Y., Weaver C.T., Lazenby A., and Elson C.O. Colitis induced by enteric bacterial antigen-specific CD4+ T cells requires CD40-CD40 ligand interactions for a sustained increase in mucosal IL-12. J Immunol 165 (2000) 2173-2182
    • (2000) J Immunol , vol.165 , pp. 2173-2182
    • Cong, Y.1    Weaver, C.T.2    Lazenby, A.3    Elson, C.O.4
  • 8
    • 0032530697 scopus 로고    scopus 로고
    • IL-12, but not IFN-gamma, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice
    • Davidson N.J., Hudak S.A., Lesley R.E., Menon S., Leach M.W., and Rennick D.M. IL-12, but not IFN-gamma, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice. J Immunol 161 (1998) 3143-3149
    • (1998) J Immunol , vol.161 , pp. 3143-3149
    • Davidson, N.J.1    Hudak, S.A.2    Lesley, R.E.3    Menon, S.4    Leach, M.W.5    Rennick, D.M.6
  • 10
    • 0032550312 scopus 로고    scopus 로고
    • T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells
    • Simpson S.J., Shah S., Comiskey M., de Jong Y.P., Wang B., Mizoguchi E., Bhan A.K., and Terhorst C. T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells. J Exp Med 187 (1998) 1225-1234
    • (1998) J Exp Med , vol.187 , pp. 1225-1234
    • Simpson, S.J.1    Shah, S.2    Comiskey, M.3    de Jong, Y.P.4    Wang, B.5    Mizoguchi, E.6    Bhan, A.K.7    Terhorst, C.8
  • 11
    • 0030612240 scopus 로고    scopus 로고
    • CD45RBhigh CD4+ T cells from IFN-gamma knockout mice do not induce wasting disease
    • Ito H., and Fathman C.G. CD45RBhigh CD4+ T cells from IFN-gamma knockout mice do not induce wasting disease. J Autoimmun 10 (1997) 455-459
    • (1997) J Autoimmun , vol.10 , pp. 455-459
    • Ito, H.1    Fathman, C.G.2
  • 12
    • 0032707491 scopus 로고    scopus 로고
    • In vitro activated CD4+ T cells from interferon-gamma (IFN-gamma)-deficient mice induce intestinal inflammation in immunodeficient hosts
    • Bregenholt S., Brimnes J., Nissen M.H., and Claesson M.H. In vitro activated CD4+ T cells from interferon-gamma (IFN-gamma)-deficient mice induce intestinal inflammation in immunodeficient hosts. Clin Exp Immunol 118 (1999) 228-234
    • (1999) Clin Exp Immunol , vol.118 , pp. 228-234
    • Bregenholt, S.1    Brimnes, J.2    Nissen, M.H.3    Claesson, M.H.4
  • 14
  • 18
    • 0032536827 scopus 로고    scopus 로고
    • CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease
    • Cong Y., Brandwein S.L., McCabe R.P., Lazenby A., Birkenmeier E.H., Sundberg J.P., and Elson C.O. CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease. J Exp Med 187 (1998) 855-864
    • (1998) J Exp Med , vol.187 , pp. 855-864
    • Cong, Y.1    Brandwein, S.L.2    McCabe, R.P.3    Lazenby, A.4    Birkenmeier, E.H.5    Sundberg, J.P.6    Elson, C.O.7
  • 19
    • 0036883901 scopus 로고    scopus 로고
    • Bacterial-reactive T regulatory cells inhibit pathogenic immune responses to the enteric flora
    • Cong Y., Weaver C.T., Lazenby A., and Elson C.O. Bacterial-reactive T regulatory cells inhibit pathogenic immune responses to the enteric flora. J Immunol 169 (2002) 6112-6119
    • (2002) J Immunol , vol.169 , pp. 6112-6119
    • Cong, Y.1    Weaver, C.T.2    Lazenby, A.3    Elson, C.O.4
  • 20
    • 14044278784 scopus 로고    scopus 로고
    • Generation of antigen-specific, Foxp3-expressing CD4+ regulatory T cells by inhibition of APC proteosome function
    • Cong Y., Konrad A., Iqbal N., Hatton R.D., Weaver C.T., and Elson C.O. Generation of antigen-specific, Foxp3-expressing CD4+ regulatory T cells by inhibition of APC proteosome function. J Immunol 174 (2005) 2787-2795
    • (2005) J Immunol , vol.174 , pp. 2787-2795
    • Cong, Y.1    Konrad, A.2    Iqbal, N.3    Hatton, R.D.4    Weaver, C.T.5    Elson, C.O.6
  • 22
