메뉴 건너뛰기




Volumn 200, Issue , 2004, Pages 249-260

V(D)J recombination: How to tame a transposase

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; IMMUNOGLOBULIN; INTEGRASE; RAG1 PROTEIN; RAG2 PROTEIN; TRANSPOSASE;

EID: 3242883717     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0105-2896.2004.00161.x     Document Type: Review
Times cited : (22)

References (80)
  • 1
    • 0025324784 scopus 로고
    • Chromosomal translocations in lymphoid neoplasia: A reappraisal of the recombinase model
    • Tycko B, Sklar J. Chromosomal translocations in lymphoid neoplasia: a reappraisal of the recombinase model. Cancer Cells 1990;2:1-8.
    • (1990) Cancer Cells , vol.2 , pp. 1-8
    • Tycko, B.1    Sklar, J.2
  • 2
    • 0032785839 scopus 로고    scopus 로고
    • Regulated genomic instability and neoplasia in the lymphoid lineage
    • Vanasse GJ, Concannon P, Willerford DM. Regulated genomic instability and neoplasia in the lymphoid lineage. Blood 1999;94:3997-4010.
    • (1999) Blood , vol.94 , pp. 3997-4010
    • Vanasse, G.J.1    Concannon, P.2    Willerford, D.M.3
  • 3
    • 0141720776 scopus 로고    scopus 로고
    • Restraining the V(D)J recombinase
    • Roth DB. Restraining the V(D)J recombinase. Nat Rev Immunol 2003;3:656-666.
    • (2003) Nat Rev Immunol , vol.3 , pp. 656-666
    • Roth, D.B.1
  • 4
    • 0032555758 scopus 로고    scopus 로고
    • DNA transposition by the RAG1 and RAG2 proteins: A possible source of oncogenic translocations
    • Hiom K, Melek M, Gellert M. DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations. Cell 1998;94:463-470.
    • (1998) Cell , vol.94 , pp. 463-470
    • Hiom, K.1    Melek, M.2    Gellert, M.3
  • 5
    • 0032551829 scopus 로고    scopus 로고
    • Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system
    • Agrawal A, Eastman QM, Schatz DG. Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system. Nature 1998;394:744-751.
    • (1998) Nature , vol.394 , pp. 744-751
    • Agrawal, A.1    Eastman, Q.M.2    Schatz, D.G.3
  • 6
    • 0030009253 scopus 로고    scopus 로고
    • The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination
    • van Gent DC, Ramsden DA, Gellert M. The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination. Cell 1996;85:107-113.
    • (1996) Cell , vol.85 , pp. 107-113
    • Van Gent, D.C.1    Ramsden, D.A.2    Gellert, M.3
  • 7
    • 0024255703 scopus 로고
    • Novel strand exchanges in V(D)J recombination
    • Lewis SM, Hesse JE, Mizuuchi K, Gellert M. Novel strand exchanges in V(D)J recombination. Cell 1988;55:1099-1107.
    • (1988) Cell , vol.55 , pp. 1099-1107
    • Lewis, S.M.1    Hesse, J.E.2    Mizuuchi, K.3    Gellert, M.4
  • 8
    • 0030887862 scopus 로고    scopus 로고
    • RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination
    • Agrawal A, Schatz DG. RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination. Cell 1997;89:43-53.
    • (1997) Cell , vol.89 , pp. 43-53
    • Agrawal, A.1    Schatz, D.G.2
  • 9
    • 0032084698 scopus 로고    scopus 로고
    • Assembly of a 12/23 paired signal complex: A critical control point in V(D)J recombination
    • Hiom K, Gellert M. Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination. Mol Cell 1998;1:1011-1019.
    • (1998) Mol Cell , vol.1 , pp. 1011-1019
    • Hiom, K.1    Gellert, M.2
  • 10
    • 0035108439 scopus 로고    scopus 로고
    • Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination
    • Qiu JX, Kale SB, Yarnell Schultz H, Roth DB. Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination. Mol Cell 2001;7:77-87.
