DNA double-strand breaks: Prior to but not sufficient in targeting hypermutation

Journal of Experimental Medicine

Volumn 195, Issue 9, 2002, Pages 1187-1192

  Bross, Linda ^a,c   Muramatsu, Masamichi ^b   Kinoshita, Kazuo ^b   Honjo, Tasuku ^b   Jacobs, Heinz ^a,c  

^a BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^b KYOTO UNIVERSITY   (Japan)

^c MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

AID; Class switch recombination; DSB; Ig ; Somatic hypermutation

Indexed keywords

CYTIDINE DEAMINASE; DEOXYCYTIDINE; DEOXYURIDINE PHOSPHATE; DNA GLYCOSYLTRANSFERASE; DOUBLE STRANDED DNA; HOLOENZYME; IMMUNOGLOBULIN; SINGLE STRANDED DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DNA STRAND BREAKAGE; EXCISION REPAIR; GENE FUNCTION; GENE REARRANGEMENT; GENE SWITCHING; GENETIC RECOMBINATION; GERMINAL CENTER; IMMUNOGLOBULIN GENE; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SOMATIC MUTATION;

ANIMALS; B-LYMPHOCYTES; CYTIDINE DEAMINASE; CYTOSINE DEAMINASE; DEOXYCYTIDINE; DNA; DNA DAMAGE; DNA PRIMERS; GENES, IMMUNOGLOBULIN; IMMUNOGLOBULIN KAPPA-CHAINS; INTRONS; MICE; MICE, KNOCKOUT; MUTAGENESIS; NUCLEOSIDE DEAMINASES; RNA EDITING; SPLEEN;

EID: 0037029663     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20011749     Document Type: Article

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