-
1
-
-
0017199306
-
Selective in vitro growth of T lymphocytes from normal human bone marrows
-
Morgan DA, Ruscetti FW, Gallo R. 1976. Selective in vitro growth of T lymphocytes from normal human bone marrows. Science 193:1007-8
-
(1976)
Science
, vol.193
, pp. 1007-1008
-
-
Morgan, D.A.1
Ruscetti, F.W.2
Gallo, R.3
-
2
-
-
0017402665
-
Long-term culture of tumour-specific cytotoxic T cells
-
Gillis S, Smith KA. 1977. Long-term culture of tumour-specific cytotoxic T cells. Nature 268:154-56
-
(1977)
Nature
, vol.268
, pp. 154-156
-
-
Gillis, S.1
Smith, K.A.2
-
3
-
-
0020699991
-
Structure and expression of a cloned cDNA for human interleukin-2
-
Taniguchi T, Matsui H, Fujita T, Takaoka C, Kashima N, et al. 1983. Structure and expression of a cloned cDNA for human interleukin-2. Nature 302:305-10
-
(1983)
Nature
, vol.302
, pp. 305-310
-
-
Taniguchi, T.1
Matsui, H.2
Fujita, T.3
Takaoka, C.4
Kashima, N.5
-
4
-
-
0027369395
-
Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
-
Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75:253-61
-
(1993)
Cell
, vol.75
, pp. 253-261
-
-
Sadlack, B.1
Merz, H.2
Schorle, H.3
Schimpl, A.4
Feller, A.C.5
Horak, I.6
-
6
-
-
0028784289
-
Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment
-
Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW. 1995. Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3:521-30
-
(1995)
Immunity
, vol.3
, pp. 521-530
-
-
Willerford, D.M.1
Chen, J.2
Ferry, J.A.3
Davidson, L.4
Ma, A.5
Alt, F.W.6
-
7
-
-
0029028363
-
Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor β
-
Suzuki H, Kundig TM, Furlonger C, Wakeham A, Timms E, et al. 1995. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor β. Science 268:1472-76
-
(1995)
Science
, vol.268
, pp. 1472-1476
-
-
Suzuki, H.1
Kundig, T.M.2
Furlonger, C.3
Wakeham, A.4
Timms, E.5
-
8
-
-
2442484053
-
+ regulatory T cells for immunologic self-tolerance and negative control of immune responses
-
+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22:531-62
-
(2004)
Annu. Rev. Immunol
, vol.22
, pp. 531-562
-
-
Sakaguchi, S.1
-
9
-
-
7144259082
-
Regulatory CD4 T cells: Expression of IL-2Rα chain, resistance to clonal deletion and IL-2 dependency
-
Papiernik M, de Moraes ML, Pontoux C, Vasseur F, Penit C. 1997. Regulatory CD4 T cells: expression of IL-2Rα chain, resistance to clonal deletion and IL-2 dependency. Int. Immunol. 10:371-78
-
(1997)
Int. Immunol
, vol.10
, pp. 371-378
-
-
Papiernik, M.1
de Moraes, M.L.2
Pontoux, C.3
Vasseur, F.4
Penit, C.5
-
10
-
-
0342632839
-
Normal regulatory α/β T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor β in vivo
-
Suzuki H, Zhou YW, Kato M, Mak TW, Nakashima I. 1999. Normal regulatory α/β T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor β in vivo. J. Exp. Med. 190:1561-72
-
(1999)
J. Exp. Med
, vol.190
, pp. 1561-1572
-
-
Suzuki, H.1
Zhou, Y.W.2
Kato, M.3
Mak, T.W.4
Nakashima, I.5
-
11
-
-
0034965185
-
+ T cells: Evidence for two distinct regulatory mechanisms
-
+ T cells: evidence for two distinct regulatory mechanisms. Eur. J. Immunol. 31:1637-45
-
(2001)
Eur. J. Immunol
, vol.31
, pp. 1637-1645
-
-
Wolf, M.1
Schimpl, A.2
Hunig, T.3
-
12
-
-
0030560797
-
Interleukin-2 is indispensable for development of immunological self-tolerance
-
Klebb G, Autenrieth IB, Haber H, Gillert E, Sadlack B, et al. 1996. Interleukin-2 is indispensable for development of immunological self-tolerance. Clin. Immunol. Immunopathol. 81:282-86
-
(1996)
Clin. Immunol. Immunopathol
, vol.81
, pp. 282-286
-
-
Klebb, G.1
Autenrieth, I.B.2
Haber, H.3
Gillert, E.4
Sadlack, B.5
-
14
-
-
0036669298
-
CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rβ-deficient mice. Implications for the nonredundant function of IL-2
-
Malek TR, Yu A, Vincek V, Scibelli P, Kong L. 2002. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rβ-deficient mice. Implications for the nonredundant function of IL-2. Immunity 17:167-78
-
(2002)
Immunity
, vol.17
, pp. 167-178
-
-
Malek, T.R.1
Yu, A.2
Vincek, V.3
Scibelli, P.4
Kong, L.5
-
16
-
-
0027688772
-
Immune responses in interleukin-2-deficient mice
-
Kundig TM, Schorle H, Bachmann MF, Hengartner H, Zinkernagel RM, Horak I. 1993. Immune responses in interleukin-2-deficient mice. Science 262:1059-61
-
(1993)
Science
, vol.262
, pp. 1059-1061
-
-
Kundig, T.M.1
Schorle, H.2
Bachmann, M.F.3
Hengartner, H.4
Zinkernagel, R.M.5
Horak, I.6
-
17
-
-
0029025841
-
Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4
-
Bachmann MF, Schorle H, Kuhn R, Muller W, Hengartner H, et al. 1995. Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4. J. Virol. 69:4842-46
-
(1995)
J. Virol
, vol.69
, pp. 4842-4846
-
-
Bachmann, M.F.1
Schorle, H.2
Kuhn, R.3
Muller, W.4
Hengartner, H.5
-
18
-
-
0028997995
-
IL-2 knockout recipient mice reject islet cell allografts
-
Steiger J, Nickerson PW, Steurer W, Moscovitch-Lopatin M, Strom TB. 1995. IL-2 knockout recipient mice reject islet cell allografts. J. Immunol. 155:489-98
-
(1995)
J. Immunol
, vol.155
, pp. 489-498
-
-
Steiger, J.1
Nickerson, P.W.2
Steurer, W.3
Moscovitch-Lopatin, M.4
Strom, T.B.5
-
19
-
-
4544241811
-
Tolerance, not immunity, crucially depends on IL-2
-
Malek TR, Bayer AL. 2004. Tolerance, not immunity, crucially depends on IL-2. Nat. Rev. Immunol. 4:665-74
-
(2004)
Nat. Rev. Immunol
, vol.4
, pp. 665-674
-
-
Malek, T.R.1
Bayer, A.L.2
-
22
-
-
0033491981
-
Biology of the interleukin-2 receptor
-
Nelson BH, Willerford DM. 1998. Biology of the interleukin-2 receptor. Adv. Immunol. 70:1-81
-
(1998)
Adv. Immunol
, vol.70
, pp. 1-81
-
-
Nelson, B.H.1
Willerford, D.M.2
-
23
-
-
0035102242
-
Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: Implications for immunotherapy
-
Waldmann TA, Dubois S, Tagaya Y. 2001. Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: implications for immunotherapy. Immunity 14:105-10
-
(2001)
Immunity
, vol.14
, pp. 105-110
-
-
Waldmann, T.A.1
Dubois, S.2
