How to make ends meet in V(D)J recombination

Current Opinion in Immunology

Volumn 13, Issue 2, 2001, Pages 186-194

  Grawunder, Ulf ^a   Harfst, Eva ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; B LYMPHOCYTE; GENETIC RECOMBINATION; LYMPHOPOIESIS; NONHUMAN; PROTEIN PROCESSING; REVIEW; T LYMPHOCYTE;

ANIMALS; DNA; DNA LIGASES; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; GENE REARRANGEMENT; HOMEODOMAIN PROTEINS; HUMANS; MICE; MUTATION; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RECOMBINATION, GENETIC; TRANSPOSASES;

EID: 0035313998     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(00)00203-X     Document Type: Review

References (75)

1. Somatic generation of antibody diversity
2. Accessibility and the developmental regulation of V(D)J recombination
3. A role for histone acetylation in the developmental regulation of V(D)J recombination
4. Stimulation of V(D)J recombination by histone acetylation
5. Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule
6. Cleavage at the V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps
7. The V(D)J recombination activating gene, RAG-1
8. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
9. RAG-1-deficient mice have no mature B and T lymphocytes
10. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
11. Mice lacking TdT: Mature animals with an immature lymphocyte repertoire
12. Ku, a DNA repair protein with multiple cellular functions?
13. The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen
14. Productive and nonproductive complexes of Ku and DNA-dependent protein kinase at DNA termini
15. DNA-dependent protein kinase: DNA binding and activation in the absence of Ku
16. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation
17. Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse
18. Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes
19. A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination
20. Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity
21. Requirement for Ku80 in growth and immunoglobulin V(D)J recombination
22. Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates
23. Growth retardation and leaky SCID phenotype of Ku70-deficient mice
24. Ku70 is required for DNA repair but nor for T cell antigen receptor recombination in vivo
25. The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination
26. Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells
27. Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV
28. Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV
29. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis
30. DNA end-joining: From yeast to man
31. The RAG proteins and V(D)J recombination: Complexes, ends, and transposition
32. Cell-free V(D)J recombination
33. Initiation of V(D)J recombination in a cell-free system
34. The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination
35. Initiation of V(D)J recombination in vitro obeying the 12/23 rule
36. V(D)J recombination: Modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteins
37. A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage
38. Rejoining of DNA by the RAG1 and RAG2 proteins
39. Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system
40. DNA transposition by the RAG1 and RAG2 proteins: A possible source of oncogenic translocations
41. Similarities between initiation of V(D)J recombination and retroviral integration
42. Hairpin coding end opening is mediated by RAG1 and RAG2 proteins
43. DNA hairpin opening mediated by the RAG1 and RAG2 proteins
44. V(D)J recombination: Broken DNA molecules with covalently sealed (hairpin) coding end in scid mouse thymocytes
45. V(D)J recombination intermediates and non-standard products in XRCC4-deficient cells
46. RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination
47. Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex
48. The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
49. Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome
50. Ku80-deficient cells exhibit excess degradation of extrachromosomal DNA
51. V(D)J recombination in Ku86-deficient mice: Distinct effects on coding, signal, and hybrid joint formation
52. Association of terminal deoxynucleotidyl transferase with Ku
53. Extent to which homology can constrain coding exon junctional diversity in V(D)J recombination
54. The RAG1/RAG2 complex constitutes a 3′ flap endonuclease: Implications for junctional diversity in V(D)J and transpositional recombination
55. The 3′ to 5′ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks
56. A mechanistic basis for Mre11-directed DNA joining at microhomologies
57. The characterization of a mammalian DNA structure-specific endonuclease
58. A role for FEN-1 in nonhomologous DNA end joining: The order of strand annealing and nucleolytic processing events
59. DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes
60. Ku recruits the XRCC4-ligase IV complex to DNA ends
61. Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase
62. DNA binding of XRCC4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity
63. Lif1p targets the DNA ligase Lig4p to sites of DNA double-strand breaks
64. Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination
65. The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination
66. Analysis of variable (diversity) joining recombination in DNA dependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation
67. Mammalian X-ray-sensitive mutants which are defective in non-homologous (illegitimate) DNA double-strand break repair
68. DNA-PK is essential only for coding joint formation in V(D)J recombination
69. Equine severe combined immunodeficiency: A defect in V(D)J recombination and DNA-dependent protein kinase activity
70. XR-C1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formation
71. Murine cell line SX9 bearing a mutation in the dna-pkcs gene exhibits aberrant V(D)J recombination not only in the coding joint but also in the signal joint
72. Analyses of TCRβ rearrangements substantiate a profound deficit in recombination signal sequence joining in SCID foals: Implications for the role of DNA-dependent protein kinase in V(D)J recombination
73. Signal joint formation is also impaired in DNA-dependent protein kinase catalytic subunit knockout cells
74. DNA end-joining catalyzed by human cell-free extracts
75. A new gene involved in DNA double-strand break repair and V(D)J recombination is located on human chromosome 10p