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Volumn 8, Issue 8, 2007, Pages 801-808

Antigen receptor diversification and chromosome translocations

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; FANCONI ANEMIA PROTEIN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; LYMPHOCYTE ANTIGEN RECEPTOR; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE 4; PROTEIN BCL 2; PROTEIN P53; PROTEIN XRCC4; RAG1 PROTEIN; RAG2 PROTEIN; SINGLE STRANDED DNA; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; UNCLASSIFIED DRUG;

EID: 34547115451     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1498     Document Type: Review
Times cited : (51)

References (165)
  • 1
  • 3
    • 3242883717 scopus 로고    scopus 로고
    • (D)J recombination: How to tame a transposase
    • Brandt, V.L. & Roth, D.B.V. (D)J recombination: How to tame a transposase. Immunol. Rev. 200, 249-260 (2004).
    • (2004) Immunol. Rev , vol.200 , pp. 249-260
    • Brandt, V.L.1    Roth, D.B.V.2
  • 4
    • 0021442649 scopus 로고
    • Ordered rearrangement of immunoglobulin heavy chain variable region segments
    • Alt, F.W. et al. Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J. 3, 1209-1219 (1984).
    • (1984) EMBO J , vol.3 , pp. 1209-1219
    • Alt, F.W.1
  • 5
    • 0041689676 scopus 로고    scopus 로고
    • Predominant autoantibody production by early human B cell precursors
    • Wardemann, H. et al. Predominant autoantibody production by early human B cell precursors. Science 301, 1374-1377 (2003).
    • (2003) Science , vol.301 , pp. 1374-1377
    • Wardemann, H.1
  • 6
    • 0027499537 scopus 로고
    • Receptor editing: An approach by autoreactive B cells to escape tolerance
    • Gay, D., Saunders, T., Camper, S. & Weigert, M. Receptor editing: An approach by autoreactive B cells to escape tolerance. J. Exp. Med. 177, 999-1008 (1993).
    • (1993) J. Exp. Med , vol.177 , pp. 999-1008
    • Gay, D.1    Saunders, T.2    Camper, S.3    Weigert, M.4
  • 7
    • 0027478391 scopus 로고
    • Receptor editing in self-reactive bone marrow B cells
    • Tiegs, S.L., Russell, D.M. & Nemazee, D. Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177, 1009-1020 (1993).
    • (1993) J. Exp. Med , vol.177 , pp. 1009-1020
    • Tiegs, S.L.1    Russell, D.M.2    Nemazee, D.3
  • 8
    • 0035936833 scopus 로고    scopus 로고
    • Contribution of receptor editing to the antibody repertoire
    • Casellas, R. et al. Contribution of receptor editing to the antibody repertoire. Science 291, 1541-1544 (2001).
    • (2001) Science , vol.291 , pp. 1541-1544
    • Casellas, R.1
  • 9
    • 33847206141 scopus 로고    scopus 로고
    • In vivo imaging of germinal centres reveals a dynamic open structure
    • Schwickert, T.A. et al. In vivo imaging of germinal centres reveals a dynamic open structure. Nature 446, 83-87 (2007).
    • (2007) Nature , vol.446 , pp. 83-87
    • Schwickert, T.A.1
  • 10
    • 0030022218 scopus 로고    scopus 로고
    • Antibody class switching
    • Stavnezer, J. Antibody class switching. Adv. Immunol. 61, 79-146 (1996).
    • (1996) Adv. Immunol , vol.61 , pp. 79-146
    • Stavnezer, J.1
  • 11
    • 0035940511 scopus 로고    scopus 로고
    • A hallmark of active class switch recombination: Transcripts directed by I promoters on looped-out circular DNAs
    • Kinoshita, K., Harigai, M., Fagarasan, S., Muramatsu, M. & Honjo, T. A hallmark of active class switch recombination: Transcripts directed by I promoters on looped-out circular DNAs. Proc. Natl. Acad. Sci. USA 98, 12620-12623 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 12620-12623
    • Kinoshita, K.1    Harigai, M.2    Fagarasan, S.3    Muramatsu, M.4    Honjo, T.5
  • 12
    • 33846606769 scopus 로고    scopus 로고
    • Antibody class switching mediated by yeast endonuclease-generated DNA breaks
    • Zarrin, A.A. et al. Antibody class switching mediated by yeast endonuclease-generated DNA breaks. Science 315, 377-381 (2007).
    • (2007) Science , vol.315 , pp. 377-381
    • Zarrin, A.A.1
  • 13
    • 0033603340 scopus 로고    scopus 로고
    • Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
    • Muramatsu, M. et al. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J. Biol. Chem. 274, 18470-18476 (1999).
    • (1999) J. Biol. Chem , vol.274 , pp. 18470-18476
    • Muramatsu, M.1
  • 14
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Muramatsu, M. et al. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102, 553-563 (2000).
    • (2000) Cell , vol.102 , pp. 553-563
    • Muramatsu, M.1
  • 15
    • 0034264851 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
    • Revy, P. et al. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell 102, 565-575 (2000).
    • (2000) Cell , vol.102 , pp. 565-575
    • Revy, P.1
  • 16
    • 0037019315 scopus 로고    scopus 로고
    • AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification
    • Petersen-Mahrt, S.K., Harris, R.S. & Neuberger, M.S. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature 418, 99-103 (2002).
    • (2002) Nature , vol.418 , pp. 99-103
    • Petersen-Mahrt, S.K.1    Harris, R.S.2    Neuberger, M.S.3
  • 17
    • 0037026482 scopus 로고    scopus 로고
    • Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase
    • Di Noia, J. & Neuberger, M.S. Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. Nature 419 43-48 (2002).
    • (2002) Nature , vol.419 , pp. 43-48
    • Di Noia, J.1    Neuberger, M.S.2
  • 18
    • 6344256944 scopus 로고    scopus 로고
    • Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation
    • Rada, C., Di Noia, J.M. & Neuberger, M.S. Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation. Mol. Cell 16, 163-171 (2004).
    • (2004) Mol. Cell , vol.16 , pp. 163-171
    • Rada, C.1    Di Noia, J.M.2    Neuberger, M.S.3
  • 19
    • 0038293484 scopus 로고    scopus 로고
    • Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand
    • Ramiro, A.R., Stavropoulos, P., Jankovic, M. & Nussenzweig, M.C. Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nat. Immunol. 4 452-456 (2003).
    • (2003) Nat. Immunol , vol.4 , pp. 452-456
    • Ramiro, A.R.1    Stavropoulos, P.2    Jankovic, M.3    Nussenzweig, M.C.4
  • 20
    • 0037561998 scopus 로고    scopus 로고
    • AID mediates hypermutation by deaminating single stranded DNA
    • Dickerson, S.K., Market, E., Besmer, E. & Papavasiliou, F.N. AID mediates hypermutation by deaminating single stranded DNA. J. Exp. Med. 197, 1291-1296 (2003).
    • (2003) J. Exp. Med , vol.197 , pp. 1291-1296
    • Dickerson, S.K.1    Market, E.2    Besmer, E.3    Papavasiliou, F.N.4
  • 21
    • 0037452080 scopus 로고    scopus 로고
    • Transcription-targeted DNA deamination by the AID antibody diversification enzyme
    • Chaudhuri, J. et al. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature 422, 726-730 (2003).
