메뉴 건너뛰기




Volumn 194, Issue , 2003, Pages 77-95

The role of DNA breaks in genomic instability and tumorigenesis

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE; CANCER GROWTH; CARCINOGENESIS; CELL DEATH; CELL METABOLISM; CELL TRANSFORMATION; CHROMOSOME DAMAGE; DISEASE ASSOCIATION; DNA REPAIR; DNA STRAND BREAKAGE; GENE MUTATION; GENETIC STABILITY; GENOME; KARYOTYPE; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE;

EID: 0037660900     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-065X.2003.00060.x     Document Type: Review
Times cited : (311)

References (198)
  • 1
    • 0035093737 scopus 로고    scopus 로고
    • DNA double-strand breaks: Signaling, repair and the cancer connection
    • Kharma KK, Jackson SP. DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet 2001;27:247-254.
    • (2001) Nat Genet , vol.27 , pp. 247-254
    • Kharma, K.K.1    Jackson, S.P.2
  • 2
    • 0035839840 scopus 로고    scopus 로고
    • DNA double strand break repair and chromosomal translocation: Lessons from animal models
    • Ferguson DO, Alt FW. DNA double strand break repair and chromosomal translocation: lessons from animal models. Oncogene 2001;20:5572-5559.
    • (2001) Oncogene , vol.20 , pp. 5572-5559
    • Ferguson, D.O.1    Alt, F.W.2
  • 3
    • 0036240127 scopus 로고    scopus 로고
    • The mechanism and regulation of chromosomal V(D)J recombination
    • Bassing CH, Swat W, Alt FW. The mechanism and regulation of chromosomal V(D)J recombination. Cell 2002;109:S45-S55.
    • (2002) Cell , vol.109
    • Bassing, C.H.1    Swat, W.2    Alt, F.W.3
  • 4
    • 0034969086 scopus 로고    scopus 로고
    • Factors and forces controlling V(D)J recombination
    • Hesslein DGT, Schatz DG. Factors and forces controlling V(D)J recombination. Adv Immunol 2001;78:169-232.
    • (2001) Adv Immunol , vol.78 , pp. 169-232
    • Hesslein, D.G.T.1    Schatz, D.G.2
  • 6
    • 0030272590 scopus 로고    scopus 로고
    • Developmental regulation of V(D)J recombination and lymphocyte differentiation
    • Willerford DM, Swat W, Alt FW. Developmental regulation of V(D)J recombination and lymphocyte differentiation. Curr Opin Genet Dev 1996;6:603-609.
    • (1996) Curr Opin Genet Dev , vol.6 , pp. 603-609
    • Willerford, D.M.1    Swat, W.2    Alt, F.W.3
  • 7
    • 0031842201 scopus 로고    scopus 로고
    • Regulation of immunoglobulin light chain isotype expression
    • Gorman JR, Alt FW. Regulation of immunoglobulin light chain isotype expression. Adv Immunol 1998;69:113-181.
    • (1998) Adv Immunol , vol.69 , pp. 113-181
    • Gorman, J.R.1    Alt, F.W.2
  • 8
    • 0035313993 scopus 로고    scopus 로고
    • Molecular determinants of TCR expression and selection
    • Berg LJ, Kang J. Molecular determinants of TCR expression and selection. Curr Opin Immunol 2001;13:232-241.
    • (2001) Curr Opin Immunol , vol.13 , pp. 232-241
    • Berg, L.J.1    Kang, J.2
  • 9
    • 0034093662 scopus 로고    scopus 로고
    • Regulation of RAG expression in developing lymphocytes
    • Nagaoka H, Yu W, Nussenzweig MC. Regulation of RAG expression in developing lymphocytes. Curr Opin Immunol 2000;12:187-190.
    • (2000) Curr Opin Immunol , vol.12 , pp. 187-190
    • Nagaoka, H.1    Yu, W.2    Nussenzweig, M.C.3
  • 10
    • 0030422634 scopus 로고    scopus 로고
    • Regulation of recombination activating gene expression during lymphocyte development
    • Grawunder U, Winkler TH, Melchers F. Regulation of recombination activating gene expression during lymphocyte development. Curr Top Microbiol Immunol 1996;217:31-43.
    • (1996) Curr Top Microbiol Immunol , vol.217 , pp. 31-43
    • Grawunder, U.1    Winkler, T.H.2    Melchers, F.3
  • 11
    • 0029014910 scopus 로고
    • V(D)J recombination and the cell cycle
    • Lin WC, Desiderio S. V(D)J recombination and the cell cycle. Immunol Today 1995;16:279-289.
    • (1995) Immunol Today , vol.16 , pp. 279-289
    • Lin, W.C.1    Desiderio, S.2
  • 12
    • 0033180183 scopus 로고    scopus 로고
    • RAG2: GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues
    • Monroe RJ, et al. RAG2: GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues. Immunity 1999;11:201-212.
    • (1999) Immunity , vol.11 , pp. 201-212
    • Monroe, R.J.1
  • 13
    • 0033549813 scopus 로고    scopus 로고
    • Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization
    • Yu W, et al. Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization. Nature 1999;400:682-687.
    • (1999) Nature , vol.400 , pp. 682-687
    • Yu, W.1
  • 14
    • 0034608364 scopus 로고    scopus 로고
    • Revising B cell receptors
    • Nemazee D, Weigert M. Revising B cell receptors. J Exp Med 2000;191:1813-1817.
    • (2000) J Exp Med , vol.191 , pp. 1813-1817
    • Nemazee, D.1    Weigert, M.2
  • 15
    • 0028364447 scopus 로고
    • A DNA repair defect in Chinese hamster ovary cells affects V(D)J recombination similarly to the routine scid mutation
    • Taccioli GE, Cheng HL, Varghese AJ, Whitmore G, Alt FW. A DNA repair defect in Chinese hamster ovary cells affects V(D)J recombination similarly to the routine scid mutation. J Biol Chem 1994;269:7439-7442.
    • (1994) J Biol Chem , vol.269 , pp. 7439-7442
    • Taccioli, G.E.1    Cheng, H.L.2    Varghese, A.J.3    Whitmore, G.4    Alt, F.W.5
  • 17
    • 0025811882 scopus 로고
    • The SCID mouse mutant: Definition, characterization, and potential uses
    • Bosma MJ, Carroll AM. The SCID mouse mutant: definition, characterization, and potential uses. Annu Rev Immunol 1991;9:323-350.
    • (1991) Annu Rev Immunol , vol.9 , pp. 323-350
    • Bosma, M.J.1    Carroll, A.M.2
  • 18
    • 0037198145 scopus 로고    scopus 로고
    • DNA-dependent protein kinase complex: A multifunctional protein in DNA repair and damage checkpoint
    • Lee SH, Kim CH. DNA-dependent protein kinase complex: a multifunctional protein in DNA repair and damage checkpoint. Mol Ceils 2002;13:159-166.
    • (2002) Mol Ceils , vol.13 , pp. 159-166
    • Lee, S.H.1    Kim, C.H.2
  • 19
    • 0034011881 scopus 로고    scopus 로고
    • Ku autoantigen: A multifunctional DNA-binding protein
    • Tuteja R, Tuteja N. Ku autoantigen: a multifunctional DNA-binding protein. Crit Rev Biochem Mol Biol 2000;35:1-33.
    • (2000) Crit Rev Biochem Mol Biol , vol.35 , pp. 1-33
    • Tuteja, R.1    Tuteja, N.2
  • 20
    • 0031059531 scopus 로고    scopus 로고
    • Tying loose ends: Roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks
    • Lieber MR, Grawunder U, Wu X, Yaneva M. Tying loose ends: roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks. Curr Opin Genet Dev 1997;7:99-104.
    • (1997) Curr Opin Genet Dev , vol.7 , pp. 99-104
    • Lieber, M.R.1    Grawunder, U.2    Wu, X.3    Yaneva, M.4
  • 21
    • 0037019597 scopus 로고    scopus 로고
    • The Greek goddess, Artemis, reveals the secrets of her cleavage
    • Amst
    • Jeggo P, O'Neill P. The Greek goddess, Artemis, reveals the secrets of her cleavage. DNA Repair (Amst) 2002;1:771-777.
    • (2002) DNA Repair , vol.1 , pp. 771-777
    • Jeggo, P.1    O'Neill, P.2
  • 23
    • 0028788816 scopus 로고
    • Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases
    • Poltoratsky VP, Shi X, York JD, Lieber MR, Carter TH. Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases. J Immunol 1995;155:4529-4533.
    • (1995) J Immunol , vol.155 , pp. 4529-4533
    • Poltoratsky, V.P.1    Shi, X.2    York, J.D.3    Lieber, M.R.4    Carter, T.H.5
  • 24
    • 0035313998 scopus 로고    scopus 로고
    • How to make ends meet in V(D)J recombination
    • Grawunder U, Harfst E. How to make ends meet in V(D)J recombination. Curr Opin Immunol 2001;13:186-194.
