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Volumn 6, Issue 7, 2005, Pages 655-661

AID to overcome the limitations of genomic information

Author keywords

[No Author keywords available]

Indexed keywords

DEAMINASE; DNA; RNA; URACIL;

EID: 22144443194     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1218     Document Type: Review
Times cited : (89)

References (102)
  • 1
    • 7244245762 scopus 로고    scopus 로고
    • Finishing the euchromatic sequence of the human genome
    • International Human Genome Sequencing Consortium. Finishing the euchromatic sequence of the human genome. Nature 431, 931-945 (2004).
    • (2004) Nature , vol.431 , pp. 931-945
  • 2
    • 0035997348 scopus 로고    scopus 로고
    • V(D)J recombination: RAG proteins, repair factors, and regulation
    • Gellert, M. V(D)J recombination: RAG proteins, repair factors, and regulation. Annu. Rev. Biochem. 71, 101-132 (2002).
    • (2002) Annu. Rev. Biochem. , vol.71 , pp. 101-132
    • Gellert, M.1
  • 4
    • 0031920677 scopus 로고    scopus 로고
    • Cis-acting sequences that affect somatic hypermutation of Ig genes
    • Storb, U. et al. Cis-acting sequences that affect somatic hypermutation of Ig genes. Immunol. Rev. 162, 153-160 (1998).
    • (1998) Immunol. Rev. , vol.162 , pp. 153-160
    • Storb, U.1
  • 5
    • 0027510316 scopus 로고
    • Mutations of the chloramphenicol acetyl transferase transgene driven by the immunoglobulin promoter and intron enhancer
    • Azuma, T., Motoyama, N., Fields, L.E. & Loh, D.Y. Mutations of the chloramphenicol acetyl transferase transgene driven by the immunoglobulin promoter and intron enhancer. Int. Immunol. 5, 121-130 (1993).
    • (1993) Int. Immunol. , vol.5 , pp. 121-130
    • Azuma, T.1    Motoyama, N.2    Fields, L.E.3    Loh, D.Y.4
  • 6
    • 0032954944 scopus 로고    scopus 로고
    • Hypermutation targets a green fluorescent protein-encoding transgene in the presence of immunoglobulin enhancers
    • Bachl, J. & Olsson, C. Hypermutation targets a green fluorescent protein-encoding transgene in the presence of immunoglobulin enhancers. Eur. J. Immunol. 29, 1383-1389 (1999).
    • (1999) Eur. J. Immunol. , vol.29 , pp. 1383-1389
    • Bachl, J.1    Olsson, C.2
  • 7
    • 0029067875 scopus 로고
    • Targeting of non-Ig sequences in place of the V segment by somatic hypermutation
    • Yelamos, J. et al. Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. Nature 376, 225-229 (1995).
    • (1995) Nature , vol.376 , pp. 225-229
    • Yelamos, J.1
  • 8
    • 0026443954 scopus 로고
    • Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis
    • Rogozin, I.B. & Kolchanov, N.A. Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis. Biochim. Biophys. Acta 1171, 11-18 (1992).
    • (1992) Biochim. Biophys. Acta , vol.1171 , pp. 11-18
    • Rogozin, I.B.1    Kolchanov, N.A.2
  • 9
    • 0036212917 scopus 로고    scopus 로고
    • Molecular mechanism of class switch recombination: Linkage with somatic hypermutation
    • Honjo, T., Kinoshita, K. & Muramatsu, M. Molecular mechanism of class switch recombination: linkage with somatic hypermutation. Annu. Rev. Immunol. 20, 165-196 (2002).
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 165-196
    • Honjo, T.1    Kinoshita, K.2    Muramatsu, M.3
  • 10
    • 0025345212 scopus 로고
    • Circular DNA is excised by immunoglobulin class switch recombination
    • Iwasato, T., Shimizu, A., Honjo, T. & Yamagishi, H. Circular DNA is excised by immunoglobulin class switch recombination. Cell 62, 143-149 (1990).
    • (1990) Cell , vol.62 , pp. 143-149
    • Iwasato, T.1    Shimizu, A.2    Honjo, T.3    Yamagishi, H.4
  • 11
    • 0025369706 scopus 로고
    • Switch circular DNA formed in cytokine-treated mouse splenocytes: Evidence for intramolecular DNA deletion in immunoglobulin class switching
    • Matsuoka, M., Yoshida, K., Maeda, T., Usuda, S. & Sakano, H. Switch circular DNA formed in cytokine-treated mouse splenocytes: evidence for intramolecular DNA deletion in immunoglobulin class switching. Cell 62, 135-142 (1990).
    • (1990) Cell , vol.62 , pp. 135-142
    • Matsuoka, M.1    Yoshida, K.2    Maeda, T.3    Usuda, S.4    Sakano, H.5
  • 12
    • 0025307495 scopus 로고
    • Circular DNA is a product of the immunoglobulin class switch rearrangement
    • von Schwedler, U., Jack, H.M. & Wabl, M. Circular DNA is a product of the immunoglobulin class switch rearrangement. Nature 345, 452-456 (1990).