    • (2003) Nature , vol.422 , pp. 726-730
    • Chaudhuri, J.1
  • 22
    • 0037388165 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
    • Bransteitter, R., Pham, P., Scharff, M.D. & Goodman, M.F. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc. Natl. Acad. Sci. USA 100, 4102-4107 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 4102-4107
    • Bransteitter, R.1    Pham, P.2    Scharff, M.D.3    Goodman, M.F.4
  • 23
    • 25144496639 scopus 로고    scopus 로고
    • AID from bony fish catalyzes class switch recombination
    • Barreto, V.M. et al. AID from bony fish catalyzes class switch recombination. J. Exp. Med. 202, 733-738 (2005).
    • (2005) J. Exp. Med , vol.202 , pp. 733-738
    • Barreto, V.M.1
  • 24
    • 33745316013 scopus 로고    scopus 로고
    • Structural phylogenetic analysis of activation-induced deaminase function
    • Ichikawa, H.T. et al. Structural phylogenetic analysis of activation-induced deaminase function. J. Immunol. 177, 355-361 (2006).
    • (2006) J. Immunol , vol.177 , pp. 355-361
    • Ichikawa, H.T.1
  • 25
    • 30344463017 scopus 로고    scopus 로고
    • Evolution of class switch recombination function in fish activation-induced cytidine deaminase
    • Wakae, K. et al. Evolution of class switch recombination function in fish activation-induced cytidine deaminase, AID. Int. Immunol. 18, 41-47 (2006).
    • (2006) AID. Int. Immunol , vol.18 , pp. 41-47
    • Wakae, K.1
  • 26
    • 0035818990 scopus 로고    scopus 로고
    • AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
    • Petersen, S. et al. AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching. Nature 414 660-665 (2001).
    • (2001) Nature , vol.414 , pp. 660-665
    • Petersen, S.1
  • 27
    • 22144443194 scopus 로고    scopus 로고
    • AID to overcome the limitations of genomic information
    • Honjo, T., Nagaoka, H., Shinkura, R. & Muramatsu, M. AID to overcome the limitations of genomic information. Nat. Immunol. 6, 655-661 (2005).
    • (2005) Nat. Immunol , vol.6 , pp. 655-661
    • Honjo, T.1    Nagaoka, H.2    Shinkura, R.3    Muramatsu, M.4
  • 29
    • 27644524833 scopus 로고    scopus 로고
    • MRE11/RAD50 cleaves DNA in the AID/UNG-dependent pathway of immunoglobulin gene diversification
    • Larson, E.D., Cummings, W.J., Bednarski, D.W. & Maizels, N. MRE11/RAD50 cleaves DNA in the AID/UNG-dependent pathway of immunoglobulin gene diversification. Mol. Cell 20, 367-375 (2005).
    • (2005) Mol. Cell , vol.20 , pp. 367-375
    • Larson, E.D.1    Cummings, W.J.2    Bednarski, D.W.3    Maizels, N.4
  • 30
    • 33748623634 scopus 로고    scopus 로고
    • Common fragile sites as targets for chromosome rearrangements
    • Arlt, M.F., Durkin, S.G., Ragland, R.L. & Glover, T.W. Common fragile sites as targets for chromosome rearrangements. DNA Repair (Amst.) 5, 1126-1135 (2006).
    • (2006) DNA Repair (Amst.) , vol.5 , pp. 1126-1135
    • Arlt, M.F.1    Durkin, S.G.2    Ragland, R.L.3    Glover, T.W.4
  • 31
    • 0022380768 scopus 로고
    • The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
    • Adams, J.M. et al. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 318, 533-538 (1985).
    • (1985) Nature , vol.318 , pp. 533-538
    • Adams, J.M.1
  • 32
    • 0025939204 scopus 로고
    • Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease
    • Strasser, A. et al. Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc. Natl. Acad. Sci. USA 88, 8661-8665 (1991).
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 8661-8665
    • Strasser, A.1
  • 33
    • 0027969316 scopus 로고
    • Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells
    • Madisen, L. & Groudine, M. Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells. Genes Dev. 8, 2212-2226 (1994).
    • (1994) Genes Dev , vol.8 , pp. 2212-2226
    • Madisen, L.1    Groudine, M.2
  • 34
    • 0035839959 scopus 로고    scopus 로고
    • Mechanisms of chromosomal translocations in B cell lymphomas
    • Kuppers, R. & Dalla-Favera, R. Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene 20, 5580-5594 (2001).
    • (2001) Oncogene , vol.20 , pp. 5580-5594
    • Kuppers, R.1    Dalla-Favera, R.2
  • 35
    • 0037365789 scopus 로고    scopus 로고
    • ATM and related protein kinases: Safeguarding genome integrity
    • Shiloh, Y. ATM and related protein kinases: Safeguarding genome integrity. Nat. Rev. Cancer 3, 155-168 (2003).
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 155-168
    • Shiloh, Y.1
  • 36
    • 12944328742 scopus 로고    scopus 로고
    • Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice
    • Borghesani, P.R. et al. Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice. Proc. Natl. Acad. Sci. USA 97 3336-3341 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 3336-3341
    • Borghesani, P.R.1
  • 37
    • 0029848286 scopus 로고    scopus 로고
    • Pleiotropic defects in ataxia-telangiectasia protein-deficient mice
    • Elson, A. et al. Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proc. Natl. Acad. Sci. USA 93, 13084-13089 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 13084-13089
    • Elson, A.1
  • 38
    • 0029844048 scopus 로고    scopus 로고
    • Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
    • Xu, Y. et al. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev. 10, 2411-2422 (1996).
    • (1996) Genes Dev , vol.10 , pp. 2411-2422
    • Xu, Y.1
  • 39
    • 15844426692 scopus 로고    scopus 로고
    • Atm-deficient mice: A paradigm of ataxia telangiectasia
    • Barlow, C. et al. Atm-deficient mice: A paradigm of ataxia telangiectasia. Cell 86, 159-171 (1996).
    • (1996) Cell , vol.86 , pp. 159-171
    • Barlow, C.1
  • 40
    • 0034284341 scopus 로고    scopus 로고
    • Abnormal rearrangement within the α/δ T-cell receptor locus in lymphomas from Atm-deficient mice
    • Liyanage, M. et al. Abnormal rearrangement within the α/δ T-cell receptor locus in lymphomas from Atm-deficient mice. Blood 96 1940-1946 (2000).
    • (2000) Blood , vol.96 , pp. 1940-1946
    • Liyanage, M.1
  • 42
    • 0033563099 scopus 로고    scopus 로고
    • Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma
    • Liao, M.J. & Van Dyke, T. Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma. Genes Dev. 13, 1246-1250 (1999).
    • (1999) Genes Dev , vol.13 , pp. 1246-1250
    • Liao, M.J.1    Van Dyke, T.2
  • 43
    • 0036232666 scopus 로고    scopus 로고
    • RAG-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice
    • Petiniot, L.K. et al. RAG-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice. Mol. Cell. Biol. 22, 3174-3177 (2002).
