Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of stat3 in macrophages and neutrophils

Immunity

Volumn 10, Issue 1, 1999, Pages 39-49

  Takeda, Kiyoshi ^a,d   Clausen, Björn E ^c,e   Kaisho, Tsuneyasu ^a,d   Tsujimura, Tohru ^b   Terada, Nobuyuki ^b   Förster, Irmgard ^c,f   Akira, Shizuo ^a,d  

^a Department of Biochemistry ^*  (Japan)

^b HYOGO COLLEGE OF MEDICINE   (Japan)

^c UNIVERSITY OF COLOGNE   (Germany)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^e ROCKEFELLER UNIVERSITY   (United States)

^f TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 6; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; ENTEROCOLITIS; IMMUNOREGULATION; INFECTION RISK; MACROPHAGE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0033034365     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80005-9     Document Type: Article

References (40)

1. Adams, D.O., and Hamilton, T.A. (1987). Molecular transductional mechanisms by which IFNγ and other signals regulate macrophage development. Immunol. Rev. 97, 5-27.
2. Akaishi, H., Takeda, K., Kaisho, T., Shineha, R., Satomi, S., Takeda, J., and Akira, S. (1998). Defective IL-2-mediated IL-2 receptor α chain expression in Stat3-deficient T lymphocytes. Int. Immunol., 10, 1747-1751.
3. Akira, S., Nishio, Y., Inoue, M., Wang, X., Wei, S., Matsusaka, T., Yoshida, K., Sudo, T., Naruto, M., and Kishimoto, T. (1994). Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 77, 63-71.
4. Akira, S. (1997). Il-6-regulated transcription factors. Int. J. Biochem. Cell. Biol. 29, 1401-1418.
5. + TH1-like responses. J. Clin. Invest. 98, 1010-1020.
6. Bonifer, C., Bosch, F.X., Faust, N., Schuhmann, A., and Sippel, A.E. (1994). Evolution of gene regulation as revealed by differential regulation of the chicken lysozyme transgene and the endogenous mouse lysozyme gene in mouse macrophages. Eur. J. Biochem. 226, 227-235.
7. Cross, M., Mangelsdorf, l., Wedel, A., and Renkawitz, R. (1988). Mouse lysozyme M gene: Isolation, characterization, and expression studies. Proc. Natl. Acad. Sci. USA. 85, 6232-6236.
8. Darnell, J.E., Jr. (1997). Stats and gene regulation. Science 277, 1630-1635.
9. + T cells, but not B cells, mediate colitis in interleukin-10 deficient mice. J. Exp. Med. 184, 241-251.
10. de Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C.G., and de Vries, J.E. (1991). Lnterleukin-10 (IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174, 1209-1220.
11. Durbin, J.E., Hackenmiller, R., Simon, M.C., and Levy, D.E. (1996). Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84, 443-450.
12. Finbloom, D.S., and Winestock, K.D. (1995) IL-10 induces the tyrosine phosphorylation of tyk2 and jak1 and the differential assembly of stat1a and Stat3 complexes in human T cells and monocytes. J. Immunol. 155, 1079-1090.
13. + T cells. J. Exp. Med. 184, 19-29.
14. Gu, H., Marth, J.D., Orban, P.C., Mossmann, H., and Rajewsky, K. (1994). Deletion of a DNA polymerase β gene segment in T cells using cell type-specific gene targeting. Science 265, 103-106.
15. Hollander, G.A., Simpson, S.J., Mizoguchi, E., Nichogiannopoulou, A., She, J., Gutierrez-Ramos, J.-C., Bhan, A.K., Burakoff, S.J., Wang, B., and Terhorst, C. (1995). Severe colitis in mice with aberrant thymic selection. Immunity 3, 27-38.
16. Ihle, J.N. (1996). Stats: Signal transducers and activators of transcription. Cell 84, 331-334.
17. Kaplan, M.H., Schindler, U., Smiley, ST., and Grusby, M.J. (1996a). Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4, 313-319.
18. Kaplan, M.H., Sun, Y.L., Hoey, T., and Grusby, M.J. (1996b). Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382, 174-177.
19. Kühn, R., Löhler, J., Rennick, D., Rajewsky, K., and Müller, W. (1993). Lnterleukin-10-deficient mice develop chronic enterocolitis. Cell 75, 263-274.
20. Kühn, R., and Schwenk, F. (1997). Advances in gene targeting methods. Curr. Opin. Immunol. 9, 183-188.
