Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 5, 2007, Pages 1616-1620

  Kotani, Ai ^a   Kakazu, Naoki ^b   Tsuruyama, Tatsuaki ^a   Okazaki, Il Mi ^a   Muramatsu, Masamichi ^a   Kinoshita, Kazuo ^c   Nagaoka, Hitoshi ^a   Yabe, Daisuke ^a   Honjo, Tasuku ^a  

^a KYOTO UNIVERSITY   (Japan)

^b SHIMANE UNIVERSITY   (Japan)

^c Shiga Medical Center Research Institute   (Japan)

Author keywords

Clonal expansion; Pim1; Secondary hit; Somatic hypermutation

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; CYTIDINE DEAMINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B CELL LYMPHOMA; CARCINOGENESIS; CONTROLLED STUDY; GENE OVEREXPRESSION; MOUSE; NONHUMAN; ONCOGENE C MYC; ONCOGENE EMU; PHENOTYPE; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTO ONCOGENE; SOMATIC HYPERMUTATION; TRANSGENIC MOUSE;

ANIMALS; B-LYMPHOCYTES; CELL SEPARATION; CYTIDINE DEAMINASE; DNA DAMAGE; GENE EXPRESSION REGULATION, NEOPLASTIC; LYMPHOMA, B-CELL; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, BIOLOGICAL; MUTATION; PHENOTYPE; PROTO-ONCOGENE PROTEINS C-MYC; PROTO-ONCOGENE PROTEINS C-PIM-1; TRANSLOCATION, GENETIC;

MUS MUSCULUS;

EID: 33846804438     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0610732104     Document Type: Article

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