    • (2002) Mol. Cell. Biol , vol.22 , pp. 3174-3177
    • Petiniot, L.K.1
  • 44
    • 0034732239 scopus 로고    scopus 로고
    • DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation
    • Difilippantonio, M.J. et al. DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Nature 404, 510-514 (2000).
    • (2000) Nature , vol.404 , pp. 510-514
    • Difilippantonio, M.J.1
  • 45
    • 0037136318 scopus 로고    scopus 로고
    • Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification
    • Difilippantonio, M.J. et al. Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification. J. Exp. Med. 196, 469-480 (2002).
    • (2002) J. Exp. Med , vol.196 , pp. 469-480
    • Difilippantonio, M.J.1
  • 46
    • 0034690249 scopus 로고    scopus 로고
    • Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development
    • Gao, Y. et al. Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature 404 897-900 (2000).
    • (2000) Nature , vol.404 , pp. 897-900
    • Gao, Y.1
  • 47
    • 0037188898 scopus 로고    scopus 로고
    • Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations
    • Zhu, C. et al. Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell 109, 811-821 (2002).
    • (2002) Cell , vol.109 , pp. 811-821
    • Zhu, C.1
  • 48
    • 0037824720 scopus 로고    scopus 로고
    • The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice
    • Gladdy, R.A. et al. The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice. Cancer Cell 3, 37-50 (2003).
    • (2003) Cancer Cell , vol.3 , pp. 37-50
    • Gladdy, R.A.1
  • 49
    • 0035800747 scopus 로고    scopus 로고
    • Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints
    • Raghavan, S.C., Kirsch, I.R. & Lieber, M.R. Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints. J. Biol. Chem. 276, 29126-29133 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 29126-29133
    • Raghavan, S.C.1    Kirsch, I.R.2    Lieber, M.R.3
  • 50
    • 0037033440 scopus 로고    scopus 로고
    • (D)J-mediated translocations in lymphoid neoplasms: A functional assessment of genomic instability by cryptic sites
    • Marculescu, R., Le, T., Simon, P., Jaeger, U. & Nadel, B.V. (D)J-mediated translocations in lymphoid neoplasms: A functional assessment of genomic instability by cryptic sites. J. Exp. Med. 195, 85-98 (2002).
    • (2002) J. Exp. Med , vol.195 , pp. 85-98
    • Marculescu, R.1    Le, T.2    Simon, P.3    Jaeger, U.4    Nadel, B.V.5
  • 51
    • 1542287213 scopus 로고    scopus 로고
    • A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex
    • Raghavan, S.C., Swanson, P.C., Wu, X., Hsieh, C.L. & Lieber, M.R. A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex. Nature 428, 88-93 (2004).
    • (2004) Nature , vol.428 , pp. 88-93
    • Raghavan, S.C.1    Swanson, P.C.2    Wu, X.3    Hsieh, C.L.4    Lieber, M.R.5
  • 52
    • 1942421722 scopus 로고    scopus 로고
    • RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination
    • Lee, G.S., Neiditch, M.B., Salus, S.S. & Roth, D.B. RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination. Cell 117, 171-184 (2004).
    • (2004) Cell , vol.117 , pp. 171-184
    • Lee, G.S.1    Neiditch, M.B.2    Salus, S.S.3    Roth, D.B.4
  • 53
    • 34548420553 scopus 로고    scopus 로고
    • A role for AID in chromosome translocations between c-myc and the IgH variable region
    • in the press
    • Dorsett, Y. et al. A role for AID in chromosome translocations between c-myc and the IgH variable region. J. Exp. Med. (in the press).
    • J. Exp. Med
    • Dorsett, Y.1
  • 55
    • 0038336667 scopus 로고    scopus 로고
    • Neoplastic development in plasma cells
    • Potter, M. Neoplastic development in plasma cells. Immunol. Rev. 194, 177-195 (2003).
    • (2003) Immunol. Rev , vol.194 , pp. 177-195
    • Potter, M.1
  • 56
    • 0026604568 scopus 로고
    • Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice
    • Suematsu, S. et al. Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice. Proc. Natl. Acad. Sci. USA 89, 232-235 (1992).
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 232-235
    • Suematsu, S.1
  • 57
    • 0026767880 scopus 로고
    • Plasmacytomagenesis in mice: Model of neoplastic development dependent upon chromosomal translocations
    • Potter, M. & Wiener, F. Plasmacytomagenesis in mice: Model of neoplastic development dependent upon chromosomal translocations. Carcinogenesis 13, 1681-1697 (1992).
    • (1992) Carcinogenesis , vol.13 , pp. 1681-1697
    • Potter, M.1    Wiener, F.2
  • 58
    • 9244241060 scopus 로고    scopus 로고
    • Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc
    • Unniraman, S., Zhou, S. & Schatz, D.G. Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc. Nat. Immunol. 5, 1117-1123 (2004).
    • (2004) Nat. Immunol , vol.5 , pp. 1117-1123
    • Unniraman, S.1    Zhou, S.2    Schatz, D.G.3
  • 59
    • 4644257592 scopus 로고    scopus 로고
    • AID is required for c-myc/IgH chromosome translocations in vivo
    • Ramiro, A.R. et al. AID is required for c-myc/IgH chromosome translocations in vivo. Cell 118, 431-438 (2004).
    • (2004) Cell , vol.118 , pp. 431-438
    • Ramiro, A.R.1
  • 60
    • 33644643189 scopus 로고    scopus 로고
    • Role of genomic instability and p53 in AID-induced c-myc-Igh translocations
    • Ramiro, A.R. et al. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature 440, 105-109 (2006).
    • (2006) Nature , vol.440 , pp. 105-109
    • Ramiro, A.R.1
  • 61
    • 0037388211 scopus 로고    scopus 로고
    • Somatic hypermutation of the B cell receptor genes B29 (Igβ, CD79b) and mb1 (Igα, CD79a)
    • Gordon, M.S., Kanegai, C.M., Doerr, J.R. & Wall, R. Somatic hypermutation of the B cell receptor genes B29 (Igβ, CD79b) and mb1 (Igα, CD79a). Proc. Natl. Acad. Sci. USA 100, 4126-4131 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 4126-4131
    • Gordon, M.S.1    Kanegai, C.M.2    Doerr, J.R.3    Wall, R.4
  • 62
    • 2642623612 scopus 로고    scopus 로고
    • Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes
    • Shen, H.M., Peters, A., Baron, B., Zhu, X. & Storb, U. Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes. Science 280, 1750-1752 (1998).
    • (1998) Science , vol.280 , pp. 1750-1752
    • Shen, H.M.1    Peters, A.2    Baron, B.3    Zhu, X.4    Storb, U.5
  • 63
    • 33845604556 scopus 로고    scopus 로고
    • DNA double-strand break repair: All's well that ends well
    • Wyman, C. & Kanaar, R. DNA double-strand break repair: All's well that ends well. Annu. Rev. Genet. 40, 363-383 (2006).
