메뉴 건너뛰기




Volumn 9, Issue 6, 1998, Pages 859-869

TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; B LYMPHOCYTE; DNA STRAND BREAKAGE; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOMA CELL LINE; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; STOP CODON;

EID: 0032435650     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80651-2     Document Type: Article
Times cited : (238)

References (55)
  • 1
    • 0017784252 scopus 로고
    • Molecular analysis of spontaneous somatic mutants
    • Adetugbo, K., Milstein, C., and Secher, D.S. (1977). Molecular analysis of spontaneous somatic mutants. Nature 265, 299-304.
    • (1977) Nature , vol.265 , pp. 299-304
    • Adetugbo, K.1    Milstein, C.2    Secher, D.S.3
  • 3
    • 0030071749 scopus 로고    scopus 로고
    • An immunoglobulin mutator that targets G.C base pairs
    • Bachl, J., and Wabl, M. (1996). An immunoglobulin mutator that targets G.C base pairs. Proc. Natl. Acad. Sci. USA 93, 851-855.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 851-855
    • Bachl, J.1    Wabl, M.2
  • 4
    • 0026636759 scopus 로고
    • Clonal evolution of a follicular lymphoma: Evidence for antigen selection
    • Bahler, D.W., and Levy, R. (1992). Clonal evolution of a follicular lymphoma: evidence for antigen selection. Proc. Natl. Acad. Sci. USA 89, 6770-6774.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 6770-6774
    • Bahler, D.W.1    Levy, R.2
  • 5
    • 0023821895 scopus 로고
    • The dynamic nature of the antibody repertoire
    • Berek, C., and Milstein, C. (1988). The dynamic nature of the antibody repertoire, Immunol. Rev. 105, 5-26.
    • (1988) Immunol. Rev. , vol.105 , pp. 5-26
    • Berek, C.1    Milstein, C.2
  • 6
    • 0027227311 scopus 로고
    • Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes
    • Betz, A.G., Neuberger, M.S., and Milstein, C. (1993). Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes. Immunol. Today 14, 405-411.
    • (1993) Immunol. Today , vol.14 , pp. 405-411
    • Betz, A.G.1    Neuberger, M.S.2    Milstein, C.3
  • 8
    • 0030834265 scopus 로고    scopus 로고
    • Hodgkin and Reed-Sternberg cells in lymphocyte predominant disease represent clonal populations of germinal center-derived tumor B cells
    • Braeuninger, A., Küppers, R., Strickler, J.G., Wacker, H.-H., Rajewsky, K., and Hansmann, M.-L. (1997). Hodgkin and Reed-Sternberg cells in lymphocyte predominant disease represent clonal populations of germinal center-derived tumor B cells. Proc. Natl. Acad. Sci. USA 94, 9337-9342.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 9337-9342
    • Braeuninger, A.1    Küppers, R.2    Strickler, J.G.3    Wacker, H.-H.4    Rajewsky, K.5    Hansmann, M.-L.6
  • 9
    • 0020338539 scopus 로고
    • Immunoglobulin V region variants in hybridoma cells. I. Isolation of a variant with altered idiotypic and antigen binding specificity
    • Brüggemann, M., Radbruch, A., and Rajewsky, K. (1982). Immunoglobulin V region variants in hybridoma cells. I. Isolation of a variant with altered idiotypic and antigen binding specificity. EMBO J. 1, 629-634.
    • (1982) EMBO J. , vol.1 , pp. 629-634
    • Brüggemann, M.1    Radbruch, A.2    Rajewsky, K.3
  • 10
    • 0015544411 scopus 로고
    • A table for the estimation of the spontaneous mutation rate of cells in culture
    • Capizzi, R.L., and Jameson, J.W. (1973). A table for the estimation of the spontaneous mutation rate of cells in culture. Mutat. Res. 17, 147-148.
    • (1973) Mutat. Res. , vol.17 , pp. 147-148
    • Capizzi, R.L.1    Jameson, J.W.2
  • 11
    • 0028985744 scopus 로고
    • H genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity
    • H genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity. Blood 85, 2176-2181.
    • (1995) Blood , vol.85 , pp. 2176-2181
    • Chapman, C.J.1    Mockridge, C.I.2    Rowe, M.3    Rickinson, A.B.4    Stevenson, F.K.5
  • 12
    • 0029661825 scopus 로고    scopus 로고
    • H and VL gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity and a role for antigen selection
    • H and VL gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity and a role for antigen selection. Blood 88, 3562-3568.