    • 29744450121 scopus 로고    scopus 로고
    • Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody
    • Fuss I.J., Becker C., Yang Z., Groden C., Hornung R.L., Heller F., Neurath M.F., Strober W., and Mannon P.J. Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody. Inflamm Bowel Dis 12 (2006) 9-15
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 9-15
    • Fuss, I.J.1    Becker, C.2    Yang, Z.3    Groden, C.4    Hornung, R.L.5    Heller, F.6    Neurath, M.F.7    Strober, W.8    Mannon, P.J.9
  • 23
    • 5644277476 scopus 로고    scopus 로고
    • Interleukin-17 family members and inflammation
    • Kolls J.K., and Linden A. Interleukin-17 family members and inflammation. Immunity 21 (2004) 467-476
    • (2004) Immunity , vol.21 , pp. 467-476
    • Kolls, J.K.1    Linden, A.2
  • 24
    • 15244344110 scopus 로고    scopus 로고
    • Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17
    • Stark M.A., Huo Y., Burcin T.L., Morris M.A., Olson T.S., and Ley K. Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity 22 (2005) 285-294
    • (2005) Immunity , vol.22 , pp. 285-294
    • Stark, M.A.1    Huo, Y.2    Burcin, T.L.3    Morris, M.A.4    Olson, T.S.5    Ley, K.6
  • 26
  • 28
    • 3242814586 scopus 로고    scopus 로고
    • Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice
    • Huang W., Na L., Fidel P.L., and Schwarzenberger P. Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J Infect Dis 190 (2004) 624-631
    • (2004) J Infect Dis , vol.190 , pp. 624-631
    • Huang, W.1    Na, L.2    Fidel, P.L.3    Schwarzenberger, P.4
  • 29
    • 0344585384 scopus 로고    scopus 로고
    • Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice
    • Nakae S., Nambu A., Sudo K., and Iwakura Y. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J Immunol 171 (2003) 6173-6177
    • (2003) J Immunol , vol.171 , pp. 6173-6177
    • Nakae, S.1    Nambu, A.2    Sudo, K.3    Iwakura, Y.4
  • 30
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4(+) effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington L.E., Hatton R.D., Mangan P.R., Turner H., Murphy T.L., Murphy K.M., and Weaver C.T. Interleukin 17-producing CD4(+) effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6 (2005) 1123-1132
    • (2005) Nat Immunol , vol.6 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3    Turner, H.4    Murphy, T.L.5    Murphy, K.M.6    Weaver, C.T.7
  • 32
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen M., Hocking R.J., Atkins C.J., Locksley R.M., and Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24 (2006) 179-189
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 34
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., Weiner H.L., and Kuchroo V.K. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441 (2006) 235-238
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6    Weiner, H.L.7    Kuchroo, V.K.8
  • 36
    • 13944281011 scopus 로고    scopus 로고
    • Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis
    • Schmidt C., Giese T., Ludwig B., Mueller-Molaian I., Marth T., Zeuzem S., Meuer S.C., and Stallmach A. Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis. Inflamm Bowel Dis 11 (2005) 16-23
    • (2005) Inflamm Bowel Dis , vol.11 , pp. 16-23
    • Schmidt, C.1    Giese, T.2    Ludwig, B.3    Mueller-Molaian, I.4    Marth, T.5    Zeuzem, S.6    Meuer, S.C.7    Stallmach, A.8
  • 42
    • 33744489569 scopus 로고    scopus 로고
    • TGF-beta, a 'double agent' in the immune pathology war
    • Cua D.J., and Kastelein R.A. TGF-beta, a 'double agent' in the immune pathology war. Nat Immunol 7 (2006) 557-559
    • (2006) Nat Immunol , vol.7 , pp. 557-559
    • Cua, D.J.1    Kastelein, R.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.