    • (2001) Mol Cell , vol.7 , pp. 77-87
    • Qiu, J.X.1    Kale, S.B.2    Yarnell Schultz, H.3    Roth, D.B.4
  • 11
    • 0035108780 scopus 로고    scopus 로고
    • Joining-deficient RAG1 mutants block V(D)J recombination in vivo and hairpin opening in vitro
    • Yarnall Schultz H, Landree MA, Qiu JX, Kale SB, Roth DB. Joining-deficient RAG1 mutants block V(D)J recombination in vivo and hairpin opening in vitro. Mol Cell 2001;7:65-75.
    • (2001) Mol Cell , vol.7 , pp. 65-75
    • Yarnall Schultz, H.1    Landree, M.A.2    Qiu, J.X.3    Kale, S.B.4    Roth, D.B.5
  • 12
    • 0036240040 scopus 로고    scopus 로고
    • Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinase
    • Huye LE, Purugganan MM, Jiang MM, Roth DB. Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinase. Mol Cell Biol 2002;22:3460-3473.
    • (2002) Mol Cell Biol , vol.22 , pp. 3460-3473
    • Huye, L.E.1    Purugganan, M.M.2    Jiang, M.M.3    Roth, D.B.4
  • 13
    • 0036682980 scopus 로고    scopus 로고
    • Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination
    • Tsai CL, Drejer AH, Schatz DG. Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination. Genes Dev 2002;16:1934-1949.
    • (2002) Genes Dev , vol.16 , pp. 1934-1949
    • Tsai, C.L.1    Drejer, A.H.2    Schatz, D.G.3
  • 14
    • 0032555695 scopus 로고    scopus 로고
    • VDJ recombination: A transposase goes to work
    • Roth DB, Craig NL. VDJ recombination: a transposase goes to work. Cell 1998;94:411-414.
    • (1998) Cell , vol.94 , pp. 411-414
    • Roth, D.B.1    Craig, N.L.2
  • 15
    • 0029967722 scopus 로고    scopus 로고
    • Similarities between initiation of V(D)J recombination and retroviral integration
    • van Gent DC, Mizuuchi K, Gellert M. Similarities between initiation of V(D)J recombination and retroviral integration. Science 1996;271:1592-1594.
    • (1996) Science , vol.271 , pp. 1592-1594
    • Van Gent, D.C.1    Mizuuchi, K.2    Gellert, M.3
  • 18
    • 0018627375 scopus 로고
    • Sequences at the somatic recombination sites of immunoglobulin light-chain genes
    • Sakano H, Huppi K, Heinrich G, Tonegawa S. Sequences at the somatic recombination sites of immunoglobulin light-chain genes. Nature 1979;280:288-294.
    • (1979) Nature , vol.280 , pp. 288-294
    • Sakano, H.1    Huppi, K.2    Heinrich, G.3    Tonegawa, S.4
  • 19
    • 0025301095 scopus 로고
    • RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
    • Oettinger MA, Schatz DG, Gorka C, Baltimore D. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 1990;248:1517-1523.
    • (1990) Science , vol.248 , pp. 1517-1523
    • Oettinger, M.A.1    Schatz, D.G.2    Gorka, C.3    Baltimore, D.4
  • 20
    • 0028867419 scopus 로고
    • New insights into V(D)J recombination and its role in the evolution of the immune system
    • Thompson CB. New insights into V(D)J recombination and its role in the evolution of the immune system. Immunity 1995;3:531-539.
    • (1995) Immunity , vol.3 , pp. 531-539
    • Thompson, C.B.1
  • 21
    • 0034568266 scopus 로고    scopus 로고
    • From lymphocytes to sharks: V(D)J recombinase moves to the germline
    • reviews1014.1-1014.4
    • Roth DB. From lymphocytes to sharks: V(D)J recombinase moves to the germline. Genome Biol 2000;1:reviews1014.1-1014.4.
    • (2000) Genome Biol , vol.1
    • Roth, D.B.1
  • 22
    • 0033970135 scopus 로고    scopus 로고
    • Recombination-activating genes, transposition, and the lymphoid-specific combinatorial immune system: A common evolutionary connection
    • Hansen JD, McBlane JF. Recombination-activating genes, transposition, and the lymphoid-specific combinatorial immune system: a common evolutionary connection. Curr Top Microbiol Immunol 2000;248:111-135.
