CCL25 mediates the localization of recently activated CD8αβ+ lymphocytes to the small-intestinal mucosa

Journal of Clinical Investigation

Volumn 110, Issue 8, 2002, Pages 1113-1121

  Svensson, Marcus ^a   Marsal, Jan ^a   Ericsson, Anna ^a   Carramolino, Laura ^b   Brodén, Therese ^a   Márquez, Gabriel ^b   Agace, William W ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCL25; CHEMOKINE RECEPTOR CCR9; OVALBUMIN; RNA; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; CELL DIVISION; FLOW CYTOMETRY; GENE EXPRESSION; IMMUNE RESPONSE; INTESTINE LYMPHATIC TISSUE; INTESTINE MUCOSA; LYMPH NODE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SMALL INTESTINE MUCOSA; T LYMPHOCYTE;

EID: 0036802422     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0215988     Document Type: Article

References (29)

1. Springer, T.A. 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell. 76:301-314.
2. Butcher, E.C., and Picker, L.J. 1996. Lymphocyte homing and homeostasis. Science. 272:60-66.
3. Wagner, N., et al. 1996. Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue. Nature. 382:366-370.
4. Lefrancois, L., et al. 1999. The role of beta7 integrins in CD8 T cell trafficking during an antiviral immune response. J. Exp. Med. 189:1631-1638.
5. Kim, C.H., and Broxmeyer, H.E. 1999. Chemokines: Signal lamps for trafficking of T and B cells for development and effector function. J. Leukoc. Biol. 65:6-15.
6. Reiss, Y., Proudfoot, A.E., Power, C.A., Campbell, J.J., and Butcher, E.C. 2001. CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin. J. Exp. Med. 194:1541-1547.
7. Homey, B., et al. 2002. CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Nat. Med. 8:157-165.
8. Zabel, B.A., et al. 1999. Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis. J. Exp. Med. 190:1241-1256.
9. Wurbel, M.A., et al. 2000. The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9. Eur. J. Immunol. 30:262-271.
10. Kunkel, E.J., et al. 2000. Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity. J. Exp. Med. 192:761-768.
11. Wurbel, M.A., et al. 2001. Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor gammadelta(+) gut intraepithelial lymphocytes. Blood. 98:2626-2632.
12. Uehara, S., Grinberg, A., Farber, J.M., and Love, P.E. 2002. A role for CCR9 in T lymphocyte development and migration. J. Immunol. 168:2811-2819.
13. Agace, W.W., et al. 2000. Constitutive expression of scromal derived factor-1 by mucosal epithelia and its role in HIV transmission and propagation. Curr. Biol. 10:325-328.
14. Pan, J., et al. 2000. A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues. J. Immunol. 165:2943-2949.
15. Muehlhoefer, A., et al. 2000. Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa. J. Immunol. 164:3368-3376.
16. Carramolino, L., et al. 2001. Expression of CCR9 beta-chemokine receptor is modulated in thymocyte differentiation and is selectively maintained in CD8(+) T cells from secondary lymphoid organs. Blood. 97:850-857.
17. Schon, M.P., et al. 1999. Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice. J. Immunol. 162:6641-6649.
18. Harriman, G.R., Hornqvist, E., and Lycke, N.Y. 1992. Antigen-specific and polyclonal CD4+ lamina propria T-cell lines: Phenotypic and functional characterization. Immunology. 75:66-73.
19. Agace, W.W., et al. 2000. Human intestinal lamina propria and intraepithelial lymphocytes express receptors specific for chemokines induced by inflammation. Eur. J. Immunol. 30:819-826,.
20. Kim, S.K., et. al. 1997. Activation and migration of CD8 T cells in the intestinal mucosa. J. Immunol. 159:4295-4306.
21. Vicari, A.P., et al. 1997. TECK: A novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development. Immunity. 7:291-301.
22. Papadakis, K.A., et al. 2000. The role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system. J. Immunol. 165:5069-5076.
23. Cerf-Bensussan, N., et al. 1987. A monoclonal antibody (HML-1) defining a novel membrane molecule present on human intestinal lymphocytes. Eur. J. Immunol. 17:1279-1285.
24. Sallusto, F., Lenig, D., Forster, R., Lipp, M., and Lanzavecchia, A 1999. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 401:708-712.
25. Weninger, W., Crowley, M.A., Manjunath, N., and von Andrian, U.H. 2001. Migratory properties of naive, effector, and memory CD8(+) T cells. J. Exp. Med. 194:953-966.
26. Manjunath, N., et al. 2001. Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes. J. Clin. Invest. 108:871-878. doi:10.1172/JCI200113296.
27. Campbell, D.J., and Butcher, E.C. 2002. Rapid acquisition of tissue-specific homing phenotypes by CD4(+) T cells activated in cutaneous or mucosal lymphoid tissues. J. Exp. Med. 195:135-141.
28. + intraepithelial lymphocyte compartment. Eur. J. Immunol. In press.
29. Gosling, J., et al. 2000. Cutting edge: Identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. J. Immunol. 164:2851-2856.