    • (1990) Nature , vol.345 , pp. 452-456
    • Von Schwedler, U.1    Jack, H.M.2    Wabl, M.3
  • 13
    • 0033603340 scopus 로고    scopus 로고
    • Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
    • Muramatsu, M. et al. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J. Biol. Chem. 274, 18470-18476 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 18470-18476
    • Muramatsu, M.1
  • 14
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Muramatsu, M. et al. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102, 553-563 (2000).
    • (2000) Cell , vol.102 , pp. 553-563
    • Muramatsu, M.1
  • 15
    • 0034264851 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2)
    • Revy, P. et al. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2). Cell 102, 565-575 (2000).
    • (2000) Cell , vol.102 , pp. 565-575
    • Revy, P.1
  • 16
    • 0037019315 scopus 로고    scopus 로고
    • AID mutates E. Coli suggesting a DNA deamination mechanism for antibody diversification
    • Petersen-Mahrt, S.K., Harris, R.S. & Neuberger, M.S. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature 418, 99-103 (2002).
    • (2002) Nature , vol.418 , pp. 99-103
    • Petersen-Mahrt, S.K.1    Harris, R.S.2    Neuberger, M.S.3
  • 17
    • 0037026482 scopus 로고    scopus 로고
    • Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase
    • Di Noia, J. & Neuberger, M.S. Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. Nature 419, 43-48 (2002).
    • (2002) Nature , vol.419 , pp. 43-48
    • Di Noia, J.1    Neuberger, M.S.2
  • 18
    • 12744259733 scopus 로고    scopus 로고
    • Activation-induced deaminase: Controversies and open questions
    • Barreto, V.M., Ramiro, A.R. & Nussenzweig, M.C. Activation-induced deaminase: controversies and open questions. Trends Immunol. 26, 90-96 (2005).
    • (2005) Trends Immunol , vol.26 , pp. 90-96
    • Barreto, V.M.1    Ramiro, A.R.2    Nussenzweig, M.C.3
  • 20
    • 3142765336 scopus 로고    scopus 로고
    • Class-switch recombination: Interplay of transcription, DNA deamination and DNA repair
    • Chaudhuri, J. & Alt, F.W. Class-switch recombination: interplay of transcription, DNA deamination and DNA repair. Nat. Rev. Immunol. 4, 541-552 (2004).
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 541-552
    • Chaudhuri, J.1    Alt, F.W.2
  • 21
    • 1842555407 scopus 로고    scopus 로고
    • Transcription-coupled mutagenesis by the DNA deaminase AID
    • Larson, E.D. & Maizels, N. Transcription-coupled mutagenesis by the DNA deaminase AID. Genome Biol. 5, 211-213 (2004).
    • (2004) Genome Biol. , vol.5 , pp. 211-213
    • Larson, E.D.1    Maizels, N.2
  • 22
    • 8844219684 scopus 로고    scopus 로고
    • Cell development leads off with a base hit: DU:dG mismatches in class switching and hypermutation
    • Lee, G.S., Brandt, V.L. & Roth, D.B. B cell development leads off with a base hit: dU:dG mismatches in class switching and hypermutation. Mol. Cell 16, 505-508 (2004).
    • (2004) Mol Cell , vol.16 , pp. 505-508
    • Lee, G.S.1    Brandt, V.L.2    Roth, D.B.B.3
  • 23
    • 4944257670 scopus 로고    scopus 로고
    • The role of activation-induced cytidine deaminase in antibody diversification, immunodeficiency, and B-cell malignancies
    • Luo, Z., Ronai, D. & Scharff, M.D. The role of activation-induced cytidine deaminase in antibody diversification, immunodeficiency, and B-cell malignancies. J. Allergy Clin. Immunol. 114, 726-735 (2004).
    • (2004) J. Allergy Clin. Immunol. , vol.114 , pp. 726-735
    • Luo, Z.1    Ronai, D.2    Scharff, M.D.3
  • 24
    • 13444259474 scopus 로고    scopus 로고
    • Opinion: Somatic hypermutation at A.T pairs: Polymerase error versus dUTP incorporation
    • Neuberger, M.S. et al. Opinion: Somatic hypermutation at A.T pairs: polymerase error versus dUTP incorporation. Nat. Rev. Immunol. 5, 171-178 (2005).
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 171-178
    • Neuberger, M.S.1
  • 25
    • 13144254209 scopus 로고    scopus 로고
    • DNA deamination in immunity
    • Petersen-Mahrt, S. DNA deamination in immunity. Immunol. Rev. 203, 80-97 (2005).
