-
1
-
-
0034094425
-
The RAG proteins and V(D)J recombination: Complexes, ends, and transposition
-
Fugmann, S.D., Lee, A.I., Shockett, P.E., Villey, I.J., and Schatz, D.G. 2000. The RAG proteins and V(D)J recombination: complexes, ends, and transposition. Annu. Rev. Immunol. 18:495-527.
-
(2000)
Annu. Rev. Immunol.
, vol.18
, pp. 495-527
-
-
Fugmann, S.D.1
Lee, A.I.2
Shockett, P.E.3
Villey, I.J.4
Schatz, D.G.5
-
2
-
-
0032904693
-
The biochemistry and biological significance of nonhomologous DNA end joining: An essential repair process in multicellular eukaryotes
-
Lieber, M.R. 1999. The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes. Genes Cells. 4:77-85.
-
(1999)
Genes Cells
, vol.4
, pp. 77-85
-
-
Lieber, M.R.1
-
3
-
-
0026585781
-
RAG-1 deficient mice have no mature B and T lymphocytes
-
Mombaerts, P., et al. 1992. RAG-1 deficient mice have no mature B and T lymphocytes. Cell. 68:869-877.
-
(1992)
Cell
, vol.68
, pp. 869-877
-
-
Mombaerts, P.1
-
4
-
-
0026581936
-
RAG-2 deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
-
Shinkai, Y., et al. 1992. RAG-2 deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell. 68:855-867.
-
(1992)
Cell
, vol.68
, pp. 855-867
-
-
Shinkai, Y.1
-
5
-
-
0029778191
-
Requirement for Ku80 in growth and immunoglobulin V(D)J recombination
-
Nussenzweig, A., et al. 1996. Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature. 382:551-555.
-
(1996)
Nature
, vol.382
, pp. 551-555
-
-
Nussenzweig, A.1
-
6
-
-
0030576534
-
Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates
-
Zhu, C., Bogue, M.A., Lim, D.S., Hasty, P., and Roth, D.B. 1996. Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Cell. 86:379-389.
-
(1996)
Cell
, vol.86
, pp. 379-389
-
-
Zhu, C.1
Bogue, M.A.2
Lim, D.S.3
Hasty, P.4
Roth, D.B.5
-
7
-
-
0030698851
-
DNA-PKcs: A T-cell tumour suppressor encoded at the mouse scid locus
-
Jhappan, C., Morse, H.C., 3rd, Fleischmann, R.D., Gottesman, M.M., and Merlino, G. 1997. DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus. Nat. Genet. 17:483-486.
-
(1997)
Nat. Genet.
, vol.17
, pp. 483-486
-
-
Jhappan, C.1
Morse H.C. III2
Fleischmann, R.D.3
Gottesman, M.M.4
Merlino, G.5
-
8
-
-
0031569608
-
A kinase-negative mutation of DNA-PKCS in equine SCID results in defective coding and signal joint formation
-
Shin, E.K., Perryman, L.E., and Meek, K. 1997. A kinase-negative mutation of DNA-PKCS in equine SCID results in defective coding and signal joint formation. J. Immunol. 158:3565-3569.
-
(1997)
J. Immunol.
, vol.158
, pp. 3565-3569
-
-
Shin, E.K.1
Perryman, L.E.2
Meek, K.3
-
9
-
-
0032585526
-
Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice
-
Barnes, D.E., Stamp, G., Rosewell, I., Denzel, A., and Lindahl, T. 1998. Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice. Curr. Biol. 31:1395-1398.
-
(1998)
Curr. Biol.
, vol.31
, pp. 1395-1398
-
-
Barnes, D.E.1
Stamp, G.2
Rosewell, I.3
Denzel, A.4
Lindahl, T.5
-
10
-
-
0032511976
-
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV
-
Frank, K.M., et al. 1998. Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature. 396:173-177.
-
(1998)
Nature
, vol.396
, pp. 173-177
-
-
Frank, K.M.1
-
11
-
-
0032167446
-
A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination
-
Gao, Y., et al. 1998. A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Immunity. 9:367-376.
