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Volumn 17, Issue 8, 1998, Pages 2404-2411

Ku80 is required for immunoglobulin isotype switching

Author keywords

Class switch recombination; DNA repair; Immunoglobulin genes; Ku80

Indexed keywords

DNA; IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN M; INTERLEUKIN 4; LIPOPOLYSACCHARIDE;

EID: 0032522564     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.8.2404     Document Type: Article
Times cited : (292)

References (65)
  • 1
    • 0030887862 scopus 로고    scopus 로고
    • RAG1 and RAG2 form a stable poscleavage synaptic complex with DNA containing signal ends in V(D)J recombination
    • Agrawal,A. and Schatz,D. (1997) RAG1 and RAG2 form a stable poscleavage synaptic complex with DNA containing signal ends in V(D)J recombination. Cell, 89, 43-53.
    • (1997) Cell , vol.89 , pp. 43-53
    • Agrawal, A.1    Schatz, D.2
  • 2
    • 0028960511 scopus 로고
    • Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation
    • Blunt,T. et al. (1995) Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell, 80, 813-823.
    • (1995) Cell , vol.80 , pp. 813-823
    • Blunt, T.1
  • 3
    • 0020663062 scopus 로고
    • A severe combined immunodeficiency mutation in the mouse
    • Bosma,G.C. Custer,R.P. and Bosma,M. J. (1983) A severe combined immunodeficiency mutation in the mouse. Nature, 301, 527-530.
    • (1983) Nature , vol.301 , pp. 527-530
    • Bosma, G.C.1    Custer, R.P.2    Bosma, M.J.3
  • 4
    • 0029843408 scopus 로고    scopus 로고
    • Identification of a Saccharomyces cerevisiae Ku80 homologue: Roles in DNA double strand break rejoining and in telomeric maintenance
    • Boulton,S.J. and Jackson,S.P. (1996a) Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance. Nucleic Acids Res., 24, 4639-4648.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 4639-4648
    • Boulton, S.J.1    Jackson, S.P.2
  • 5
    • 0029791694 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways
    • Boulton,S.J. and Jackson,S.P. (1996b) Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways. EMBO J., 15, 5093-5103.
    • (1996) EMBO J. , vol.15 , pp. 5093-5103
    • Boulton, S.J.1    Jackson, S.P.2
  • 6
    • 0028979706 scopus 로고
    • Development of B cells in scid mice with immunoglobulin transgenes: Implications for the control of V(D)J recombination
    • Chang,Y. Bosma,G.C. and Bosma,M.J. (1995) Development of B cells in scid mice with immunoglobulin transgenes: implications for the control of V(D)J recombination. Immunity, 2, 607-616.
    • (1995) Immunity , vol.2 , pp. 607-616
    • Chang, Y.1    Bosma, G.C.2    Bosma, M.J.3
  • 7
    • 0026636784 scopus 로고
    • Quantitaten of immunoglobulin mu-gamma l heavy chain switch region recombination by a digestion-circularization polymerase chain reaction method
    • Chu,C.C., Paul,W.E. and Max,E.E. (1992) Quantitaten of immunoglobulin mu-gamma l heavy chain switch region recombination by a digestion-circularization polymerase chain reaction method. Proc. Natl Acad. Sci. USA, 89, 6978-6982.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 6978-6982
    • Chu, C.C.1    Paul, W.E.2    Max, E.E.3
  • 8
    • 0018988674 scopus 로고
    • Rearrangement of immunoglobulin heavy chain genes during B-lymphocyte development as revealed by studies of mouse plasmacytoma cells
    • Coleclough,C., Cooper,D. and Perry,R.P. (1980) Rearrangement of immunoglobulin heavy chain genes during B-lymphocyte development as revealed by studies of mouse plasmacytoma cells. Proc. Natl Acad. Sci.USA, 77, 1422-1426.
    • (1980) Proc. Natl Acad. Sci.USA , vol.77 , pp. 1422-1426
    • Coleclough, C.1    Cooper, D.2    Perry, R.P.3
  • 9
    • 0019308438 scopus 로고
    • Deletions in the constant region locus can account for switches in immunoglobulin heavy chain expression
    • Cory,S., Jackson,J. and Adams,J.M. (1980) Deletions in the constant region locus can account for switches in immunoglobulin heavy chain expression. Nature, 285, 450-456.