    • (2006) Annu. Rev. Genet , vol.40 , pp. 363-383
    • Wyman, C.1    Kanaar, R.2
  • 64
    • 0032478071 scopus 로고    scopus 로고
    • Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease
    • Goossens, T., Klein, U. & Kuppers, R. Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease. Proc. Natl. Acad. Sci. USA 95, 2463-2468 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 2463-2468
    • Goossens, T.1    Klein, U.2    Kuppers, R.3
  • 65
    • 0031983725 scopus 로고    scopus 로고
    • Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes
    • Wilson, P.C. et al. Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes. J. Exp. Med. 187, 59-70 (1998).
    • (1998) J. Exp. Med , vol.187 , pp. 59-70
    • Wilson, P.C.1
  • 66
    • 0032435650 scopus 로고    scopus 로고
    • TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line
    • Sale, J.E. & Neuberger, M.S. TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line. Immunity 9, 859-869 (1998).
    • (1998) Immunity , vol.9 , pp. 859-869
    • Sale, J.E.1    Neuberger, M.S.2
  • 67
    • 0034626802 scopus 로고    scopus 로고
    • Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes
    • Papavasiliou, F.N. & Schatz, D.G. Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes. Nature 408, 216-221 (2000).
    • (2000) Nature , vol.408 , pp. 216-221
    • Papavasiliou, F.N.1    Schatz, D.G.2
  • 68
    • 0035003254 scopus 로고    scopus 로고
    • DNA breaks in hypermutating immunoglobulin genes: Evidence for a break-and-repair pathway of somatic hypermutation
    • Kong, Q. & Maizels, N. DNA breaks in hypermutating immunoglobulin genes: evidence for a break-and-repair pathway of somatic hypermutation. Genetics 158, 369-378 (2001).
    • (2001) Genetics , vol.158 , pp. 369-378
    • Kong, Q.1    Maizels, N.2
  • 69
    • 0037029663 scopus 로고    scopus 로고
    • DNA double-strand breaks: Prior to but not sufficient in targeting hypermutation
    • Bross, L., Muramatsu, M., Kinoshita, K., Honjo, T. & Jacobs, H. DNA double-strand breaks: Prior to but not sufficient in targeting hypermutation. J. Exp. Med. 195, 1187-1192 (2002).
    • (2002) J. Exp. Med , vol.195 , pp. 1187-1192
    • Bross, L.1    Muramatsu, M.2    Kinoshita, K.3    Honjo, T.4    Jacobs, H.5
  • 70
    • 33846424933 scopus 로고    scopus 로고
    • Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation
    • Ronai, D. et al. Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation. J. Exp. Med. 204, 181-190 (2007).
    • (2007) J. Exp. Med , vol.204 , pp. 181-190
    • Ronai, D.1
  • 71
    • 15444366646 scopus 로고    scopus 로고
    • A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression
    • Kotani, A. et al. A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression. Proc. Natl. Acad. Sci. USA 102 4506-4511 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 4506-4511
    • Kotani, A.1
  • 72
    • 0037881911 scopus 로고    scopus 로고
    • Constitutive expression of AID leads to tumorigenesis
    • Okazaki, I.M. et al. Constitutive expression of AID leads to tumorigenesis. J. Exp. Med. 197, 1173-1181 (2003).
    • (2003) J. Exp. Med , vol.197 , pp. 1173-1181
    • Okazaki, I.M.1
  • 73
    • 33846804438 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice
    • Kotani, A. et al. Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice. Proc. Natl. Acad. Sci. USA 104, 1616-1620 (2007).
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 1616-1620
    • Kotani, A.1
  • 74
    • 34547941093 scopus 로고    scopus 로고
    • Expression of activation-induced cytidine deaminase in human hepatocytes via NF-κB signaling
    • publication; 2 April, doi:10.1038/sj.onc.1210344
    • Endo, Y. et al. Expression of activation-induced cytidine deaminase in human hepatocytes via NF-κB signaling. Oncogene advance online publication; 2 April 2007 (doi:10.1038/sj.onc.1210344). (2007).
    • (2007) Oncogene advance online
    • Endo, Y.1
  • 75
    • 34147180434 scopus 로고    scopus 로고
    • Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium
    • Matsumoto, Y. et al. Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Nat. Med. 13, 470-476 (2007).
    • (2007) Nat. Med , vol.13 , pp. 470-476
    • Matsumoto, Y.1
  • 76
    • 3242882820 scopus 로고    scopus 로고
    • 3-kinase related kinases: 'big' players in stress-induced signaling pathways
    • Abraham, R.T. PI 3-kinase related kinases: 'big' players in stress-induced signaling pathways. DNA Repair (Amst.) 3, 883-887 (2004).
    • (2004) DNA Repair (Amst.) , vol.3 , pp. 883-887
    • Abraham, R.T.P.1
  • 77
    • 3943107573 scopus 로고    scopus 로고
    • Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
    • Sancar, A., Lindsey-Boltz, L.A., Unsal-Kacmaz, K. & Linn, S. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu. Rev. Biochem. 73, 39-85 (2004).
    • (2004) Annu. Rev. Biochem , vol.73 , pp. 39-85
    • Sancar, A.1    Lindsey-Boltz, L.A.2    Unsal-Kacmaz, K.3    Linn, S.4
  • 78
    • 15844394846 scopus 로고    scopus 로고
    • Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
    • Falck, J., Coates, J. & Jackson, S.P. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 434, 605-611 (2005).
    • (2005) Nature , vol.434 , pp. 605-611
    • Falck, J.1    Coates, J.2    Jackson, S.P.3
  • 79
    • 33749261770 scopus 로고    scopus 로고
    • The role of NBS1 in the modulation of PIKK family proteins ATM and ATR in the cellular response to DNA damage
    • Zhou, J., Lim, C.U., Li, J.J., Cai, L. & Zhang, Y. The role of NBS1 in the modulation of PIKK family proteins ATM and ATR in the cellular response to DNA damage. Cancer Lett. 243, 9-15 (2006).
    • (2006) Cancer Lett , vol.243 , pp. 9-15
    • Zhou, J.1    Lim, C.U.2    Li, J.J.3    Cai, L.4    Zhang, Y.5
  • 80
    • 31344465936 scopus 로고    scopus 로고
    • Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation
    • Pan-Hammarstrom, Q. et al. Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation. J. Exp. Med. 203, 99-110 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 99-110
    • Pan-Hammarstrom, Q.1
  • 81
    • 3242891189 scopus 로고    scopus 로고
    • The Mre11 complex and the metabolism of chromosome breaks: The importance of communicating and holding things together
    • Stracker, T.H., Theunissen, J.W., Morales, M. & Petrini, J.H. The Mre11 complex and the metabolism of chromosome breaks: The importance of communicating and holding things together. DNA Repair (Amst.) 3 845-854 (2004).
    • (2004) DNA Repair (Amst.) , vol.3 , pp. 845-854
    • Stracker, T.H.1    Theunissen, J.W.2    Morales, M.3    Petrini, J.H.4
  • 83
    • 0034623860 scopus 로고    scopus 로고
    • Response to RAG-mediated VDJ cleavage by NBS1 and γ-H2AX
    • Chen, H.T. et al. Response to RAG-mediated VDJ cleavage by NBS1 and γ-H2AX. Science 290, 1962-1965 (2000).