-
(1998)
Immunity
, vol.9
, pp. 367-376
-
-
Gao, Y.1
-
12
-
-
0032417640
-
A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis
-
Gao, Y., et al. 1998. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell. 95:891-902.
-
(1998)
Cell
, vol.95
, pp. 891-902
-
-
Gao, Y.1
-
13
-
-
0032167545
-
Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity
-
Taccioli, G.E., et al. 1998. Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity. Immunity. 9:355-366.
-
(1998)
Immunity
, vol.9
, pp. 355-366
-
-
Taccioli, G.E.1
-
14
-
-
0035917489
-
ARTEMIS, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency
-
Moshous, D, et al. 2001. ARTEMIS, a novel DNA double-strand break repair / V(D)J recombination protein, is mutated in human severe combined immune deficiency. Cell. 105:177-186.
-
(2001)
Cell
, vol.105
, pp. 177-186
-
-
Moshous, D.1
-
15
-
-
0033302071
-
An evolutionary classification of the matallo-β-lactamase fold
-
Aravind, L. 1997. An evolutionary classification of the matallo-β-lactamase fold. In Silico Biol. 1:69-91.
-
(1997)
In Silico Biol.
, vol.1
, pp. 69-91
-
-
Aravind, L.1
-
16
-
-
0037155703
-
Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination
-
Ma, Y., Pannicke, U., Schwarz, K., and Lieber, M.R. 2002. Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell. 108:781-794.
-
(2002)
Cell
, vol.108
, pp. 781-794
-
-
Ma, Y.1
Pannicke, U.2
Schwarz, K.3
Lieber, M.R.4
-
17
-
-
0035500805
-
Double-strand breaks and tumorigenesis
-
Pierce, A.J., et al. 2001. Double-strand breaks and tumorigenesis. Trends Cell Bzol. 11:S52-S59.
-
(2001)
Trends Cell Bzol.
, vol.11
-
-
Pierce, A.J.1
-
18
-
-
0031466618
-
Ataxia-telangiectasia and the Nijmegen breakage syndrome: Related disorders but genes apart
-
Shiloh, Y. 1997. Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart. Annu. Rev. Genet. 31:635-662.
-
(1997)
Annu. Rev. Genet.
, vol.31
, pp. 635-662
-
-
Shiloh, Y.1
-
19
-
-
0032785839
-
Regulated genomic instability and neoplasia in the lymphoid lineage
-
Vanasse, G.J., Concannon, P., and Willerford, D.M. 1999. Regulated genomic instability and neoplasia in the lymphoid lineage. Blood. 94:3997-4010.
-
(1999)
Blood
, vol.94
, pp. 3997-4010
-
-
Vanasse, G.J.1
Concannon, P.2
Willerford, D.M.3
-
20
-
-
0035839840
-
DNA double strand break repair and chromosomal translocation: Lessons from animal models
-
Ferguson, D.O., and Alt, F.W. 2001. DNA double strand break repair and chromosomal translocation: lessons from animal models. Oncogene. 20:5572-5579.
-
(2001)
Oncogene
, vol.20
, pp. 5572-5579
-
-
Ferguson, D.O.1
Alt, F.W.2
-
21
-
-
0037188898
-
Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations
-
Zhu, C., et al. 2002. Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell. 109:811-821.
-
(2002)
Cell
, vol.109
, pp. 811-821
-
-
Zhu, C.1
-
22
-
-
0037136318
-
Evidence For replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification
-
Difilippantonio, M.J., et al. 2002. Evidence For replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification. J. Exp. Med. 196:469-480.
-
(2002)
J. Exp. Med.
, vol.196
, pp. 469-480
-
-
Difilippantonio, M.J.1
-
23
-
-
0027972658
-
Epstein-Barr virus is infrequently identified in non-Hodgkin's lymphomas associated with Hodgkin's disease
-
Kingma, D.W., et al. 1994. Epstein-Barr virus is infrequently identified in non-Hodgkin's lymphomas associated with Hodgkin's disease. Am. J. Surg. Pathol. 18:48-61.
-
(1994)
Am. J. Surg. Pathol.