    • (2005) Immunol. Rev. , vol.203 , pp. 80-97
    • Petersen-Mahrt, S.1
  • 26
    • 0035818990 scopus 로고    scopus 로고
    • AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
    • Petersen, S. et al. AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching. Nature 414, 660-665 (2001).
    • (2001) Nature , vol.414 , pp. 660-665
    • Petersen, S.1
  • 27
    • 4344560868 scopus 로고    scopus 로고
    • Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch
    • Begum, N.A. et al. Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch. Science 305, 1160-1163 (2004).
    • (2004) Science , vol.305 , pp. 1160-1163
    • Begum, N.A.1
  • 28
    • 4444377646 scopus 로고    scopus 로고
    • De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination
    • Begum, N.A. et al. De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination. Proc. Natl. Acad. Sci. USA 101, 13003-13007 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 13003-13007
    • Begum, N.A.1
  • 29
    • 13844315325 scopus 로고    scopus 로고
    • DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylase
    • Nagaoka, H., Ito, S., Muramatsu, M., Nakata, M. & Honjo, T. DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylase. Proc. Natl. Acad. Sci. USA 102, 2022-2027 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 2022-2027
    • Nagaoka, H.1    Ito, S.2    Muramatsu, M.3    Nakata, M.4    Honjo, T.5
  • 30
    • 1242341972 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1
    • Ito, S. et al. Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1. Proc. Natl. Acad. Sci. USA 101, 1975-1980 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 1975-1980
    • Ito, S.1
  • 31
    • 3242795967 scopus 로고    scopus 로고
    • Separate domains of AID are required for somatic hypermutation and class-switch recombination
    • Shinkura, R. et al. Separate domains of AID are required for somatic hypermutation and class-switch recombination. Nat. Immunol. 5, 707-712 (2004).
    • (2004) Nat. Immunol. , vol.5 , pp. 707-712
    • Shinkura, R.1
  • 32
    • 0041381361 scopus 로고    scopus 로고
    • AID mutant analyses indicate requirement for class-switch-specific cofactors
    • Ta, V.T. et al. AID mutant analyses indicate requirement for class-switch-specific cofactors. Nat. Immunol. 4, 843-848 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 843-848
    • Ta, V.T.1
  • 33
    • 0142188274 scopus 로고    scopus 로고
    • Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin
    • Woo, C.J., Martin, A. & Scharff, M.D. Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin. Immunity 19,479-489 (2003).
    • (2003) Immunity , vol.19 , pp. 479-489
    • Woo, C.J.1    Martin, A.2    Scharff, M.D.3
  • 34
    • 0035003254 scopus 로고    scopus 로고
    • DNA breaks in hypermutating immunoglobulin genes: Evidence for a break-and-repair pathway of somatic hypermutation
    • Kong, Q. & Maizels, N. DNA breaks in hypermutating immunoglobulin genes: evidence for a break-and-repair pathway of somatic hypermutation. Genetics 158, 369-378 (2001).
    • (2001) Genetics , vol.158 , pp. 369-378
    • Kong, Q.1    Maizels, N.2
  • 35
    • 0043023488 scopus 로고    scopus 로고
    • By-products of immunoglobulin somatic hypermutation
    • Bemark, M. & Neuberger, M.S. By-products of immunoglobulin somatic hypermutation. Genes Chromosom. Cancer 38, 32-39 (2003).
    • (2003) Genes Chromosom. Cancer , vol.38 , pp. 32-39
    • Bemark, M.1    Neuberger, M.S.2
  • 36
    • 0037418279 scopus 로고    scopus 로고
    • De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination
    • Doi, T., Kinoshita, K., Ikegawa, M., Muramatsu, M. & Honjo, T. De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination. Proc. Natl. Acad. Sci. USA 100, 2634-2638 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 2634-2638
    • Doi, T.1    Kinoshita, K.2    Ikegawa, M.3    Muramatsu, M.4    Honjo, T.5
  • 37
    • 19344362934 scopus 로고    scopus 로고
    • Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G
    • Sawyer, S.L., Emerman, M. & Malik, H.S. Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G. PLoS Biol. 2, 1278-1285 (2004).
    • (2004) PLoS Biol , vol.2 , pp. 1278-1285
    • Sawyer, S.L.1    Emerman, M.2    Malik, H.S.3
  • 39
    • 2342633240 scopus 로고    scopus 로고
    • Single-strand specificity of APOBEC3G accounts for minus-strand examination of the HIV genome
    • Yu, Q. et al. Single-strand specificity of APOBEC3G accounts for minus-strand examination of the HIV genome. Nat. Struct. Mol. Biol. 11, 435-442 (2004).
    • (2004) Nat. Struct. Mol. Biol. , vol.11 , pp. 435-442
    • Yu, Q.1
  • 40
    • 0036200070 scopus 로고    scopus 로고
    • An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22
    • Jarmuz, A. et al. An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22. Genomics 79, 285-296 (2002).