    • (1996) Blood , vol.88 , pp. 3562-3568
    • Chapman, C.J.1    Zhou, J.X.2    Gregory, C.3    Rickinson, A.B.4    Stevenson, F.K.5
  • 13
    • 0029072264 scopus 로고
    • A reporter gene to analyse the hypermutation of immunoglobulin genes
    • Chui, Y.-L., Lozano, F., Jarvis, J.M., Pannell, R., and Milstein, C. (1995). A reporter gene to analyse the hypermutation of immunoglobulin genes. J. Mol. Biol. 249, 555-563.
    • (1995) J. Mol. Biol. , vol.249 , pp. 555-563
    • Chui, Y.-L.1    Lozano, F.2    Jarvis, J.M.3    Pannell, R.4    Milstein, C.5
  • 14
    • 0023734473 scopus 로고
    • Novel non-templated nucleotide addition reactions catalysed by the procaryotic and eucaryotic DNA polymerases
    • Clark, J.M. (1988). Novel non-templated nucleotide addition reactions catalysed by the procaryotic and eucaryotic DNA polymerases. Nucleic Acids Res. 16, 9667-9686.
    • (1988) Nucleic Acids Res. , vol.16 , pp. 9667-9686
    • Clark, J.M.1
  • 15
    • 0014975799 scopus 로고
    • Rate of somatic mutation in immunoglobulin production by mouse myeloma cells
    • Coffino, P., and Scharff, M.D. (1971). Rate of somatic mutation in immunoglobulin production by mouse myeloma cells. Proc. Natl. Acad. Sci. USA 68, 219-223.
    • (1971) Proc. Natl. Acad. Sci. USA , vol.68 , pp. 219-223
    • Coffino, P.1    Scharff, M.D.2
  • 17
    • 0031894290 scopus 로고    scopus 로고
    • Evolution of somatic hypermutation and gene conversion in adaptive immunity
    • Diaz, M., and Flajnik, M.F. (1998). Evolution of somatic hypermutation and gene conversion in adaptive immunity. Immunol. Rev. 162, 13-24.
    • (1998) Immunol. Rev. , vol.162 , pp. 13-24
    • Diaz, M.1    Flajnik, M.F.2
  • 18
    • 0032127811 scopus 로고    scopus 로고
    • Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process
    • Frey, S., Bertocci, B., Delbos, F., Quint, L., Weill, J.-C., and Reynaud, C.-A. (1998) Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process. Immunity 9, 127-134.
    • (1998) Immunity , vol.9 , pp. 127-134
    • Frey, S.1    Bertocci, B.2    Delbos, F.3    Quint, L.4    Weill, J.-C.5    Reynaud, C.-A.6
  • 19
    • 0026470102 scopus 로고
    • Somatic recombination of heavy chain V region transgenes with the endogenous heavy chain locus in mice
    • Giusti, A., Coffee, R., and Manser, T. (1992). Somatic recombination of heavy chain V region transgenes with the endogenous heavy chain locus in mice. Proc. Natl. Acad. Sci. USA 89, 10321-10325.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 10321-10325
    • Giusti, A.1    Coffee, R.2    Manser, T.3
  • 20
    • 0032478071 scopus 로고    scopus 로고
    • Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogenic translocations and heavy chain disease
    • Goossens, T., Klein, U., and Küppers, R. (1998). Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogenic translocations and heavy chain disease. Proc. Natl. Acad. Sci. USA 95, 2463-2468.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 2463-2468
    • Goossens, T.1    Klein, U.2    Küppers, R.3
  • 21
    • 0031942085 scopus 로고    scopus 로고
    • Immunoglobulin hypermutation in cultured cells
    • Green, N.S., Lin, M.M., and Scharff, M.D. (1998). Immunoglobulin hypermutation in cultured cells. Immunol. Rev. 162, 77-87.
    • (1998) Immunol. Rev. , vol.162 , pp. 77-87
    • Green, N.S.1    Lin, M.M.2    Scharff, M.D.3
  • 22
    • 0031944925 scopus 로고    scopus 로고
    • Mutation, selection and memory in B lymphocytes of exothermic vertebrates
    • Hsu, E. (1998). Mutation, selection and memory in B lymphocytes of exothermic vertebrates, Immunol. Rev. 162, 25-36.