    • (1980) Nature , vol.285 , pp. 450-456
    • Cory, S.1    Jackson, J.2    Adams, J.M.3
  • 10
    • 0018908498 scopus 로고
    • An immunoglobulin heavy-chain gene is formed by at least two recombinational events
    • Davis,M.M., Calame,K., Early,P.W., Livant,D.L., Joho,R., Weissman,I.L. and Hood,L. (1980a) An immunoglobulin heavy-chain gene is formed by at least two recombinational events. Nature, 283, 733-739.
    • (1980) Nature , vol.283 , pp. 733-739
    • Davis, M.M.1    Calame, K.2    Early, P.W.3    Livant, D.L.4    Joho, R.5    Weissman, I.L.6    Hood, L.7
  • 11
    • 0019120050 scopus 로고
    • DNA sequences mediating class switching in alpha-immunoglobulins
    • Davis,M.M., Kim,S.K. and Hood,L.E. (1980b) DNA sequences mediating class switching in alpha-immunoglobulins. Science, 209, 1360-1365.
    • (1980) Science , vol.209 , pp. 1360-1365
    • Davis, M.M.1    Kim, S.K.2    Hood, L.E.3
  • 12
    • 0019179349 scopus 로고
    • An immunoglobulin deletion mutant with implications for the heavy-chain switch and RNA splicing
    • Dunnick,W., Rabbitts,T.H. and Milstein,C. (1980) An immunoglobulin deletion mutant with implications for the heavy-chain switch and RNA splicing. Nature, 286, 669-675.
    • (1980) Nature , vol.286 , pp. 669-675
    • Dunnick, W.1    Rabbitts, T.H.2    Milstein, C.3
  • 13
    • 0029864993 scopus 로고    scopus 로고
    • Initiation of V(D)J recombination in vitro obeying 12/23 rule
    • Eastman,Q.M., Leu,T.M.L. and Schatz,D.G. (1996) Initiation of V(D)J recombination in vitro obeying 12/23 rule. Nature, 380, 85-88.
    • (1996) Nature , vol.380 , pp. 85-88
    • Eastman, Q.M.1    Leu, T.M.L.2    Schatz, D.G.3
  • 14
    • 0027397867 scopus 로고
    • The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen
    • Gottlieb,T.M. and Jackson,S.P. (1993) The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell, 72, 131-142.
    • (1993) Cell , vol.72 , pp. 131-142
    • Gottlieb, T.M.1    Jackson, S.P.2
  • 15
    • 0027739352 scopus 로고
    • Rearrangement and expression of kappa light chain genes can occur without mu heavy chain expression during differentiation of pre-B cells
    • Grawunder,U., Haasner,D., Melchers,F. and Rolink,A. (1993) Rearrangement and expression of kappa light chain genes can occur without mu heavy chain expression during differentiation of pre-B cells. Int. Immunol., 5, 1609-1618.
    • (1993) Int. Immunol. , vol.5 , pp. 1609-1618
    • Grawunder, U.1    Haasner, D.2    Melchers, F.3    Rolink, A.4
  • 17
    • 0008411148 scopus 로고
    • Organization of immunoglobulin heavy chain genes and allelic deletion model
    • Honjo,T. and Kataoka,T. (1978) Organization of immunoglobulin heavy chain genes and allelic deletion model. Proc. Natl Acad. Sci. USA, 75, 2140-2144.
    • (1978) Proc. Natl Acad. Sci. USA , vol.75 , pp. 2140-2144
    • Honjo, T.1    Kataoka, T.2
  • 18
    • 0025345212 scopus 로고
    • Circular DNA is excised by immunoglobulin class switch recombination
    • Iwasato,T., Shimizu,A., Honjo,T. and Yamagishi,H. (1990) Circular DNA is excised by immunoglobulin class switch recombination. Cell, 62, 143-149.
    • (1990) Cell , vol.62 , pp. 143-149
    • Iwasato, T.1    Shimizu, A.2    Honjo, T.3    Yamagishi, H.4
  • 19
    • 0029395076 scopus 로고
    • Menage a trois: Double strand break repair, V(D)J recombination and DNA-PK
    • Jeggo,P.A., Taccioli,G.E. and Jackson,S.P. (1995) Menage a trois: double strand break repair, V(D)J recombination and DNA-PK. BioEssays, 17, 949-957.
