Oxazolone colitis: A murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4

Journal of Experimental Medicine

Volumn 188, Issue 10, 1998, Pages 1929-1939

  Boirivant, Monica ^a,b   Fuss, Ivan J ^a   Chu, Alan ^a   Strober, Warren ^a,c  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Cytokine; Hapten; Inflammation; T helper cell type 2; Transforming growth factor

Indexed keywords

ANTIBODY; CYTOKINE; HAPTEN; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 5; OXAZOLONE; TRANSFORMING GROWTH FACTOR BETA;

ADOLESCENT; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; COLITIS; CROHN DISEASE; CYTOKINE PRODUCTION; HELPER CELL; INFLAMMATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ULCERATIVE COLITIS;

ADMINISTRATION, RECTAL; ANIMALS; ANTIBODIES; COLITIS; COLITIS, ULCERATIVE; COLON; CYTOKINES; DISEASE MODELS, ANIMAL; HISTOCYTOCHEMISTRY; HUMANS; INFLAMMATION; INTERLEUKIN-4; INTERLEUKINS; MICE; MICE, INBRED STRAINS; OXAZOLONE; TH2 CELLS;

EID: 0032538915     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.10.1929     Document Type: Article

References (43)

1. Neurath, M.F., I. Fuss, B.L. Kelsall, E. Stüber, and W. Strober 1995. Antibodies to IL-12 abrogate established experimental colitis in mice. J. Exp. Med. 182:1281-1290.
2. + lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of 1L-5. J. Immunol. 157:1261-1270.
3. Parronchi, P., P. Romagni, F. Annunziato, S. Sampognaro, A. Becchio, L. Giannarini, E. Maggi, C. Pupilli, F. Tonelli, and S. Romagni. 1997. Type 1 T-helper cell predominance and IL-12 expression in the gut of patients with Crohn's disease. Am. J. Pathol. 150:823-832.
4. Breese, E., C.P. Braegger, C.J. Corrigan, J.A. Walker-Smith, and T.T. MacDonald. 1993. Interleukin-2 and interferon-γ secreting T cells in normal and diseased human intestinal mucosa. Immunology. 78:127-131.
5. Monteleone, G., L. Biancone, R. Marasco, G. Marrone, O. Marasco, F. Luzza, and F. Pallone. 1997. Interleukin-12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology. 112:1169-1178.
6. Neurath, M.F., I. Fuss, B.L. Kelsall, D.H. Presky, W. Waegell, and W. Strober. 1996. Experimental granulomatous colitis in mice is abrogated by induction of TGF-γ-mediated oral tolerance. J. Exp. Med. 183:2605-2616.
7. Elson, C.O., K.W. Beagley, A.T. Sharmanov, K. Fujihashi, H. Kiyono, G.S. Tennyson, V. Cong, C.A. Black, B.W. Ridwan, and J.R. McGhee. 1996. Hapten-induced model of murine inflammatory bowel disease: mucosa immune responses and protection by tolerance. J. Immunol. 157:2174-2185.
8. Strober, W., B. Kelsall, I. Fuss, T. Marth, B. Ludviksson, R. Ehrhardt, and M. Neurath. 1997. Reciprocal IFN-γ and TGF-β responses regulate the occurrence of mucosal inflammation. Immunol. Today. 18:61-64.
9. + T cells. J. Exp. Med. 183:2669-2674.
10. Ludviksson, B.R., R.O. Ehrhardt, and W. Strober. 1997. TGF-β production regulates the development of the 2,4,6-trinitrophenol-conjugated keyhole limpet hemocyanin-induced colonie inflammation in IL-2-deficient mice. J. Immunol. 159:3622-3628.
11. Asherson, G.L., M.A.C. Perera, and W.R. Thomas. 1979. Contact sensitivity and the DNA response in mice to high and low doses of oxazalone: low dose unresponsiveness following painting and feeding and its prevention by treatment with cyclophosphamide. Immunology. 36:449-459.
12. Asherson, G.L., and M. Zembala. 1980. T suppressor cells and suppressor factor act at the efferent stage of the contact sensitivity skin reaction: their production by mice injected with water-soluble, chemically reactive derivatives of oxazalone and picyrl chloride. Immunology. 42:1005-1013.
13. Ferreira, A.M., M. Hurme, M. Kaartinen, and O. Mäkelä. 1981. Fine-specificity of the immune response to oxazalone. I. Contact sensitivity and early antibodies. J. Immunol. 127: 2366-2371.
14. Kraal, G., R. Verdan, and A. Twisk. 1987. The influence of oxazalone on the recirculation capacity of B and T cells. Immunobiology. 174:326-338.
15. Gautan, S.C., N.F. Chikkala, and J.R. Battisto. 1990. Oral administration of the contact sensitizer trinitrochlorobenzene: initial sensitization and subsequent appearance of a suppressor population. Cell. Immunol. 125:437-448.
16. Kimber, I., J.R. Foster, D. Baker, and J.L. Turk. 1991. Selective impairment of T lymphocyte activation following contact sensitization with oxazalone. Int. Arch. Allergy Appl. Immunol. 95:142-148.
17. Miller, A., O. Lider, A.B. Roberts, M.B. Sporn, and H.L. Weiner. 1992. Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor B after antigen-specific triggering. Prof. Natl. Acad. Sci. USA. 89:421-425.