    • (2000) Curr Top Microbiol Immunol , vol.248 , pp. 111-135
    • Hansen, J.D.1    McBlane, J.F.2
  • 23
    • 0030934860 scopus 로고    scopus 로고
    • Ku86 is not required for protection of signal ends or for formation of nonstandard V(D)J recombination products
    • Han J-O, Steen SB, Roth DB. Ku86 is not required for protection of signal ends or for formation of nonstandard V(D)J recombination products. Mol Cell Biol 1997;17:2226-2234.
    • (1997) Mol Cell Biol , vol.17 , pp. 2226-2234
    • Han, J.-O.1    Steen, S.B.2    Roth, D.B.3
  • 25
    • 0030837472 scopus 로고    scopus 로고
    • V(D)J recombination in Ku86-deficient mice: Distinct effects on coding, signal, and hybrid joint formation
    • Bogue MA, Wang C, Zhu C, Roth DB. V(D)J recombination in Ku86-deficient mice: distinct effects on coding, signal, and hybrid joint formation. Immunity 1997;7:37-47.
    • (1997) Immunity , vol.7 , pp. 37-47
    • Bogue, M.A.1    Wang, C.2    Zhu, C.3    Roth, D.B.4
  • 26
    • 0032438115 scopus 로고    scopus 로고
    • Analysis of variable (diversity) joining recombination in DNA-dependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation
    • Bogue MA, Jhappan C, Roth DB. Analysis of variable (diversity) joining recombination in DNA-dependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation. Proc Natl Acad Sci USA 1998;95:15559-15564.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 15559-15564
    • Bogue, M.A.1    Jhappan, C.2    Roth, D.B.3
  • 27
    • 0032502886 scopus 로고    scopus 로고
    • Rejoining of DNA by the RAG1 and RAG2 proteins
    • Melek M, Gellert M, van Gent DC. Rejoining of DNA by the RAG1 and RAG2 proteins. Science 1998;280:301-303.
    • (1998) Science , vol.280 , pp. 301-303
    • Melek, M.1    Gellert, M.2    Van Gent, D.C.3
  • 28
    • 0032913232 scopus 로고    scopus 로고
    • Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination
    • Steen SB, Han J-O, Mundy C, Oettinger MA, Roth DB. Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination. Mol Cell Biol 1999;19:3010-3017.
    • (1999) Mol Cell Biol , vol.19 , pp. 3010-3017
    • Steen, S.B.1    Han, J.-O.2    Mundy, C.3    Oettinger, M.A.4    Roth, D.B.5
  • 29
    • 0034625261 scopus 로고    scopus 로고
    • RAG1/2-mediated resolution of transposition intermediates: Two pathways and possible consequences
    • Melek M, Gellert M. RAG1/2-mediated resolution of transposition intermediates: two pathways and possible consequences. Cell 2000;101:625-633.
    • (2000) Cell , vol.101 , pp. 625-633
    • Melek, M.1    Gellert, M.2
  • 30
    • 0026719238 scopus 로고
    • Residues critical for retroviral integrative recombination in a region that is highly conserved among retroviral/retrotransposon integrases and bacterial insertion sequence transposases
    • Kulkosky J, Jones KS, Katz RA, Mack JPG, Skalka AM. Residues critical for retroviral integrative recombination in a region that is highly conserved among retroviral/retrotransposon integrases and bacterial insertion sequence transposases. Mol Cell Biol 1992;12:2331-2338.
    • (1992) Mol Cell Biol , vol.12 , pp. 2331-2338
    • Kulkosky, J.1    Jones, K.S.2    Katz, R.A.3    Mack, J.P.G.4    Skalka, A.M.5
  • 31
    • 0029609126 scopus 로고
    • DNA transposition: From a black box to a color monitor
    • Grindley NDF, Leschziner AE. DNA transposition: from a black box to a color monitor. Cell 1995;83:1063-1066.