    • (1998) Immunol. Rev. , vol.162 , pp. 25-36
    • Hsu, E.1
  • 26
    • 0030845386 scopus 로고    scopus 로고
    • Rapid methods for the analysis of immunoglobulin gene hypermutation: Application to transgenic and gene targeted mice
    • Jolly, C.J., Klix, N., and Neuberger, M.S. (1997). Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice. Nucleic Acids Res. 25, 1913-1919.
    • (1997) Nucleic Acids Res. , vol.25 , pp. 1913-1919
    • Jolly, C.J.1    Klix, N.2    Neuberger, M.S.3
  • 27
    • 0019847882 scopus 로고
    • Antibody diversity: Somatic hypermutation of rearranged VH genes
    • Kim, S., Davis, M., Sinn, E., Patten, P., and Hood, L. (1981). Antibody diversity: somatic hypermutation of rearranged VH genes. Cell 27, 573-581.
    • (1981) Cell , vol.27 , pp. 573-581
    • Kim, S.1    Davis, M.2    Sinn, E.3    Patten, P.4    Hood, L.5
  • 28
    • 0016803494 scopus 로고
    • An EBV negative cell line established from a American Burkitt lymphoma; receptor characteristics, EBV infectability and permanent conversion into EBV-positive sublines by in vitro infection
    • Klein, G., Giovanella, B., Westman, A., Stehlin, J., and Mumford, D. (1975). An EBV negative cell line established from a American Burkitt lymphoma; receptor characteristics, EBV infectability and permanent conversion into EBV-positive sublines by in vitro infection. Intervirology 5, 319-334.
    • (1975) Intervirology , vol.5 , pp. 319-334
    • Klein, G.1    Giovanella, B.2    Westman, A.3    Stehlin, J.4    Mumford, D.5
  • 29
    • 0031944788 scopus 로고    scopus 로고
    • Recombination based mechanisms for somatic hypermutation
    • Kong, Q., Harris, R.S., and Maizels, N. (1998). Recombination based mechanisms for somatic hypermutation. Immunol. Rev. 162, 67-76.
    • (1998) Immunol. Rev. , vol.162 , pp. 67-76
    • Kong, Q.1    Harris, R.S.2    Maizels, N.3
  • 31
    • 0030835816 scopus 로고    scopus 로고
    • Strand breaks in immunoglobulin gene hypermutation
    • Lo, A.K., Ching, A.K., Lim, P.L., and Chui, Y.L. (1997). Strand breaks in immunoglobulin gene hypermutation. Ann. NY Acad. Sci. 815, 432-435.
    • (1997) Ann. NY Acad. Sci. , vol.815 , pp. 432-435
    • Lo, A.K.1    Ching, A.K.2    Lim, P.L.3    Chui, Y.L.4
  • 32
    • 0001641514 scopus 로고
    • Mutations of bacteria from virus sensitivity to virus resistance
    • Luria, S.E., and Delbrück, M. (1943). Mutations of bacteria from virus sensitivity to virus resistance. Genetics 28, 491-511.
    • (1943) Genetics , vol.28 , pp. 491-511
    • Luria, S.E.1    Delbrück, M.2
  • 33
    • 0028818503 scopus 로고
    • Somatic hypermutation: How many mechanisms diversify V region sequences?
    • Maizels, N. (1995). Somatic hypermutation: how many mechanisms diversify V region sequences? Cell 83, 9-12.
    • (1995) Cell , vol.83 , pp. 9-12
    • Maizels, N.1
  • 34
    • 0008476550 scopus 로고
    • Generation of antibody diversity in the immune response of BALB/c mice to influenza virus haemagglutinin
    • McKean, D., Huppi, K., Bell, M., Staudt, L., Gerhard, W., and Weigert, M. (1984). Generation of antibody diversity in the immune response of BALB/c mice to influenza virus haemagglutinin. Proc. Natl. Acad. Sci. USA 81, 3180-3184.