    • (2002) Genomics , vol.79 , pp. 285-296
    • Jarmuz, A.1
  • 41
    • 0041524056 scopus 로고    scopus 로고
    • The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay
    • Chester, A. et al. The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay. EMBO J. 22, 3971-3982 (2003).
    • (2003) EMBO J , vol.22 , pp. 3971-3982
    • Chester, A.1
  • 42
    • 2942722486 scopus 로고    scopus 로고
    • Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks
    • Brar, S.S., Watson, M. & Diaz, M. Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks. J. Biol. Chem. 279, 26395-26401 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 26395-26401
    • Brar, S.S.1    Watson, M.2    Diaz, M.3
  • 43
    • 2442474264 scopus 로고    scopus 로고
    • Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase
    • McBride, K.M., Barreto, V., Ramiro, A.R., Stavropoulos, P. & Nussenzweig, M.C. Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase. J. Exp. Med. 199, 1235-1244 (2004).
    • (2004) J. Exp. Med. , vol.199 , pp. 1235-1244
    • McBride, K.M.1    Barreto, V.2    Ramiro, A.R.3    Stavropoulos, P.4    Nussenzweig, M.C.5
  • 44
    • 8644241815 scopus 로고    scopus 로고
    • Expression of the AID protein in normal and neoplastic B cells
    • Pasqualucci, L. et al. Expression of the AID protein in normal and neoplastic B cells. Blood 104, 3318-3325 (2004).
    • (2004) Blood , vol.104 , pp. 3318-3325
    • Pasqualucci, L.1
  • 45
    • 0037076208 scopus 로고    scopus 로고
    • AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization
    • Rada, C., Jarvis, J.M. & Milstein, C. AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization. Proc. Natl. Acad. Sci. USA 99, 7003-7008 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 7003-7008
    • Rada, C.1    Jarvis, J.M.2    Milstein, C.3
  • 46
    • 0141992113 scopus 로고    scopus 로고
    • C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion
    • Barreto, V., Reina-San-Martin, B., Ramiro, A.R., McBride, K.M. & Nussenzweig, M.C. C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion. Mol. Cell 12, 501-508 (2003).
    • (2003) Mol Cell , vol.12 , pp. 501-508
    • Barreto, V.1    Reina-San-Martin, B.2    Ramiro, A.R.3    McBride, K.M.4    Nussenzweig, M.C.5
  • 47
    • 0033970066 scopus 로고    scopus 로고
    • Molecular cloning of apobec-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA
    • Mehta, A., Kinter, M.T., Sherman, N.E. & Driscoll, D.M. Molecular cloning of apobec-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA. Mol. Cell. Biol. 20, 1846-1854 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 1846-1854
    • Mehta, A.1    Kinter, M.T.2    Sherman, N.E.3    Driscoll, D.M.4
  • 48
    • 0038293484 scopus 로고    scopus 로고
    • Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand
    • Ramiro, A.R., Stavropoulos, P., Jankovic, M. & Nussenzweig, M.C. Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nat. Immunol. 4, 452-456 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 452-456
    • Ramiro, A.R.1    Stavropoulos, P.2    Jankovic, M.3    Nussenzweig, M.C.4
  • 49
    • 0037901850 scopus 로고    scopus 로고
    • Human activation-induced cytidine deaminase causes transcription- dependent, strand-biased C to U deaminations
    • Sohail, A., Klapacz, J., Samaranayake, M., Ullah, A. & Bhagwat, A.S. Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations. Nucleic Acids Res. 31, 2990-2994 (2003).
    • (2003) Nucleic Acids Res. , vol.31 , pp. 2990-2994
    • Sohail, A.1    Klapacz, J.2    Samaranayake, M.3    Ullah, A.4    Bhagwat, A.S.5
  • 50
    • 10944223445 scopus 로고    scopus 로고
    • Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase
    • Bransteitter, R., Pham, P., Calabrese, P. & Goodman, M.F. Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase. J. Biol. Chem. 279, 51612-51621 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 51612-51621
    • Bransteitter, R.1    Pham, P.2    Calabrese, P.3    Goodman, M.F.4
  • 51
    • 0037388165 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
    • Bransteitter, R., Pham, P., Scharff, M.D. & Goodman, M.F. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc. Natl. Acad. Sci. USA 100, 4102-4107 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 4102-4107
    • Bransteitter, R.1    Pham, P.2    Scharff, M.D.3    Goodman, M.F.4
  • 52
    • 4344700569 scopus 로고    scopus 로고
    • Replication protein a interacts with AID to promote deamination of somatic hypermutation targets
    • Chaudhuri, J., Khuong, C. & Alt, F.W. Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature 430, 992-998 (2004).