Tagaya, Y.3
-
24
-
-
0035925887
-
Signaling domains of the interleukin 2 receptor
-
Gaffen SL. 2001. Signaling domains of the interleukin 2 receptor. Cytokine 14:63-77
-
(2001)
Cytokine
, vol.14
, pp. 63-77
-
-
Gaffen, S.L.1
-
25
-
-
0035554678
-
Inducible IL-2 production by dendritic cells revealed by global gene expression analysis
-
Granucci F, Vizzardelli C, Pavelka N, Feau S, Persico M, et al. 2001. Inducible IL-2 production by dendritic cells revealed by global gene expression analysis. Nat. Immunol. 2:882-88
-
(2001)
Nat. Immunol
, vol.2
, pp. 882-888
-
-
Granucci, F.1
Vizzardelli, C.2
Pavelka, N.3
Feau, S.4
Persico, M.5
-
26
-
-
15444374646
-
+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
-
+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J. Exp. Med. 201:723-35
-
(2005)
J. Exp. Med
, vol.201
, pp. 723-735
-
-
Setoguchi, R.1
Hori, S.2
Takahashi, T.3
Sakaguchi, S.4
-
27
-
-
0035253697
-
A new regulatory region of the IL-2 locus that confers position-independent transgene expression
-
Yui MA, Hernandez-Hoyos G, Rothenberg EV. 2001. A new regulatory region of the IL-2 locus that confers position-independent transgene expression. J. Immunol. 166:1730-39
-
(2001)
J. Immunol
, vol.166
, pp. 1730-1739
-
-
Yui, M.A.1
Hernandez-Hoyos, G.2
Rothenberg, E.V.3
-
28
-
-
1842581852
-
Preferential activation of an IL-2 regulatory sequence transgene in TCR γδ and NKT cells: Subset-specific differences in IL-2 regulation
-
Yui MA, Sharp LL, Havran WL, Rothenberg EV. 2004. Preferential activation of an IL-2 regulatory sequence transgene in TCR γδ and NKT cells: subset-specific differences in IL-2 regulation. J. Immunol. 172:4691-99
-
(2004)
J. Immunol
, vol.172
, pp. 4691-4699
-
-
Yui, M.A.1
Sharp, L.L.2
Havran, W.L.3
Rothenberg, E.V.4
-
30
-
-
0029025964
-
The architecture of the interleukin-2 promoter: A reflection of T lymphocyte activation
-
Serfling E, Avots A, Neumann M. 1995. The architecture of the interleukin-2 promoter: a reflection of T lymphocyte activation. Biochim. Biophys. Acta 1263:181-200
-
(1995)
Biochim. Biophys. Acta
, vol.1263
, pp. 181-200
-
-
Serfling, E.1
Avots, A.2
Neumann, M.3
-
31
-
-
0029041568
-
Transcriptional regulation of the IL-2 gene
-
Jain J, Loh C, Rao A. 1995. Transcriptional regulation of the IL-2 gene. Curr. Opin. Immunol. 7:333-42
-
(1995)
Curr. Opin. Immunol
, vol.7
, pp. 333-342
-
-
Jain, J.1
Loh, C.2
Rao, A.3
-
32
-
-
0023886642
-
Mechanisms regulating the level of IL-2 mRNA in T lymphocytes
-
Shaw J, Meerovitch K, Bleackley RC, Paetkau V. 1988. Mechanisms regulating the level of IL-2 mRNA in T lymphocytes. J. Immunol. 140:2243-48
-
(1988)
J. Immunol
, vol.140
, pp. 2243-2248
-
-
Shaw, J.1
Meerovitch, K.2
Bleackley, R.C.3
Paetkau, V.4
-
33
-
-
0024506159
-
Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway
-
Lindstein T, June CH, Ledbetter JA, Stella G, Thompson CB. 1989. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 244:339-43
-
(1989)
Science
, vol.244
, pp. 339-343
-
-
Lindstein, T.1
June, C.H.2
Ledbetter, J.A.3
Stella, G.4
Thompson, C.B.5
-
34
-
-
0026061865
-
Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28
-
Fraser JD, Irving BA, Crabtree GR, Weiss A. 1991. Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Science 251:313-16
-
(1991)
Science
, vol.251
, pp. 313-316
-
-
Fraser, J.D.1
Irving, B.A.2
Crabtree, G.R.3
Weiss, A.4
-
35
-
-
34247215187
-
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
-
Ono M, Yaguchi H, Ohkura N, Kitabayashi I, Nagamura Y, et al. 2007. Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature 446:685-89
-
(2007)
Nature
, vol.446
, pp. 685-689
-
-
Ono, M.1
Yaguchi, H.2
Ohkura, N.3
Kitabayashi, I.4
Nagamura, Y.5
-
36
-
-
0027957227
-
IL-2 promoter-driven lacZ expression as a monitoring tool for IL-2 expression in primary T cells of transgenic mice
-
Brombacher F, Schafer T, Weissenstein U, Tschopp C, Andersen E, et al. 1994. IL-2 promoter-driven lacZ expression as a monitoring tool for IL-2 expression in primary T cells of transgenic mice. Int. Immunol. 6:189-97
-
(1994)
Int. Immunol
, vol.6
, pp. 189-197
-
-
Brombacher, F.1
Schafer, T.2
Weissenstein, U.3
Tschopp, C.4
Andersen, E.5
-
37
-
-
0031239636
-
Interleukin 2 promoter/enhancer controlled expression of a synthetic cecropin-class lytic peptide in transgenic mice and subsequent resistance to Brucella abortus
-
Reed WA, Elzer PH, Enright FM, Jaynes JM, Morrey JD, White KL. 1997. Interleukin 2 promoter/enhancer controlled expression of a synthetic cecropin-class lytic peptide in transgenic mice and subsequent resistance to Brucella abortus. Transgenic Res. 6:337-47
-
(1997)
Transgenic Res
, vol.6
, pp. 337-347
-
-
Reed, W.A.1
Elzer, P.H.2
Enright, F.M.3
Jaynes, J.M.4
Morrey, J.D.5
White, K.L.6
-
38
-
-
0027512573
-
The selective ablation of interleukin 2-producing cells isolated from transgenic mice
-
Minasi LE, Kamogawa Y, Carding S, Bottomly K, Flavell RA. 1993. The selective ablation of interleukin 2-producing cells isolated from transgenic mice. J. Exp. Med. 177:1451-59
-
(1993)
J. Exp. Med
, vol.177
, pp. 1451-1459
-
-
Minasi, L.E.1
Kamogawa, Y.2
Carding, S.3
Bottomly, K.4
Flavell, R.A.5
-
39
-
-
0030043836
-
Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB
-
Barton K, Muthusamy N, Chanyangam M, Fischer C, Clendenin C, Leiden JM. 1996. Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB. Nature 379:81-85
-
(1996)
Nature
, vol.379
, pp. 81-85
-
-
Barton, K.1
Muthusamy, N.2
Chanyangam, M.3
Fischer, C.4
Clendenin, C.5
Leiden, J.M.6
-
40
-
-
16844376445
-
Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV
-
Juang YT, Wang Y, Solomou EE, Li Y, Mawrin C, et al. 2005. Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV. J. Clin. Invest. 115:996-1005
-
(2005)
J. Clin. Invest
, vol.115
, pp. 996-1005
-
-
Juang, Y.T.1
Wang, Y.2
Solomou, E.E.3
Li, Y.4
Mawrin, C.5
-
41
-
-
0033840025
-
Suppression of T cell function: A potential role for transcriptional repressor ICER