    • (1995) Cell , vol.83 , pp. 1063-1066
    • Grindley, N.D.F.1    Leschziner, A.E.2
  • 32
    • 0029129435 scopus 로고
    • Structure of the bacteriophage Mu transposase core: A common structural motif for DNA transposition and retroviral integration
    • Rice P, Mizuuchi K. Structure of the bacteriophage Mu transposase core: a common structural motif for DNA transposition and retroviral integration. Cell 1995;82:209-220.
    • (1995) Cell , vol.82 , pp. 209-220
    • Rice, P.1    Mizuuchi, K.2
  • 33
    • 0033380368 scopus 로고    scopus 로고
    • Mutational analysis of RAG-1 and RAG-2 identifies three active site amino acids in RAG-1 critical for both cleavage steps of V(D)J recombination
    • Landree MA, Wibbenmeyer JA, Roth DB. Mutational analysis of RAG-1 and RAG-2 identifies three active site amino acids in RAG-1 critical for both cleavage steps of V(D)J recombination. Genes Dev 1999;13:3059-3069.
    • (1999) Genes Dev , vol.13 , pp. 3059-3069
    • Landree, M.A.1    Wibbenmeyer, J.A.2    Roth, D.B.3
  • 34
    • 0033634859 scopus 로고    scopus 로고
    • Unexpected structural diversity in DNA recombination: The restriction endonuclease connection
    • Hickman AB, Li Y, Mathew SV, May EW, Craig NL, Dyda F. Unexpected structural diversity in DNA recombination: the restriction endonuclease connection. Mol Cell 2000;5:1025-1034.
    • (2000) Mol Cell , vol.5 , pp. 1025-1034
    • Hickman, A.B.1    Li, Y.2    Mathew, S.V.3    May, E.W.4    Craig, N.L.5    Dyda, F.6
  • 35
    • 0000675571 scopus 로고    scopus 로고
    • Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase
    • Kim DR, Dai Y, Mundy CL, Yang W, Oettinger MA. Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase. Genes Dev 1999;13:3070-3080.
    • (1999) Genes Dev , vol.13 , pp. 3070-3080
    • Kim, D.R.1    Dai, Y.2    Mundy, C.L.3    Yang, W.4    Oettinger, M.A.5
  • 36
    • 0028865574 scopus 로고
    • High-resolution structure of the catalytic domain of avian sarcoma virus integrase
    • Bujacz G, et al. High-resolution structure of the catalytic domain of avian sarcoma virus integrase. J Mol Biol 1995;253:333-346.
    • (1995) J Mol Biol , vol.253 , pp. 333-346
    • Bujacz, G.1
  • 37
    • 0029643858 scopus 로고    scopus 로고
    • The catalytic domain of avian sarcoma virus integrase: Conformation of the active-site residues in the presence of divalent cations
    • Bujacz G, et al. The catalytic domain of avian sarcoma virus integrase: conformation of the active-site residues in the presence of divalent cations. Structure 1996;4:89-96.
    • (1996) Structure , vol.4 , pp. 89-96
    • Bujacz, G.1
  • 38
    • 0032483022 scopus 로고    scopus 로고
    • Three new structures of the core domain of HIV-1 integrase: An active site that binds magnesium
    • Goldgur Y, Dyda F, Hickman AB, Jenkins TM, Craigie R. Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium. Proc Natl Acad Sci USA 1998;95:9150-9154.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9150-9154
    • Goldgur, Y.1    Dyda, F.2    Hickman, A.B.3    Jenkins, T.M.4    Craigie, R.5
  • 39
    • 0032544311 scopus 로고    scopus 로고
    • Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: High level of similarity of the active site with other viral integrases
    • Maignan S, Guilloteau J-P, Zhou-Liu Q, Clement-Mella C, Mikol V. Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases. J Mol Biol 1998;282:359-368.
    • (1998) J Mol Biol , vol.282 , pp. 359-368
    • Maignan, S.1    Guilloteau, J.-P.2    Zhou-Liu, Q.3    Clement-Mella, C.4    Mikol, V.5
  • 40
    • 0033954892 scopus 로고    scopus 로고
    • Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex
    • Fugmann SD, Villey IJ, Ptaszek LM, Schatz DG. Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex. Mol Cell 2000; 5:97-107.
