Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

Journal of Experimental Medicine

Volumn 204, Issue 8, 2007, Pages 1775-1785

  Sun, Cheng Ming ^a   Hall, Jason A ^a,b   Blank, Rebecca B ^a   Bouladoux, Nicolas ^a   Oukka, Mohamed ^c   Mora, J Rodrigo ^d   Belkaid, Yasmine ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOIC ACID; TRANSCRIPTION FACTOR FOXP3;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ T LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; LAMINA PROPRIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SMALL INTESTINE;

ADMINISTRATION, ORAL; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; DENDRITIC CELLS; FORKHEAD TRANSCRIPTION FACTORS; IMMUNE SYSTEM; INTESTINE, SMALL; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUCOUS MEMBRANE; SPLEEN; T-LYMPHOCYTES, REGULATORY; TRETINOIN;

EID: 34547757390     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20070602     Document Type: Article

References (36)

1. Fontenot, J.D., J.L. Dooley, A.G. Farr, and A.Y. Rudensky. 2005. Developmental regulation of Foxp3 expression during ontogeny. J. Exp. Med. 202:901-906.
2. + immunoregulatory T cells. J. Exp. Med. 194:427-438.
3. + regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2:301-306.
4. + regulatory T cells by TGF- β induction of transcription factor Foxp3. J. Exp. Med. 198:1875-1886.
5. Bettelli, E., Y. Carrier, W. Gao, T. Korn, T.B. Strom, M. Oukka, H.L. Weiner, and V.K. Kuchroo. 2006. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 441:235-238.
6. Fantini, M.C., C. Becker, G. Monteleone, F. Pallone, P.R. Galle, and M.F. Neurath. 2004. Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and downregulation of Smad7. J. Immunol. 172:5149-5153.
7. Kretschmer, K., I. Apostolou, D. Hawiger, K. Khazaie, M.C. Nussenzweig, and H. von Boehmer. 2005. Inducing and expanding regulatory T cell populations by foreign antigen. Nat. Immunol. 6:1219-1227.
8. Knoechel, B., J. Lohr, E. Kahn, J.A. Bluestone, and A.K. Abbas. 2005. Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J. Exp. Med. 202:1375-1386.
9. Wan, Y.Y., and R.A. Flavell. 2005. Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc. Natl. Acad. Sci. USA. 102:5126-5131.
10. Fontenot, J.D., J.P. Rasmussen, L.M. Williams, J.L. Dooley, A.G. Farr, and A.Y. Rudensky. 2005. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity. 22:329-341.
11. Powrie, F., S. Read, C. Mottet, H. Uhlig, and K. Maloy. 2003. Control of immune pathology by regulatory T cells. Novartis Found. Symp. 252:92-114.
12. Iwasaki, A., and B.L. Kelsall. 2001. Unique functions of CD11b+, CD8 alpha+, and double-negative Peyer ' s patch dendritic cells. J. Immunol. 166:4884-4890.
13. Mowat, A.M. 2003. Anatomical basis of tolerance and immunity to intestinal antigens. Nat. Rev. Immunol. 3:331-341.
14. Chirdo, F.G., O.R. Millington, H. Beacock-Sharp, and A.M. Mowat. 2005. Immunomodulatory dendritic cells in intestinal lamina propria. Eur. J. Immunol. 35:1831-1840.
15. Johansson-Lindbom, B., M. Svensson, M.A. Wurbel, B. Malissen, G. Marquez, and W. Agace. 2003. Selective generation of gut tropic T cells in gut-associated lymphoid tissue (GALT): requirement for GALT dendritic cells and adjuvant. J. Exp. Med. 198:963-969.
16. + dendritic cells in the regulation of tissue-selective T cell homing. J. Exp. Med. 202:1063-1073.
17. Siewert, C., A. Menning, J. Dudda, K. Siegmund, U. Lauer, S. Floess, D.J. Campbell, A. Hamann, and J. Huehn. 2007. Induction of organ-selective CD4(+) regulatory T cell homing. Eur. J. Immunol. 37:978-989.