    • (2004) Nature , vol.430 , pp. 992-998
    • Chaudhuri, J.1    Khuong, C.2    Alt, F.W.3
  • 53
    • 0037452080 scopus 로고    scopus 로고
    • Transcription-targeted DNA deamination by the AID antibody diversification enzyme
    • Chaudhuri, J. et al. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature 422, 726-730 (2003).
    • (2003) Nature , vol.422 , pp. 726-730
    • Chaudhuri, J.1
  • 54
    • 0037561998 scopus 로고    scopus 로고
    • AID mediates hypermutation by deaminating single stranded DNA
    • Dickerson, S.K., Market, E., Besmer, E. & Papavasiliou, F.N. AID mediates hypermutation by deaminating single stranded DNA. J. Exp. Med. 197, 1291-1296 (2003).
    • (2003) J. Exp. Med. , vol.197 , pp. 1291-1296
    • Dickerson, S.K.1    Market, E.2    Besmer, E.3    Papavasiliou, F.N.4
  • 55
    • 10644282845 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: Implications for epigenetic reprogramming
    • Morgan, H.D., Dean, W., Coker, H.A., Reik, W. & Petersen-Mahrt, S.K. Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming. J. Biol. Chem. 279, 52353-52360 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 52353-52360
    • Morgan, H.D.1    Dean, W.2    Coker, H.A.3    Reik, W.4    Petersen-Mahrt, S.K.5
  • 56
    • 0037926476 scopus 로고    scopus 로고
    • Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation
    • Pham, P., Bransteitter, R., Petruska, J. & Goodman, M.F. Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation. Nature 424, 103-107 (2003).
    • (2003) Nature , vol.424 , pp. 103-107
    • Pham, P.1    Bransteitter, R.2    Petruska, J.3    Goodman, M.F.4
  • 57
    • 1342282983 scopus 로고    scopus 로고
    • DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine
    • Yu, K., Huang, F.T. & Lieber, M.R. DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine. J. Biol. Chem. 279, 6496-6500 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 6496-6500
    • Yu, K.1    Huang, F.T.2    Lieber, M.R.3
  • 58
    • 1642406222 scopus 로고    scopus 로고
    • Recombinogenic phenotype of human activation-induced cytosine deaminase
    • Poltoratsky, V.P., Wilson, S.H., Kunkel, TA. & Pavlov, Y.I. Recombinogenic phenotype of human activation-induced cytosine deaminase. J. Immunol. 172, 4308-4313 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 4308-4313
    • Poltoratsky, V.P.1    Wilson, S.H.2    Kunkel, T.A.3    Pavlov, Y.I.4
  • 59
    • 0038375028 scopus 로고    scopus 로고
    • In vitro deamination of cytosine to uracil in single-stranded DNA by apolipoprotein B editing complex catalytic subunit 1 (APOBEC1)
    • Petersen-Mahrt, S.K. & Neuberger, M.S. In vitro deamination of cytosine to uracil in single-stranded DNA by apolipoprotein B editing complex catalytic subunit 1 (APOBEC1). J. Biol. Chem. 278, 19583-19586 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 19583-19586
    • Petersen-Mahrt, S.K.1    Neuberger, M.S.2
  • 60
    • 0036863733 scopus 로고    scopus 로고
    • RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators
    • Harris, R.S., Petersen-Mahrt, S.K. & Neuberger, M.S. RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators. Mol. Cell 10, 1247-1253 (2002).
    • (2002) Mol Cell , vol.10 , pp. 1247-1253
    • Harris, R.S.1    Petersen-Mahrt, S.K.2    Neuberger, M.S.3
  • 61
    • 0037108463 scopus 로고    scopus 로고
    • Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
    • Rada, C. et al. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr. Biol. 12, 1748-1755 (2002).
    • (2002) Curr. Biol. , vol.12 , pp. 1748-1755
    • Rada, C.1
  • 62
    • 6344256944 scopus 로고    scopus 로고
    • Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation
    • Rada, C., Di Noia, J.M. & Neuberger, M.S. Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation. Mol. Cell 16, 163-171 (2004).
    • (2004) Mol Cell , vol.16 , pp. 163-171
    • Rada, C.1    Di Noia, J.M.2    Neuberger, M.S.3
  • 63
    • 0037011116 scopus 로고    scopus 로고
    • DNA-dependent protein kinase activity is not required for immunoglobulin class switching
    • Bosma, G.C. et al. DNA-dependent protein kinase activity is not required for immunoglobulin class switching. J. Exp. Med. 196, 1483-1495 (2002).
    • (2002) J. Exp. Med. , vol.196 , pp. 1483-1495
    • Bosma, G.C.1
  • 64
    • 0036224604 scopus 로고    scopus 로고
    • IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells
    • Manis, J.P., Dudley, D., Kaylor, L. & Alt, F.W. IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells. Immunity 16, 607-617 (2002).