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 3180-3184
    • McKean, D.1    Huppi, K.2    Bell, M.3    Staudt, L.4    Gerhard, W.5    Weigert, M.6
  • 35
    • 0032555232 scopus 로고    scopus 로고
    • Both strands of antibody genes are hypermutation targets
    • Milstein, C., Neuberger, M.S., and Staden, R. (1998). Both strands of antibody genes are hypermutation targets. Proc. Natl. Acad. Sci. USA 95, 8791-9784.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 8791-9784
    • Milstein, C.1    Neuberger, M.S.2    Staden, R.3
  • 37
    • 0000296526 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes
    • Copenhagen, Denmark: Munksgaard
    • Parham, P. (1998). Somatic hypermutation of immunoglobulin genes. Immunol. Rev. 162 (Copenhagen, Denmark: Munksgaard).
    • (1998) Immunol. Rev. , vol.162
    • Parham, P.1
  • 38
    • 0028065121 scopus 로고
    • Illegitimate recombination induced by DNA double-strand breaks in a mammalian chromosome
    • Phillips, J.W., and Morgan, J.W. (1994). Illegitimate recombination induced by DNA double-strand breaks in a mammalian chromosome. Mol. Cell. Biol. 14, 5794-5803.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 5794-5803
    • Phillips, J.W.1    Morgan, J.W.2
  • 39
    • 0032101611 scopus 로고    scopus 로고
    • Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein
    • Phung, Q.H., Winter, D.B., Cranston, A., Tarone, R.E., Bohr, V.A., Fishel, R., and Gearhart, P.J. (1998). Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein. J. Exp. Med. 187, 1745-1751.
    • (1998) J. Exp. Med. , vol.187 , pp. 1745-1751
    • Phung, Q.H.1    Winter, D.B.2    Cranston, A.3    Tarone, R.E.4    Bohr, V.A.5    Fishel, R.6    Gearhart, P.J.7
  • 40
    • 0032127804 scopus 로고    scopus 로고
    • Somatic hypermutation in MSH2 deficient mice is more focussed on intrinsic hotspots suggesting targeting to be a two stage process
    • Rada, C.A., Ehrenstein, M.R., Neuberger, M.S., and Milstein, C. (1998). Somatic hypermutation in MSH2 deficient mice is more focussed on intrinsic hotspots suggesting targeting to be a two stage process. Immunity 9, 135-141.
    • (1998) Immunity , vol.9 , pp. 135-141
    • Rada, C.A.1    Ehrenstein, M.R.2    Neuberger, M.S.3    Milstein, C.4
  • 41
    • 0026554228 scopus 로고
    • Rapid cloning of rearranged immunoglobulin heavy chain genes from human B-cell lines using anchored polymerase chain reaction
    • Ratech, H. (1992). Rapid cloning of rearranged immunoglobulin heavy chain genes from human B-cell lines using anchored polymerase chain reaction. Biochem. Biophys. Res. Commun. 182, 1260-1263.
    • (1992) Biochem. Biophys. Res. Commun. , vol.182 , pp. 1260-1263
    • Ratech, H.1
  • 42
    • 0013509248 scopus 로고    scopus 로고
    • Somatic hypermutation: Mechanisms and signals
    • Reynaud, C.-A., and Weill, J.-C. (1996). Somatic hypermutation: mechanisms and signals. Semin. Immunol. 8, 125-184.
    • (1996) Semin. Immunol. , vol.8 , pp. 125-184
    • Reynaud, C.-A.1    Weill, J.-C.2
  • 43
    • 0026443954 scopus 로고
    • Somatic hypermutation of immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis
    • Rogozin, I.B., and Kolchanov, N.A. (1992). Somatic hypermutation of immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis. Biochem. Biophys. Acta 1171, 11-18.
    • (1992) Biochem. Biophys. Acta , vol.1171 , pp. 11-18
    • Rogozin, I.B.1    Kolchanov, N.A.2
  • 44
    • 0004981090 scopus 로고    scopus 로고
    • Medical Research Council, Centre for Protein Engineering, UK
    • Tomlinson, I.M. (1997). V Base database of human antibody genes. Medical Research Council, Centre for Protein Engineering, UK. http://www.mrc-cpe.cam.ac.uk/.
    • (1997) V Base Database of Human Antibody Genes
    • Tomlinson, I.M.1
  • 45
  • 47
    • 0029871507 scopus 로고    scopus 로고
    • Somatic hypermutation of Ig genes in patients with xeroderma-pigmentosum (XP-D)
    • Wagner, S.D., Elvin, J.G., Norris, P., McGregor, J.M., and Neuberger, M.S. (1996). Somatic hypermutation of Ig genes in patients with xeroderma-pigmentosum (XP-D). Int. Immunol. 8, 701-705.