    • (1995) BioEssays , vol.17 , pp. 949-957
    • Jeggo, P.A.1    Taccioli, G.E.2    Jackson, S.P.3
  • 20
    • 0019460884 scopus 로고
    • Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes
    • Kataoka,T., Miyata,T. and Honjo,T. (1981) Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes. Cell, 23, 357-368.
    • (1981) Cell , vol.23 , pp. 357-368
    • Kataoka, T.1    Miyata, T.2    Honjo, T.3
  • 22
    • 0028013486 scopus 로고
    • Two different types of double-strand breaks in Saccharomyces crevisiae are repaired by similar RAD52-independent, nonhomologous recombination events
    • Kramer,K.M., Brock,J.A., Bloom,K., Moore, J.K. and Haber,J.E. (1994) Two different types of double-strand breaks in Saccharomyces crevisiae are repaired by similar RAD52-independent, nonhomologous recombination events. Mol. Cell. Biol., 14, 1293-1301.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 1293-1301
    • Kramer, K.M.1    Brock, J.A.2    Bloom, K.3    Moore, J.K.4    Haber, J.E.5
  • 24
    • 15844385545 scopus 로고    scopus 로고
    • Ku-80 deficient cells exhibit excess degradation of extrachromosomal DNA
    • Liang,F. and Jasin,M. (1996) Ku-80 deficient cells exhibit excess degradation of extrachromosomal DNA. J. Biol. Chem., 271, 14405-14411.
    • (1996) J. Biol. Chem. , vol.271 , pp. 14405-14411
    • Liang, F.1    Jasin, M.2
  • 26
    • 0030422949 scopus 로고    scopus 로고
    • Developmental and molecular regulation of immunoglobulin class switch recombination
    • Lorenz,M. and Radbruch,A. (1996) Developmental and molecular regulation of immunoglobulin class switch recombination. Curr. Top. Microbiol. Immunol., 217, 151-169.
    • (1996) Curr. Top. Microbiol. Immunol. , vol.217 , pp. 151-169
    • Lorenz, M.1    Radbruch, A.2
  • 27
    • 0025369706 scopus 로고
    • Switch circular DNA formed in cytokine-treated mouse splenocytes: Evidence for intramolecular DNA deletion in immunoglobulin class switching
    • Matsuoka,M., Yoshida,K., Maeda,T., Usuda,S. and Sakano,H. (1990) Switch circular DNA formed in cytokine-treated mouse splenocytes: evidence for intramolecular DNA deletion in immunoglobulin class switching. Cell, 62, 135-142.
    • (1990) Cell , vol.62 , pp. 135-142
    • Matsuoka, M.1    Yoshida, K.2    Maeda, T.3    Usuda, S.4    Sakano, H.5
  • 28
    • 0029954821 scopus 로고    scopus 로고
    • Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae
    • Milne,G.T., Jin,S., Shannon,K.B. and Weaver,D.T. (1996) Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae. Mol. Cell. Biol., 16, 4189-4198.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4189-4198
    • Milne, G.T.1    Jin, S.2    Shannon, K.B.3    Weaver, D.T.4
  • 29
    • 0023018810 scopus 로고
    • Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders
    • Mimori,T., Hardin,J.A. and Steitz,J.A. (1986) Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders. J. Biol. Chem., 261, 2274-2278.
    • (1986) J. Biol. Chem. , vol.261 , pp. 2274-2278
    • Mimori, T.1    Hardin, J.A.2    Steitz, J.A.3
  • 30
    • 0029976325 scopus 로고    scopus 로고
    • Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae
    • Moore,J.K. and Haber,J.E. (1996) Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae. Mol Cell. Biol., 16, 2164-2173.
    • (1996) Mol Cell. Biol. , vol.16 , pp. 2164-2173
    • Moore, J.K.1    Haber, J.E.2
  • 31
    • 0028286463 scopus 로고
    • DNA-dependent protein kinase is activated by nicks and larger single-stranded gaps
    • Morozov,V.E., Falzon,M., Anderson,W.C. and Kuff,E.L. (1994) DNA-dependent protein kinase is activated by nicks and larger single-stranded gaps. J. Biol. Chem., 269, 16684-16688.