-
Bodor J, Bodorova J, Gress RE. 2000. Suppression of T cell function: a potential role for transcriptional repressor ICER. J. Leukoc. Biol. 67:774-79
-
(2000)
J. Leukoc. Biol
, vol.67
, pp. 774-779
-
-
Bodor, J.1
Bodorova, J.2
Gress, R.E.3
-
42
-
-
0032080450
-
Transcriptional repression of the IL-2 gene in Th cells by ZEB
-
Yasui DH, Genetta T, Kadesch T, Williams TM, Swain SL, et al. 1998. Transcriptional repression of the IL-2 gene in Th cells by ZEB. J. Immunol. 160:4433-40
-
(1998)
J. Immunol
, vol.160
, pp. 4433-4440
-
-
Yasui, D.H.1
Genetta, T.2
Kadesch, T.3
Williams, T.M.4
Swain, S.L.5
-
43
-
-
0026320871
-
Identification of a zinc finger protein that inhibits IL-2 gene expression
-
Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, et al. 1991. Identification of a zinc finger protein that inhibits IL-2 gene expression. Science 254:1791-94
-
(1991)
Science
, vol.254
, pp. 1791-1794
-
-
Williams, T.M.1
Moolten, D.2
Burlein, J.3
Romano, J.4
Bhaerman, R.5
-
44
-
-
27744461314
-
IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508
-
Hwang ES, Hong JH, Glimcher LH. 2005. IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508. J. Exp. Med. 202:1289-300
-
(2005)
J. Exp. Med
, vol.202
, pp. 1289-1300
-
-
Hwang, E.S.1
Hong, J.H.2
Glimcher, L.H.3
-
45
-
-
33846419491
-
Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals
-
Villarino AV, Tato CM, Stumhofer JS, Yao Z, Cui YK, et al. 2007. Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals. J. Exp. Med. 204:65-71
-
(2007)
J. Exp. Med
, vol.204
, pp. 65-71
-
-
Villarino, A.V.1
Tato, C.M.2
Stumhofer, J.S.3
Yao, Z.4
Cui, Y.K.5
-
46
-
-
33845958028
-
Cytokine-dependent Blimp-1 expression in activated T cells inhibits IL-2 production
-
Gong D, Malek TR. 2007. Cytokine-dependent Blimp-1 expression in activated T cells inhibits IL-2 production. J. Immunol. 178:242-52
-
(2007)
J. Immunol
, vol.178
, pp. 242-252
-
-
Gong, D.1
Malek, T.R.2
-
47
-
-
33646010346
-
Transcriptional repressor Blimp-1 regulates T cell homeostasis and function
-
Martins GA, Cimmino L, Shapiro-Shelef M, Szabolcs M, Herron A, et al. 2006. Transcriptional repressor Blimp-1 regulates T cell homeostasis and function. Nat. Immunol. 7:457-65
-
(2006)
Nat. Immunol
, vol.7
, pp. 457-465
-
-
Martins, G.A.1
Cimmino, L.2
Shapiro-Shelef, M.3
Szabolcs, M.4
Herron, A.5
-
48
-
-
33645979374
-
Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance
-
Kallies A, Hawkins ED, Belz GT, Metcalf D, Hommel M, et al. 2006. Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance. Nat. Immunol. 7:466-74
-
(2006)
Nat. Immunol
, vol.7
, pp. 466-474
-
-
Kallies, A.1
Hawkins, E.D.2
Belz, G.T.3
Metcalf, D.4
Hommel, M.5
-
49
-
-
33644540157
-
Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor
-
Stauber DJ, Debler EW, Horton PA, Smith KA, Wilson IA. 2006. Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor. Proc. Natl. Acad. Sci. USA 103:2788-93
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 2788-2793
-
-
Stauber, D.J.1
Debler, E.W.2
Horton, P.A.3
Smith, K.A.4
Wilson, I.A.5
-
50
-
-
20344387872
-
The structure of interleukin-2 complexed with its α receptor
-
Ricken M, Wang X, Boulanger MJ, Goriatcheva N, Garcia KC. 2005. The structure of interleukin-2 complexed with its α receptor. Science 308:1477-80
-
(2005)
Science
, vol.308
, pp. 1477-1480
-
-
Ricken, M.1
Wang, X.2
Boulanger, M.J.3
Goriatcheva, N.4
Garcia, K.C.5
-
51
-
-
0034283961
-
Efficient internalization of IL-2 depends upon the distal portion of the cytoplasmic tail of the IL-2R γc subunit and a lymphoid cell environment
-
Yu A, Olosz F, Choi C, Malek T. 2000. Efficient internalization of IL-2 depends upon the distal portion of the cytoplasmic tail of the IL-2R γc subunit and a lymphoid cell environment. J. Immunol. 165:2556-62
-
(2000)
J. Immunol
, vol.165
, pp. 2556-2562
-
-
Yu, A.1
Olosz, F.2
Choi, C.3
Malek, T.4
-
52
-
-
0030983549
-
Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation
-
Yu CL, Burakoff SJ. 1997. Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation. J. Biol. Chem. 272:14017-20
-
(1997)
J. Biol. Chem
, vol.272
, pp. 14017-14020
-
-
Yu, C.L.1
Burakoff, S.J.2
-
53
-
-
0028913166
-
Endocytosis of interleukin 2 receptors in human T lymphocytes: Distinct intracellular localization and fate of the receptor α, β, and γ chains
-
Hemar A, Subtil A, Lieb M, Morelon E, Hellio R. 1995. Endocytosis of interleukin 2 receptors in human T lymphocytes: distinct intracellular localization and fate of the receptor α, β, and γ chains. J. Cell Biol. 129:55-64
-
(1995)
J. Cell Biol
, vol.129
, pp. 55-64
-
-
Hemar, A.1
Subtil, A.2
Lieb, M.3
Morelon, E.4
Hellio, R.5
-
54
-
-
0035808301
-
The proteasome regulates receptor-mediated endocytosis of interleukin-2
-
Yu A, Malek TR. 2001. The proteasome regulates receptor-mediated endocytosis of interleukin-2. J. Biol. Chem. 276:381-85
-
(2001)
J. Biol. Chem
, vol.276
, pp. 381-385
-
-
Yu, A.1
Malek, T.R.2
-
55
-
-
0021271862
-
The interleukin-2 T-cell system: A new cell growth model
-
Cantrell DA, Smith KA. 1984. The interleukin-2 T-cell system: a new cell growth model. Science 224:1312-16
-
(1984)
Science
, vol.224
, pp. 1312-1316
-
-
Cantrell, D.A.1
Smith, K.A.2
-
56
-
-
0035752146
-
Cytokines and immunodeficiency diseases
-
Leonard WJ. 2001. Cytokines and immunodeficiency diseases. Nat. Rev. Immunol. 1:200-8
-
(2001)
Nat. Rev. Immunol
, vol.1
, pp. 200-208
-
-
Leonard, W.J.1
-
57
-
-
33646186619
-
Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis
-
Ma A, Koka R, Burkett P. 2006. Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis. Annu. Rev. Immunol. 24:657-79
-
(2006)
Annu. Rev. Immunol
, vol.24
, pp. 657-679
-
-
Ma, A.1
Koka, R.2
Burkett, P.3
-
58
-
-
33750219508
-
Both integrated and differential regulation of components of the IL-2/IL-2 receptor system
-
Kim HP, Imbert J, Leonard WJ. 2006. Both integrated and differential regulation of components of the IL-2/IL-2 receptor system. Cytokine Growth Factor Rev. 17:349-66