    • (2002) Immunity , vol.16 , pp. 607-617
    • Manis, J.P.1    Dudley, D.2    Kaylor, L.3    Alt, F.W.4
  • 65
    • 0142250270 scopus 로고    scopus 로고
    • Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination
    • Martin, A. et al. Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination. J. Exp. Med. 198, 1171-1178 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 1171-1178
    • Martin, A.1
  • 66
    • 0033564878 scopus 로고    scopus 로고
    • Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: Parallels with somatic hypermutation
    • Ehrenstein, M.R. & Neuberger, M.S. Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation. EMBO J. 18, 3484-3490 (1999).
    • (1999) EMBO J , vol.18 , pp. 3484-3490
    • Ehrenstein, M.R.1    Neuberger, M.S.2
  • 67
    • 0033517129 scopus 로고    scopus 로고
    • Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes
    • Schrader, C.E., Edelmann, W., Kucherlapati, R. & Stavnezer, J. Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes. J. Exp. Med. 190, 323-330 (1999).
    • (1999) J. Exp. Med. , vol.190 , pp. 323-330
    • Schrader, C.E.1    Edelmann, W.2    Kucherlapati, R.3    Stavnezer, J.4
  • 68
    • 14244250387 scopus 로고    scopus 로고
    • MSH2-MSH6 stimulates DNA polymerase η, suggesting a role for A:T mutations in antibody genes
    • Wilson, T.M. et al. MSH2-MSH6 stimulates DNA polymerase η, suggesting a role for A:T mutations in antibody genes. J. Exp. Med. 201, 637-645 (2005).
    • (2005) J. Exp. Med. , vol.201 , pp. 637-645
    • Wilson, T.M.1
  • 69
    • 0142092610 scopus 로고    scopus 로고
    • Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination
    • Imai, K. et al. Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination. Nat. Immunol. 4, 1023-1028 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 1023-1028
    • Imai, K.1
  • 70
    • 0347763510 scopus 로고    scopus 로고
    • DNA double strand breaks occur independent of AID in hypermutating Ig genes
    • Bross, L. & Jacobs, H. DNA double strand breaks occur independent of AID in hypermutating Ig genes. Clin. Dev. Immunol. 10, 83-89 (2003).
    • (2003) Clin. Dev. Immunol. , vol.10 , pp. 83-89
    • Bross, L.1    Jacobs, H.2
  • 71
    • 0037029606 scopus 로고    scopus 로고
    • The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process
    • Papavasiliou, F.N. & Schatz, D.G. The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process. J. Exp. Med. 195, 1193-1198 (2002).
    • (2002) J. Exp. Med. , vol.195 , pp. 1193-1198
    • Papavasiliou, F.N.1    Schatz, D.G.2
  • 72
    • 0346362489 scopus 로고    scopus 로고
    • Transcription-coupled events associating with immunoglobulin switch region chromatin
    • Nambu, Y. et al. Transcription-coupled events associating with immunoglobulin switch region chromatin. Science 302, 2137-2140 (2003).
    • (2003) Science , vol.302 , pp. 2137-2140
    • Nambu, Y.1
  • 73
    • 11844264903 scopus 로고    scopus 로고
    • The double-edged sword of activation-induced cytidine deaminase
    • Wu, X., Geraldes, P., Platt, J.L. & Cascalho, M. The double-edged sword of activation-induced cytidine deaminase. J. Immunol. 174, 934-941 (2005).
    • (2005) J. Immunol. , vol.174 , pp. 934-941
    • Wu, X.1    Geraldes, P.2    Platt, J.L.3    Cascalho, M.4
  • 74
    • 0036674618 scopus 로고    scopus 로고
    • AID and mismatch repair in antibody diversification
    • Martin, A. & Scharff, M.D. AID and mismatch repair in antibody diversification. Nat. Rev. Immunol. 2, 605-614 (2002).
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 605-614
    • Martin, A.1    Scharff, M.D.2
  • 75
    • 0037126038 scopus 로고    scopus 로고
    • Somatic hypermutation of the AID transgene in B and non-B cells
    • Martin, A. & Scharff, M.D. Somatic hypermutation of the AID transgene in B and non-B cells. Proc. Natl. Acad. Sci. USA 99, 12304-12308 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 12304-12308
    • Martin, A.1    Scharff, M.D.2
  • 76
    • 0037881911 scopus 로고    scopus 로고
    • Constitutive expression of AID leads to tumorigenesis
    • Okazaki, I.M. et al. Constitutive expression of AID leads to tumorigenesis. J. Exp. Med. 197, 1173-1181 (2003).
    • (2003) J. Exp. Med. , vol.197 , pp. 1173-1181
    • Okazaki, I.M.1
  • 77
    • 0037076967 scopus 로고    scopus 로고
    • AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts
    • Yoshikawa, K. et al. AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts. Science 296, 2033-2036 (2002).