    • (2001) Curr Opin Immunol , vol.13 , pp. 186-194
    • Grawunder, U.1    Harfst, E.2
  • 26
    • 0037023491 scopus 로고    scopus 로고
    • Does artemis end the hunt for the hairpin-opening activity in V(D)J recombination?
    • Schlissel MS. Does artemis end the hunt for the hairpin-opening activity in V(D)J recombination? Cell 2002;109:1-4.
    • (2002) Cell , vol.109 , pp. 1-4
    • Schlissel, M.S.1
  • 27
    • 0037097787 scopus 로고    scopus 로고
    • A founder mutation in Artemis, an SNM1-like protein, causes SCID in Athabascan-speaking Native Americans
    • Li L, et al. A founder mutation in Artemis, an SNM1-like protein, causes SCID in Athabascan-speaking Native Americans. J Immunol 2002;168:6323-6329.
    • (2002) J Immunol , vol.168 , pp. 6323-6329
    • Li, L.1
  • 28
    • 0035917489 scopus 로고    scopus 로고
    • Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency
    • Moshous D, et al. Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency. Cell 2001;105:177-186.
    • (2001) Cell , vol.105 , pp. 177-186
    • Moshous, D.1
  • 29
    • 0038160177 scopus 로고    scopus 로고
    • Radiosensitive SCID patients with Artemis gene mutations show a complete B-cell differentiation arrest at the pre-BCR checkpoint in bone marrow
    • Noordzij JG, et al. Radiosensitive SCID patients with Artemis gene mutations show a complete B-cell differentiation arrest at the pre-BCR checkpoint in bone marrow. Blood 2002;24:24.
    • (2002) Blood , vol.24 , pp. 24
    • Noordzij, J.G.1
  • 30
    • 0032541313 scopus 로고    scopus 로고
    • A human severe combined immunodeficiency (SCID) condition with increased sensitivity to ionizing radiations and impaired V(D)J rearrangements defines a new DNA recombination/repair deficiency
    • Nicolas N, et al. A human severe combined immunodeficiency (SCID) condition with increased sensitivity to ionizing radiations and impaired V(D)J rearrangements defines a new DNA recombination/repair deficiency. J Exp Med 1998;188:627-634.
    • (1998) J Exp Med , vol.188 , pp. 627-634
    • Nicolas, N.1
  • 31
    • 0036932453 scopus 로고    scopus 로고
    • Leaky scid phenotype associated with defective v(d)j coding end processing in artemis-deficient mice
    • Rooney S, et al. Leaky scid phenotype associated with defective v(d)j coding end processing in artemis-deficient mice. Mol Cell 2002;10:1379-1390.
    • (2002) Mol Cell , vol.10 , pp. 1379-1390
    • Rooney, S.1
  • 32
    • 0037155703 scopus 로고    scopus 로고
    • Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination
    • Ma Y, Pannicke U, Schwarz K, Lieber MR. Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell 2002;108: 781-794.
    • (2002) Cell , vol.108 , pp. 781-794
    • Ma, Y.1    Pannicke, U.2    Schwarz, K.3    Lieber, M.R.4
  • 33
    • 0037416138 scopus 로고    scopus 로고
    • Defective DNA repair and increased genome instability in Artemis-deficient murine cells
    • Rooney S, et al. Defective DNA repair and increased genome instability in Artemis-deficient murine cells. J Exp Med 2003;197:553-565.
    • (2003) J Exp Med , vol.197 , pp. 553-565
    • Rooney, S.1
  • 34
    • 0034292370 scopus 로고    scopus 로고
    • Signal joint formation is also impaired in DNA-dependent protein kinase catalytic subunit knockout cells
    • Fukumura R, et al. Signal joint formation is also impaired in DNA-dependent protein kinase catalytic subunit knockout cells. J Immunol 2000;165:3883-3889.
    • (2000) J Immunol , vol.165 , pp. 3883-3889
    • Fukumura, R.1
  • 35
    • 0033574001 scopus 로고    scopus 로고
    • Catalytic subunit of DNA-dependent protein kinase: Impact on lymphocyte development and tumorigenesis
    • Kurimasa A, et al. Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis. Proc Nad Acad Sci USA 1999;96:1403-1408.
    • (1999) Proc Nad Acad Sci USA , vol.96 , pp. 1403-1408
    • Kurimasa, A.1
  • 36
    • 0032167446 scopus 로고    scopus 로고
    • A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination
    • Gao Y, Chaudhuri J, Zhu C, Davidson L, Weaver DT, Alt FW. A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Immunity 1998;9:367-376.
    • (1998) Immunity , vol.9 , pp. 367-376
    • Gao, Y.1    Chaudhuri, J.2    Zhu, C.3    Davidson, L.4    Weaver, D.T.5    Alt, F.W.6
  • 37
    • 0032167545 scopus 로고    scopus 로고
    • Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity
    • Taccioli GE, et al. Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity. Immunity 1998;9:355-366.
    • (1998) Immunity , vol.9 , pp. 355-366
    • Taccioli, G.E.1
  • 38
    • 0035361714 scopus 로고    scopus 로고
    • Increased gene amplification in immortal rodent cells deficient for the DNA-dependent protein kinase catalytic subunit
    • Mondello C, Rebuzzini P, Dolzan M, Edmonson S, Taccioli GE, Giulotto E. Increased gene amplification in immortal rodent cells deficient for the DNA-dependent protein kinase catalytic subunit. Cancer Res 2001;61:4520-4525.
    • (2001) Cancer Res , vol.61 , pp. 4520-4525
    • Mondello, C.1    Rebuzzini, P.2    Dolzan, M.3    Edmonson, S.4    Taccioli, G.E.5    Giulotto, E.6
  • 39
    • 0032585526 scopus 로고    scopus 로고
    • Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryomc mice
    • Barnes DE, Stamp G, Rosewell I, Denzel A, Lindahl T. Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryomc mice. Curr Biol 1998;8:1395-1398.
    • (1998) Curr Biol , vol.8 , pp. 1395-1398
    • Barnes, D.E.1    Stamp, G.2    Rosewell, I.3    Denzel, A.4    Lindahl, T.5
  • 40
    • 0032417640 scopus 로고    scopus 로고
    • A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis
    • Gao Y, et al. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell 1998;95:891-902.
    • (1998) Cell , vol.95 , pp. 891-902
    • Gao, Y.1
  • 41
    • 0032511976 scopus 로고    scopus 로고
    • Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV
    • Frank KM, et al. Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature 1998;396:173-177.
    • (1998) Nature , vol.396 , pp. 173-177
    • Frank, K.M.1
  • 42
    • 0034646304 scopus 로고    scopus 로고
    • Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice
    • Gu Y, et al. Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice. Proc Nad Acad Sci USA 2000;97:2668-2673.
    • (2000) Proc Nad Acad Sci USA , vol.97 , pp. 2668-2673
    • Gu, Y.1
  • 43
    • 0033497924 scopus 로고    scopus 로고
    • Non-homologous end-joining proteins are required for V(D)J recombination, normal growth and neurogenesis
    • Sekiguchi JM, et al. Non-homologous end-joining proteins are required for V(D)J recombination, normal growth and neurogenesis. Cold Spring Harb Symp Quant Biol 1999;64:169-181.
    • (1999) Cold Spring Harb Symp Quant Biol , vol.64 , pp. 169-181
    • Sekiguchi, J.M.1
  • 44
    • 0037027853 scopus 로고    scopus 로고
    • The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: Implications for unifying the heterogeneous phenotypes of NHEJ mutants
    • Amst
    • Karanjawala ZE, et al. The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants. DNA Repair (Amst) 2002;1:1017-1026.
    • (2002) DNA Repair , vol.1 , pp. 1017-1026
    • Karanjawala, Z.E.1
  • 45
    • 0033634973 scopus 로고    scopus 로고
    • DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway
    • Frank KM, et al. DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol Cell 2000;5:993-1002.
    • (2000) Mol Cell , vol.5 , pp. 993-1002
    • Frank, K.M.1
  • 46
    • 0034690249 scopus 로고    scopus 로고
    • Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development
    • Gao Y, et al. Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature 2000;404:897-900.
    • (2000) Nature , vol.404 , pp. 897-900
    • Gao, Y.1
  • 47
    • 0034732239 scopus 로고    scopus 로고
    • DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation
    • Difilippantonio MJ, et al. DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Nature 2000;404:510-514.
    • (2000) Nature , vol.404 , pp. 510-514
    • Difilippantonio, M.J.1
  • 48
    • 0036152242 scopus 로고    scopus 로고
    • Mechanism and control of class-switch recombination
    • Manis JP, Tian M, Alt FW. Mechanism and control of class-switch recombination. Trends Immunol 2002;23:31-39.
    • (2002) Trends Immunol , vol.23 , pp. 31-39
    • Manis, J.P.1    Tian, M.2    Alt, F.W.3
  • 49
    • 0034107832 scopus 로고    scopus 로고
    • Unique and unprecedented recombination mechanisms in class switching
    • Kinoshita K, Honjo T. Unique and unprecedented recombination mechanisms in class switching. Curr Opin Immunol 2000;12:195-198.