    • (2000) Mol Cell , vol.5 , pp. 97-107
    • Fugmann, S.D.1    Villey, I.J.2    Ptaszek, L.M.3    Schatz, D.G.4
  • 41
  • 42
    • 0028048275 scopus 로고
    • The mechanism of V(D)J joining: Lessons from molecular immunological and comparative analyses
    • Lewis SM. The mechanism of V(D)J joining: lessons from molecular immunological and comparative analyses. Adv Immunol 1994;56:27-150.
    • (1994) Adv Immunol , vol.56 , pp. 27-150
    • Lewis, S.M.1
  • 43
    • 2942680399 scopus 로고    scopus 로고
    • V(D)J recombination and the evolution of the adaptive immune system
    • Market E, Papavasiliou FN. V(D)J recombination and the evolution of the adaptive immune system. PLos Biol 2003;1:E16.
    • (2003) PLos Biol , vol.1
    • Market, E.1    Papavasiliou, F.N.2
  • 44
    • 0026792892 scopus 로고
    • V(D)J recombination: Broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes
    • Roth DB, Menetski JP, Nakajima PB, Bosma MJ, Gellert M. V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes. Cell 1992;70:983-991.
    • (1992) Cell , vol.70 , pp. 983-991
    • Roth, D.B.1    Menetski, J.P.2    Nakajima, P.B.3    Bosma, M.J.4    Gellert, M.5
  • 45
    • 0027769386 scopus 로고
    • Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated RAG-dependent, and cell cycle regulated
    • Schlissel M, Constantinescu A, Morrow T, Baxter M, Peng A. Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated RAG-dependent, and cell cycle regulated. Genes Dev 1993;7:2520-2532.
    • (1993) Genes Dev , vol.7 , pp. 2520-2532
    • Schlissel, M.1    Constantinescu, A.2    Morrow, T.3    Baxter, M.4    Peng, A.5
  • 46
    • 0028958942 scopus 로고
    • Characterization of coding ends in thymocytes of scid mice: Implications for the mechanism of V(D)J recombination
    • Zhu C, Roth DB. Characterization of coding ends in thymocytes of scid mice: implications for the mechanism of V(D)J recombination. Immunity 1995;2:101-112.
    • (1995) Immunity , vol.2 , pp. 101-112
    • Zhu, C.1    Roth, D.B.2
  • 47
    • 0030069149 scopus 로고    scopus 로고
    • T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells
    • Livak F, Schatz DG. T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells. Mol Cell Biol 1996;16:609-618.
    • (1996) Mol Cell Biol , vol.16 , pp. 609-618
    • Livak, F.1    Schatz, D.G.2
  • 48
    • 0028801363 scopus 로고
    • Formation and resolution of double-strand break intermediates in V(D)J rearrangement
    • Ramsden DA, Gellert M. Formation and resolution of double-strand break intermediates in V(D)J rearrangement. Genes Dev 1995;9:2409-2420.
    • (1995) Genes Dev , vol.9 , pp. 2409-2420
    • Ramsden, D.A.1    Gellert, M.2
  • 49
    • 0035818603 scopus 로고    scopus 로고
    • Intermediates in V(D)J recombination: A stable RAG1/2 complex sequesters cleaved RSS ends
    • Jones JM, Gellert M. Intermediates in V(D)J recombination: a stable RAG1/2 complex sequesters cleaved RSS ends. Proc Natl Acad Sci USA 2001;98:12926-12931.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12926-12931
    • Jones, J.M.1    Gellert, M.2
  • 50
    • 0021885386 scopus 로고
    • DNA elements are asymmetrically joined during the site-specific recombination of kappa immunoglobulin genes
    • Lewis S, Gifford A, Baltimore D. DNA elements are asymmetrically joined during the site-specific recombination of kappa immunoglobulin genes. Science 1985;228:677-685.
    • (1985) Science , vol.228 , pp. 677-685
    • Lewis, S.1    Gifford, A.2    Baltimore, D.3
  • 51
    • 0023659483 scopus 로고
    • Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V(D)J joining signals
    • Hesse JE, Lieber MR, Gellert M, Mizuuchi K. Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V(D)J joining signals. Cell 1987;49:775-783.