    • (1994) J. Biol. Chem. , vol.269 , pp. 16684-16688
    • Morozov, V.E.1    Falzon, M.2    Anderson, W.C.3    Kuff, E.L.4
  • 32
    • 0019889717 scopus 로고
    • Switch region of immunoglobulin Cmu gene is composed of simple tandem repetitive sequences
    • Nikaido,T., Nakai,S. and Honjo,T. (1981) Switch region of immunoglobulin Cmu gene is composed of simple tandem repetitive sequences. Nature. 292, 845-848.
    • (1981) Nature. , vol.292 , pp. 845-848
    • Nikaido, T.1    Nakai, S.2    Honjo, T.3
  • 33
    • 0020479257 scopus 로고
    • Nucleotide sequences of switch regions of immunoglobulin C epsilon and C gamma genes and their comparison
    • Nikaido,T., Yamawaki-Kataoka,Y. and Honjo,T. (1982) Nucleotide sequences of switch regions of immunoglobulin C epsilon and C gamma genes and their comparison. J. Biol. Chem., 257, 7322-7329.
    • (1982) J. Biol. Chem. , vol.257 , pp. 7322-7329
    • Nikaido, T.1    Yamawaki-Kataoka, Y.2    Honjo, T.3
  • 36
    • 0030885974 scopus 로고    scopus 로고
    • Ku70 is required for DNA repair but not for TCR gene recombination in vivo
    • Ouyang,H. et al. (1997) Ku70 is required for DNA repair but not for TCR gene recombination in vivo. J. Exp. M ed., 186, 921-930.
    • (1997) J. Exp. m Ed. , vol.186 , pp. 921-930
    • Ouyang, H.1
  • 38
    • 0030249394 scopus 로고    scopus 로고
    • A prematurely expressed Ig(kappa) transgene, but not V(kappa)J(kappa) gene segment targeted into the Ig(kappa) locus, can rescue B cell development in lambda5-deficient mice
    • Pelanda,R., Schaal,S., Torres,R.M. and Rajewsky,K. (1996) A prematurely expressed Ig(kappa) transgene, but not V(kappa)J(kappa) gene segment targeted into the Ig(kappa) locus, can rescue B cell development in lambda5-deficient mice. Immunity, 5, 229-239.
    • (1996) Immunity , vol.5 , pp. 229-239
    • Pelanda, R.1    Schaal, S.2    Torres, R.M.3    Rajewsky, K.4
  • 39
    • 0027245559 scopus 로고
    • V(D)J recombination in mammalian mutants defective in DNA double-strand break repair
    • Pergola,R, Zdzienicka,M.Z. and Lieber,M.R. (1993) V(D)J recombination in mammalian mutants defective in DNA double-strand break repair. Mol. Cell. Biol., 13, 3464-3471.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 3464-3471
    • Pergola, R.1    Zdzienicka, M.Z.2    Lieber, M.R.3
  • 40
    • 0018823555 scopus 로고
    • The role of gene deletion in the immunoglobulin heavy chain switch
    • Rabbits,T., Forster,A., Dunnick,W. and Bentley,D.L. (1980) The role of gene deletion in the immunoglobulin heavy chain switch. Nature, 283, 351-356.
    • (1980) Nature , vol.283 , pp. 351-356
    • Rabbits, T.1    Forster, A.2    Dunnick, W.3    Bentley, D.L.4
  • 41
    • 0032518680 scopus 로고    scopus 로고
    • Ku protein stimulates DNA end joining by mammalian DNA ligases: A direct role for Ku in repair of DNA double-stranded breaks
    • Ramsden,D.A. and Gellert,M. (1998) Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double-stranded breaks. EMBO J., 17, 609-614.
    • (1998) EMBO J. , vol.17 , pp. 609-614
    • Ramsden, D.A.1    Gellert, M.2
  • 42
    • 0028342645 scopus 로고
    • A DNA end-binding factor involved in double-strand break repair and V(D)J recombination
    • Rathmell,W.K. and Chu,G. (1994) A DNA end-binding factor involved in double-strand break repair and V(D)J recombination. Mol. Cell. Biol., 14, 4741-4748.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 4741-4748
    • Rathmell, W.K.1    Chu, G.2
  • 43
    • 0030273141 scopus 로고    scopus 로고
    • The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching
    • Rolink,A., Melchers,F. and Andersson,J. (1996) The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching. Immunity, 5, 319-330.