    • (2000) Science , vol.290 , pp. 1962-1965
    • Chen, H.T.1
  • 84
    • 0037711771 scopus 로고    scopus 로고
    • Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks
    • Celeste, A. et al. Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat. Cell Biol. 5, 675-679 (2003).
    • (2003) Nat. Cell Biol , vol.5 , pp. 675-679
    • Celeste, A.1
  • 85
    • 22144462810 scopus 로고    scopus 로고
    • Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models
    • Difilippantonio, S. et al. Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models. Nat. Cell Biol. 7, 675-685 (2005).
    • (2005) Nat. Cell Biol , vol.7 , pp. 675-685
    • Difilippantonio, S.1
  • 86
    • 0027304013 scopus 로고
    • (D)J recombination in ataxia telangiectasia, Bloom's syndrome, and a DNA ligase I-associated immunodeficiency disorder
    • Hsieh, C.L., Arlett, C.F. & Lieber, M.R.V. (D)J recombination in ataxia telangiectasia, Bloom's syndrome, and a DNA ligase I-associated immunodeficiency disorder. J. Biol. Chem. 268, 20105-20109 (1993).
    • (1993) J. Biol. Chem , vol.268 , pp. 20105-20109
    • Hsieh, C.L.1    Arlett, C.F.2    Lieber, M.R.V.3
  • 87
    • 0037080679 scopus 로고    scopus 로고
    • Sensing of intermediates in V(D)J recombination by ATM
    • Perkins, E.J. et al. Sensing of intermediates in V(D)J recombination by ATM. Genes Dev. 16, 159-164 (2002).
    • (2002) Genes Dev , vol.16 , pp. 159-164
    • Perkins, E.J.1
  • 88
    • 33747097562 scopus 로고    scopus 로고
    • ATM stabilizes DNA double-strand-break complexes during V(D)J recombination
    • Bredemeyer, A.L. et al. ATM stabilizes DNA double-strand-break complexes during V(D)J recombination. Nature 442, 466-470 (2006).
    • (2006) Nature , vol.442 , pp. 466-470
    • Bredemeyer, A.L.1
  • 89
    • 4444339751 scopus 로고    scopus 로고
    • ATM and ataxia telangiectasia
    • 772-776
    • McKinnon, P.J. ATM and ataxia telangiectasia. EMBO Rep. 5, 772-776 (2004).
    • (2004) EMBO Rep , vol.5
    • McKinnon, P.J.1
  • 90
    • 8644242383 scopus 로고    scopus 로고
    • Immunoglobulin class switch recombination is impaired in Atm-deficient mice
    • Lumsden, J.M. et al. Immunoglobulin class switch recombination is impaired in Atm-deficient mice. J. Exp. Med. 200, 1111-1121 (2004).
    • (2004) J. Exp. Med , vol.200 , pp. 1111-1121
    • Lumsden, J.M.1
  • 91
    • 8644238314 scopus 로고    scopus 로고
    • ATM is required for efficient recombination between immunoglobulin switch regions
    • Reina-San-Martin, B., Chen, H.T., Nussenzweig, A. & Nussenzweig, M.C. ATM is required for efficient recombination between immunoglobulin switch regions. J. Exp. Med. 200, 1103-1110 (2004).
    • (2004) J. Exp. Med , vol.200 , pp. 1103-1110
    • Reina-San-Martin, B.1    Chen, H.T.2    Nussenzweig, A.3    Nussenzweig, M.C.4
  • 92
    • 30744445418 scopus 로고    scopus 로고
    • H2AX prevents DNA breaks from progressing to chromosome breaks and translocations
    • Franco, S. et al. H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol. Cell 21, 201-214 (2006).
    • (2006) Mol. Cell , vol.21 , pp. 201-214
    • Franco, S.1
  • 93
    • 17644409069 scopus 로고    scopus 로고
    • ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
    • Lee, J.H. & Paull, T.T. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 308, 551-554 (2005).
    • (2005) Science , vol.308 , pp. 551-554
    • Lee, J.H.1    Paull, T.T.2
  • 94
    • 34249048548 scopus 로고    scopus 로고
    • Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis
    • Difilippantonio, M. J. et al. Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis. J. Exp. Med. 204 1003-1011 (2007).
    • (2007) J. Exp. Med , vol.204 , pp. 1003-1011
    • Difilippantonio, M.J.1
  • 95
    • 0032076190 scopus 로고    scopus 로고
    • Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome
    • Varon, R. et al. Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. Cell 93, 467-476 (1998).
    • (1998) Cell , vol.93 , pp. 467-476
    • Varon, R.1
  • 96
    • 0032076248 scopus 로고    scopus 로고
    • The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
    • Carney, J.P. et al. The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response. Cell 93, 477-486 (1998).
    • (1998) Cell , vol.93 , pp. 477-486
    • Carney, J.P.1
  • 97
    • 0035936554 scopus 로고    scopus 로고
    • Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice
    • Zhu, J., Petersen, S., Tessarollo, L. & Nussenzweig, A. Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice. Curr. Biol. 11, 105-109 (2001).
    • (2001) Curr. Biol , vol.11 , pp. 105-109
    • Zhu, J.1    Petersen, S.2    Tessarollo, L.3    Nussenzweig, A.4
  • 98
    • 0037086702 scopus 로고    scopus 로고
    • Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair
    • Kang, J., Bronson, R.T. & Xu, Y. Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair. EMBO J. 21, 1447-1455 (2002).
    • (2002) EMBO J , vol.21 , pp. 1447-1455
    • Kang, J.1    Bronson, R.T.2    Xu, Y.3
  • 99
    • 0037117410 scopus 로고    scopus 로고
    • A murine model of Nijmegen breakage syndrome
    • Williams, B.R. et al. A murine model of Nijmegen breakage syndrome. Curr. Biol. 12, 648-653 (2002).
    • (2002) Curr. Biol , vol.12 , pp. 648-653
    • Williams, B.R.1
  • 100
    • 0000858524 scopus 로고    scopus 로고
    • V(D)J rearrangement in Nijmegen breakage syndrome
    • Yeo, T.C. et al. V(D)J rearrangement in Nijmegen breakage syndrome. Mol. Immunol. 37, 1131-1139 (2000).
    • (2000) Mol. Immunol , vol.37 , pp. 1131-1139
    • Yeo, T.C.1
  • 101
    • 0035085624 scopus 로고    scopus 로고
    • Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome
    • Harfst, E. et al. Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome. Mol. Immunol. 37, 915-929 (2000).
    • (2000) Mol. Immunol , vol.37 , pp. 915-929
    • Harfst, E.1
  • 102
    • 0036404927 scopus 로고    scopus 로고
    • Heterogeneity of humoral immune abnormalities in children with Nijmegen breakage syndrome: An 8-year follow-up study in a single centre
    • Gregorek, H., Chrzanowska, K.H., Michalkiewicz, J., Syczewska, M. & Madalinski, K. Heterogeneity of humoral immune abnormalities in children with Nijmegen breakage syndrome: An 8-year follow-up study in a single centre. Clin. Exp. Immunol. 130, 319-324 (2002).
