IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells

Immunity

Volumn 16, Issue 4, 2002, Pages 607-617

  Manis, John P ^a   Dudley, Darryll ^a   Kaylor, Lianne ^a   Alt, Frederick W ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; IMMUNOGLOBULIN M; PROTEIN; PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CELL ACTIVATION; CELL PROLIFERATION; CELL STIMULATION; CELLULAR PARAMETERS; CHROMOSOME; CONTROLLED STUDY; DNA DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; ENZYME SUBUNIT; GENE SWITCHING; GENETIC COMPLEMENTATION; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; GERM LINE; IN VITRO STUDY; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; TRANSGENE; WILD TYPE;

EID: 0036224604     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(02)00306-0     Document Type: Article

References (58)

1. Efficient recombination of a switch substrate retrovector in CD40-activated B lymphocytes: Implications for the control of CH gene switch recombination
2. cs) or recombination-activating gene (RAG) 1 activity
3. Analysis of variable (diversity) joining recombination in DNA-dependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation
4. The SCID mouse mutant: Definition, characterization, and potential uses
5. Evidence of functional lymphocytes in some (leaky) scid mice
6. Deletion of the IgH intronic enhancer and associated matrix-attachment regions decreases, but does not abolish, class switching at the mu locus
7. Ku80 is required for immunoglobulin isotype switching
8. Development of B cells in scid mice with immunoglobulin transgenes: Implications for the control of V(D)J recombination
9. DNA rearrangement can account for in vitro switching to IgG1
10. DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA
11. DNA end-joining: From yeast to man
12. Potential regulatory elements for germline transcription in or near murine Sγ1
13. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
14. DNA sequences at immunoglobulin switch region recombination
15. Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: Parallels with somatic hypermutation
16. Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination
17. DNA double-strand break repair
18. DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway
19. A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination
20. Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development
21. Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice
22. Enhancer control of V(D)J recombination at the TCRβ locus: Differential effects on DNA cleavage and joining
23. Factors and forces controlling V(D)J recombination
24. B cell differentiation and isotype switching is related to division cycle number
25. Circular DNA is excised by immunoglobulin class switch recombination
26. Towards an understanding of somatic hypermutation
27. Linking class-switch recombination with somatic hypermutation
28. Molecular mechanism of immunoglobulin class switch recombination
29. Ig heavy chain class switching in Rag-deficient mice
30. Frequent but biased class switch recombination in the S mu flanking regions
31. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver
32. Activation of NF-κB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cγ1 promoter
33. The mu switch region tandem repeats are important, but not required, for antibody class switch recombination
34. Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: Potential role of Ets family members
35. Ku70 is required for late B cell development and immunoglobulin heavy chain class switching
36. Class switching in B cells lacking 3′ immunoglobulin heavy chain enhancers
37. Mechanism and control of class-switch recombination
38. Switch circular DNA formed in cytokine-treated mouse splenocytes: Evidence for intramolecular DNA deletion in immunoglobulin class switching
39. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
40. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
41. Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes
42. Receptor editing in a transgenic mouse model: Site, efficiency, and role in B cell tolerance and antibody diversification
43. Localization of the 3′ IgH locus elements that effect long-distance regulation of class switch recombination
44. Class switch recombination is IgG1 specific on active and inactive IgH loci of IgG1-secreting B-cell blasts
45. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
46. The SCID but not the RAG-2 gene product is required for Sμ-Sε heavy chain class switching
47. Reduced isotope switching in splenic B cells from mice deficient in mismatch repair enzymes
48. Role for mismatch repair proteins Msh2, Mlhl, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions
49. Nonhomologous end-joining proteins are required for V(D)J recombination, normal growth, and neurogenesis
50. Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development
51. B cell development under the condition of allelic inclusion
52. Antibody class switching
53. Molecular processes that regulate class switching
54. The molecular basis of somatic hypermutation of immunoglobulin genes
55. Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity
56. Circular DNA is a product of the immunoglobulin class switch rearrangement
57. Directed Ig class switch recombination in activated murine B cells
58. Ig Sγ3 DNA-specifc double strand breaks are induced in mitogen-activated B cells and are implicated in switch recombination