    • (2000) Curr Opin Immunol , vol.12 , pp. 195-198
    • Kinoshita, K.1    Honjo, T.2
  • 50
    • 0032522564 scopus 로고    scopus 로고
    • Ku80 is required for immunoglobulin isotype switching
    • Casellas R, et al. Ku80 is required for immunoglobulin isotype switching. EMBO J 1998;17:2404-2411.
    • (1998) EMBO J , vol.17 , pp. 2404-2411
    • Casellas, R.1
  • 51
    • 0032526290 scopus 로고    scopus 로고
    • Ku70 is required for late B cell development and immunoglobulin heavy chain class switching
    • Manis JP, et al. Ku70 is required for late B cell development and immunoglobulin heavy chain class switching. J Exp Med 1998;187:2081-2089.
    • (1998) J Exp Med , vol.187 , pp. 2081-2089
    • Manis, J.P.1
  • 52
    • 0030273141 scopus 로고    scopus 로고
    • The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching
    • Rolink A, Melchers F, Andersson J. The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching. Immunity 1996;5:319-330.
    • (1996) Immunity , vol.5 , pp. 319-330
    • Rolink, A.1    Melchers, F.2    Andersson, J.3
  • 53
    • 0033603340 scopus 로고    scopus 로고
    • Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase famfiy in germinal center B cells
    • Muramatsu M, et al. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase famfiy in germinal center B cells. J Biol Chem 1999;274:18470-18476.
    • (1999) J Biol Chem , vol.274 , pp. 18470-18476
    • Muramatsu, M.1
  • 54
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000;102:553-563.
    • (2000) Cell , vol.102 , pp. 553-563
    • Muramatsu, M.1    Kinoshita, K.2    Fagarasan, S.3    Yamada, S.4    Shinkai, Y.5    Honjo, T.6
  • 55
    • 0034264851 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
    • Revy P, et al. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell 2000;102:565-575.
    • (2000) Cell , vol.102 , pp. 565-575
    • Revy, P.1
  • 56
    • 0037195272 scopus 로고    scopus 로고
    • Immunoglobulin genes: Generating diversity with AID and UNG
    • Storb U, Stavnezer J. Immunoglobulin genes: generating diversity with AID and UNG. Curr Biol 2002;12:R725-R727.
    • (2002) Curr Biol , vol.12
    • Storb, U.1    Stavnezer, J.2
  • 57
    • 0037108463 scopus 로고    scopus 로고
    • Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
    • Rada C, Williams GT, Nilsen H, Barnes DE, Lindahl T, Neuberger MS. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr Biol 2002;12:1748-1755.
    • (2002) Curr Biol , vol.12 , pp. 1748-1755
    • Rada, C.1    Williams, G.T.2    Nilsen, H.3    Barnes, D.E.4    Lindahl, T.5    Neuberger, M.S.6
  • 58
    • 0037452080 scopus 로고    scopus 로고
    • Transcription-targeted DNA deamination by the AID antibody diversification enzyme
    • Chaudhuri J, Tian M, Khuong C, Chua K, Pinaud E, Alt FW. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature 2003;422:726-730.
    • (2003) Nature , vol.422 , pp. 726-730
    • Chaudhuri, J.1    Tian, M.2    Khuong, C.3    Chua, K.4    Pinaud, E.5    Alt, F.W.6
  • 59
    • 0035974862 scopus 로고    scopus 로고
    • Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation
    • Sale JE, Calandrini DM, Takata M, Takeda S, Neuberger MS. Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation. Nature 2001;412:921-926.
    • (2001) Nature , vol.412 , pp. 921-926
    • Sale, J.E.1    Calandrini, D.M.2    Takata, M.3    Takeda, S.4    Neuberger, M.S.5
  • 60
    • 0037026482 scopus 로고    scopus 로고
    • Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase
    • Di Noia J, Neuberger MS. Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. Nature 2002;419:43-48.
    • (2002) Nature , vol.419 , pp. 43-48
    • Di Noia, J.1    Neuberger, M.S.2
  • 61
    • 0036234455 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes: Merging mechanisms for genetic diversity
    • Papavasiliou FN, Schatz DG. Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity. Cell 2002;109:S35-S44.
    • (2002) Cell , vol.109
    • Papavasiliou, F.N.1    Schatz, D.G.2
  • 62
    • 0032555715 scopus 로고    scopus 로고
    • Somatic hypermutation, transcription, and DNA mismatch repair
    • Wiesendanger M, Scharff MID, Edelmann W. Somatic hypermutation, transcription, and DNA mismatch repair. Cell 1998;94:415-418.
    • (1998) Cell , vol.94 , pp. 415-418
    • Wiesendanger, M.1    Scharff, M.D.2    Edelmann, W.3
  • 63
    • 0034266876 scopus 로고    scopus 로고
    • A novel cytidine deaminase affects antibody diversity
    • Longacre A, Storb U. A novel cytidine deaminase affects antibody diversity. Cell 2000;102:541-544.
    • (2000) Cell , vol.102 , pp. 541-544
    • Longacre, A.1    Storb, U.2
  • 64
    • 0033637358 scopus 로고    scopus 로고
    • DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation
    • Bross L, Fukita Y, McBlane F, Demolliere C, Rajewsky K, Jacobs H. DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation. Immunity 2000;13:589-897.
    • (2000) Immunity , vol.13 , pp. 589-897
    • Bross, L.1    Fukita, Y.2    McBlane, F.3    Demolliere, C.4    Rajewsky, K.5    Jacobs, H.6
  • 65
    • 0037029663 scopus 로고    scopus 로고
    • DNA double-strand breaks: Prior to but not sufficient in targeting hypermutation
    • Bross L, Muramatsu M, Kinoshita K, Honjo T, Jacobs H. DNA double-strand breaks: prior to but not sufficient in targeting hypermutation. J Exp Med 2002;195:1187-1192.
    • (2002) J Exp Med , vol.195 , pp. 1187-1192
    • Bross, L.1    Muramatsu, M.2    Kinoshita, K.3    Honjo, T.4    Jacobs, H.5
  • 66
    • 0037029606 scopus 로고    scopus 로고
    • The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process
    • Papavasiliou FN, Schatz DG. The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process. J Exp Med 2002;195:1193-1198.
    • (2002) J Exp Med , vol.195 , pp. 1193-1198
    • Papavasiliou, F.N.1    Schatz, D.G.2
  • 67
    • 0037029631 scopus 로고    scopus 로고
    • The function of AID in somatic mutation and class switch recombination: Upstream or downstream of DNA breaks
    • Chua KF, Alt FW, Manis JP. The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks. J Exp Med 2002;195:F37-F41.
    • (2002) J Exp Med , vol.195
    • Chua, K.F.1    Alt, F.W.2    Manis, J.P.3
  • 68
    • 0037011116 scopus 로고    scopus 로고
    • DNA-dependent protein kinase activity is not required for immunoglobulin class switching
    • Bosma GC, et al. DNA-dependent protein kinase activity is not required for immunoglobulin class switching. J Exp Med 2002;196:1483-1495.
    • (2002) J Exp Med , vol.196 , pp. 1483-1495
    • Bosma, G.C.1
  • 69
    • 0036224604 scopus 로고    scopus 로고
    • IgH class switch recombination to IgG1 in DNA-PKcs-deflcient B cells
    • Manis JP, Dudley D, Kaylor L, Alt FW. IgH class switch recombination to IgG1 in DNA-PKcs-deflcient B cells. Immunity 2002;16:607-617.
    • (2002) Immunity , vol.16 , pp. 607-617
    • Manis, J.P.1    Dudley, D.2    Kaylor, L.3    Alt, F.W.4
  • 70
    • 0034694086 scopus 로고    scopus 로고
    • Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activity
    • Bemark M, Sale JE, Kim HJ, Berek C, Cosgrove RA, Neuberger MS. Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activity. J Exp Med 2000;192:1509-1514.
    • (2000) J Exp Med , vol.192 , pp. 1509-1514
    • Bemark, M.1    Sale, J.E.2    Kim, H.J.3    Berek, C.4    Cosgrove, R.A.5    Neuberger, M.S.6
  • 71
    • 0037083364 scopus 로고    scopus 로고
    • Requirement of the activation-induced deaminase (AID) gene for immunoglobuhn gene conversion
    • Arakawa H, Hanschild J, Buerstedde JM. Requirement of the activation-induced deaminase (AID) gene for immunoglobuhn gene conversion. Science 2002;295:1301-1306.
    • (2002) Science , vol.295 , pp. 1301-1306
    • Arakawa, H.1    Hanschild, J.2    Buerstedde, J.M.3
  • 72
    • 0036900066 scopus 로고    scopus 로고
    • Genetic and environmental factors in cancer and neurodegenerative diseases
    • Migliore L, Coppede F. Genetic and environmental factors in cancer and neurodegenerative diseases. Mutat Res 2002;512:135-153.
    • (2002) Mutat Res , vol.512 , pp. 135-153
    • Migliore, L.1    Coppede, F.2
  • 73
    • 0037115955 scopus 로고    scopus 로고
    • How DNA lesions are turned into mutations within cells?