    • (2002) Clin. Exp. Immunol , vol.130 , pp. 319-324
    • Gregorek, H.1    Chrzanowska, K.H.2    Michalkiewicz, J.3    Syczewska, M.4    Madalinski, K.5
  • 103
    • 13444309097 scopus 로고    scopus 로고
    • Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1
    • Reina-San-Martin, B., Nussenzweig, M.C., Nussenzweig, A. & Difilippantonio, S. Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1. Proc. Natl. Acad. Sci. USA 102, 1590-1595 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 1590-1595
    • Reina-San-Martin, B.1    Nussenzweig, M.C.2    Nussenzweig, A.3    Difilippantonio, S.4
  • 104
    • 13444281917 scopus 로고    scopus 로고
    • Nibrin functions in Ig class-switch recombination
    • Kracker, S. et al. Nibrin functions in Ig class-switch recombination. Proc. Natl. Acad. Sci. USA 102, 1584-1589 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 1584-1589
    • Kracker, S.1
  • 105
    • 0037012845 scopus 로고    scopus 로고
    • Genomic instability in mice lacking histone H2AX
    • Celeste, A. et al. Genomic instability in mice lacking histone H2AX. Science 296, 922-927 (2002).
    • (2002) Science , vol.296 , pp. 922-927
    • Celeste, A.1
  • 106
    • 0037062492 scopus 로고    scopus 로고
    • Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX
    • Bassing, C.H. et al. Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc. Natl. Acad. Sci. USA 99, 8173-8178 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 8173-8178
    • Bassing, C.H.1
  • 107
    • 0042991383 scopus 로고    scopus 로고
    • H2AX haploinsufficiency modifies genomic stability and tumor susceptibility
    • Celeste, A. et al. H2AX haploinsufficiency modifies genomic stability and tumor susceptibility. Cell 114, 371-383 (2003).
    • (2003) Cell , vol.114 , pp. 371-383
    • Celeste, A.1
  • 108
    • 0042991379 scopus 로고    scopus 로고
    • Histone H2AX: A dosage-dependent suppressor of oncogenic translocations and tumors
    • Bassing, C.H. et al. Histone H2AX: A dosage-dependent suppressor of oncogenic translocations and tumors. Cell 114, 359-370 (2003).
    • (2003) Cell , vol.114 , pp. 359-370
    • Bassing, C.H.1
  • 109
    • 0037866984 scopus 로고    scopus 로고
    • H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation
    • Reina-San-Martin, B. et al. H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation. J. Exp. Med. 197, 1767-1778 (2003).
    • (2003) J. Exp. Med , vol.197 , pp. 1767-1778
    • Reina-San-Martin, B.1
  • 112
    • 9244252580 scopus 로고    scopus 로고
    • Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks
    • Huyen, Y. et al. Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Nature 432, 406-411 (2004).
    • (2004) Nature , vol.432 , pp. 406-411
    • Huyen, Y.1
  • 113
    • 33845666681 scopus 로고    scopus 로고
    • Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair
    • Botuyan, M.V. et al. Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell 127, 1361-1373 (2006).
    • (2006) Cell , vol.127 , pp. 1361-1373
    • Botuyan, M.V.1
  • 114
    • 0038143321 scopus 로고    scopus 로고
    • Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX
    • Ward, I.M., Minn, K., Jorda, K.G. & Chen, J. Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. J. Biol. Chem. 278, 19579-19582 (2003).
    • (2003) J. Biol. Chem , vol.278 , pp. 19579-19582
    • Ward, I.M.1    Minn, K.2    Jorda, K.G.3    Chen, J.4
  • 115
    • 0036903037 scopus 로고    scopus 로고
    • DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1
    • Fernandez-Capetillo, O. et al. DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat. Cell Biol. 4, 993-997 (2002).
    • (2002) Nat. Cell Biol , vol.4 , pp. 993-997
    • Fernandez-Capetillo, O.1
  • 116
    • 22944462083 scopus 로고    scopus 로고
    • Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1
    • Bekker-Jensen, S., Lukas, C., Melander, F., Bartek, J. & Lukas, J. Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1. J. Cell Biol. 170, 201-211 (2005).
    • (2005) J. Cell Biol , vol.170 , pp. 201-211
    • Bekker-Jensen, S.1    Lukas, C.2    Melander, F.3    Bartek, J.4    Lukas, J.5
  • 117
    • 0037378527 scopus 로고    scopus 로고
    • p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice
    • Ward, I.M., Minn, K., van Deursen, J. & Chen, J. p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Mol. Cell. Biol. 23, 2556-2563 (2003).
    • (2003) Mol. Cell. Biol , vol.23 , pp. 2556-2563
    • Ward, I.M.1    Minn, K.2    van Deursen, J.3    Chen, J.4
  • 118
    • 2542463148 scopus 로고    scopus 로고
    • 53BP1 is required for class switch recombination
    • Ward, I.M. et al. 53BP1 is required for class switch recombination. J. Cell Biol. 165, 459-464 (2004).
    • (2004) J. Cell Biol , vol.165 , pp. 459-464
    • Ward, I.M.1
  • 119
    • 2442707746 scopus 로고    scopus 로고
    • 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination
    • Manis, J.P. et al. 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. Nat. Immunol. 5, 481-487 (2004).
    • (2004) Nat. Immunol , vol.5 , pp. 481-487
    • Manis, J.P.1
  • 120
    • 0037772381 scopus 로고    scopus 로고
    • Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability
    • Morales, J.C. et al. Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability. J. Biol. Chem. 278, 14971-14977 (2003).
    • (2003) J. Biol. Chem , vol.278 , pp. 14971-14977
    • Morales, J.C.1
  • 122
    • 3242881500 scopus 로고    scopus 로고
    • The cellular response to general and programmed DNA double strand breaks
    • Bassing, C.H. & Alt, F.W. The cellular response to general and programmed DNA double strand breaks. DNA Repair (Amst.) 3, 781-796 (2004).
    • (2004) DNA Repair (Amst.) , vol.3 , pp. 781-796
    • Bassing, C.H.1    Alt, F.W.2
  • 123
    • 3242879122 scopus 로고    scopus 로고
    • The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination
    • Lieber, M.R., Ma, Y., Pannicke, U. & Schwarz, K. The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination. DNA Repair (Amst.) 3, 817-826 (2004).
    • (2004) DNA Repair (Amst.) , vol.3 , pp. 817-826
    • Lieber, M.R.1    Ma, Y.2    Pannicke, U.3    Schwarz, K.4
  • 124
    • 0027156278 scopus 로고
    • Impairment of V(D)J recombination in double-strand break repair mutants
    • Taccioli, G.E. et al. Impairment of V(D)J recombination in double-strand break repair mutants. Science 260, 207-210 (1993).
    • (1993) Science , vol.260 , pp. 207-210
    • Taccioli, G.E.1
  • 125
    • 0026018228 scopus 로고
    • T-lymphocyte development in scid mice is arrested shortly after the initiation of T-cell receptor δ gene recombination
    • Carroll, A.M. & Bosma, M.J. T-lymphocyte development in scid mice is arrested shortly after the initiation of T-cell receptor δ gene recombination. Genes Dev. 5, 1357-1366 (1991).