    • (1987) Cell , vol.49 , pp. 775-783
    • Hesse, J.E.1    Lieber, M.R.2    Gellert, M.3    Mizuuchi, K.4
  • 52
    • 0035312712 scopus 로고    scopus 로고
    • The RAG proteins in V(D)J recombination: More than just a nuclease
    • Sadofsky MJ. The RAG proteins in V(D)J recombination: more than just a nuclease. Nucleic Acids Res 2001;29:1399-1409.
    • (2001) Nucleic Acids Res , vol.29 , pp. 1399-1409
    • Sadofsky, M.J.1
  • 53
    • 0026052160 scopus 로고
    • Cutting and closing without recombination in V(D)J joining
    • Lewis SM, Hesse JE. Cutting and closing without recombination in V(D)J joining. EMBO J 1991;10:3631-3639.
    • (1991) EMBO J , vol.10 , pp. 3631-3639
    • Lewis, S.M.1    Hesse, J.E.2
  • 54
    • 0027410476 scopus 로고
    • V(D)J recombination: Signal and coding joint resolution are uncoupled and depend on parallel synapsis of the sites
    • Sheehan KM, Lieber MR. V(D)J recombination: signal and coding joint resolution are uncoupled and depend on parallel synapsis of the sites. Mol Cell Biol 1993;13:1363-1370.
    • (1993) Mol Cell Biol , vol.13 , pp. 1363-1370
    • Sheehan, K.M.1    Lieber, M.R.2
  • 55
    • 0036242313 scopus 로고    scopus 로고
    • The V(D)J recombinase efficiently cleaves and transposes signal joints
    • Neiditch MB, Lee GS, Huye LE, Brandt VL, Roth DB. The V(D)J recombinase efficiently cleaves and transposes signal joints. Mol Cell 2002;9:871-878.
    • (2002) Mol Cell , vol.9 , pp. 871-878
    • Neiditch, M.B.1    Lee, G.S.2    Huye, L.E.3    Brandt, V.L.4    Roth, D.B.5
  • 56
    • 0030576534 scopus 로고    scopus 로고
    • Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates
    • Zhu C, Bogue MA, Lim D-S, Hasty P, Roth DB. Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Cell 1996;86:379-389.
    • (1996) Cell , vol.86 , pp. 379-389
    • Zhu, C.1    Bogue, M.A.2    Lim, D.-S.3    Hasty, P.4    Roth, D.B.5
  • 57
    • 0037370378 scopus 로고    scopus 로고
    • Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL
    • Marculescu R, Vanura K, Le T, Simon P, Jager U, Nadel B. Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL. Nat Genet 2003;33:342-344.
    • (2003) Nat Genet , vol.33 , pp. 342-344
    • Marculescu, R.1    Vanura, K.2    Le, T.3    Simon, P.4    Jager, U.5    Nadel, B.6
  • 58
    • 0034967436 scopus 로고    scopus 로고
    • RAG transposase can capture and commit to target DNA before or after donor cleavage
    • Neiditch MB, Lee GS, Landree MA, Roth DB. RAG transposase can capture and commit to target DNA before or after donor cleavage. Mol Cell Biol 2001;21:4302-4310.
    • (2001) Mol Cell Biol , vol.21 , pp. 4302-4310
    • Neiditch, M.B.1    Lee, G.S.2    Landree, M.A.3    Roth, D.B.4
  • 59
    • 0030967281 scopus 로고    scopus 로고
    • The Tn10 synaptic complex can capture a target DNA only after transposon excision
    • Sakai J, Kleckner N. The Tn10 synaptic complex can capture a target DNA only after transposon excision. Cell 1997;89:205-214.
    • (1997) Cell , vol.89 , pp. 205-214
    • Sakai, J.1    Kleckner, N.2
  • 60
    • 0345379607 scopus 로고    scopus 로고
    • A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination
    • Bailin T, Mo X, Sadofsky MJ. A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination. Mol Cell Biol 1999;19:4664-4671.