-
(2006)
Cytokine Growth Factor Rev
, vol.17
, pp. 349-366
-
-
Kim, H.P.1
Imbert, J.2
Leonard, W.J.3
-
59
-
-
26644431598
-
Smad-dependent cooperative regulation of interleukin 2 receptor α chain gene expression by T cell receptor and transforming growth factor-β
-
Kim HP, Kim BG, Letterio J, Leonard WJ. 2005. Smad-dependent cooperative regulation of interleukin 2 receptor α chain gene expression by T cell receptor and transforming growth factor-β. J. Biol. Chem. 280:34042-47
-
(2005)
J. Biol. Chem
, vol.280
, pp. 34042-34047
-
-
Kim, H.P.1
Kim, B.G.2
Letterio, J.3
Leonard, W.J.4
-
60
-
-
0031567888
-
Visualization of antigen-specific T cell activation and cytokine expression in vivo
-
Rogers WO, Weaver CT, Kraus LA, Li J, Li L, Bucy RP. 1997. Visualization of antigen-specific T cell activation and cytokine expression in vivo. J. Immunol. 158:649-57
-
(1997)
J. Immunol
, vol.158
, pp. 649-657
-
-
Rogers, W.O.1
Weaver, C.T.2
Kraus, L.A.3
Li, J.4
Li, L.5
Bucy, R.P.6
-
62
-
-
0032449386
-
Spontaneous expression of interleukin-2 in vivo in specific tissues of young mice
-
Yang-Snyder JA, Rothenberg EV. 1998. Spontaneous expression of interleukin-2 in vivo in specific tissues of young mice. Dev. Immunol. 5:223-45
-
(1998)
Dev. Immunol
, vol.5
, pp. 223-245
-
-
Yang-Snyder, J.A.1
Rothenberg, E.V.2
-
63
-
-
0037097659
-
Developmental and functional defects of thymic and epidermal Vγ3 cells in IL-15-deficient and IFN regulatory factor-1-deficient mice
-
De Creus A, Van Beneden K, Stevenaert F, Debacker V, Plum J, Leclercq G. 2002. Developmental and functional defects of thymic and epidermal Vγ3 cells in IL-15-deficient and IFN regulatory factor-1-deficient mice. J. Immunol. 168:6486-93
-
(2002)
J. Immunol
, vol.168
, pp. 6486-6493
-
-
De Creus, A.1
Van Beneden, K.2
Stevenaert, F.3
Debacker, V.4
Plum, J.5
Leclercq, G.6
-
64
-
-
0035881676
-
Differential roles of cytokine receptors in the development of epidermal γδ T cells
-
Ye SK, Maki K, Lee HC, Ito A, Kawai K, et al. 2001. Differential roles of cytokine receptors in the development of epidermal γδ T cells. J. Immunol. 167:1929-34
-
(2001)
J. Immunol
, vol.167
, pp. 1929-1934
-
-
Ye, S.K.1
Maki, K.2
Lee, H.C.3
Ito, A.4
Kawai, K.5
-
65
-
-
0031834196
-
Requirement of the IL-2 receptor β chain for the development of Vγ3 dendritic epidermal T cells
-
Kawai K, Suzuki H, Tomiyama K, Minagawa M, Mak TW, Ohashi PS. 1998. Requirement of the IL-2 receptor β chain for the development of Vγ3 dendritic epidermal T cells. J. Invest. Dermatol. 110:961-65
-
(1998)
J. Invest. Dermatol
, vol.110
, pp. 961-965
-
-
Kawai, K.1
Suzuki, H.2
Tomiyama, K.3
Minagawa, M.4
Mak, T.W.5
Ohashi, P.S.6
-
66
-
-
0033248123
-
-/- mice: Roles for both IL-2 and IL-15 in CD8αα IEL development
-
-/- mice: roles for both IL-2 and IL-15 in CD8αα IEL development. J. Immunol. 163:5906-12
-
(1999)
J. Immunol
, vol.163
, pp. 5906-5912
-
-
Porter, B.O.1
Malek, T.R.2
-
69
-
-
0031965469
-
A natural immunological adjuvant enhances T cell clonal expansion through a CD28-dependent, interleukin (IL)-2-independent mechanism
-
Khoruts A, Mondino A, Pape KA, Reiner SL, Jenkins MK. 1998. A natural immunological adjuvant enhances T cell clonal expansion through a CD28-dependent, interleukin (IL)-2-independent mechanism. J. Exp. Med. 187:225-36
-
(1998)
J. Exp. Med
, vol.187
, pp. 225-236
-
-
Khoruts, A.1
Mondino, A.2
Pape, K.A.3
Reiner, S.L.4
Jenkins, M.K.5
-
70
-
-
2442496266
-
+ T cells in vivo is rapid, transient, and influenced by TCR-specific competition
-
+ T cells in vivo is rapid, transient, and influenced by TCR-specific competition. J. Immunol. 172:6136-43
-
(2004)
J. Immunol
, vol.172
, pp. 6136-6143
-
-
Sojka, D.K.1
Bruniquel, D.2
Schwartz, R.H.3
Singh, N.J.4
-
71
-
-
9244226471
-
Frontline: An in-depth evaluation of the production of IL-2 by antigen-specific CD8 T cells in vivo
-
D'Souza WN, Lefrancois L. 2004. Frontline: an in-depth evaluation of the production of IL-2 by antigen-specific CD8 T cells in vivo. Eur. J. Immunol. 34:2977-85
-
(2004)
Eur. J. Immunol
, vol.34
, pp. 2977-2985
-
-
D'Souza, W.N.1
Lefrancois, L.2
-
72
-
-
33344458030
-
T cells use two directionally distinct pathways for cytokine secretion
-
Huse M, Lillemeier BF, Kuhns MS, Chen DS, Davis MM. 2006. T cells use two directionally distinct pathways for cytokine secretion. Nat. Immunol. 7:247-55
-
(2006)
Nat. Immunol
, vol.7
, pp. 247-255
-
-
Huse, M.1
Lillemeier, B.F.2
Kuhns, M.S.3
Chen, D.S.4
Davis, M.M.5
-
74
-
-
0347785480
-
Control of regulatory T cell development by the transcription factor Foxp3
-
Hori S, Nomura T, Sakaguchi S. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299:1057-61
-
(2003)
Science
, vol.299
, pp. 1057-1061
-
-
Hori, S.1
Nomura, T.2
Sakaguchi, S.3
-
78
-
-
33646007658
-
Interleukin-2-dependent mechanisms of tolerance and immunity in vivo
-
Antony PA, Paulos CM, Ahmadzadeh M, Akpinarli A, Palmer DC, et al. 2006. Interleukin-2-dependent mechanisms of tolerance and immunity in vivo. J. Immunol. 176:5255-66
-
(2006)
J. Immunol
, vol.176
, pp. 5255-5266
-
-
Antony, P.A.1
Paulos, C.M.2
Ahmadzadeh, M.3
Akpinarli, A.4
Palmer, D.C.5
-
79
-
-
27544446622
-
+ regulatory T cells in the absence of interleukin 2 signaling
-
+ regulatory T cells in the absence of interleukin 2 signaling. Nat. Immunol. 6:1152-59
-
(2005)
Nat. Immunol
, vol.6
, pp. 1152-1159
-
-
D'Cruz, L.M.1
Klein, L.2
-
80
-
-
27944455288
-
Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen
-
Knoechel B, Lohr J, Kahn E, Bluestone JA, Abbas AK. 2005. Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J. Exp. Med. 202:1375-86
-
(2005)
J. Exp. Med
, vol.202
, pp. 1375-1386
-
-
Knoechel, B.1
Lohr, J.2
Kahn, E.3
Bluestone, J.A.4
Abbas, A.K.5
-
81
-
-
33744912490
-
3+ T regulatory cells suppress autoimmunity while establishing transplantation tolerance
-