    • Pages V, Fuchs RP. How DNA lesions are turned into mutations within cells? Oncogene 2002;21:8957-8966.
    • (2002) Oncogene , vol.21 , pp. 8957-8966
    • Pages, V.1    Fuchs, R.P.2
  • 74
    • 0030974861 scopus 로고    scopus 로고
    • Human chromosomal fragile site FRA16B is an amplified AT-rich minisatellite repeat
    • Yu S, et al. Human chromosomal fragile site FRA16B is an amplified AT-rich minisatellite repeat. Cell 1997;88:367-374.
    • (1997) Cell , vol.88 , pp. 367-374
    • Yu, S.1
  • 76
    • 0023614553 scopus 로고
    • Induction of sister chromatid exchanges at common fragile sites
    • Glover TW, Stein CK. Induction of sister chromatid exchanges at common fragile sites. Am J Hum Genet 1987;41:882-890.
    • (1987) Am J Hum Genet , vol.41 , pp. 882-890
    • Glover, T.W.1    Stein, C.K.2
  • 77
    • 0037206935 scopus 로고    scopus 로고
    • Induction of multiple double-strand breaks within an hsr by meganucleaseI-SceI expression or fragile site activation leads to formation of double minutes and other chromosomal rearrangements
    • Coquelle A, Rozier L, Dutrillaux B, Debatisse M. Induction of multiple double-strand breaks within an hsr by meganucleaseI-SceI expression or fragile site activation leads to formation of double minutes and other chromosomal rearrangements. Oncogene 2002;21:7671-7679.
    • (2002) Oncogene , vol.21 , pp. 7671-7679
    • Coquelle, A.1    Rozier, L.2    Dutrillaux, B.3    Debatisse, M.4
  • 78
    • 0036463767 scopus 로고    scopus 로고
    • A role for common fragile site induction in amplification of human oncogenes
    • Hellman A, et al. A role for common fragile site induction in amplification of human oncogenes. Cancer Cell 2002;1:89-97.
    • (2002) Cancer Cell , vol.1 , pp. 89-97
    • Hellman, A.1
  • 79
    • 0032132806 scopus 로고    scopus 로고
    • A new role for hypoxia in tumor progression: Induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs
    • Coquelle A, Toledo F, Stern S, Bieth A, Debatisse M. A new role for hypoxia in tumor progression: induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs. Mol Cell 1998;2:259-265.
    • (1998) Mol Cell , vol.2 , pp. 259-265
    • Coquelle, A.1    Toledo, F.2    Stern, S.3    Bieth, A.4    Debatisse, M.5
  • 80
    • 0030904279 scopus 로고    scopus 로고
    • Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons
    • Coquelle A, Pipiras E, Toledo F, Buttin G, Debatisse M. Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons. Cell 1997;89:215-225.
    • (1997) Cell , vol.89 , pp. 215-225
    • Coquelle, A.1    Pipiras, E.2    Toledo, F.3    Buttin, G.4    Debatisse, M.5
  • 81
    • 0037148277 scopus 로고    scopus 로고
    • Protection of mammalian telomeres
    • de Lange T. Protection of mammalian telomeres. Oncogene 2002;21:532-540.
    • (2002) Oncogene , vol.21 , pp. 532-540
    • De Lange, T.1
  • 82
    • 0037148270 scopus 로고    scopus 로고
    • New ways not to make ends meet telomerase, DNA damage proteins and heterochromatin
    • Chan SW, Blackburn EH. New ways not to make ends meet telomerase, DNA damage proteins and heterochromatin. Oncogene 2002;21:553-563.
    • (2002) Oncogene , vol.21 , pp. 553-563
    • Chan, S.W.1    Blackburn, E.H.2
  • 83
    • 0034669104 scopus 로고    scopus 로고
    • Ku acts in a unique way at the mammalian telomere to prevent end joining
    • Hsu HL, et al. Ku acts in a unique way at the mammalian telomere to prevent end joining. Genes Dev 2000;14:2807-2812.
    • (2000) Genes Dev , vol.14 , pp. 2807-2812
    • Hsu, H.L.1
  • 84
    • 0034280093 scopus 로고    scopus 로고
    • Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang
    • Samper E, Goytisolo FA, Slijepcevic P, van Buul PP, Blasco MA. Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang. EMBO Rep 2000;1:244-252.
    • (2000) EMBO Rep , vol.1 , pp. 244-252
    • Samper, E.1    Goytisolo, F.A.2    Slijepcevic, P.3    Van Buul, P.P.4    Blasco, M.A.5
  • 86
    • 0037112834 scopus 로고    scopus 로고
    • Functional interaction between DNA-PKcs and telomerase in telomere length maintenance
    • Espejel S, et al. Functional interaction between DNA-PKcs and telomerase in telomere length maintenance. EMBO J 2002;21:6275-6287.
    • (2002) EMBO J , vol.21 , pp. 6275-6287
    • Espejel, S.1
  • 87
    • 0037824717 scopus 로고    scopus 로고
    • Take care of your chromosomes lest cancer take care of you
    • Maser RS, DePinho RA. Take care of your chromosomes lest cancer take care of you. Cancer Cell 2003;3:4-6.
    • (2003) Cancer Cell , vol.3 , pp. 4-6
    • Maser, R.S.1    DePinho, R.A.2
  • 88
    • 0033553516 scopus 로고    scopus 로고
    • p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
    • Chin L, et al. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 1999;97:527-538.
    • (1999) Cell , vol.97 , pp. 527-538
    • Chin, L.1
  • 89
    • 0034632717 scopus 로고    scopus 로고
    • Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
    • Artandi SE, et al. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 2000;406:641-645.
    • (2000) Nature , vol.406 , pp. 641-645
    • Artandi, S.E.1
  • 91
    • 0022961792 scopus 로고
    • c-myc-induced lymphomagenesis in transgenic mice and the role of the Pvt-1 locus in lymphoid neoplasia
    • Adams JM, et al. c-myc-induced lymphomagenesis in transgenic mice and the role of the Pvt-1 locus in lymphoid neoplasia. Curr Top Microbiol Immunol 1986;132:1-8.
    • (1986) Curr Top Microbiol Immunol , vol.132 , pp. 1-8
    • Adams, J.M.1
  • 92
    • 0022380768 scopus 로고
    • The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
    • Adams JM, et al. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 1985;318:533-538.
    • (1985) Nature , vol.318 , pp. 533-538
    • Adams, J.M.1
  • 93
    • 0025939204 scopus 로고
    • Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease
    • Strasser A, et al. Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc Natl Acad Sci USA 1991;88:8661-8665.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 8661-8665
    • Strasser, A.1
  • 94
    • 0025286559 scopus 로고
    • A second B cell-specific enhancer 3′ of the immunoglobulin heavy-chain locus
    • Pettersson S, Cook GP, Bruggemann M, Williams GT, Neuberger MS. A second B cell-specific enhancer 3′ of the immunoglobulin heavy-chain locus. Nature 1990;344:165-168.
    • (1990) Nature , vol.344 , pp. 165-168
    • Pettersson, S.1    Cook, G.P.2    Bruggemann, M.3    Williams, G.T.4    Neuberger, M.S.5
  • 95
    • 0033918521 scopus 로고    scopus 로고
    • The 3′ IgH regulatory region: A complex structure in a search for a function
    • Khamlichi AA, Pinaud E, Decourt C, Chauveau C, Cogne M. The 3′ IgH regulatory region: a complex structure in a search for a function. Adv Immunol 2000;75:317-345.
    • (2000) Adv Immunol , vol.75 , pp. 317-345
    • Khamlichi, A.A.1    Pinaud, E.2    Decourt, C.3    Chauveau, C.4    Cogne, M.5
  • 96
    • 0028233142 scopus 로고
    • A class switch control region at the 3′ end of the immunoglobulin heavy chain locus
    • Cogne M, et al. A class switch control region at the 3′ end of the immunoglobulin heavy chain locus. Cell 1994;77:737-747.
    • (1994) Cell , vol.77 , pp. 737-747
    • Cogne, M.1
  • 97
    • 0034741932 scopus 로고    scopus 로고
    • Localization of the 3′ IgH locus elements that effect long-distance regulation of class switch recombination
    • Pinaud E, et al. Localization of the 3′ IgH locus elements that effect long-distance regulation of class switch recombination. Immunity 2001;15:187-199.
    • (2001) Immunity , vol.15 , pp. 187-199
    • Pinaud, E.1
  • 98
    • 0027969316 scopus 로고
    • Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells
    • Madisen L, Groudine M. Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells. Genes Dev 1994;8:2212-2226.
    • (1994) Genes Dev , vol.8 , pp. 2212-2226
    • Madisen, L.1    Groudine, M.2
  • 100
    • 0035839842 scopus 로고    scopus 로고
    • Modeling Philadelphia chromosome positive leukemias
    • Wong S, Witte ON. Modeling Philadelphia chromosome positive leukemias. Oncogene 2001;20:5644-5659.