    • (1999) Mol Cell Biol , vol.19 , pp. 4664-4671
    • Bailin, T.1    Mo, X.2    Sadofsky, M.J.3
  • 61
    • 0036839614 scopus 로고    scopus 로고
    • A RAG-1/RAG-2 tetramer supports 12/23-regulated synapsis, cleavage, and transposition of V(D)J recombination signals
    • Swanson PC. A RAG-1/RAG-2 tetramer supports 12/23-regulated synapsis, cleavage, and transposition of V(D)J recombination signals. Mol Cell Biol 2002;22:7790-7801.
    • (2002) Mol Cell Biol , vol.22 , pp. 7790-7801
    • Swanson, P.C.1
  • 64
    • 0037447338 scopus 로고    scopus 로고
    • The C-terminal portion of RAG2 protects against transposition in vitro
    • Elkin SK, Matthews AG, Oettinger MA. The C-terminal portion of RAG2 protects against transposition in vitro. EMBO J 2003;22:1931-1938.
    • (2003) EMBO J , vol.22 , pp. 1931-1938
    • Elkin, S.K.1    Matthews, A.G.2    Oettinger, M.A.3
  • 65
    • 1042301422 scopus 로고    scopus 로고
    • Full-length RAG-2, and not full-length RAG-1, specifically suppresses RAG-mediated transposition, but not hybrid joint formation or disintegration
    • Swanson PC, Volkmer D, Wang L. Full-length RAG-2, and not full-length RAG-1, specifically suppresses RAG-mediated transposition, but not hybrid joint formation or disintegration. J Biol Chem 2004;279:4034-4044.
    • (2004) J Biol Chem , vol.279 , pp. 4034-4044
    • Swanson, P.C.1    Volkmer, D.2    Wang, L.3
  • 66
    • 0037447298 scopus 로고    scopus 로고
    • Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2
    • Tsai CL, Schatz DG. Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2. EMBO J 2003;22:1922-1930.
    • (2003) EMBO J , vol.22 , pp. 1922-1930
    • Tsai, C.L.1    Schatz, D.G.2
  • 67
    • 0035865136 scopus 로고    scopus 로고
    • Target DNA structure plays a critical role in Tn7 transposition
    • Kuduvalli PN, Rao JE, Craig NL. Target DNA structure plays a critical role in Tn7 transposition. EMBO J 2001;20:924-932.
    • (2001) EMBO J , vol.20 , pp. 924-932
    • Kuduvalli, P.N.1    Rao, J.E.2    Craig, N.L.3
  • 68
    • 0034636031 scopus 로고    scopus 로고
    • Recognition of triple-helical DNA structures by transposon Tn7
    • Rao JE, Miller PS, Craig NL. Recognition of triple-helical DNA structures by transposon Tn7. Proc Natl Acad Sci USA 2000;97:3936-3941.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 3936-3941
    • Rao, J.E.1    Miller, P.S.2    Craig, N.L.3
  • 69
    • 0035853286 scopus 로고    scopus 로고
    • Selective recognition of pyrimidine motif triplexes by a protein encoded by the bacterial transposon Tn7
    • Rao JE, Craig NL. Selective recognition of pyrimidine motif triplexes by a protein encoded by the bacterial transposon Tn7. J Mol Biol 2001;307:1161-1170.
    • (2001) J Mol Biol , vol.307 , pp. 1161-1170
    • Rao, J.E.1    Craig, N.L.2
  • 71
    • 0345146909 scopus 로고    scopus 로고
    • In vivo transposition mediated by V(D)J recombinase in human T lymphocytes
    • Messier TL, O'Neill JP, Hou SM, Nicklas JA, Finette BA. In vivo transposition mediated by V(D)J recombinase in human T lymphocytes. EMBO J 2003;22:1381-1388.
    • (2003) EMBO J , vol.22 , pp. 1381-1388
    • Messier, T.L.1    O'Neill, J.P.2    Hou, S.M.3    Nicklas, J.A.4    Finette, B.A.5
  • 72
    • 0026575427 scopus 로고
    • S1 nuclease hypersensitive sites in an oligopurine/oligopyrimidine DNA from the t(10;14) breakpoint cluster region
    • Lu M, Zhang N, Raimondi S, Ho AD. S1 nuclease hypersensitive sites in an oligopurine/oligopyrimidine DNA from the t(10;14) breakpoint cluster region. Nucleic Acids Res 1992;20:263-266.