18. Mora, J.R., M. Iwata, B. Eksteen, S.Y. Song, T. Junt, B. Senman, K.L. Otipoby, A. Yokota, H. Takeuchi, P. Ricciardi-Castagnoli, et al. 2006. Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science. 314:1157-1160.
19. Barnard, J.A., G.J. Warwick, and L.I. Gold. 1993. Localization of transforming growth factor beta isoforms in the normal murine small intestine and colon. Gastroenterology. 105:67-73.
20. Agace, W.W., J.M. Higgins, B. Sadasivan, M.B. Brenner, and C.M. Parker. 2000. T-lymphocyte-epithelial-cell interactions: integrin alpha(E) (CD103)beta(7), LEEP-CAM and chemokines. Curr. Opin. Cell Biol. 12:563-568.
21. Mucida, D., N. Kutchukhidze, A. Erazo, M. Russo, J.J. Lafaille, and M.A. Curotto de Lafaille. 2005. Oral tolerance in the absence of naturally occurring Tregs. J. Clin. Invest. 115:1923-1933.
22. Pavli, P., C.E. Woodhams, W.F. Doe, and D.A. Hume. 1990. Isolation and characterization of antigen-presenting dendritic cells from the mouse intestinal lamina propria. Immunology. 70:40-47.
23. Niess, J.H., and H.C. Reinecker. 2005. Lamina propria dendritic cells in the physiology and pathology of the gastrointestinal tract. Curr. Opin. Gastroenterol. 21:687-691.
24. Annacker, O., J.L. Coombes, V. Malmstrom, H.H. Uhlig, T. Bourne, B. Johansson-Lindbom, W.W. Agace, C.M. Parker, and F. Powrie. 2005. Essential role for CD103 in the T cell-mediated regulation of experimental colitis. J. Exp. Med. 202:1051-1061.
25. Mora, J.R., M.R. Bono, N. Manjunath, W. Weninger, L.L. Cavanagh, M. Rosemblatt, and U.H. Von Andrian. 2003. Selective imprinting of gut-homing T cells by Peyer ' s patch dendritic cells. Nature. 424:88-93.
26. Iwata, M., A. Hirakiyama, Y. Eshima, H. Kagechika, C. Kato, and S.Y. Song. 2004. Retinoic acid imprints gut-homing specificity on T cells. Immunity. 21:527-538.
27. Chen, Y., V.K. Kuchroo, J. Inobe, D.A. Hafler, and H.L. Weiner. 1994. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science. 265: 1237-1240.
28. Worbs, T., U. Bode, S. Yan, M.W. Hoffmann, G. Hintzen, G. Bernhardt, R. Forster, and O. Pabst. 2006. Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells. J. Exp. Med. 203:519-527.
29. Rimoldi, M., M. Chieppa, V. Salucci, F. Avogadri, A. Sonzogni, G.M. Sampietro, A. Nespoli, G. Viale, P. Allavena, and M. Rescigno. 2005. Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nat. Immunol. 6:507-514.
30. Watanabe, N., Y.H. Wang, H.K. Lee, T. Ito, Y.H. Wang, W. Cao, and Y.J. Liu. 2005. Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus. Nature. 436:1181-1185.
31. Smith, T.J., L.A. Ducharme, S.K. Shaw, C.M. Parker, M.B. Brenner, P.J. Kilshaw, and J.H. Weis. 1994. Murine M290 integrin expression modulated by mast cell activation. Immunity. 1:393-403.
32. Ziegler, T.R., M.E. Evans, C. Fernandez-Estivariz, and D.P. Jones. 2003. Trophic and cytoprotective nutrition for intestinal adaptation, mucosal repair, and barrier function. Annu. Rev. Nutr. 23:229-261.
33. Paolini, M., G. Cantelli-Forti, P. Perocco, G.F. Pedulli, S.Z. Abdel-Rahman, and M.S. Legator. 1999. Co-carcinogenic effect of betacarotene. Nature. 398:760-761.
34. Sansonetti, P.J., and J.P. Di Santo. 2007. Debugging how bacteria manipulate the immune response. Immunity. 26:149-161.
35. + regulatory T cells in reactivation of persistent Leishmaniasis and control of concomitant immunity. J. Exp. Med. 200:201-210.
36. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:287-296.