    • (2001) Oncogene , vol.20 , pp. 5644-5659
    • Wong, S.1    Witte, O.N.2
  • 101
    • 0037079698 scopus 로고    scopus 로고
    • Proteins encoded by genes involved in chromosomal alterations in lymphoma and leukemia: Clinical value of their detection by immunocytochemistry
    • Falini B, Mason DY. Proteins encoded by genes involved in chromosomal alterations in lymphoma and leukemia: clinical value of their detection by immunocytochemistry. Blood 2002;99:409-426.
    • (2002) Blood , vol.99 , pp. 409-426
    • Falini, B.1    Mason, D.Y.2
  • 102
    • 0035839952 scopus 로고    scopus 로고
    • Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins
    • Ayton PM, Cleary ML. Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins. Oncogene 2001;20:5695-5707.
    • (2001) Oncogene , vol.20 , pp. 5695-5707
    • Ayton, P.M.1    Cleary, M.L.2
  • 103
    • 0027758631 scopus 로고
    • Chromosomal translocations in leukaemia
    • Gauwerky CE, Croce CM. Chromosomal translocations in leukaemia. Semin Cancer Biol 1993;4:333-340.
    • (1993) Semin Cancer Biol , vol.4 , pp. 333-340
    • Gauwerky, C.E.1    Croce, C.M.2
  • 104
    • 0025980446 scopus 로고
    • Molecular biology of lymphoid malignancies
    • Kagan J, Croce CM. Molecular biology of lymphoid malignancies. Ann Oncol 1991;2:9-21.
    • (1991) Ann Oncol , vol.2 , pp. 9-21
    • Kagan, J.1    Croce, C.M.2
  • 105
    • 0031039088 scopus 로고    scopus 로고
    • Assessing the pathogenic potential of the V(D)J recombinase by interlocus immunoglobulin hght-chain gene rearrangement
    • Bailey SN, Rosenberg N. Assessing the pathogenic potential of the V(D)J recombinase by interlocus immunoglobulin hght-chain gene rearrangement. Mol Cell Biol 1997;17:887-894.
    • (1997) Mol Cell Biol , vol.17 , pp. 887-894
    • Bailey, S.N.1    Rosenberg, N.2
  • 106
    • 0017807188 scopus 로고
    • Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells
    • Alt FW, Kellems RE, Bertino JR, Schimke RT. Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells. J Biol Chem 1978;253:1357-1370.
    • (1978) J Biol Chem , vol.253 , pp. 1357-1370
    • Alt, F.W.1    Kellems, R.E.2    Bertino, J.R.3    Schimke, R.T.4
  • 107
    • 0032104542 scopus 로고    scopus 로고
    • Amplification of oncogenes in human cancer cells
    • Schwab M. Amplification of oncogenes in human cancer cells. Bioessays 1998;20:473-479.
    • (1998) Bioessays , vol.20 , pp. 473-479
    • Schwab, M.1
  • 108
    • 0032823534 scopus 로고    scopus 로고
    • Oncogene amplification in solid tumors
    • Schwab M. Oncogene amplification in solid tumors. Semin Cancer Biol 1999;9:319-325.
    • (1999) Semin Cancer Biol , vol.9 , pp. 319-325
    • Schwab, M.1
  • 109
    • 0031893222 scopus 로고    scopus 로고
    • Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakage
    • Paulson TG, Almasan A, Brody LL, Wahl GM. Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakage. Mol Cell Biol 1998;18:3089-3100.
    • (1998) Mol Cell Biol , vol.18 , pp. 3089-3100
    • Paulson, T.G.1    Almasan, A.2    Brody, L.L.3    Wahl, G.M.4
  • 110
    • 0028938734 scopus 로고
    • p53-dependent growth arrest of REF52 cells containing newly amplified DNA
    • Ishizaka Y, Chernov MV, Burns CM, Stark GR. p53-dependent growth arrest of REF52 cells containing newly amplified DNA. Proc Natl Acad Sci USA 1995;92:3224-3228.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3224-3228
    • Ishizaka, Y.1    Chernov, M.V.2    Burns, C.M.3    Stark, G.R.4
  • 111
    • 0026801062 scopus 로고
    • Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53
    • Livingstone LR, White A, Sprouse J, Livanos E, Jacks T, Tisty TD. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell 1992;70:923-935.
    • (1992) Cell , vol.70 , pp. 923-935
    • Livingstone, L.R.1    White, A.2    Sprouse, J.3    Livanos, E.4    Jacks, T.5    Tisty, T.D.6
  • 112
    • 0026801977 scopus 로고
    • Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles
    • Yin Y, Tainsky MA, Bischoff FZ, Strong LC, Wahl GM. Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 1992;70:937-948.
    • (1992) Cell , vol.70 , pp. 937-948
    • Yin, Y.1    Tainsky, M.A.2    Bischoff, F.Z.3    Strong, L.C.4    Wahl, G.M.5
  • 113
    • 0037824720 scopus 로고    scopus 로고
    • The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-defcient mice
    • Gladdy RA, et al. The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-defcient mice. Cancer Cell 2003;3:37-50.
    • (2003) Cancer Cell , vol.3 , pp. 37-50
    • Gladdy, R.A.1
  • 114
    • 0037188898 scopus 로고    scopus 로고
    • Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amphfication subsequent to translocations
    • Zhu C, et al. Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amphfication subsequent to translocations. Cell 2002;109:811-821.
    • (2002) Cell , vol.109 , pp. 811-821
    • Zhu, C.1
  • 115
    • 0037136318 scopus 로고    scopus 로고
    • Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification
    • Difilippantonio MJ, et al. Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification. J Exp Med 2002;196:469-480.
    • (2002) J Exp Med , vol.196 , pp. 469-480
    • Difilippantonio, M.J.1
  • 116
    • 0033785391 scopus 로고    scopus 로고
    • The molecular genetics of recurring chromosome abnormalities in acute myeloid leukemia
    • Hayashi Y. The molecular genetics of recurring chromosome abnormalities in acute myeloid leukemia. Semin Hematol 2000;37:368-380.
    • (2000) Semin Hematol , vol.37 , pp. 368-380
    • Hayashi, Y.1
  • 117
    • 0026704814 scopus 로고
    • Molecular genetic aspects of myelodysplastic syndromes
    • Bartram CR. Molecular genetic aspects of myelodysplastic syndromes. Hematol Oncol Clin North Am 1992;6:557-570.
    • (1992) Hematol Oncol Clin North Am , vol.6 , pp. 557-570
    • Bartram, C.R.1
  • 118
    • 0036540314 scopus 로고    scopus 로고
    • Evaluation of ETP1/eRF1, mapping to 5q31, as a candidate myeloid tumor suppressor gene
    • Dubourg C, et al. Evaluation of ETP1/eRF1, mapping to 5q31, as a candidate myeloid tumor suppressor gene. Cancer Genet Cytogenet 2002;134:33-37.
    • (2002) Cancer Genet Cytogenet , vol.134 , pp. 33-37
    • Dubourg, C.1
  • 119
    • 0033050007 scopus 로고    scopus 로고
    • Chromosome aberrations in B-cell chronic lymphocytic leukemia: Reassessment based on molecular cytogenetic analysis
    • Dohner H, Stilgenbaner S, Dohner K, Bentz M, Lichter P. Chromosome aberrations in B-cell chronic lymphocytic leukemia: reassessment based on molecular cytogenetic analysis. J Mol Med 1999;77:266-281.
    • (1999) J Mol Med , vol.77 , pp. 266-281
    • Dohner, H.1    Stilgenbaner, S.2    Dohner, K.3    Bentz, M.4    Lichter, P.5
  • 120
    • 0029130021 scopus 로고
    • 13q deletions in lymphoid malignancies
    • Liu Y, et al. 13q deletions in lymphoid malignancies. Blood 1995;86:1911-1915.
    • (1995) Blood , vol.86 , pp. 1911-1915
    • Liu, Y.1
  • 121
    • 0034750778 scopus 로고    scopus 로고
    • Comprehensive analysis of a large genomic sequence at the putative B- cell chronic lymphocytic leukaemia (B-CLL) tumour suppresser gene locus
    • Rondeau G, et al. Comprehensive analysis of a large genomic sequence at the putative B- cell chronic lymphocytic leukaemia (B-CLL) tumour suppresser gene locus. Mutat Res 2001;458:55-70.
    • (2001) Mutat Res , vol.458 , pp. 55-70
    • Rondeau, G.1
  • 122
    • 0034969026 scopus 로고    scopus 로고
    • A role for secondary V(D)J recombination in oncogenic chromosomal translocations?
    • Davila M, Foster S, Kelsoe G, Yang K. A role for secondary V(D)J recombination in oncogenic chromosomal translocations? Adv Cancer Res 2001;81:61-92.
    • (2001) Adv Cancer Res , vol.81 , pp. 61-92
    • Davila, M.1    Foster, S.2    Kelsoe, G.3    Yang, K.4
  • 123
    • 0035839959 scopus 로고    scopus 로고
    • Mechanisms of chromosomal translocations in B cell lymphomas
    • Kuppers R, Dalla-Favera R. Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene 2001;20:5580-5594.