    • (1992) Nucleic Acids Res , vol.20 , pp. 263-266
    • Lu, M.1    Zhang, N.2    Raimondi, S.3    Ho, A.D.4
  • 73
    • 0024437912 scopus 로고
    • Alternating purine-pyrimidine tracts may promote chromosomal translocations seen in a variety of human lymphoid tumours
    • Boehm T, et al. Alternating purine-pyrimidine tracts may promote chromosomal translocations seen in a variety of human lymphoid tumours. EMBO J 1989;8:2621-2631.
    • (1989) EMBO J , vol.8 , pp. 2621-2631
    • Boehm, T.1
  • 74
    • 0033106433 scopus 로고    scopus 로고
    • Intermolecular V(D)J recombination is prohibited specifically at the joining step
    • Han J-O, Steen SB, Roth DB. Intermolecular V(D)J recombination is prohibited specifically at the joining step. Mol Cell 1999;3:331-338.
    • (1999) Mol Cell , vol.3 , pp. 331-338
    • Han, J.-O.1    Steen, S.B.2    Roth, D.B.3
  • 75
    • 0034708588 scopus 로고    scopus 로고
    • Intermolecular V(D)J recombination
    • Tevelev A, Schatz DG. Intermolecular V(D)J recombination. J Biol Chem 2000;275:8341-8348.
    • (2000) J Biol Chem , vol.275 , pp. 8341-8348
    • Tevelev, A.1    Schatz, D.G.2
  • 76
    • 0035697242 scopus 로고    scopus 로고
    • Increased accumulation of hybrid V(D)J joins in cells expressing truncated versus full-length RAGs
    • Sekiguchi JA, Whitlow S, Alt FW. Increased accumulation of hybrid V(D)J joins in cells expressing truncated versus full-length RAGs. Mol Cell 2001;8:1383-1390.
    • (2001) Mol Cell , vol.8 , pp. 1383-1390
    • Sekiguchi, J.A.1    Whitlow, S.2    Alt, F.W.3
  • 77
    • 0027285604 scopus 로고
    • V(D)J recombination generates a high frequency of nonstandard TCR delta-associated rearrangements in thymocytes
    • Carroll AM, Slack JK, Mu X. V(D)J recombination generates a high frequency of nonstandard TCR delta-associated rearrangements in thymocytes. J Immunol 1993;150:2222-2230.
    • (1993) J Immunol , vol.150 , pp. 2222-2230
    • Carroll, A.M.1    Slack, J.K.2    Mu, X.3
  • 78
    • 0028889966 scopus 로고
    • Inversions produced during V(D)J rearrangement at IgH, the immunoglobulin heavy-chain locus
    • Sollbach AE, Wu GE. Inversions produced during V(D)J rearrangement at IgH, the immunoglobulin heavy-chain locus. Mol Cell Biol 1995;15:671-681.
    • (1995) Mol Cell Biol , vol.15 , pp. 671-681
    • Sollbach, A.E.1    Wu, G.E.2
  • 79
    • 0030293631 scopus 로고    scopus 로고
    • Immunoglobulin DH recombination signal sequence targeting
    • VanDyk LF, Wise TW, Moore BB, Meek K. Immunoglobulin DH recombination signal sequence targeting. J Immunol 1996;157:4005-4015.
    • (1996) J Immunol , vol.157 , pp. 4005-4015
    • Vandyk, L.F.1    Wise, T.W.2    Moore, B.B.3    Meek, K.4
  • 80
    • 0028283180 scopus 로고
    • Abnormal deletions in the T cell receptor delta locus of mouse thymocytes
    • Fish SM, Bosma MJ. Abnormal deletions in the T cell receptor delta locus of mouse thymocytes. Mol Cell Biol 1994;14:4455-4464.
    • (1994) Mol Cell Biol , vol.14 , pp. 4455-4464
    • Fish, S.M.1    Bosma, M.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.