    • (1991) Genes Dev , vol.5 , pp. 1357-1366
    • Carroll, A.M.1    Bosma, M.J.2
  • 126
    • 0032522564 scopus 로고    scopus 로고
    • Ku80 is required for immunoglobulin isotype switching
    • Casellas, R. et al. Ku80 is required for immunoglobulin isotype switching. EMBO J. 17, 2404-2411 (1998).
    • (1998) EMBO J , vol.17 , pp. 2404-2411
    • Casellas, R.1
  • 127
    • 0032526290 scopus 로고    scopus 로고
    • Ku70 is required for late B cell development and immunoglobulin heavy chain class switching
    • Manis, J.P. et al. Ku70 is required for late B cell development and immunoglobulin heavy chain class switching. J. Exp. Med. 187, 2081-2089 (1998).
    • (1998) J. Exp. Med , vol.187 , pp. 2081-2089
    • Manis, J.P.1
  • 128
    • 33747889722 scopus 로고    scopus 로고
    • Role of non-homologous end joining (NHEJ) in maintaining genomic integrity
    • Burma, S., Chen, B.P. & Chen, D.J. Role of non-homologous end joining (NHEJ) in maintaining genomic integrity. DNA Repair (Amst.) 5 1042-1048 (2006).
    • (2006) DNA Repair (Amst.) , vol.5 , pp. 1042-1048
    • Burma, S.1    Chen, B.P.2    Chen, D.J.3
  • 129
    • 0037660900 scopus 로고    scopus 로고
    • The role of DNA breaks in genomic instability and tumorigenesis
    • Mills, K.D., Ferguson, D.O. & Alt, F.W. The role of DNA breaks in genomic instability and tumorigenesis. Immunol. Rev. 194, 77-95 (2003).
    • (2003) Immunol. Rev , vol.194 , pp. 77-95
    • Mills, K.D.1    Ferguson, D.O.2    Alt, F.W.3
  • 130
    • 0035833552 scopus 로고    scopus 로고
    • Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
    • Walker, J.R., Corpina, R.A. & Goldberg, J. Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature 412, 607-614 (2001).
    • (2001) Nature , vol.412 , pp. 607-614
    • Walker, J.R.1    Corpina, R.A.2    Goldberg, J.3
  • 131
    • 3242886503 scopus 로고    scopus 로고
    • Role of DNA-PK in the cellular response to DNA double-strand breaks
    • Burma, S. & Chen, D.J. Role of DNA-PK in the cellular response to DNA double-strand breaks. DNA Repair (Amst.) 3, 909-918 (2004).
    • (2004) DNA Repair (Amst.) , vol.3 , pp. 909-918
    • Burma, S.1    Chen, D.J.2
  • 132
    • 34247507469 scopus 로고    scopus 로고
    • Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break
    • Chen, B.P. et al. Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break. J. Biol. Chem. 282, 6582-6587 (2007).
    • (2007) J. Biol. Chem , vol.282 , pp. 6582-6587
    • Chen, B.P.1
  • 133
    • 33744827665 scopus 로고    scopus 로고
    • p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc
    • Gladdy, R.A., Nutter, L.M., Kunath, T., Danska, J.S. & Guidos, C.J. p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc. Mol. Cancer Res. 4, 311-318 (2006).
    • (2006) Mol. Cancer Res , vol.4 , pp. 311-318
    • Gladdy, R.A.1    Nutter, L.M.2    Kunath, T.3    Danska, J.S.4    Guidos, C.J.5
  • 134
    • 0035853127 scopus 로고    scopus 로고
    • Genetic interactions between ATM and the nonhomologous endjoining factors in genomic stability and development
    • Sekiguchi, J. et al. Genetic interactions between ATM and the nonhomologous endjoining factors in genomic stability and development. Proc. Natl. Acad. Sci. USA 98, 3243-3248 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 3243-3248
    • Sekiguchi, J.1
  • 136
    • 0029778191 scopus 로고    scopus 로고
    • Requirement for Ku80 in growth and immunoglobulin V(D)J recombination
    • Nussenzweig, A. et al. Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature 382, 551-555 (1996).
    • (1996) Nature , vol.382 , pp. 551-555
    • Nussenzweig, A.1
  • 137
    • 0031433517 scopus 로고    scopus 로고
    • Growth retardation and leaky SCID phenotype of Ku70-deficient mice
    • Gu, Y. et al. Growth retardation and leaky SCID phenotype of Ku70-deficient mice. Immunity 7, 653-665 (1997).
    • (1997) Immunity , vol.7 , pp. 653-665
    • Gu, Y.1
  • 138
    • 0032167545 scopus 로고    scopus 로고
    • Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity
    • Taccioli, G.E. et al. Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity. Immunity 9, 355-366 (1998).
    • (1998) Immunity , vol.9 , pp. 355-366
    • Taccioli, G.E.1
  • 139
    • 0032167446 scopus 로고    scopus 로고
    • A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination
    • Gao, Y. et al. A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Immunity 9, 367-376 (1998).
    • (1998) Immunity , vol.9 , pp. 367-376
    • Gao, Y.1
  • 140
    • 0030885974 scopus 로고    scopus 로고
    • Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination in vivo
    • Ouyang, H. et al. Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination in vivo. J. Exp. Med. 186, 921-929 (1997).
    • (1997) J. Exp. Med , vol.186 , pp. 921-929
    • Ouyang, H.1
  • 141
    • 0036240127 scopus 로고    scopus 로고
    • The mechanism and regulation of chromosomal V(D)J recombination
    • Bassing, C.H., Swat, W. & Alt, F.W. The mechanism and regulation of chromosomal V(D)J recombination. Cell 109 Suppl, S45-S55 (2002).
    • (2002) Cell , vol.109 , Issue.SUPPL.
    • Bassing, C.H.1    Swat, W.2    Alt, F.W.3
  • 142
    • 0035313998 scopus 로고    scopus 로고
    • How to make ends meet in V(D)J recombination
    • Grawunder, U. & Harfst, E. How to make ends meet in V(D)J recombination. Curr. Opin. Immunol. 13, 186-194 (2001).
    • (2001) Curr. Opin. Immunol , vol.13 , pp. 186-194
    • Grawunder, U.1    Harfst, E.2
  • 143
    • 0037011116 scopus 로고    scopus 로고
    • DNA-dependent protein kinase activity is not required for immunoglobulin class switching
    • Bosma, G.C. et al. DNA-dependent protein kinase activity is not required for immunoglobulin class switching. J. Exp. Med. 196 1483-1495 (2002).
    • (2002) J. Exp. Med , vol.196 , pp. 1483-1495
    • Bosma, G.C.1
  • 144
    • 0345735841 scopus 로고    scopus 로고
    • Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions
    • Cook, A.J. et al. Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions. J. Immunol. 171, 6556-6564 (2003).
    • (2003) J. Immunol , vol.171 , pp. 6556-6564
    • Cook, A.J.1
  • 145
    • 0036224604 scopus 로고    scopus 로고
    • IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells
    • Manis, J.P., Dudley, D., Kaylor, L. & Alt, F.W. IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells. Immunity 16, 607-617 (2002).
