Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase

Nature

Volumn 419, Issue 6902, 2002, Pages 43-48

  Di Noia, Javier ^a   Neuberger, Michael S ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; BACTERIOPHAGES; DNA; GENES;

EXCISION ACTIVITY;

IMMUNOLOGY;

DNA; GENE PRODUCT; IMMUNOGLOBULIN; IMMUNOGLOBULIN M; MESSENGER RNA; URACIL DNA GLYCOSYLTRANSFERASE;

DNA;

CHICKEN; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; GENE MUTATION; GENE REARRANGEMENT; GENETIC TRANSFECTION; HUMAN; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; NONHUMAN; PLASMID; PRIORITY JOURNAL; REVIEW;

ANIMALS; ANTIBODY DIVERSITY; B-LYMPHOCYTES; BASE SEQUENCE; CELL LINE; CHICKENS; CYTIDINE DEAMINASE; DNA GLYCOSYLASES; DNA REPAIR; DNA-BINDING PROTEINS; FIBROBLASTS; GENE DELETION; GENES, IMMUNOGLOBULIN; MICE; MUTAGENESIS; N-GLYCOSYL HYDROLASES; RNA, MESSENGER; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; TRANSFECTION; URACIL-DNA GLYCOSIDASE; VIRAL PROTEINS;

GALLUS GALLUS; UNIDENTIFIED BACTERIOPHAGE;

EID: 0037026482     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature00981     Document Type: Review

References (21)

1. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification
2. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
3. Suppression of spontaneous mutagenesis in human cells by DNA base excision-repair
4. An N-glycosidase from Escherichia coli that releases free uracil from DNA containing deaminated cytosine residues
5. Chromosome instability and defective recombinational repair in knockout mutants of the five Rad51 paralogs
6. Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation
7. Instability and decay of the primary structure of DNA
8. Structure and function in the uracil-DNA glycosylase superfamily
9. Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication
10. Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors
11. Excision of deaminated cytosine from the vertebrate genome: Role of the SMUG1 uracil-DNA glycosylase
12. N-glycosidase activity in extracts of Bacillus subtilis and its inhibition after infection with bacteriophage PBS 2
13. Uracil-DNA glycosylase inhibitor of bacteriophage PBS2: Cloning and effects of expression of the inhibitor gene in Escherichia coli
14. Specificity of the bacteriophage PBS2 induced inhibitor of uracil-DNA glycosylase
15. Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: Protein mimicry of DNA
16. The role of leucine 191 of Escherichia coli uracil DNA glycosylase in the formation of a highly stable complex with the substrate mimic, Ugi, and in uracil excision from the synthetic substrates
17. Increased spontaneous mutation frequency in human cells expressing the phage PBS2-encoded inhibitor of uracil-DNA glycosylase
18. AID is essential for immunoglobulin V gene conversion in a cultured B cell line
19. Cell lines derived from avian lymphomas exhibit two distinct phenotypes
20. Light chain gene conversion continues at high rate in an ALV-induced cell line
21. Epstein-Barr virus and the somatic hypermutation of immunoglobulin genes in Burkitt's lymphoma cells