    • (1996) Immunity , vol.5 , pp. 319-330
    • Rolink, A.1    Melchers, F.2    Andersson, J.3
  • 44
    • 0027491330 scopus 로고
    • Characterization of broken DNA molecules associated with V(D)J recombination
    • Roth,D.B., Zhu,C. and Gellert,M. (1993) Characterization of broken DNA molecules associated with V(D)J recombination. Proc. Natl Acad. Sci. USA, 90, 10788-10792.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 10788-10792
    • Roth, D.B.1    Zhu, C.2    Gellert, M.3
  • 45
    • 0019214271 scopus 로고
    • Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes
    • Sakano,H., Maki,R., Kurosawa,Y., Roeder,W. and Tonegawa,S. (1980) Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes. Nature, 286, 676-683.
    • (1980) Nature , vol.286 , pp. 676-683
    • Sakano, H.1    Maki, R.2    Kurosawa, Y.3    Roeder, W.4    Tonegawa, S.5
  • 46
    • 0027769386 scopus 로고
    • Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated, RAG-dependent, and cell cycle regulated
    • Schlissel,M., Constantinesc,U.A., Morrow,T., Baxter,M. and Peng,A. (1993) Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated, RAG-dependent, and cell cycle regulated. Genes Dev., 7, 2520-2532.
    • (1993) Genes Dev. , vol.7 , pp. 2520-2532
    • Schlissel, M.1    Constantinesc, U.A.2    Morrow, T.3    Baxter, M.4    Peng, A.5
  • 48
    • 0027410476 scopus 로고
    • V(D)J recombination: Signal and coding joint resolution are uncoupled and depend on parallel synapsis of the sites
    • Sheehan,K.M. and Lieber,M.R. (1993) V(D)J recombination: signal and coding joint resolution are uncoupled and depend on parallel synapsis of the sites. Mol. Cell. Bioi., 13, 1363-1370.
    • (1993) Mol. Cell. Bioi. , vol.13 , pp. 1363-1370
    • Sheehan, K.M.1    Lieber, M.R.2
  • 49
    • 0020059958 scopus 로고
    • Organization of the constant-region gene family of the mouse immunoglobulin heavy chain
    • Shimizu,A., Takahashi,N., Yaoita,Y. and Honjo,T. (1982) Organization of the constant-region gene family of the mouse immunoglobulin heavy chain. Cell, 28, 499-506.
    • (1982) Cell , vol.28 , pp. 499-506
    • Shimizu, A.1    Takahashi, N.2    Yaoita, Y.3    Honjo, T.4
  • 50
    • 0030033061 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae Ku autoantigen homologue affects radiosensitivity only in the absence of homologous recombination
    • Siede,W., Friedl,A.A., Dianova,I., Eckardt-Schupp,F. and Friedberg,E.C. (1996) The Saccharomyces cerevisiae Ku autoantigen homologue affects radiosensitivity only in the absence of homologous recombination. Genetics. 142, 91-102.
    • (1996) Genetics. , vol.142 , pp. 91-102
    • Siede, W.1    Friedl, A.A.2    Dianova, I.3    Eckardt-Schupp, F.4    Friedberg, E.C.5
  • 51
    • 0028112944 scopus 로고
    • Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA
    • Smider,V., Rathmell,W.K., Lieber,M.R. and Chu,G. (1994) Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. Science, 266, 288-91.
    • (1994) Science , vol.266 , pp. 288-291
    • Smider, V.1    Rathmell, W.K.2    Lieber, M.R.3    Chu, G.4
  • 52
    • 0030048332 scopus 로고    scopus 로고
    • B cells from p50/NF-κB knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching
    • Snapper,C.M., Zelazowski,P, Rosas,F.R., Kehry,M.R., Tian,M., Baltimore,D. and Sha,W.C. (1996) B cells from p50/NF-κB knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching. J. Irnmunol., 156, 183-191.
    • (1996) J. Irnmunol. , vol.156 , pp. 183-191
    • Snapper, C.M.1    Zelazowski, P.2    Rosas, F.R.3    Kehry, M.R.4    Tian, M.5    Baltimore, D.6    Sha, W.C.7
  • 54
    • 0028220059 scopus 로고
    • Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice
    • Spanopoulou,E. et al. (1994) Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice. Genes Dev., 8, 1030-1042.
    • (1994) Genes Dev. , vol.8 , pp. 1030-1042
    • Spanopoulou, E.1
  • 55
    • 0029931447 scopus 로고    scopus 로고
    • Immunoglobulin class switching
    • Stavnezer,J. (1996) Immunoglobulin class switching. Curr. Opin. Immunol., 8, 199-205.