21. Lai, C.-F., Ripperger, J., Morella, K.K., Jurlander, J., Hawley, T.S., Carson, W.E., Kordula, T., Caligiuri, M.A., Hawley, R.G., Fey, G.H., et al. (1996). Receptors for interleukin (IL)-10 and IL-6-type cytokines use similar signaling mechanisms for inducing transcription through IL-6 response elements. J. Biol. Chem. 271,13968-13975.
22. Meraz, M.A., White, J.M., Sheehan, K.C., Bach, E.A., Rodig, S.J., Dighe, A.S., Kaplan, D.H., Riley, J.K., Greenlund, A.C., Campbell, D., et al. (1996). Targeted disruption of Stat1 gene in mice reveals unexpected physiologic specificity in the jak-stat signaling pathway. Cell 84, 431-442.
23. Moore, K.W., O'Garra, A., de Waal Malefyt, R., Vieira P., and Mossman, T.R. (1993). Lnterleukin-10. Annu. Rev. Immunol. 11, 165-190.
24. + T cells that express high levels of CD45RB induce wasting disease when transfered into congenic severe combined immunodeficient mice. J. Exp. Med. 178, 237-244.
25. Nakajima, H., Liu, X., Wynshaw-Boris, A., Rosenthal, L.A., Imada, K., Finbloom, D.S., Hennighausen, L., and Leonard, W.J. (1997). An indirect effect of stat5a in IL-2-induced proliferation: A critical role for Stat5a in IL-2-mediated IL-2 receptor a chain induction. Immunity 7, 691-701.
26. Nikolaus, S., Bauditz, J., Gionchetti, P., Witt, C., Lochs, H., and Schreiber, S. (1998). Increased secretion of pro-inflammatory cytokines by circulating polymorphonuclear neutrophils and regulation by interleukin 10 during intestinal inflammation. Gut 42, 470-476.
27. O'Farrell, A.-M., Liu, Y., Moore, K.W., and Mui, A.L-F. (1998). IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: Evidence for stat3-dependent and -independent pathways. EMBO J. 17, 1006-1018.
28. Powrie, F. (1995). T cells in inflammatory bowel disease: Protective and pathogenic roles. Immunity 3, 171-174.
29. + T cells. Immunity 1, 553-562.
30. Schindler, C., and Darnell., J.E., Jr. (1995). Transcriptional responses to polypeptide ligands: The Jak-Stat pathway. Annu. Rev. Biochem. 64, 621-651.
31. Shimoda, K., van Deursen, J., Sangster, M.Y., Sarawar, S.R., Carson, R.T., Tripp, R.A., Chu, C., Quelle, F.W., Nosaka, T., Vignali, D.A.A., et al. (1996). Lack of IL-4-induced Th2 response and IgE class switching in mice disrupted Stat6 gene. Nature 380, 630-633.
32. Takeda, K., Tanaka, T., Shi, W., Matsunoto, M., Minami, M., Kashiwamura, S., Nakanishi, K., Yoshida, N., Kishimoto, T., and Akira, S. (1996a). Essential role of Stat6 in IL-4 signaling. Nature 380, 627-630.
33. Takeda, K., Kamanaka, M., Tanaka, T., Kishimoto, T., and Akira, S. (1996b). Impaired IL-13-mediated functions of macrophages in Stat6-deficient mice. J. Immunol. 157, 3220-3222.
34. Takeda, K., Noguchi, K., Shi, W., Tanaka, T., Matsumoto, M., YoShida, N., Kishimoto, T., and Akira, S. (1997). Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc. Natl. Acad. Sci. USA. 94, 3801-3804.
35. Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T., and Akira, S. (1998). Stat3 activation is responsible for IL-6-induced T cell proliferation through preventing apoptosis: Generation and characterization of T cell-specific Stat3-deficient mice. J. Immunol., 161, 4652-4660.
36. Thierfelder, W.E., van Deursen, J.M., Yamamoto, K., Tripp, R.A., Sarawar, S.R., Carson, R.T., Sangster, M.Y., Vignali, D.A., Doherty, P.C., Grosveld, G.C., et al. (1996). Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382, 171-174.
37. Trinchieri, G. (1995). Lnterleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13, 251-276.
38. Weber-Nordt, R.M., Riley, J.K., Greenlund, A.C., Moore, K.W., Darnell, J.E., and Schreiber, R.D. (1996). Stat3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domain. J. Biol. Chem. 271, 27954-27961.
39. Wehinger, J., Gouilleux, F., Groner, B., Finke, J., Mertelsman, R., and Weber-Nordt, R.M. (1996). IL-10 induces DNA binding activity of three Stat proteins (Stat1, Stat3, and Stat5) and their distinct combinational assembly in the promoters of selected genes. FEBS Lett. 394, 365-370.
40. Zhong, Z., Wen, Z., and Darnell, J.E., Jr. (1994). Stat3: A stat family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 264, 95-98.