, vol.18
, pp. 48-61
-
-
Kingma, D.W.1
-
24
-
-
0028940167
-
Description of a novel FR1 IgH PCR strategy and its comparison with three other strategies for the detection of clonality in B cell malignancies
-
Aubin, J., et al. 1995. Description of a novel FR1 IgH PCR strategy and its comparison with three other strategies for the detection of clonality in B cell malignancies. Leukemia. 9:471-479.
-
(1995)
Leukemia
, vol.9
, pp. 471-479
-
-
Aubin, J.1
-
25
-
-
0034665892
-
The incidence of clonal T-cell receptor rearrangements in B-cell precursor acute lymphoblastic leukemia varies with age and genotype
-
Brumpt, C., et al. 2000. The incidence of clonal T-cell receptor rearrangements in B-cell precursor acute lymphoblastic leukemia varies with age and genotype. Blood. 96:2254-2261.
-
(2000)
Blood
, vol.96
, pp. 2254-2261
-
-
Brumpt, C.1
-
26
-
-
0027251463
-
The sizes ofthe CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments
-
Pannetier, C., et al. 1993. The sizes ofthe CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments. Proc Natl. Acad. Sci. USA. 90:4319-4323.
-
(1993)
Proc Natl. Acad. Sci. USA
, vol.90
, pp. 4319-4323
-
-
Pannetier, C.1
-
27
-
-
0032541313
-
A human SCID condition with increased sensitivity to ionizing radiations and impaired V(D)J rearrangements defines a new DNA recombination/repair deficiency
-
Nicolas, N., et al. 1998. A human SCID condition with increased sensitivity to ionizing radiations and impaired V(D)J rearrangements defines a new DNA recombination/repair deficiency. J. Exp. Med. 188:627-634.
-
(1998)
J. Exp. Med.
, vol.188
, pp. 627-634
-
-
Nicolas, N.1
-
28
-
-
0027236954
-
Production of high-titer helper-free retroviruses by transient transfection
-
Pear, W.S., Nolan, G.P., Scott, M.L., and Baltimore, D. 1993. Production of high-titer helper-free retroviruses by transient transfection. Proc. Natl. Acad. Sci. USA. 90:8392-8396.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 8392-8396
-
-
Pear, W.S.1
Nolan, G.P.2
Scott, M.L.3
Baltimore, D.4
-
29
-
-
0030837472
-
V(D)J recombination in Ku86-deficient mice: Distinct effects on coding, signal, and hybrid joint formation
-
Bogue, M.A., Wang, C.Y., Zhu, C.M., and Roth, D.B. 1997. V(D)J recombination in Ku86-deficient mice: distinct effects on coding, signal, and hybrid joint formation. Immunity. 7:37-47.
-
(1997)
Immunity
, vol.7
, pp. 37-47
-
-
Bogue, M.A.1
Wang, C.Y.2
Zhu, C.M.3
Roth, D.B.4
-
30
-
-
0037102538
-
Metallo-β-lactamase fold within nucleic acids processing enzymes: The β-CASP family
-
Callebaut, I., Moshous, D., Mornon, J.P., and De Villartay, J.P. 2002. Metallo-β-lactamase fold within nucleic acids processing enzymes: the β-CASP family. Nucleic Acids Res. 30:3592-3601.
-
(2002)
Nucleic Acids Res.
, vol.30
, pp. 3592-3601
-
-
Callebaut, I.1
Moshous, D.2
Mornon, J.P.3
De Villartay, J.P.4
-
31
-
-
18244362081
-
DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency
-
O'Driscoll, M., et al. 2001. DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency. Mol. Cell. 8:1175-1185.
-
(2001)
Mol. Cell
, vol.8
, pp. 1175-1185
-
-
O'Driscoll, M.1
-
32
-
-
0035312286
-
Ku80 is required for addition of N nucleotides to V(D)J recombination junctions by terminal deoxynucleotidyl transferase
-
Purugganan, M.M., Shah, S., Kearney, J.F., and Roth, D.B. 2001. Ku80 is required for addition of N nucleotides to V(D)J recombination junctions by terminal deoxynucleotidyl transferase. Nucleic Acids Res. 29:1638-1646.
-
(2001)
Nucleic Acids Res.