    • (2002) Science , vol.296 , pp. 2033-2036
    • Yoshikawa, K.1
  • 78
    • 15444366646 scopus 로고    scopus 로고
    • Overexpressed activation induced cytidine deaminase mutates limited genes with variable base specificity
    • Kotani, A. et al. Overexpressed activation induced cytidine deaminase mutates limited genes with variable base specificity. Proc. Natl. Acad. Sci. USA 102, 4506-4511 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 4506-4511
    • Kotani, A.1
  • 79
    • 0035169027 scopus 로고    scopus 로고
    • The PU.1 and NF-EM5 binding motifs in the IgK 3′ enhancer are responsible for directing somatic hypermutations to the intrinsic hotspots in the transgenic VK gene
    • Kodama, M. et al. The PU.1 and NF-EM5 binding motifs in the IgK 3′ enhancer are responsible for directing somatic hypermutations to the intrinsic hotspots in the transgenic VK gene. Int. Immunol, 13, 1415-1422 (2001).
    • (2001) Int Immunol , vol.13 , pp. 1415-1422
    • Kodama, M.1
  • 80
    • 0032722893 scopus 로고    scopus 로고
    • Mismatch repair and immunoglobulin gene hypermutation: Did we learn something?
    • Reynaud, C.A. et al. Mismatch repair and immunoglobulin gene hypermutation: did we learn something? Immunol. Today 20, 522-527 (1999).
    • (1999) Immunol. Today , vol.20 , pp. 522-527
    • Reynaud, C.A.1
  • 81
    • 0032127804 scopus 로고    scopus 로고
    • Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting
    • Rada, C., Ehrenstein, M.R., Neuberger, M.S. & Milstein, C. Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. Immunity, 135-141 (1998).
    • (1998) Immunity , pp. 135-141
    • Rada, C.1    Ehrenstein, M.R.2    Neuberger, M.S.3    Milstein, C.4
  • 82
    • 0027410278 scopus 로고
    • Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: Implications for the location of cis-acting elements required for somatic mutation
    • Giusti, A.M. & Manser, T. Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutation. J. Exp. Med. 177, 797-809 (1993).
    • (1993) J. Exp. Med. , vol.177 , pp. 797-809
    • Giusti, A.M.1    Manser, T.2
  • 83
    • 0031975171 scopus 로고    scopus 로고
    • Multiple sequences from downstream of the JK cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domain, fur
    • Klix, N. et al. Multiple sequences from downstream of the JK cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domain, fur. J. Immunol. 28, 317-326 (1998).
    • (1998) J. Immunol. , vol.28 , pp. 317-326
    • Klix, N.1
  • 84
    • 0041931059 scopus 로고    scopus 로고
    • The e box motif CAGGTG enhances somatic hypermutation without enhancing transcription
    • Michael, N. et al. The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription. Immunity 19, 235-242 (2003).
    • (2003) Immunity , vol.19 , pp. 235-242
    • Michael, N.1
  • 85
    • 0037625159 scopus 로고    scopus 로고
    • What role for AID: Mutator, or assembler of the immunoglobulin mutasome?
    • Reynaud, C.A., Aoufouchi, S., Faili, A. & Weill, J.C. What role for AID: mutator, or assembler of the immunoglobulin mutasome? Nat. Immunol. 4, 631-638 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 631-638
    • Reynaud, C.A.1    Aoufouchi, S.2    Faili, A.3    Weill, J.C.4
  • 87
    • 0037388211 scopus 로고    scopus 로고
    • Somatic hypermutation of the B cell receptor genes B29 (Igβ, CD79b) and mb1 (Igα, CD79a)
    • Gordon, M.S., Kanegai, C.M., Doerr, J.R. & Wall, R. Somatic hypermutation of the B cell receptor genes B29 (Igβ, CD79b) and mb1 (Igα, CD79a). Proc. Natl. Acad. Sci. USA 100, 4126-4131 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 4126-4131
    • Gordon, M.S.1    Kanegai, C.M.2    Doerr, J.R.3    Wall, R.4
  • 88
    • 13144259651 scopus 로고    scopus 로고
    • BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci
    • Pasqualucci, L. et al. BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. Proc. Natl. Acad. Sci. USA 95, 11816-11821 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 11816-11821
    • Pasqualucci, L.1
  • 89
    • 0035913362 scopus 로고    scopus 로고
    • Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas
    • Pasqualucci, L. et al. Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature 412, 341-346 (2001).
    • (2001) Nature , vol.412 , pp. 341-346
    • Pasqualucci, L.1
  • 90
    • 0025630537 scopus 로고
    • Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is approximately 1 kb from V(D)J gene
    • Lebecque, S.G. & Gearhart, P.J. Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is approximately 1 kb from V(D)J gene. J. Exp. Med. 172, 1717-1727 (1990).