    • (1996) Int. Immunol. , vol.8 , pp. 701-705
    • Wagner, S.D.1    Elvin, J.G.2    Norris, P.3    McGregor, J.M.4    Neuberger, M.S.5
  • 48
    • 0030052281 scopus 로고    scopus 로고
    • Rearrangement/hypermutation/gene conversion: When, where and why?
    • Weill, J.-C., and Reynaud, C.-A. (1996). Rearrangement/hypermutation/gene conversion: when, where and why? Immunol. Today 17, 92-97.
    • (1996) Immunol. Today , vol.17 , pp. 92-97
    • Weill, J.-C.1    Reynaud, C.-A.2
  • 49
    • 0026470596 scopus 로고
    • What limits affinity maturation of antibodies in Xenopus, the rate of somatic mutations or the ability to select mutants?
    • Wilson, M., Hsu, E., Marcuz, A., Courtet, M., Du Pasquier, L., and Steinberg, C. (1992). What limits affinity maturation of antibodies in Xenopus, the rate of somatic mutations or the ability to select mutants? EMBO J. 11, 4337-4347.
    • (1992) EMBO J. , vol.11 , pp. 4337-4347
    • Wilson, M.1    Hsu, E.2    Marcuz, A.3    Courtet, M.4    Du Pasquier, L.5    Steinberg, C.6
  • 51
    • 0031920676 scopus 로고    scopus 로고
    • Dual enigma of somatic hypermutation of immunoglobulin variable genes; targeting and mechanism
    • Winter, D.B., and Gearhart, P.J. (1998). Dual enigma of somatic hypermutation of immunoglobulin variable genes; targeting and mechanism. Immunol. Rev. 162, 89-96.
    • (1998) Immunol. Rev. , vol.162 , pp. 89-96
    • Winter, D.B.1    Gearhart, P.J.2
  • 52
    • 0029039723 scopus 로고
    • The somatic hypermutation activity of a follicular lymphoma links to large insertions and deletions of immunoglobulin genes
    • Wu, H.Y., and Kaartinen, M. (1995). The somatic hypermutation activity of a follicular lymphoma links to large insertions and deletions of immunoglobulin genes. Scand. J. Immunol. 42, 52-59.
    • (1995) Scand. J. Immunol. , vol.42 , pp. 52-59
    • Wu, H.Y.1    Kaartinen, M.2
  • 53
    • 0029557884 scopus 로고
    • A human follicular lymphoma B cell line hypermutates its functional immunoglobulin genes in vitro
    • Wu, H.Y., Pelkonen, E., Knuutila, S., and Kaartinen, M. (1995). A human follicular lymphoma B cell line hypermutates its functional immunoglobulin genes in vitro. Eur. J. Immunol. 25, 3263-3269.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 3263-3269
    • Wu, H.Y.1    Pelkonen, E.2    Knuutila, S.3    Kaartinen, M.4
  • 54
    • 0031897509 scopus 로고    scopus 로고
    • Immunoglobulin gene hypermutation in germinal centres is independent of the RAG-1 V(D)J recombinase
    • Zheng, B., Han, S., Spanopoulou, E., and Kelsoe, G. (1998). Immunoglobulin gene hypermutation in germinal centres is independent of the RAG-1 V(D)J recombinase. Immunol. Rev. 162, 133-141.
    • (1998) Immunol. Rev. , vol.162 , pp. 133-141
    • Zheng, B.1    Han, S.2    Spanopoulou, E.3    Kelsoe, G.4
  • 55
    • 0028968928 scopus 로고
    • A well-differentiated B cell line is permissive for somatic mutation of a transfected immunoglobulin heavy-chain gene
    • Zhu, M., Rabinowitz, J.L., Green, N.S., Kobrin, B.J., and Scharff, M.D. (1995). A well-differentiated B cell line is permissive for somatic mutation of a transfected immunoglobulin heavy-chain gene. Proc. Natl. Acad. Sci. USA 92, 2810-2814.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 2810-2814
    • Zhu, M.1    Rabinowitz, J.L.2    Green, N.S.3    Kobrin, B.J.4    Scharff, M.D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.