    • (2001) Oncogene , vol.20 , pp. 5580-5594
    • Kuppers, R.1    Dalla-Favera, R.2
  • 125
    • 0032555695 scopus 로고    scopus 로고
    • VDJ recombination: A transposase goes to work
    • Roth DB, Craig NL. VDJ recombination: a transposase goes to work. Cell 1998;94:411-414.
    • (1998) Cell , vol.94 , pp. 411-414
    • Roth, D.B.1    Craig, N.L.2
  • 126
    • 0026721505 scopus 로고
    • Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes
    • Korsmeyer SJ. Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes. Annu Rev Immunol 1992;10:785-807.
    • (1992) Annu Rev Immunol , vol.10 , pp. 785-807
    • Korsmeyer, S.J.1
  • 127
    • 0034327890 scopus 로고    scopus 로고
    • Molecular biology of Burkitt's lymphoma
    • Hecht JL, Aster JC. Molecular biology of Burkitt's lymphoma. J Clin Oncol 2000;18:3707-3721.
    • (2000) J Clin Oncol , vol.18 , pp. 3707-3721
    • Hecht, J.L.1    Aster, J.C.2
  • 128
    • 0031815647 scopus 로고    scopus 로고
    • Insight into Burkitt's lymphoma from immunoglobulin variable region gene analysis
    • Chapman CJ, Wright D, Stevenson FK. Insight into Burkitt's lymphoma from immunoglobulin variable region gene analysis. Leuk Lymphoma 1998;30:257-267.
    • (1998) Leuk Lymphoma , vol.30 , pp. 257-267
    • Chapman, C.J.1    Wright, D.2    Stevenson, F.K.3
  • 130
    • 0035692027 scopus 로고    scopus 로고
    • Novel insights into the mechanism of t (14;18)(q32;q21) translocation in follicular lymphoma
    • Nadel B, Marculescu R, Le T, Rudnicki M, Bocskor S, Jager U. Novel insights into the mechanism of t (14;18)(q32;q21) translocation in follicular lymphoma. Leuk Lymphoma 2001;42:1181-1194.
    • (2001) Leuk Lymphoma , vol.42 , pp. 1181-1194
    • Nadel, B.1    Marculescu, R.2    Le, T.3    Rudnicki, M.4    Bocskor, S.5    Jager, U.6
  • 132
    • 0031391172 scopus 로고    scopus 로고
    • Expression and function of recombination activating genes in mature B cells
    • Ohmori H, Hikida M. Expression and function of recombination activating genes in mature B cells. Crit Rev Immunol 1998;18:221-235.
    • (1998) Crit Rev Immunol , vol.18 , pp. 221-235
    • Ohmori, H.1    Hikida, M.2
  • 133
    • 0028071931 scopus 로고
    • Expression of human recombination activating genes (RAG-1 and RAG-2) in lymphoma
    • Knecht H, Brousset P, Bachmann E, Pallesen G, Odermatt BF. Expression of human recombination activating genes (RAG-1 and RAG-2) in lymphoma. Leuk Lymphoma 1994;15:399-403.
    • (1994) Leuk Lymphoma , vol.15 , pp. 399-403
    • Knecht, H.1    Brousset, P.2    Bachmann, E.3    Pallesen, G.4    Odermatt, B.F.5
  • 134
    • 0026660944 scopus 로고
    • Antigen selection in human lymphomagenesis
    • Bahler DW, Zelenetz AD, Chen TT, Levy R. Antigen selection in human lymphomagenesis. Cancer Res 1992;52 (Suppl. 19):5547s-5551s.
    • (1992) Cancer Res , vol.52 , Issue.SUPPL. 19
    • Bahler, D.W.1    Zelenetz, A.D.2    Chen, T.T.3    Levy, R.4
  • 135
    • 0026636759 scopus 로고
    • Clonal evolution of a follicular lymphoma: Evidence for antigen selection
    • Bahler DW, Levy R. Clonal evolution of a follicular lymphoma: evidence for antigen selection. Proc Natl Acad Sci USA 1992;89:6770-6674.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6770-6674
    • Bahler, D.W.1    Levy, R.2
  • 136
    • 0026093494 scopus 로고
    • Follicular lymphoma: A model of lymphoid tumor progression in man
    • Zelenetz AD, et al. Follicular lymphoma: a model of lymphoid tumor progression in man. Ann Oncol 1991;2:115-122.
    • (1991) Ann Oncol , vol.2 , pp. 115-122
    • Zelenetz, A.D.1
  • 137
    • 0036937410 scopus 로고    scopus 로고
    • The proto-oncogene BCL-6 in normal and malignant B cell development
    • Niu H. The proto-oncogene BCL-6 in normal and malignant B cell development. Hematol Oncol 2002;20:155-166.
    • (2002) Hematol Oncol , vol.20 , pp. 155-166
    • Niu, H.1
  • 138
    • 0028672737 scopus 로고
    • BCL-6 and the molecular pathogenesis of B-cell lymphoma
    • Dalla-Favera R, et al. BCL-6 and the molecular pathogenesis of B-cell lymphoma Cold Spring Harb Symp Quant Biol 1994;59:117-123.
    • (1994) Cold Spring Harb Symp Quant Biol , vol.59 , pp. 117-123
    • Dalla-Favera, R.1
  • 139
    • 0031884054 scopus 로고    scopus 로고
    • Molecular mechanisms involved in receptor editing at the Ig heavy chain locus
    • Fanning L, Bertrand FE, Steinberg C, Wu GE. Molecular mechanisms involved in receptor editing at the Ig heavy chain locus. Int Immunol 1998;10:241-246.
    • (1998) Int Immunol , vol.10 , pp. 241-246
    • Fanning, L.1    Bertrand, F.E.2    Steinberg, C.3    Wu, G.E.4
  • 140
    • 0032947209 scopus 로고    scopus 로고
    • Immunoglobulin gene associated chromosomal translocations in B-cell derived tumors
    • Klein G. Immunoglobulin gene associated chromosomal translocations in B-cell derived tumors. Curr Top Microbiol Immunol 1999;246:161-167.
    • (1999) Curr Top Microbiol Immunol , vol.246 , pp. 161-167
    • Klein, G.1
  • 141
    • 0026767880 scopus 로고
    • Plasmacytomagenesis in mice: Model of neoplastic development dependent upon chromosomal translocations
    • Potter M, Wiener F. Plasmacytomagenesis in mice: model of neoplastic development dependent upon chromosomal translocations. Carcinogenesis 1992;13:1681-1697.
    • (1992) Carcinogenesis , vol.13 , pp. 1681-1697
    • Potter, M.1    Wiener, F.2
  • 142
    • 0026582025 scopus 로고
    • Perspectives on the origins of multiple myeloma and plasmacytomas in mice
    • Potter M. Perspectives on the origins of multiple myeloma and plasmacytomas in mice. Hematol Oncol Clin North Am 1992;6:211-223.
    • (1992) Hematol Oncol Clin North Am , vol.6 , pp. 211-223
    • Potter, M.1
  • 143
    • 0022856747 scopus 로고
    • Constitutive activation of oncogenes by chromosomal translocations in B-cell derived tumors
    • Klein G. Constitutive activation of oncogenes by chromosomal translocations in B-cell derived tumors. AIDS Res 1986;2:S167-S176.
    • (1986) AIDS Res , vol.2
    • Klein, G.1
  • 144
    • 0018576053 scopus 로고
    • Nonrandom chromosome changes involving the Ig gene-carrying chromosomes 12 and 6 in pristane-induced mouse plasmacytomas
    • Ohno S, Babonits M, Wiener F, Spira J, Klein G, Potter M. Nonrandom chromosome changes involving the Ig gene-carrying chromosomes 12 and 6 in pristane-induced mouse plasmacytomas. Cell 1979;18:1001-1007.
    • (1979) Cell , vol.18 , pp. 1001-1007
    • Ohno, S.1    Babonits, M.2    Wiener, F.3    Spira, J.4    Klein, G.5    Potter, M.6
  • 145
    • 0035107553 scopus 로고    scopus 로고
    • Jumping translocations are common in solid tumor cell lines and result in recurrent fusions of whole chromosome arms
    • Padilla-Nash HM, et al. Jumping translocations are common in solid tumor cell lines and result in recurrent fusions of whole chromosome arms. Genes Chromosomes Cancer 2001;30:349-363.
    • (2001) Genes Chromosomes Cancer , vol.30 , pp. 349-363
    • Padilla-Nash, H.M.1
  • 146
    • 0023680032 scopus 로고
    • Jumping translocation of chromosome 14 in a skin squamous cell carcinoma from a xeroderma pigmentosum patient
    • Aledo R, Aurias A, Chretien B, Dutrillaux B. Jumping translocation of chromosome 14 in a skin squamous cell carcinoma from a xeroderma pigmentosum patient. Cancer Genet Cytogenet 1988;33:29-33.
    • (1988) Cancer Genet Cytogenet , vol.33 , pp. 29-33
    • Aledo, R.1    Aurias, A.2    Chretien, B.3    Dutrillaux, B.4
  • 147
    • 0031838467 scopus 로고    scopus 로고
    • Segmental jumping translocation in leukemia and lymphoma with a highly complex karyotype
    • Tanaka K, Kamada N. Segmental jumping translocation in leukemia and lymphoma with a highly complex karyotype. Leuk Lymphoma 1998;29:563-575.