    • (1990) J. Exp. Med. , vol.172 , pp. 1717-1727
    • Lebecque, S.G.1    Gearhart, P.J.2
  • 91
    • 0037462721 scopus 로고    scopus 로고
    • Regulation of E2A activities by histone acetyltransferases in B lymphocyte development
    • Bradney, C. et al. Regulation of E2A activities by histone acetyltransferases in B lymphocyte development. J. Biol. Chem. 278, 2370-2376 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 2370-2376
    • Bradney, C.1
  • 92
    • 0029598833 scopus 로고
    • RNA:DNA complex formation upon transcription of immunoglobulin switch regions: Implications for the mechanism and regulation of class switch recombination
    • Daniels, G.A. & Lieber, M.R. RNA:DNA complex formation upon transcription of immunoglobulin switch regions: implications for the mechanism and regulation of class switch recombination. Nucleic Acids Res. 23, 5006-5011 (1995).
    • (1995) Nucleic Acids Res , vol.23 , pp. 5006-5011
    • Daniels, G.A.1    Lieber, M.R.2
  • 93
    • 0013277286 scopus 로고    scopus 로고
    • Molecular visualization of immunoglobulin switch region RNA/DNA complex by atomic force microscope
    • Mizuta, R. et al. Molecular visualization of immunoglobulin switch region RNA/DNA complex by atomic force microscope. J. Biol. Chem. 278, 4431-4434 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 4431-4434
    • Mizuta, R.1
  • 94
    • 0025225502 scopus 로고
    • Induction of RNA-stabilized DNA conformers by transcription of an immunoglobulin switch region
    • Reaban, M.E. & Griffin, J.A. Induction of RNA-stabilized DNA conformers by transcription of an immunoglobulin switch region. Nature 348, 342-344 (1990).
    • (1990) Nature , vol.348 , pp. 342-344
    • Reaban, M.E.1    Griffin, J.A.2
  • 95
    • 0034604622 scopus 로고    scopus 로고
    • Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro
    • Tian, M. & Alt, F.W. Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro. J. Biol. Chem. 275, 24163-24172 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 24163-24172
    • Tian, M.1    Alt, F.W.2
  • 96
    • 0037650190 scopus 로고    scopus 로고
    • R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells
    • Yu, K., Chedin, F., Hsieh, C.L., Wilson, T.E. & Lieber, M.R. R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells. Nat. Immunol. 4, 442-451 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 442-451
    • Yu, K.1    Chedin, F.2    Hsieh, C.L.3    Wilson, T.E.4    Lieber, M.R.5
  • 97
    • 0038664358 scopus 로고    scopus 로고
    • The influence of transcriptional orientation on endogenous switch region function
    • Shinkura, R. et al. The influence of transcriptional orientation on endogenous switch region function. Nat. Immunol. 4, 435-441 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 435-441
    • Shinkura, R.1
  • 98
    • 13444255004 scopus 로고    scopus 로고
    • An evolutionary conserved target motif for immunoglobulin class-switch recombination
    • Zarrin, A.A. et al. An evolutionary conserved target motif for immunoglobulin class-switch recombination. Nat. Immunol. 5, 1275-1281 (2004).
    • (2004) Nat. Immunol. , vol.5 , pp. 1275-1281
    • Zarrin, A.A.1
  • 99
    • 0035067615 scopus 로고    scopus 로고
    • Palindromic but not G-rich sequences are targets of class switch recombination
    • Tashiro, J., Kinoshita, K. & Honjo, T. Palindromic but not G-rich sequences are targets of class switch recombination. Int. Immunol. 13, 495-505 (2001).
    • (2001) Int. Immunol. , vol.13 , pp. 495-505
    • Tashiro, J.1    Kinoshita, K.2    Honjo, T.3
  • 100
    • 0035817344 scopus 로고    scopus 로고
    • Quantitative regulation of class switch recombination by switch region transcription
    • Lee, C.G. et al. Quantitative regulation of class switch recombination by switch region transcription. J. Exp. Med. 194, 365-374 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 365-374
    • Lee, C.G.1
  • 101
    • 1642488349 scopus 로고    scopus 로고
    • Hepatitis C virus induces a mutator phenotype: Enhanced mutations of immunoglobulin and protooncogenes
    • Machida, K. et al. Hepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and protooncogenes. Proc. Natl. Acad. Sci. USA 101, 4262-4267 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 4262-4267
    • Machida, K.1
  • 102
    • 0242495542 scopus 로고    scopus 로고
    • EBV-encoded latent membrane protein 1 cooperates with BAFF/BLyS and APRIL to induce T cell-independent Ig heavy chain class switching
    • He, B., Raab-Traub, N., Casali, P. & Cerutti, A. EBV-encoded latent membrane protein 1 cooperates with BAFF/BLyS and APRIL to induce T cell-independent Ig heavy chain class switching. J. Immunol. 171, 5215-5224 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 5215-5224
    • He, B.1    Raab-Traub, N.2    Casali, P.3    Cerutti, A.4


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