AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching

Nature

Volumn 414, Issue 6864, 2001, Pages 660-665

  Petersen, Simone ^a   Casellas, Rafael ^b   Reina San Martin, Bernardo ^a   Chen, Hua Tang ^b   Difilippantonio, Michael J ^a   Wilson, Patrick C ^b   Hanitsch, Leif ^b   Celeste, Arkady ^a   Muramatsu, Masamichi ^c   Pilch, Duane R ^a   Redon, Christophe ^a   Ried, Thomas ^a   Bonner, William M ^a   Honjo, Tasuku ^c   Nussenzweig, Michel C ^b   Nussenzweig, André ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; GENES; MUTAGENESIS; RNA;

BIOLOGICAL ACTIVITY;

GENETIC ENGINEERING;

ACTIVATION INDUCED CYTIDINE DEAMINASE; CYTIDINE DEAMINASE; GENE PRODUCT; IMMUNOGLOBULIN HEAVY CHAIN; PROTIEN NBS1; UNCLASSIFIED DRUG;

DNA;

ANIMAL CELL; ARTICLE; CLASS SWITCH RECOMBINATION; CONTROLLED STUDY; DNA MODIFICATION; DNA RECOMBINATION; GENE INDUCTION; GENETIC RECOMBINATION; MOLECULAR DYNAMICS; MOUSE; NIJMEGEN BREAKAGE SYNDROME; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REACTION ANALYSIS; RNA EDITING;

ANIMALS; B-LYMPHOCYTES; BASE SEQUENCE; BRCA1 PROTEIN; CELL CYCLE; CELLS, CULTURED; CLONING, MOLECULAR; CYTIDINE DEAMINASE; DNA; DNA REPAIR; DNA-BINDING PROTEINS; HISTONES; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN HEAVY CHAINS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MUTAGENESIS; NUCLEAR PROTEINS; RAD51 RECOMBINASE; RECOMBINATION, GENETIC;

EID: 0035818990     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/414660a     Document Type: Article

References (30)

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