3+ T regulatory cells suppress autoimmunity while establishing transplantation tolerance. J. Immunol. 176:7149-53
-
(2006)
J. Immunol
, vol.176
, pp. 7149-7153
-
-
Adeegbe, D.1
Bayer, A.L.2
Levy, R.B.3
Malek, T.R.4
-
82
-
-
33646240855
-
Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development
-
Gavin MA, Torgerson TR, Houston E, DeRoos P, Ho WY, et al. 2006. Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc. Natl. Acad. Sci. USA 103:6659-64
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 6659-6664
-
-
Gavin, M.A.1
Torgerson, T.R.2
Houston, E.3
DeRoos, P.4
Ho, W.Y.5
-
83
-
-
33644844341
-
Molecular mechanisms underlying FOXP3 induction in human T cells
-
Mantel PY, Ouaked N, Ruckert B, Karagiannidis C, Welz R, et al. 2006. Molecular mechanisms underlying FOXP3 induction in human T cells. J. Immunol. 176:3593-602
-
(2006)
J. Immunol
, vol.176
, pp. 3593-3602
-
-
Mantel, P.Y.1
Ouaked, N.2
Ruckert, B.3
Karagiannidis, C.4
Welz, R.5
-
85
-
-
0034075807
-
Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: Identification of a candidate segment of ancestral DNA by haplotype mapping
-
Lyons PA, Armitage N, Argentina F, Denny P, Hill NJ, et al. 2000. Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping. Genome Res. 10:446-53
-
(2000)
Genome Res
, vol.10
, pp. 446-453
-
-
Lyons, P.A.1
Armitage, N.2
Argentina, F.3
Denny, P.4
Hill, N.J.5
-
86
-
-
33847246293
-
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity
-
Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, et al. 2007. Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat. Genet. 39:329-37
-
(2007)
Nat. Genet
, vol.39
, pp. 329-337
-
-
Yamanouchi, J.1
Rainbow, D.2
Serra, P.3
Howlett, S.4
Hunter, K.5
-
87
-
-
0030903027
-
Human immune disorder arising from mutation of the α chain of the interleukin-2 receptor
-
Sharfe N, Dadi HK, Shahar M, Roifman CM. 1997. Human immune disorder arising from mutation of the α chain of the interleukin-2 receptor. Proc. Natl. Acad. Sci. USA 94:3168-71
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 3168-3171
-
-
Sharfe, N.1
Dadi, H.K.2
Shahar, M.3
Roifman, C.M.4
-
88
-
-
33846805925
-
CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes
-
Caudy AA, Reddy ST, Chatila T, Atkinson JP, Verbsky JW. 2007. CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes. J. Allergy Clin. Immunol. 119:482-87
-
(2007)
J. Allergy Clin. Immunol
, vol.119
, pp. 482-487
-
-
Caudy, A.A.1
Reddy, S.T.2
Chatila, T.3
Atkinson, J.P.4
Verbsky, J.W.5
-
89
-
-
33747763675
-
IL-2 receptor α deficiency and features of primary biliary cirrhosis
-
Aoki CA, Roifman CM, Lian ZX, Bowlus CL, Norman GL, et al. 2006. IL-2 receptor α deficiency and features of primary biliary cirrhosis. J. Autoimmun. 27:50-53
-
(2006)
J. Autoimmun
, vol.27
, pp. 50-53
-
-
Aoki, C.A.1
Roifman, C.M.2
Lian, Z.X.3
Bowlus, C.L.4
Norman, G.L.5
-
90
-
-
0033920789
-
Human IL-2 receptor α chain deficiency
-
Roifman CM. 2000. Human IL-2 receptor α chain deficiency. Pediatr. Res. 48:6-11
-
(2000)
Pediatr. Res
, vol.48
, pp. 6-11
-
-
Roifman, C.M.1
-
91
-
-
84969213492
-
Genome-wide association study of 14,000 cases of seven common diseases and 3000 shared controls
-
Wellcome Trust Case Control Consortium
-
Wellcome Trust Case Control Consortium. 2007. Genome-wide association study of 14,000 cases of seven common diseases and 3000 shared controls. Nature 447:661-78
-
(2007)
Nature
, vol.447
, pp. 661-678
-
-
-
92
-
-
0242580058
-
Loss of tolerance and autoimmunity affecting multiple organs in STAT5A/5B-deficient mice
-
Snow JW, Abraham N, Ma MC, Herndier BG, Pastuszak AW, Goldsmith MA. 2003. Loss of tolerance and autoimmunity affecting multiple organs in STAT5A/5B-deficient mice. J. Immunol. 171:5042-50
-
(2003)
J. Immunol
, vol.171
, pp. 5042-5050
-
-
Snow, J.W.1
Abraham, N.2
Ma, M.C.3
Herndier, B.G.4
Pastuszak, A.W.5
Goldsmith, M.A.6
-
95
-
-
33749320682
-
Ontogeny, function, and peripheral homeostasis of regulatory T cells in the absence of interleukin-7
-
Peffault de Latour R, Dujardin HC, Mishellany F, Burlen-Defranoux O, Zuber J, et al. 2006. Ontogeny, function, and peripheral homeostasis of regulatory T cells in the absence of interleukin-7. Blood 108:2300-6
-
(2006)
Blood
, vol.108
, pp. 2300-2306
-
-
Peffault de Latour, R.1
Dujardin, H.C.2
Mishellany, F.3
Burlen-Defranoux, O.4
Zuber, J.5
-
97
-
-
33847651713
-
Thymic development and peripheral homeostasis of regulatory T cells
-
Liston A, Rudensky AY. 2007. Thymic development and peripheral homeostasis of regulatory T cells. Curr. Opin. Immunol. 19:176-85
-
(2007)
Curr. Opin. Immunol
, vol.19
, pp. 176-185
-
-
Liston, A.1
Rudensky, A.Y.2
-
100
-
-
13944260538
-
CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
-
Tai X, Cowan M, Feigenbaum L, Singer A. 2005. CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat. Immunol. 6:152-62
-
(2005)
Nat. Immunol
, vol.6
, pp. 152-162
-
-
Tai, X.1
Cowan, M.2
Feigenbaum, L.3
Singer, A.4
-
101
-
-
34249933446
-
Tracing the action of IL-2 in tolerance to islet-specific antigen
-
Liston A, Siggs OM, Goodnow CC. 2007. Tracing the action of IL-2 in tolerance to islet-specific antigen. Immunol. Cell Biol. 85:338-42
-
(2007)
Immunol. Cell Biol
, vol.85
, pp. 338-342
-
-
Liston, A.1
Siggs, O.M.2
Goodnow, C.C.3
-
102
-
-
0034654319
-
Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors
-
Malek TR, Porter BO, Codias EK, Scibelli P, Yu A. 2000. Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors. J. Immunol. 164:2905-14
-
(2000)
J. Immunol
, vol.164
, pp. 2905-2914
-
-
Malek, T.R.1
Porter, B.O.2
Codias, E.K.3
Scibelli, P.4
Yu, A.5
-
103
-
-
33847125247
-
Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
-
Wan YY, Flavell RA. 2007. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 445:766-70
-
(2007)
Nature
, vol.445
, pp. 766-770
-
-
Wan, Y.Y.1
Flavell, R.A.2
-
105
-
-
33747801470
-
+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo
-