    • (1996) Curr. Opin. Immunol. , vol.8 , pp. 199-205
    • Stavnezer, J.1
  • 56
    • 0027156278 scopus 로고
    • Impairment of V(D)J recombination in double-strand break repair mutants
    • Taccioli,G.E., Rathbun,G., Oltz,E., Stamato,T., Jeggo,P.A. and Alt,F.W. (1993) Impairment of V(D)J recombination in double-strand break repair mutants. Science, 260, 207-210.
    • (1993) Science , vol.260 , pp. 207-210
    • Taccioli, G.E.1    Rathbun, G.2    Oltz, E.3    Stamato, T.4    Jeggo, P.A.5    Alt, F.W.6
  • 57
    • 0028025020 scopus 로고
    • Ku80: Product of the XRCC5 gene and its role in DNA repair and V(D)J recombination
    • Taccioli,G.E. et al. (1994) Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science, 265, 1442-1445.
    • (1994) Science , vol.265 , pp. 1442-1445
    • Taccioli, G.E.1
  • 58
    • 0020534965 scopus 로고
    • Somatic generation of antibody diversity
    • Tonegawa,S. (1983) Somatic generation of antibody diversity. Nature, 302, 575-581.
    • (1983) Nature , vol.302 , pp. 575-581
    • Tonegawa, S.1
  • 59
    • 0029967722 scopus 로고    scopus 로고
    • Similarities between initiation of V(D)J recombination and retroviral integration
    • van Gent,D.C., Mizuuchi,K. and Gellert,M. (1996) Similarities between initiation of V(D)J recombination and retroviral integration. Science, 271, 1592-1594.
    • (1996) Science , vol.271 , pp. 1592-1594
    • Van Gent, D.C.1    Mizuuchi, K.2    Gellert, M.3
  • 60
    • 0025307495 scopus 로고
    • Circular DNA is a product of the immunoglobulin class switch rearrangement
    • von Schwedler,U., Jack,H.M. and Wabl,M. (1990) Circular DNA is a product of the immunoglobulin class switch rearrangement. Nature, 345, 452-456.
    • (1990) Nature , vol.345 , pp. 452-456
    • Von Schwedler, U.1    Jack, H.M.2    Wabl, M.3
  • 61
    • 0021930187 scopus 로고
    • Critical test of a sister chromatid exchange model for the immunoglobulin heavy-chain class switch
    • Wabl,M., Meyer,J., Beck-Engeser,G., Tenkhoff,M. and Burrows,P.D. (1985) Critical test of a sister chromatid exchange model for the immunoglobulin heavy-chain class switch. Nature, 313, 687-689.
    • (1985) Nature , vol.313 , pp. 687-689
    • Wabl, M.1    Meyer, J.2    Beck-Engeser, G.3    Tenkhoff, M.4    Burrows, P.D.5
  • 62
    • 0031278299 scopus 로고    scopus 로고
    • Immunoglobulin Sγ3 DNA specific double stranded breaks are induced in mitogen activated B cells and are implicated in switch recombination
    • Wuerffel,R.A., Du,J., Thompson,R.J. and Kenter,A.L. (1997) Immunoglobulin Sγ3 DNA specific double stranded breaks are induced in mitogen activated B cells and are implicated in switch recombination. J. Immunol., 159, 4139-4144.
    • (1997) J. Immunol. , vol.159 , pp. 4139-4144
    • Wuerffel, R.A.1    Du, J.2    Thompson, R.J.3    Kenter, A.L.4
  • 63
    • 0019311218 scopus 로고
    • Deletion of immunoglobulin heavy chain genes from expressed allelic chromosome
    • Yaoita,Y. and Honjo,T. (1980) Deletion of immunoglobulin heavy chain genes from expressed allelic chromosome. Nature, 286, 850-853.
    • (1980) Nature , vol.286 , pp. 850-853
    • Yaoita, Y.1    Honjo, T.2
  • 65
    • 0030576534 scopus 로고    scopus 로고
    • Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates
    • Zhu,C. Bogue,M.A., Lim,D.-S., Hasty,P. and Roth,D.B. (1996) Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Cell, 86, 379-389.
    • (1996) Cell , vol.86 , pp. 379-389
    • Zhu, C.1    Bogue, M.A.2    Lim, D.-S.3    Hasty, P.4    Roth, D.B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.