    • (2002) Immunity , vol.16 , pp. 607-617
    • Manis, J.P.1    Dudley, D.2    Kaylor, L.3    Alt, F.W.4
  • 146
    • 0035917489 scopus 로고    scopus 로고
    • Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency
    • Moshous, D. et al. Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency. Cell 105, 177-186 (2001).
    • (2001) Cell , vol.105 , pp. 177-186
    • Moshous, D.1
  • 147
    • 0036932453 scopus 로고    scopus 로고
    • Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice
    • Rooney, S. et al. Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice. Mol. Cell 10, 1379-1390 (2002).
    • (2002) Mol. Cell , vol.10 , pp. 1379-1390
    • Rooney, S.1
  • 148
    • 0037155703 scopus 로고    scopus 로고
    • Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination
    • Ma, Y., Pannicke, U., Schwarz, K. & Lieber, M.R. Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell 108 781-794 (2002).
    • (2002) Cell , vol.108 , pp. 781-794
    • Ma, Y.1    Pannicke, U.2    Schwarz, K.3    Lieber, M.R.4
  • 149
    • 20644471358 scopus 로고    scopus 로고
    • Harmonising the response to DSBs: A new string in the ATM bow
    • Lobrich, M. & Jeggo, P.A. Harmonising the response to DSBs: A new string in the ATM bow. DNA Repair (Amst.) 4, 749-759 (2005).
    • (2005) DNA Repair (Amst.) , vol.4 , pp. 749-759
    • Lobrich, M.1    Jeggo, P.A.2
  • 150
    • 20644463916 scopus 로고    scopus 로고
    • The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps
    • Ma, Y., Schwarz, K. & Lieber, M.R. The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps. DNA Repair (Amst.) 4, 845-851 (2005).
    • (2005) DNA Repair (Amst.) , vol.4 , pp. 845-851
    • Ma, Y.1    Schwarz, K.2    Lieber, M.R.3
  • 151
    • 33748089029 scopus 로고    scopus 로고
    • DNA-PK autophosphorylation facilitates Artemis endonuclease activity
    • Goodarzi, A.A. et al. DNA-PK autophosphorylation facilitates Artemis endonuclease activity. EMBO J. 25, 3880-3889 (2006).
    • (2006) EMBO J , vol.25 , pp. 3880-3889
    • Goodarzi, A.A.1
  • 152
    • 0037312006 scopus 로고    scopus 로고
    • Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis
    • Moshous, D. et al. Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis. J. Clin. Invest. 111, 381-387 (2003).
    • (2003) J. Clin. Invest , vol.111 , pp. 381-387
    • Moshous, D.1
  • 153
    • 1442306125 scopus 로고    scopus 로고
    • Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells
    • Rooney, S. et al. Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells. Proc. Natl. Acad. Sci. USA 101, 2410-2415 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 2410-2415
    • Rooney, S.1
  • 154
    • 14044253569 scopus 로고    scopus 로고
    • Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development
    • Rooney, S., Alt, F.W., Sekiguchi, J. & Manis, J.P. Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development. Proc. Natl. Acad. Sci. USA 102 2471-2475 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 2471-2475
    • Rooney, S.1    Alt, F.W.2    Sekiguchi, J.3    Manis, J.P.4
  • 155
    • 34247602569 scopus 로고    scopus 로고
    • Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK
    • Costantini, S., Woodbine, L., Andreoli, L., Jeggo, P.A. & Vindigni, A. Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK. DNA Repair (Amst) 6, 712-722 (2007).
    • (2007) DNA Repair (Amst) , vol.6 , pp. 712-722
    • Costantini, S.1    Woodbine, L.2    Andreoli, L.3    Jeggo, P.A.4    Vindigni, A.5
  • 156
    • 33845484385 scopus 로고    scopus 로고
    • Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4
    • Mari, P.O. et al. Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4. Proc. Natl. Acad. Sci. USA 103, 18597-18602 (2006).
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 18597-18602
    • Mari, P.O.1
  • 157
    • 0032417640 scopus 로고    scopus 로고
    • A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis
    • Gao, Y. et al. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell 95, 891-902 (1998).
    • (1998) Cell , vol.95 , pp. 891-902
    • Gao, Y.1
  • 158
    • 0032511976 scopus 로고    scopus 로고
    • Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV
    • Frank, K.M. et al. Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature 396, 173-177 (1998).
    • (1998) Nature , vol.396 , pp. 173-177
    • Frank, K.M.1
  • 159
    • 0032585526 scopus 로고    scopus 로고
    • Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice
    • Barnes, D.E., Stamp, G., Rosewell, I., Denzel, A. & Lindahl, T. Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice. Curr. Biol. 8, 1395-1398 (1998).
    • (1998) Curr. Biol , vol.8 , pp. 1395-1398
    • Barnes, D.E.1    Stamp, G.2    Rosewell, I.3    Denzel, A.4    Lindahl, T.5
  • 160
    • 0034668060 scopus 로고    scopus 로고
    • Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm
    • Lee, Y., Barnes, D.E., Lindahl, T. & McKinnon, P.J. Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm. Genes Dev. 14, 2576-2580 (2000).
    • (2000) Genes Dev , vol.14 , pp. 2576-2580
    • Lee, Y.1    Barnes, D.E.2    Lindahl, T.3    McKinnon, P.J.4
  • 161
    • 0037027853 scopus 로고    scopus 로고
    • The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: Implications for unifying the heterogeneous phenotypes of NHEJ mutants
    • Karanjawala, Z.E. et al. The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: Implications for unifying the heterogeneous phenotypes of NHEJ mutants. DNA Repair (Amst.) 1, 1017-1026 (2002).
    • (2002) DNA Repair (Amst.) , vol.1 , pp. 1017-1026
    • Karanjawala, Z.E.1
  • 162
    • 31044432090 scopus 로고    scopus 로고
    • XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining
    • Ahnesorg, P., Smith, P. & Jackson, S.P. XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell 124, 301-313 (2006).
    • (2006) Cell , vol.124 , pp. 301-313
    • Ahnesorg, P.1    Smith, P.2    Jackson, S.P.3
  • 163
    • 31044440630 scopus 로고    scopus 로고
    • Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly
    • Buck, D. et al. Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly. Cell 124, 287-299 (2006).
    • (2006) Cell , vol.124 , pp. 287-299
    • Buck, D.1
  • 164
    • 34248400443 scopus 로고    scopus 로고
    • Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells
    • Zha, S., Alt, F.W., Cheng, H.L., Brush, J.W. & Li, G. Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells. Proc. Natl. Acad. Sci. USA 104, 4518-4523 (2007).
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 4518-4523
    • Zha, S.1    Alt, F.W.2    Cheng, H.L.3    Brush, J.W.4    Li, G.5
  • 165
    • 13244268505 scopus 로고    scopus 로고
    • Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells
    • Pan-Hammarstrom, Q. et al. Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells. J. Exp. Med. 201, 189-194 (2005).
    • (2005) J. Exp. Med , vol.201 , pp. 189-194
    • Pan-Hammarstrom, Q.1


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