+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. Blood 108:1571-79
-
(2006)
Blood
, vol.108
, pp. 1571-1579
-
-
Zorn, E.1
Nelson, E.A.2
Mohseni, M.3
Porcheray, F.4
Kim, H.5
-
106
-
-
34247564147
-
Nonredundant roles for Stat5a/b in directly regulating Foxp3
-
Yao Z, Kanno Y, Kerenyi M, Stephens G, Durant L, et al. 2007. Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood 109:4368-75
-
(2007)
Blood
, vol.109
, pp. 4368-4375
-
-
Yao, Z.1
Kanno, Y.2
Kerenyi, M.3
Stephens, G.4
Durant, L.5
-
109
-
-
0037243278
-
Neonates support lymphopenia-induced proliferation
-
Min B, McHugh R, Sempowski GD, Mackall C, Foucras G, Paul WE. 2003. Neonates support lymphopenia-induced proliferation. Immunity 18:131-40
-
(2003)
Immunity
, vol.18
, pp. 131-140
-
-
Min, B.1
McHugh, R.2
Sempowski, G.D.3
Mackall, C.4
Foucras, G.5
Paul, W.E.6
-
111
-
-
34250356020
-
Anti-CD25 treatment and FOXP3-positive regulatory T cells in heart transplantation
-
Vlad G, Ho EK, Vasilescu ER, Fan J, Liu Z, et al. 2007. Anti-CD25 treatment and FOXP3-positive regulatory T cells in heart transplantation. Transpl. Immunol. 18:13-21
-
(2007)
Transpl. Immunol
, vol.18
, pp. 13-21
-
-
Vlad, G.1
Ho, E.K.2
Vasilescu, E.R.3
Fan, J.4
Liu, Z.5
-
113
-
-
34249734842
-
Daclizumab (anti-Tac, Zenapax) in the treatment of leukemia/lymphoma
-
Waldmann TA. 2007. Daclizumab (anti-Tac, Zenapax) in the treatment of leukemia/lymphoma. Oncogene 26:3699-703
-
(2007)
Oncogene
, vol.26
, pp. 3699-3703
-
-
Waldmann, T.A.1
-
115
-
-
0031821875
-
+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
-
+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:287-96
-
(1998)
J. Exp. Med
, vol.188
, pp. 287-296
-
-
Thornton, A.M.1
Shevach, E.M.2
-
122
-
-
33745296472
-
+ regulatory T cells is indexed to the number of IL-2-producing cells
-
+ regulatory T cells is indexed to the number of IL-2-producing cells. J. Immunol. 177:192-200
-
(2006)
J. Immunol
, vol.177
, pp. 192-200
-
-
Almeida, A.R.1
Zaragoza, B.2
Freitas, A.A.3
-
123
-
-
32644484706
-
Instruction of Treg commitment in peripheral T cells is suited to reverse autoimmunity
-
Jaeckel E, Kretschmer K, Apostolou I, von Boehmer H. 2006. Instruction of Treg commitment in peripheral T cells is suited to reverse autoimmunity. Semin. Immunol. 18:89-92
-
(2006)
Semin. Immunol
, vol.18
, pp. 89-92
-
-
Jaeckel, E.1
Kretschmer, K.2
Apostolou, I.3
von Boehmer, H.4
-
126
-
-
1242290580
-
- cells to develop suppressive activity: The role of IL-2, TGFβ, and IL-10
-
- cells to develop suppressive activity: the role of IL-2, TGFβ, and IL-10. J. Immunol. 172:5213-21
-
(2004)
J. Immunol
, vol.172
, pp. 5213-5221
-
-
Zheng, S.G.1
Wang, J.H.2
Gray, J.D.3
Soucier, H.4
Horwitz, D.A.5
-
129
-
-
33646577466
-
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
-
Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, et al. 2006. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441:235-38
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
Carrier, Y.2
Gao, W.3
Korn, T.4
Strom, T.B.5
-
130
-
-
33847153417
-
Foxp3-dependent programme of regulatory T-cell differentiation
-
Gavin MA, Rasmussen JP, Fontenot JD, Vasta V, Manganiello VC, et al. 2007. Foxp3-dependent programme of regulatory T-cell differentiation. Nature 445:771-75
-
(2007)
Nature
, vol.445
, pp. 771-775
-
-
Gavin, M.A.1
Rasmussen, J.P.2
Fontenot, J.D.3
Vasta, V.4
Manganiello, V.C.5
-
131
-
-
32244442562
-
TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
-
Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. 2006. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24:179-89
-
(2006)
Immunity
, vol.24
, pp. 179-189
-
-
Veldhoen, M.1
Hocking, R.J.2
Atkins, C.J.3
Locksley, R.M.4
Stockinger, B.5
-
132
-
-
33947162110
-
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
-
Laurence A, Tato CM, Davidson TS, Kanno Y, Chen Z, et al. 2007. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26:371-81
-
(2007)
Immunity
, vol.26
, pp. 371-381
-
-
Laurence, A.1
Tato, C.M.2
Davidson, T.S.3
Kanno, Y.4
Chen, Z.5
-
133
-
-
34249806717
-
Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment
-
Kryczek I, Wei S, Zou L, Altuwaijri S, Szeliga W, et al. 2007. Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment. J. Immunol. 178:6730-33
-
(2007)
J. Immunol
, vol.178
, pp. 6730-6733
-
-
Kryczek, I.1
Wei, S.2
Zou, L.3
Altuwaijri, S.4
Szeliga, W.5
-
134
-
-
6344231287
-
+ regulatory T cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene
-
+ regulatory T cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene. J. Immunol. 173:4994-5001
-
(2004)
J. Immunol
, vol.173
, pp. 4994-5001
-
-
Su, L.1
Creusot, R.J.2
Gallo, E.M.3
Chan, S.M.4
Utz, P.J.5
-
135
-
-
33746228122
-
FOXP3 controls regulatory T cell function through cooperation with NFAT
-
Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan AD, et al. 2006. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 126:375-87
-
(2006)
Cell
, vol.126
, pp. 375-387
-
-
Wu, Y.1
Borde, M.2
Heissmeyer, V.3
Feuerer, M.4
Lapan, A.D.5
-
136
-
-
33947600584
-
Regulatory T cell development in the absence of functional Foxp3
-
Lin W, Haribhai D, Relland LM, Truong N, Carlson MR, et al. 2007. Regulatory T cell development in the absence of functional Foxp3. Nat. Immunol. 8:359-68
-
(2007)
Nat. Immunol
, vol.8
, pp. 359-368
-
-
Lin, W.1
Haribhai, D.2
Relland, L.M.3
Truong, N.4
Carlson, M.R.5
-
137
-
-
34247271308
-
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
-
Williams LM, Rudensky AY. 2007. Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat. Immunol. 8:277-84
-
(2007)
Nat. Immunol
, vol.8
, pp. 277-284
-
-
Williams, L.M.1
Rudensky, A.Y.2
-
138
-
-
6344275307
-
Transgenic expression of CTLA-4 controls lymphoproliferation in IL-2-deficient mice
-
Hwang KW, Sweatt WB, Mashayekhi M, Palucki DA, Sattar H, et al. 2004. Transgenic expression of CTLA-4 controls lymphoproliferation in IL-2-deficient mice. J. Immunol. 173:5415-24
-
(2004)
J. Immunol
, vol.173