    • (1998) Leuk Lymphoma , vol.29 , pp. 563-575
    • Tanaka, K.1    Kamada, N.2
  • 148
    • 0033564353 scopus 로고    scopus 로고
    • Jumping translocation breakpoint regions lead to amplification of rearranged Myc
    • Coleman AE, Kovalchuk AL, Janz S, Pahni A, Ried T. Jumping translocation breakpoint regions lead to amplification of rearranged Myc. Blood 1999;93:4442-4444.
    • (1999) Blood , vol.93 , pp. 4442-4444
    • Coleman, A.E.1    Kovalchuk, A.L.2    Janz, S.3    Pahni, A.4    Ried, T.5
  • 149
    • 0021705664 scopus 로고
    • Activated expression of the N-myc gene in human neuroblastomas and related tumors
    • Kohl NE, Gee CE, Alt FW. Activated expression of the N-myc gene in human neuroblastomas and related tumors. Science 1984;226:1335-1337.
    • (1984) Science , vol.226 , pp. 1335-1337
    • Kohl, N.E.1    Gee, C.E.2    Alt, F.W.3
  • 150
    • 0021047844 scopus 로고
    • Transposition and amplification of oncogene-related sequences in human neuroblastomas
    • Kohl NE, et al. Transposition and amplification of oncogene-related sequences in human neuroblastomas. Cell 1983;35:359-367.
    • (1983) Cell , vol.35 , pp. 359-367
    • Kohl, N.E.1
  • 151
    • 0021063273 scopus 로고
    • Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour
    • Schwab M, et al. Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour. Nature 1983;305:245-248.
    • (1983) Nature , vol.305 , pp. 245-248
    • Schwab, M.1
  • 152
    • 0022388606 scopus 로고
    • Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas
    • Seeger RC, et al. Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. N Engl J Med 1985;313:1111-1116.
    • (1985) N Engl J Med , vol.313 , pp. 1111-1116
    • Seeger, R.C.1
  • 153
    • 0034049468 scopus 로고    scopus 로고
    • Amplification of the MLL gene on double minutes, a homogeneously staining region, and ring chromosomes in five patients with acute myeloid leukemia or myelodysplastic syndrome
    • Streubel B, et al. Amplification of the MLL gene on double minutes, a homogeneously staining region, and ring chromosomes in five patients with acute myeloid leukemia or myelodysplastic syndrome. Genes Chromosomes Cancer 2000;27:380-386.
    • (2000) Genes Chromosomes Cancer , vol.27 , pp. 380-386
    • Streubel, B.1
  • 154
    • 0035870781 scopus 로고    scopus 로고
    • Segmental amplification of 11q23 region identified by fluorescence in situ hybridization in four patients with myeloid disorders: A review
    • Reddy KS, et al. Segmental amplification of 11q23 region identified by fluorescence in situ hybridization in four patients with myeloid disorders: a review. Cancer Genet Cytogenet 2001;126:139-146.
    • (2001) Cancer Genet Cytogenet , vol.126 , pp. 139-146
    • Reddy, K.S.1
  • 155
    • 0035141787 scopus 로고    scopus 로고
    • Amplification of the AML1 (CBFA2) gene on ring chromosomes in a patient with acute myeloid leukemia and a constitutional ring chromosome 21
    • Streubel B, Valent P, Lechner K, Fonatsch C. Amplification of the AML1 (CBFA2) gene on ring chromosomes in a patient with acute myeloid leukemia and a constitutional ring chromosome 21. Cancer Genet Cytogenet 2001;124:42-46.
    • (2001) Cancer Genet Cytogenet , vol.124 , pp. 42-46
    • Streubel, B.1    Valent, P.2    Lechner, K.3    Fonatsch, C.4
  • 156
    • 0036211828 scopus 로고    scopus 로고
    • Double minute chromosomes in acute myeloid leukemia and myelodysplastic syndrome: Identification of new amplification regions by fluorescence in situ hybridization and spectral karyotyping
    • Sait SN, Qadir MU, Conroy JM, Matsin S, Nowak NJ, Baer MR. Double minute chromosomes in acute myeloid leukemia and myelodysplastic syndrome: identification of new amplification regions by fluorescence in situ hybridization and spectral karyotyping. Genes Chromosomes Cancer 2002;34:42-47.
    • (2002) Genes Chromosomes Cancer , vol.34 , pp. 42-47
    • Sait, S.N.1    Qadir, M.U.2    Conroy, J.M.3    Matsin, S.4    Nowak, N.J.5    Baer, M.R.6
  • 157
    • 0036132094 scopus 로고    scopus 로고
    • Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH
    • Van Limbergen H, et al. Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH. Genes Chromosomes Cancer 2002;33:60-72.
    • (2002) Genes Chromosomes Cancer , vol.33 , pp. 60-72
    • Van Limbergen, H.1
  • 159
    • 0036512435 scopus 로고    scopus 로고
    • Multiple myeloma: Evolving genetic events and host interactions
    • Kuehl WM, Bergsagel PL. Multiple myeloma: evolving genetic events and host interactions. Nature Rev 2002;2:175-187.
    • (2002) Nature Rev , vol.2 , pp. 175-187
    • Kuehl, W.M.1    Bergsagel, P.L.2
  • 161
    • 0036796603 scopus 로고    scopus 로고
    • Molecular aspects of multiple myeloma
    • Pratt G. Molecular aspects of multiple myeloma. Mol Pathol 2002;55:273-283.
    • (2002) Mol Pathol , vol.55 , pp. 273-283
    • Pratt, G.1
  • 162
    • 0036909535 scopus 로고    scopus 로고
    • Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination
    • Roddam PL, Rollinson S, O'Driscoll M, Jeggo PA, Jack A, Morgan GJ. Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination. J Med Genet 2002;39:900-905.
    • (2002) J Med Genet , vol.39 , pp. 900-905
    • Roddam, P.L.1    Rollinson, S.2    O'Driscoll, M.3    Jeggo, P.A.4    Jack, A.5    Morgan, G.J.6
  • 164
    • 0344541696 scopus 로고    scopus 로고
    • Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase
    • Vanasse GJ, et al. Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase. J Clin Invest 1999;103:1669-1675.
    • (1999) J Clin Invest , vol.103 , pp. 1669-1675
    • Vanasse, G.J.1
  • 165
    • 0029858044 scopus 로고    scopus 로고
    • Mutations in the p53 and SCID genes cooperate in tumorigenesis
    • Nacht M, et al. Mutations in the p53 and SCID genes cooperate in tumorigenesis. Genes Dev 1996;10:2055-2066.
    • (1996) Genes Dev , vol.10 , pp. 2055-2066
    • Nacht, M.1
  • 166
    • 0030837472 scopus 로고    scopus 로고
    • V(D)J recombination in Ku86-deficient mice, distinct effects on coding, signal, and hybrid joint formation
    • Bogue MA, Wang C, Zhu C, Roth DB. V(D)J recombination in Ku86-deficient mice, distinct effects on coding, signal, and hybrid joint formation. Immunity 1997;7:37-47.
    • (1997) Immunity , vol.7 , pp. 37-47
    • Bogue, M.A.1    Wang, C.2    Zhu, C.3    Roth, D.B.4
  • 167
    • 0029585872 scopus 로고
    • The XRCC4 gene encodes a novel protein revolved in DNA double-strand break repair and V(D)J recombination
    • Li Z, et al. The XRCC4 gene encodes a novel protein revolved in DNA double-strand break repair and V(D)J recombination. Cell 1995;83:1079-1089.
    • (1995) Cell , vol.83 , pp. 1079-1089
    • Li, Z.1
  • 168
    • 0036206462 scopus 로고    scopus 로고
    • Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells
    • Verkaik NS, et al. Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells. Eur J Immunol 2002;32:701-709.
    • (2002) Eur J Immunol , vol.32 , pp. 701-709
    • Verkaik, N.S.1
  • 169
    • 0037047387 scopus 로고    scopus 로고
    • BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks
    • Zhong Q, Chen CF, Chen PL, Lee WH. BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks. J Biol Chem 2002;277:28641-28647.
    • (2002) J Biol Chem , vol.277 , pp. 28641-28647
    • Zhong, Q.1    Chen, C.F.2    Chen, P.L.3    Lee, W.H.4
  • 170
    • 0032113987 scopus 로고    scopus 로고
    • Ku70: A candidate tumor suppressor gene for murine T cell lymphoma
    • Li GC, et al. Ku70: a candidate tumor suppressor gene for murine T cell lymphoma. Mol Cell 1998;2:1-8.
    • (1998) Mol Cell , vol.2 , pp. 1-8
    • Li, G.C.1
  • 171
    • 0031433517 scopus 로고    scopus 로고
    • Growth retardation and leaky SCID phenotype of Ku70-deficient mice
    • Gu Y, et al. Growth retardation and leaky SCID phenotype of Ku70-deficient mice. Immunity 1997;7:653-665.