18. Khoury, S.J., W.W. Hancock, and H.L. Weiner. 1992. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and a differential upregulation of transforming growth factor-β, interleukin 4, and prostaglandin E expression in the brain. J. Exp. Med. 176:1355-1364.
19. Weiner, H.L. 1994. Oral tolerance. Proc. Natl. Acad. Sci. USA. 91:10764-10765.
20. Strober, W., B. Kelsall, and T. Marth. 1998. Oral tolerance. J. Clin. Immunol. 18:1-30.
21. Asherson, G.L., and W. Ptak. 1970. Contact and delayed hypersensitivity in the mouse. III. Depression of contact sensitivity by pretreatment with antigen and the restoration of immune competence in tolerant mice by normal lymphoid and bone marrow cells. Immunology. 18:99-106.
22. Glaister, J.R. 1973. Some effects of oral administration of oxazalone to mice. Int. Arch. Allergy. 45:828-843.
23. Asherson, G.L., M. Zembala, M.A.C. Perera, B. Mayhew, and W.R. Thomas. 1997. Production of immunity and unresponsiveness in the mouse by feeding contact sensitizing agents and the role of suppressor cells in the Peyer's patches, mesenteric lymph nodes and other lymphoid tissues. Cell. Immunol. 33:145-155.
24. Asherson, G.L., G.G. Allwood, and B. Mayhew. 1973. Contact sensitivity in the mouse. XI. Movement of lymphoblasts in the draining lymph nodes to sites of inflammation. Immunology. 25:485-492.
25. Griswald, D.E., J.A. DiLorenzo, and P. Calabresi. 1974. Quantification and pharmacological dissection of oxazalone-induced contact sensitivity in the mouse. Cell. Immunol. 11: 198-204.
26. Van der Heijden, P.J., and W. Stok. 1987. Improved procedure for the isolation of functionally active lymphoid cells from the murine intestine. J. Immunol. Methods. 103:161-167.
27. Kruisbeek, A.M. 1996. In vitro assays for mouse lymphocyte function. In Current Protocols in Immunology. Volume 1. J.E. Coligan, A.M. Kruisbeek, D.H. Margulies, E.M. Shevach, and W. Strober, editors. John Wiley and Sons, Inc., New York. 3.1.2-3.1.5.
28. Andrew, A.M., and J.A. Titus. 1997. Purification and fragmentation of antibodies. In Current Protocol in Immunology. Volume 1. J.E. Coligan, A.M. Kruisbeek, D.H. Margulies, E.M. Shevach, and W. Strober, editors. John Wiley and Sons, Inc., New York. 2.7.1-2.7.11.
29. Morris, G.P., P.L. Beck, M.S. Herridge, W.T. Depew, M.R. Szewczuk, and J.L. Wallace. 1989. Hapten-induced model of colonic inflammation and ulceration in the rat colon. Gastroenterology. 96:795-803.
30. Yamada, T., S. Marshall, R.D. Specian, and M.B. Grisham. 1992. A comparative analysis of two models of colitis in rats. Gastroenterology. 102:1524-1534.
31. Mullin, G.E., Z.R. Maycon, L. Braun-Elwert, R. Cerchia, S.P. James, S. Katz, G.S. Weissman, M.J. McKinley, and S.E. Fisher. 1996. Inflammatory bowel disease mucosal biopsies have specialized lymphokine mRNA profiles. Inflam. Bowel Dis. 2:16-26.
32. + T cells. Immunity. 1:553-562.
33. Kühn, R., J. Löhler, D. Rennick, K. Rajewsky, and W. Müller. 1993. Interleukin-10-deficient mice develop chronic enterocolitis. Cell. 75:263-274.
34. Ehrhardt, R.O., B.R. Ludviksson, B. Gray, M. Neurath, and W. Strober. 1997. Induction and prevention of colonic inflammation in IL-2-deficient mice. J. Immunol. 158:566-573.
35. Kosiewicz, M.M., A. Krishnan, M. Shah, M. Bentz, C. Nast, S. Matsumoto, and F. Cominelli. 1998. Characterization of a new spontaneous murine model of inflammatory bowel disease. Gastroenterology. 114:64143. (Abstr.)
36. Mombaertz, P., E. Mizoguchi, M.J. Grusby, L.H. Glimcher, A.K. Bhan, and S. Tonegawa. 1993. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell. 75:275-282.
37. Mizoguchi, A., E. Mizoguchi, C. Chiba, G.M. Spiekermann, S. Tonegawa, C. Nagler-Anderson, and A.K. Bhan. 1996. Cytokine imbalance and autoantibody production in T cell receptor-α mutant mice with inflammatory bowel disease. J. Exp. Med. 183:847-856.
38. + T-cell population mediates development of inflammatory bowel disease in T-cell receptor a chain-deficient mice. Gastroenterology. 112:1876-1886.
39. Mizoguchi, A., E. Mizoguchi, C. Chiba, and A.K. Bhan. 1996. Role of appendix in the development of inflammatory bowel disease in TCR-α mutant mice. J. Exp. Med. 184: 707-715.
40. Mizoguchi, E., A. Mizoguchi, and A.K. Bhan. 1997. Role of cytokines in the early stages of chronic colitis in TCR α-mutant mice. Lab. Investig. 76:385-397.
41. Babyatsky, M.W., G. Rossiter, and D.K. Podolsky. 1996. Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease. Gastroenterology. 110:975-984.
42. Marth, T., W. Strober, R.A. Seder, and B.L. Kelsall. 1997. Regulation of transforming growth factor-ß production by interleukin-12. Eur. J. Immunol. 27:1213-1220.
43. McIntyre, T.M., M.R. Kehry, and C.M. Snapper. 1995. Novel in vitro model for high rate IgA class switching. J. Immunol. 154:3156-3161.