, pp. 5415-5424
-
-
Hwang, K.W.1
Sweatt, W.B.2
Mashayekhi, M.3
Palucki, D.A.4
Sattar, H.5
-
139
-
-
33845942398
-
Th3 cells in peripheral tolerance. II. TGF-β-transgenic Th3 cells rescue IL-2-deficient mice from autoimmunity
-
Carrier Y, Yuan J, Kuchroo VK, Weiner HL. 2007. Th3 cells in peripheral tolerance. II. TGF-β-transgenic Th3 cells rescue IL-2-deficient mice from autoimmunity. J. Immunol. 178:172-78
-
(2007)
J. Immunol
, vol.178
, pp. 172-178
-
-
Carrier, Y.1
Yuan, J.2
Kuchroo, V.K.3
Weiner, H.L.4
-
140
-
-
0038025292
-
Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo
-
Blattman JN, Grayson JM, Wherry EJ, Kaech SM, Smith KA, Ahmed R. 2003. Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo. Nat. Med. 9:540-47
-
(2003)
Nat. Med
, vol.9
, pp. 540-547
-
-
Blattman, J.N.1
Grayson, J.M.2
Wherry, E.J.3
Kaech, S.M.4
Smith, K.A.5
Ahmed, R.6
-
142
-
-
0036839499
-
+ T cells increases tbe size of the acute antiviral response and of the resulting memory T cell pool
-
+ T cells increases tbe size of the acute antiviral response and of the resulting memory T cell pool. J. Immunol. 169:4990-97
-
(2002)
J. Immunol
, vol.169
, pp. 4990-4997
-
-
Cheng, L.E.1
Greenberg, P.D.2
-
143
-
-
0028843720
-
Endogenous IL-2 contributes to T cell expansion and IFN-γ production during lymphocytic choriomeningitis virus infection
-
Cousens LP, Orange JS, Biron CA. 1995. Endogenous IL-2 contributes to T cell expansion and IFN-γ production during lymphocytic choriomeningitis virus infection. J. Immunol. 155:5690-99
-
(1995)
J. Immunol
, vol.155
, pp. 5690-5699
-
-
Cousens, L.P.1
Orange, J.S.2
Biron, C.A.3
-
145
-
-
0034177560
-
Regulation of lymphoid homeostasis by IL-2 receptor signals in vivo
-
Leung DT, Morefield S, Willerford DM. 2000. Regulation of lymphoid homeostasis by IL-2 receptor signals in vivo. J. Immunol. 164:3527-34
-
(2000)
J. Immunol
, vol.164
, pp. 3527-3534
-
-
Leung, D.T.1
Morefield, S.2
Willerford, D.M.3
-
147
-
-
0028142358
-
Thymic selection and peptide-induced activation of T cell receptor-transgenic CD8 T cells in interleukin-2-deficient mice
-
Krämer S, Mamalaki C, Schimpl A, Kioussis D, Hünig T. 1994. Thymic selection and peptide-induced activation of T cell receptor-transgenic CD8 T cells in interleukin-2-deficient mice. Eur. J. Immunol. 24:2317-22
-
(1994)
Eur. J. Immunol
, vol.24
, pp. 2317-2322
-
-
Krämer, S.1
Mamalaki, C.2
Schimpl, A.3
Kioussis, D.4
Hünig, T.5
-
149
-
-
0036604208
-
Essential role for IL-2 in the regulation of antiviral extralymphoid CD8 T cell responses
-
D'Souza WN, Schluns KS, Masopust D, Lefrancois L. 2002. Essential role for IL-2 in the regulation of antiviral extralymphoid CD8 T cell responses. J. Immunol. 168:5566-72
-
(2002)
J. Immunol
, vol.168
, pp. 5566-5572
-
-
D'Souza, W.N.1
Schluns, K.S.2
Masopust, D.3
Lefrancois, L.4
-
150
-
-
0345447666
-
IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion
-
D'Souza WN, Lefrancois L. 2003. IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion. J. Immunol. 171:5727-35
-
(2003)
J. Immunol
, vol.171
, pp. 5727-5735
-
-
D'Souza, W.N.1
Lefrancois, L.2
-
152
-
-
0037222183
-
Efficient induction of primary and secondary T cell-dependent immune responses in vivo in the absence of functional IL-2 and IL-15 receptors
-
Yu A, Zhou J, Marten N, Bergmann CC, Mammolenti M, et al. 2003. Efficient induction of primary and secondary T cell-dependent immune responses in vivo in the absence of functional IL-2 and IL-15 receptors. J. Immunol. 170:236-42
-
(2003)
J. Immunol
, vol.170
, pp. 236-242
-
-
Yu, A.1
Zhou, J.2
Marten, N.3
Bergmann, C.C.4
Mammolenti, M.5
-
153
-
-
33645238946
-
Quantitative assessment concerning the contribution of IL-2Rβ for superantigen-mediated T cell responses in vivo
-
Jin H, Gong D, Adeegbe D, Bayer AL, Rolle C, et al. 2006. Quantitative assessment concerning the contribution of IL-2Rβ for superantigen-mediated T cell responses in vivo. Int. Immunol. 18:565-72
-
(2006)
Int. Immunol
, vol.18
, pp. 565-572
-
-
Jin, H.1
Gong, D.2
Adeegbe, D.3
Bayer, A.L.4
Rolle, C.5
-
154
-
-
0026017971
-
Interleukin-2 programs αβ T lymphocytes for apoptosis
-
Lenardo MJ. 1991. Interleukin-2 programs αβ T lymphocytes for apoptosis. Nature 353:858-61
-
(1991)
Nature
, vol.353
, pp. 858-861
-
-
Lenardo, M.J.1
-
155
-
-
0035253708
-
Broad programming by IL-2 receptor signaling for extended growth to multiple cytokines and functional maturation of antigen-activated T cells
-
Malek TR, Yu A, Scibelli P, Lichtenheld MG, Codias EK. 2001. Broad programming by IL-2 receptor signaling for extended growth to multiple cytokines and functional maturation of antigen-activated T cells. J. Immunol. 166:1675-83
-
(2001)
J. Immunol
, vol.166
, pp. 1675-1683
-
-
Malek, T.R.1
Yu, A.2
Scibelli, P.3
Lichtenheld, M.G.4
Codias, E.K.5
-
158
-
-
2442599173
-
IL-2 induces a competitive survival advantage in T lymphocytes
-
Dooms H, Kahn E, Knoechel B, Abbas AK. 2004. IL-2 induces a competitive survival advantage in T lymphocytes. J. Immunol. 172:5973-79
-
(2004)
J. Immunol
, vol.172
, pp. 5973-5979
-
-
Dooms, H.1
Kahn, E.2
Knoechel, B.3
Abbas, A.K.4
-
159
-
-
0038487052
-
Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells
-
Seddon B, Tomlinson P, Zamoyska R. 2003. Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat. Immunol. 4:680-86
-
(2003)
Nat. Immunol
, vol.4
, pp. 680-686
-
-
Seddon, B.1
Tomlinson, P.2
Zamoyska, R.3
-
160
-
-
0347594000
-
IL-7 promotes the transition of CD4 effectors to persistent memory cells
-
Li J, Huston G, Swain SL. 2003. IL-7 promotes the transition of CD4 effectors to persistent memory cells. J. Exp. Med. 198:1807-15
-
(2003)
J. Exp. Med
, vol.198
, pp. 1807-1815
-
-
Li, J.1
Huston, G.2
Swain, S.L.3
-
161
-
-
0347281680
-
Interleukin 7 regulates the survival and generation of memory CD4 cells
-
Kondrack RM, Harbertson J, Tan JT, McBreen ME, Surh CD, Bradley LM. 2003. Interleukin 7 regulates the survival and generation of memory CD4 cells. J. Exp. Med. 198:1797-806