    • (1997) Immunity , vol.7 , pp. 653-665
    • Gu, Y.1
  • 173
    • 0022257878 scopus 로고
    • Severe combined immunodeficiency (SCID) in the mouse. Pathology, reconstitution, neoplasms
    • Custer RP Bosma GC Bosma MJ. Severe combined immunodeficiency (SCID) in the mouse. Pathology, reconstitution, neoplasms. Am J Pathol 1985;120:464-477.
    • (1985) Am J Pathol , vol.120 , pp. 464-477
    • Custer, R.P.1    Bosma, G.C.2    Bosma, M.J.3
  • 174
    • 0037112505 scopus 로고    scopus 로고
    • DNA ligase IV suppresses medulloblastoma formation
    • Lee Y McKinnon PJ. DNA ligase IV suppresses medulloblastoma formation. Cancer Res 2002;62:6395-6399.
    • (2002) Cancer Res , vol.62 , pp. 6395-6399
    • Lee, Y.1    McKinnon, P.J.2
  • 175
    • 0026561121 scopus 로고
    • Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
    • Donehower LA, et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 1992;356:215-221.
    • (1992) Nature , vol.356 , pp. 215-221
    • Donehower, L.A.1
  • 176
    • 0028118111 scopus 로고
    • Tumor spectrum analysis in p53-mutant mice
    • Jacks T, et al. Tumor spectrum analysis in p53-mutant mice. Curr Biol 1994;4:1-7.
    • (1994) Curr Biol , vol.4 , pp. 1-7
    • Jacks, T.1
  • 177
    • 0033427205 scopus 로고    scopus 로고
    • Cychn A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair
    • Lee J, Desiderio S. Cychn A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair. Immunity 1999;11:771-781.
    • (1999) Immunity , vol.11 , pp. 771-781
    • Lee, J.1    Desiderio, S.2
  • 178
    • 0027109075 scopus 로고
    • Cancer. p53, guardian of the genome
    • Lane DP, Cancer. p53, guardian of the genome. Nature 1992;358:15-16.
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 179
    • 0001294157 scopus 로고
    • The stability of broken ends of chromosomes in Zea mays
    • McClintock B. The stability of broken ends of chromosomes in Zea mays. Genetics 1941;26:234-282.
    • (1941) Genetics , vol.26 , pp. 234-282
    • McClintock, B.1
  • 180
    • 0027218485 scopus 로고
    • Regulation and mechanisms of mammalian gene amplification
    • Stark GR. Regulation and mechanisms of mammalian gene amplification. Adv Cancer Res 1993;61:87-113.
    • (1993) Adv Cancer Res , vol.61 , pp. 87-113
    • Stark, G.R.1
  • 181
    • 0032542364 scopus 로고    scopus 로고
    • Genetic instabilities in human cancers
    • Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature 1998;396:643-649.
    • (1998) Nature , vol.396 , pp. 643-649
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 182
    • 0034621854 scopus 로고    scopus 로고
    • Frequent chromosomal translocations induced by DNA double-strand breaks
    • Richardson C, Jasin M. Frequent chromosomal translocations induced by DNA double-strand breaks. Nature 2000;405:697-700.
    • (2000) Nature , vol.405 , pp. 697-700
    • Richardson, C.1    Jasin, M.2
  • 183
    • 0031737723 scopus 로고    scopus 로고
    • Chromosome break-induced DNA replication leads to nonreciprocal translocations and telomere capture
    • Bosco G, Haber JE. Chromosome break-induced DNA replication leads to nonreciprocal translocations and telomere capture. Genetics 1998;150:1037-1047.
    • (1998) Genetics , vol.150 , pp. 1037-1047
    • Bosco, G.1    Haber, J.E.2
  • 184
    • 0032472367 scopus 로고    scopus 로고
    • Interstitial deletions and intrachromosomal amplification initiated from a double-strand break targeted to a mammalian chromosome
    • Pipiras E, Coquelle A, Bieth A, Debatisse M. Interstitial deletions and intrachromosomal amplification initiated from a double-strand break targeted to a mammalian chromosome. EMBO J 1998;17:325-333.
    • (1998) EMBO J , vol.17 , pp. 325-333
    • Pipiras, E.1    Coquelle, A.2    Bieth, A.3    Debatisse, M.4
  • 185
    • 0034608950 scopus 로고    scopus 로고
    • Amplification of the human dihydrofolate reductase gene via double minutes is initiated by chromosome breaks
    • Singer MJ, Mesner LD, Friedman CL, Trask BJ, Hamlin JL. Amplification of the human dihydrofolate reductase gene via double minutes is initiated by chromosome breaks. Proc Natl Acad Sci USA 2000;97:7921-7926.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 7921-7926
    • Singer, M.J.1    Mesner, L.D.2    Friedman, C.L.3    Trask, B.J.4    Hamlin, J.L.5
  • 186
  • 187
    • 0035796037 scopus 로고    scopus 로고
    • Human cancer: Etiologic agents/dose-responses/DNA repair/cellular and animal models
    • Setlow RB. Human cancer: etiologic agents/dose-responses/DNA repair/cellular and animal models. Mutat Res 2001;477:1-6.
    • (2001) Mutat Res , vol.477 , pp. 1-6
    • Setlow, R.B.1
  • 188
    • 0037268338 scopus 로고    scopus 로고
    • The Fanconi anaemia/BRCA pathway
    • D'Andrea AD, Grompe M. The Fanconi anaemia/BRCA pathway. Nat Rev Cancer 2003;3:23-34.
    • (2003) Nat Rev Cancer , vol.3 , pp. 23-34
    • D'Andrea, A.D.1    Grompe, M.2
  • 189
    • 0037202608 scopus 로고    scopus 로고
    • Recombinational DNA repair and human disease
    • Thompson LH, Schild D. Recombinational DNA repair and human disease. Mutat Res 2002;509:49-78.
    • (2002) Mutat Res , vol.509 , pp. 49-78
    • Thompson, L.H.1    Schild, D.2
  • 191
    • 18244379848 scopus 로고    scopus 로고
    • Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions
    • Sharpless NE, et al. Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions. Mol Cell 2001;8:1187-1196.
    • (2001) Mol Cell , vol.8 , pp. 1187-1196
    • Sharpless, N.E.1
  • 192
    • 18244362081 scopus 로고    scopus 로고
    • DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency
    • O'Driscoll M, et al. DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency. Mol Cell 2001;8:1175-1185.
    • (2001) Mol Cell , vol.8 , pp. 1175-1185
    • O'Driscoll, M.1
  • 193
    • 0037312006 scopus 로고    scopus 로고
    • Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis
    • Moshous D, et al. Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis. J Clin Invest 2003;111:381-387.
    • (2003) J Clin Invest , vol.111 , pp. 381-387
    • Moshous, D.1
  • 194
    • 0036802254 scopus 로고    scopus 로고
    • DNA repair gene XRCC3 241Met variant is not associated with risk of cutaneous malignant melanoma
    • Duan Z, et al. DNA repair gene XRCC3 241Met variant is not associated with risk of cutaneous malignant melanoma. Cancer Epidemiol Biomarkers Prev 2002;11:1142-1143.
    • (2002) Cancer Epidemiol Biomarkers Prev , vol.11 , pp. 1142-1143
    • Duan, Z.1
  • 195
    • 0037142183 scopus 로고    scopus 로고
    • A variant of the DNA repair gene XRCC3 and risk of squamous cell carcinoma of the head and neck: A case-control analysis
    • Shen H, Sturgis EM, Dahlstrom KR, Zheng Y, Spitz MR, Wei Q. A variant of the DNA repair gene XRCC3 and risk of squamous cell carcinoma of the head and neck: a case-control analysis. Int J Cancer 2002;99:869-872.
    • (2002) Int J Cancer , vol.99 , pp. 869-872
    • Shen, H.1    Sturgis, E.M.2    Dahlstrom, K.R.3    Zheng, Y.4    Spitz, M.R.5    Wei, Q.6
  • 196
    • 71749090715 scopus 로고    scopus 로고
    • Variants in DNA double-strand break repair genes and breast cancer susceptibility
    • Kuschel B, et al. Variants in DNA double-strand break repair genes and breast cancer susceptibility. Hum Mol Genet 2002;11:1399-1407.
    • (2002) Hum Mol Genet , vol.11 , pp. 1399-1407
    • Kuschel, B.1
  • 197
    • 71749087375 scopus 로고    scopus 로고
    • A potential role for the XRCC2 R188H polymorphic site in DNA-damage repair and breast cancer
    • Rafii S, et al. A potential role for the XRCC2 R188H polymorphic site in DNA-damage repair and breast cancer. Hum Mol Genet 2002;11:1433-1438.
    • (2002) Hum Mol Genet , vol.11 , pp. 1433-1438
    • Rafii, S.1
  • 198
    • 0034667360 scopus 로고    scopus 로고
    • A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer
    • Winsey SL, et al. A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer. Cancer Res 2000;60:5612-5616.
    • (2000) Cancer Res , vol.60 , pp. 5612-5616
    • Winsey, S.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.