, vol.29
, pp. 1638-1646
-
-
Purugganan, M.M.1
Shah, S.2
Kearney, J.F.3
Roth, D.B.4
-
33
-
-
0033598831
-
Association of terminal deoxynucleotidyl transferase with Ku
-
Mahajan, K.N., et al. 1999. Association of terminal deoxynucleotidyl transferase with Ku. Proc. Natl. Acad. Sci. USA. 96:13926-13931.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 13926-13931
-
-
Mahajan, K.N.1
-
34
-
-
0033565878
-
Modulation of terminal deoxynucleotidyltransferase activity by the DNA-dependent protein kinase
-
Mickelsen, S., et al. 1999. Modulation of terminal deoxynucleotidyltransferase activity by the DNA-dependent protein kinase. J. Immunol. 163:834-843.
-
(1999)
J. Immunol.
, vol.163
, pp. 834-843
-
-
Mickelsen, S.1
-
35
-
-
0035353213
-
Identical mutations in RAG1 and RAG2 genes leading to defective V(D)J recombinase activity can cause either T-B-severe combined immune deficiency or Omenn syndrome
-
Corneo, B., et al. 2001. Identical mutations in RAG1 and RAG2 genes leading to defective V(D)J recombinase activity can cause either T-B-severe combined immune deficiency or Omenn syndrome. Blood. 97:2772-2776.
-
(2001)
Blood
, vol.97
, pp. 2772-2776
-
-
Corneo, B.1
-
36
-
-
0035161258
-
V(D)J recombination defects in lymphocytes due to RAG mutations: Severe immunodeficiency with a spectrum of clinical presentations
-
Villa, A., et al. 2001. V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations. Blood. 97:81-88.
-
(2001)
Blood
, vol.97
, pp. 81-88
-
-
Villa, A.1
-
37
-
-
0030932869
-
Cancer-susceptiibility genes. Gatekeepers and caretakers
-
Kinzler, K.W., and Vogelstein, B. 1997. Cancer-susceptiibility genes. Gatekeepers and caretakers. Nature. 386:761, 763.
-
(1997)
Nature
, vol.386
, pp. 761
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
38
-
-
0034612308
-
The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations
-
Ferguson, D.O., et al. 2000. The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proc Natl. Acad. Sci. USA. 97:6630-6633.
-
(2000)
Proc Natl. Acad. Sci. USA
, vol.97
, pp. 6630-6633
-
-
Ferguson, D.O.1
-
39
-
-
0034732239
-
DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation
-
Difilippantonio, M.J., et al. 2000. DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Nature. 404:510-514.
-
(2000)
Nature
, vol.404
, pp. 510-514
-
-
Difilippantonio, M.J.1
-
40
-
-
0034765256
-
Identification of basic residues in RAG2 critical for DNA binding by the RAG1-RAG2 complex
-
Fugmann, S.D., and Schatz, D.G. 2001. Identification of basic residues in RAG2 critical for DNA binding by the RAG1-RAG2 complex. Mol. Cell. 8:899-910.
-
(2001)
Mol. Cell.
, vol.8
, pp. 899-910
-
-
Fugmann, S.D.1
Schatz, D.G.2
-
41
-
-
0035108439
-
Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination
-
Qiu, J.X., Kale, S.B., Yarnell Schultz, H., and Roth, D.B. 2001. Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination. Mol. Cell. 7:77-87.
-
(2001)
Mol. Cell.
, vol.7
, pp. 77-87
-
-
Qiu, J.X.1
Kale, S.B.2
Yarnell Schultz, H.3
Roth, D.B.4
-
42
-
-
0036240040
-
Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinase
-
Huye, L.E., Purugganan, M.M., Jiang, M.M., and Roth, D.B. 2002. Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinase. Mol. Cell. Biol. 22:3460-3473.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 3460-3473
-
-
Huye, L.E.1
Purugganan, M.M.2
Jiang, M.M.3
Roth, D.B.4
-
43
-
-
0036932453
-
Leaky scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice
-
Rooney, S., et al. 2002. Leaky scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice. Mol. Cell. 10:1379-1390.
-
(2002)
Mol. Cell.
, vol.10
, pp. 1379-1390
-
-
Rooney, S.1
|