-
(2003)
J. Exp. Med
, vol.198
, pp. 1797-1806
-
-
Kondrack, R.M.1
Harbertson, J.2
Tan, J.T.3
McBreen, M.E.4
Surh, C.D.5
Bradley, L.M.6
-
162
-
-
34247849183
-
Effector and memory CTL differentiation
-
Williams MA, Bevan MJ. 2007. Effector and memory CTL differentiation. Annu. Rev. Immunol. 25:171-92
-
(2007)
Annu. Rev. Immunol
, vol.25
, pp. 171-192
-
-
Williams, M.A.1
Bevan, M.J.2
-
163
-
-
0842343444
-
Disparate in vitro and in vivo requirements for IL-2 during antigen-independent CD8 T cell expansion
-
Wong P, Pamer EG. 2004. Disparate in vitro and in vivo requirements for IL-2 during antigen-independent CD8 T cell expansion. J. Immunol. 172:2171-76
-
(2004)
J. Immunol
, vol.172
, pp. 2171-2176
-
-
Wong, P.1
Pamer, E.G.2
-
164
-
-
33746238541
-
Duration of CTL activation regulates IL-2 production required for autonomous clonal expansion
-
Spierings DC, Lemmens EE, Grewal K, Schoenberger SP, Green DR. 2006. Duration of CTL activation regulates IL-2 production required for autonomous clonal expansion. Eur. J. Immunol. 36:1707-17
-
(2006)
Eur. J. Immunol
, vol.36
, pp. 1707-1717
-
-
Spierings, D.C.1
Lemmens, E.E.2
Grewal, K.3
Schoenberger, S.P.4
Green, D.R.5
-
166
-
-
33644784733
-
+ regulatory T cells in cancer patients
-
+ regulatory T cells in cancer patients. Blood 107:2409-14
-
(2006)
Blood
, vol.107
, pp. 2409-2414
-
-
Ahmadzadeh, M.1
Rosenberg, S.A.2
-
168
-
-
34247524959
-
Effects of the administration of high-dose interleukin-2 on immunoregulatory cell subsets in patients with advanced melanoma and renal cell cancer
-
van Dervliet HJ, Koon HB, Yue SC, Uzunparmak B, Seery V, et al. 2007. Effects of the administration of high-dose interleukin-2 on immunoregulatory cell subsets in patients with advanced melanoma and renal cell cancer. Clin. Cancer Res. 13:2100-8
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 2100-2108
-
-
van Dervliet, H.J.1
Koon, H.B.2
Yue, S.C.3
Uzunparmak, B.4
Seery, V.5
-
171
-
-
0027531423
-
Selective modulation of human natural killer cells in vivo after prolonged infusion of low dose recombinant interleukin 2
-
Caligiuri MA, Murray C, Robertson MJ, Wang E, Cochran K, et al. 1993. Selective modulation of human natural killer cells in vivo after prolonged infusion of low dose recombinant interleukin 2. J. Clin. Invest. 91:123-32
-
(1993)
J. Clin. Invest
, vol.91
, pp. 123-132
-
-
Caligiuri, M.A.1
Murray, C.2
Robertson, M.J.3
Wang, E.4
Cochran, K.5
-
172
-
-
33746369415
-
Regulatory T-cell physiology and application to treat autoimmunity
-
Tang Q, Bluestone JA. 2006. Regulatory T-cell physiology and application to treat autoimmunity. Immunol. Rev. 212:217-37
-
(2006)
Immunol. Rev
, vol.212
, pp. 217-237
-
-
Tang, Q.1
Bluestone, J.A.2
-
177
-
-
1542409971
-
A late, prolonged activation of the phosphatidylinositol 3-kinase pathway is required for T cell proliferation
-
Lali FV, Crawley J, McCulloch DA, Foxwell BM. 2004. A late, prolonged activation of the phosphatidylinositol 3-kinase pathway is required for T cell proliferation. J. Immunol. 172:3527-34
-
(2004)
J. Immunol
, vol.172
, pp. 3527-3534
-
-
Lali, F.V.1
Crawley, J.2
McCulloch, D.A.3
Foxwell, B.M.4
-
181
-
-
33645465526
-
Selective stimulation of T cell subsets with antibody-cytokine immune complexes
-
Boyman O, Kovar M, Rubinstein MP, Surh CD, Sprent J. 2006. Selective stimulation of T cell subsets with antibody-cytokine immune complexes. Science 311:1924-27
-
(2006)
Science
, vol.311
, pp. 1924-1927
-
-
Boyman, O.1
Kovar, M.2
Rubinstein, M.P.3
Surh, C.D.4
Sprent, J.5
-
182
-
-
0029118133
-
Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice
-
Kneitz B, Herrmann T, Yonehara S, Schimpl A. 1995. Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice. Eur. J. Immunol. 25:2572-77
-
(1995)
Eur. J. Immunol
, vol.25
, pp. 2572-2577
-
-
Kneitz, B.1
Herrmann, T.2
Yonehara, S.3
Schimpl, A.4
-
183
-
-
0032529195
-
Impaired alloantigen-mediated T cell apoptosis and failure to induce long-term allograft survival in IL-2-deficient mice
-
Dai Z, Konieczny BT, Baddoura FK, Lakkis FG. 1998. Impaired alloantigen-mediated T cell apoptosis and failure to induce long-term allograft survival in IL-2-deficient mice. J. Immunol. 161:1659-63
-
(1998)
J. Immunol
, vol.161
, pp. 1659-1663
-
-
Dai, Z.1
Konieczny, B.T.2
Baddoura, F.K.3
Lakkis, F.G.4
-
184
-
-
0013195631
-
-
Li XC, Roy-Chaudhury P, Hancock WW, Manfro R, Zand MS, et al. 1998. IL-2 and IL-4 double knockout mice reject islet allografts: a role for novel T cell growth factors in allograft rejection. J. Immunol. 161:890-96
-
Li XC, Roy-Chaudhury P, Hancock WW, Manfro R, Zand MS, et al. 1998. IL-2 and IL-4 double knockout mice reject islet allografts: a role for novel T cell growth factors in allograft rejection. J. Immunol. 161:890-96
-
-
-
-
186
-
-
0030861424
-
Normal thymic selection, superantigen-induced deletion and Fas-mediated apoptosis of T cells in IL-2 receptor β-chain deficient mice
-
Suzuki H, Hayakawa A, Bouchard D, Nakashima I, Mak TW. 1997. Normal thymic selection, superantigen-induced deletion and Fas-mediated apoptosis of T cells in IL-2 receptor β-chain deficient mice. Int. Immmunol. 9:1367-74
-
(1997)
Int. Immmunol
, vol.9
, pp. 1367-1374
-
-
Suzuki, H.1
Hayakawa, A.2
Bouchard, D.3
Nakashima, I.4
Mak, T.W.5
-
187
-
-
0035142107
-
Mice lacking interleukin-2 (IL-2)/IL-15 receptor β chain are susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar choleraesuis but mice lacking IL-2 are resistant
-
Nishimura H, Tagaya M, Tsunobuchi H, Suzuki H, Nakashima I, Yoshikai Y. 2001. Mice lacking interleukin-2 (IL-2)/IL-15 receptor β chain are susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar choleraesuis but mice lacking IL-2 are resistant. Infect. Immun. 69:1226-29
-
(2001)
Infect. Immun
, vol.69
, pp. 1226-1229
-
-
Nishimura, H.1
Tagaya, M.2
Tsunobuchi, H.3
Suzuki, H.4
Nakashima, I.5
Yoshikai, Y.6
|