Molecular Imaging of Murine Intestinal Inflammation With 2-Deoxy-2-[18F]Fluoro-d-Glucose and Positron Emission Tomography

Gastroenterology

Volumn 135, Issue 3, 2008, Pages 744-755

  Brewer, Sarah ^a   McPherson, Michael ^a   Fujiwara, Daisuke ^a   Turovskaya, Olga ^b   Ziring, David ^a   Chen, Ling ^a   Takedatsu, Hidetoshi ^c   Targan, Stephan R ^c   Wei, Bo ^a   Braun, Jonathan ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GLUCOSE TRANSPORTER 1; PIROXICAM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; C3H MOUSE; CD4+ T LYMPHOCYTE; CELL TRANSFER; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; ENTERITIS; EXPERIMENTAL MODEL; FLOW CYTOMETRY; IMMUNOCOMPETENT CELL; IN VIVO STUDY; MOLECULAR IMAGING; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

EID: 51249119001     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2008.06.040     Document Type: Article

References (32)

1. MacDonald T.T., and Monteleone G. Immunity, inflammation, and allergy in the gut. Science 307 (2005) 1920-1925
2. Xavier R.J., and Podolsky D.K. Unravelling the pathogenesis of inflammatory bowel disease. Nature 448 (2007) 427-434
3. Baumgart D.C., and Sandborn W.J. Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet 369 (2007) 1641-1657
4. Herschman H.R. Micro-PET imaging and small animal models of disease. Curr Opin Immunol 15 (2003) 378-384
5. Frauwirth K.A., Riley J.L., Harris M.H., et al. The CD28 signaling pathway regulates glucose metabolism. Immunity 16 (2002) 769-777
6. Fox C.J., Hammerman P.S., and Thompson C.B. Fuel feeds function: energy metabolism and the T-cell response. Nat Rev Immunol 5 (2005) 844-852
7. Ishimori T., Saga T., Mamede M., et al. Increased (18)F-FDG uptake in a model of inflammation: concanavalin A-mediated lymphocyte activation. J Nucl Med 43 (2002) 658-663
8. Kubota R., Yamada S., Kubota K., et al. Intratumoral distribution of fluorine-18-fluorodeoxyglucose in vivo: high accumulation in macrophages and granulation tissues studied by microautoradiography. J Nucl Med 33 (1992) 1972-1980
9. Radu C.G., Shu C.J., Shelly S.M., et al. Positron emission tomography with computed tomography imaging of neuroinflammation in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 104 (2007) 1937-1942
10. Louis E., Ancion G., Colard A., et al. Noninvasive assessment of Crohn's disease intestinal lesions with (18)F-FDG PET/CT. J Nucl Med 48 (2007) 1053-1059
11. Meisner R.S., Spier B.J., Einarsson S., et al. Pilot study using PET/CT as a novel, noninvasive assessment of disease activity in inflammatory bowel disease. Inflamm Bowel Dis 13 (2007) 993-1000
12. Loffler M., Weckesser M., Franzius C., et al. High diagnostic value of 18F-FDG-PET in pediatric patients with chronic inflammatory bowel disease. Ann N Y Acad Sci 1072 (2006) 379-385
13. Neurath M.F., Vehling D., Schunk K., et al. Noninvasive assessment of Crohn's disease activity: a comparison of 18F-fluorodeoxyglucose positron emission tomography, hydromagnetic resonance imaging, and granulocyte scintigraphy with labeled antibodies. Am J Gastroenterol 97 (2002) 1978-1985
14. Pio B.S., Byrne F.R., Aranda R., et al. Noninvasive quantification of bowel inflammation through positron emission tomography imaging of 2-deoxy-2-[18F]fluoro-D-glucose-labeled white blood cells. Mol Imaging Biol 5 (2003) 271-277
15. Mahler M., and Leiter E.H. Genetic and environmental context determines the course of colitis developing in IL-10-deficient mice. Inflamm Bowel Dis 8 (2002) 347-355
16. Rudolph U., Finegold M.J., Rich S.S., et al. Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice. Nat Genet 10 (1995) 143-150
17. Bjursten M., Willen R., and Hultgren Hornquist E. Transfer of colitis by Galphai2-deficient T lymphocytes: impact of subpopulations and tissue origin. Inflamm Bowel Dis 11 (2005) 997-1005
18. Wei B., Velazquez P., Turovskaya O., et al. Mesenteric B cells centrally inhibit CD4+ T cell colitis through interaction with regulatory T cell subsets. Proc Natl Acad Sci U S A 102 (2005) 2010-2015
19. Leach M.W., Bean A.G., Mauze S., et al. Inflammatory bowel disease in C.B-17 scid mice reconstituted with the CD45RBhigh subset of CD4+ T cells. Am J Pathol 148 (1996) 1503-1515
20. Aranda R., Sydora B.C., McAllister P.L., et al. Analysis of intestinal lymphocytes in mouse colitis mediated by transfer of CD4+, CD45RBhigh T cells to SCID recipients. J Immunol 158 (1997) 3464-3473
21. Berg D.J., Zhang J., Weinstock J.V., et al. Rapid development of colitis in NSAID-treated IL-10-deficient mice. Gastroenterology 123 (2002) 1527-1542
22. Hale L.P., Gottfried M.R., and Swidsinski A. Piroxicam treatment of IL-10-deficient mice enhances colonic epithelial apoptosis and mucosal exposure to intestinal bacteria. Inflamm Bowel Dis 11 (2005) 1060-1069
23. Velazquez P., Wei B., McPherson M., et al. Villous B cells of the small intestine are specialized for invariant NK T cell dependence. J Immunol 180 (2008) 4629-4638
24. Bamias G., Mishina M., Nyce M., et al. Role of TL1A and its receptor DR3 in two models of chronic murine ileitis. Proc Natl Acad Sci U S A 103 (2006) 8441-8446
25. Papadakis K.A., Zhu D., Prehn J.L., et al. Dominant role for TL1A/DR3 pathway in IL-12 plus IL-18-induced IFN-gamma production by peripheral blood and mucosal CCR9+ T lymphocytes. J Immunol 174 (2005) 4985-4990
26. Takedatsu H., Michelsen K.S., Wei B., et al. TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-Helper 1 and T-Helper 17 activation. Gastroenterology 135 (2008) 550-565
27. Maloy K.J., Mowat A.M., Zamoyska R., et al. Phenotypic heterogeneity of intraepithelial T lymphocytes from mouse small intestine. Immunology 72 (1991) 555-562
28. Kuhn R., Lohler J., Rennick D., et al. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75 (1993) 263-274
29. Yamagiwa S., Yoshida Y., Halder R.C., et al. Mechanisms involved in enteropathy induced by administration of nonsteroidal antiinflammatory drugs (NSAIDS). Dig Dis Sci 46 (2001) 192-199
30. Kunisawa J., Kurashima Y., Higuchi M., et al. Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium. J Exp Med 204 (2007) 2335-2348
31. Maloy K.J., Salaun L., Cahill R., et al. CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J Exp Med 197 (2003) 111-119
32. Strober W., Fuss I.J., and Blumberg R.S. The immunology of mucosal models of inflammation. Annu Rev Immunol 20 (2002) 495-549