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Volumn 202, Issue 4, 2005, Pages 561-568

Inducible DNA breaks in Ig S regions are dependent on AID and UNG

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; CYTIDINE DEAMINASE; DNA; DOUBLE STRANDED DNA; GUANINE NUCLEOTIDE; IMMUNOGLOBULIN; PYRIMIDINE NUCLEOTIDE; SINGLE STRANDED DNA; UNCLASSIFIED DRUG; URACIL DNA GLYCOSYLTRANSFERASE;

EID: 23944431983     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20050872     Document Type: Article
Times cited : (146)

References (42)
  • 1
    • 0032858194 scopus 로고    scopus 로고
    • Molecular processes that regulate class switching
    • Stavnezer, J. 2000. Molecular processes that regulate class switching. Curr. Top. Microbiol. Immunol. 245:127-168.
    • (2000) Curr. Top. Microbiol. Immunol. , vol.245 , pp. 127-168
    • Stavnezer, J.1
  • 2
    • 0036152242 scopus 로고    scopus 로고
    • Mechanism and control of class-switch recombination
    • Manis, J.P., M. Tian, and F.W. Alt. 2002. Mechanism and control of class-switch recombination. Trends Immunol. 23:31-39.
    • (2002) Trends Immunol. , vol.23 , pp. 31-39
    • Manis, J.P.1    Tian, M.2    Alt, F.W.3
  • 3
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Muramatsu, M., K. Kinoshita, S. Fagarasan, S. Yamada, Y. Shinkai, and T. Honjo. 2000. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell. 102:553-563.
    • (2000) Cell , vol.102 , pp. 553-563
    • Muramatsu, M.1    Kinoshita, K.2    Fagarasan, S.3    Yamada, S.4    Shinkai, Y.5    Honjo, T.6
  • 6
    • 0042931069 scopus 로고    scopus 로고
    • The block in immunoglobulin class switch recombination caused by activation-induced cytidine deaminase deficiency occurs prior to the generation of DNA double strand breaks in switch mu region
    • Catalan, N., F. Selz, K. Imai, P. Revy, A. Fischer, and A. Durandy. 2003. The block in immunoglobulin class switch recombination caused by activation-induced cytidine deaminase deficiency occurs prior to the generation of DNA double strand breaks in switch mu region. J. Immunol. 171:2504-2509.
    • (2003) J. Immunol. , vol.171 , pp. 2504-2509
    • Catalan, N.1    Selz, F.2    Imai, K.3    Revy, P.4    Fischer, A.5    Durandy, A.6
  • 7
    • 1842865725 scopus 로고    scopus 로고
    • Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S mu in Ig class switch recombination
    • Rush, J.S., S.D. Fugmann, and D.G. Schatz. 2004. Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S mu in Ig class switch recombination. Int. Immunol. 16:549-557.
    • (2004) Int. Immunol. , vol.16 , pp. 549-557
    • Rush, J.S.1    Fugmann, S.D.2    Schatz, D.G.3
  • 8
    • 0037019315 scopus 로고    scopus 로고
    • AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification
    • Petersen-Mahrt, S.K., R.S. Harris, and M.S. Neuberger. 2002. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature. 418:99-104.
    • (2002) Nature , vol.418 , pp. 99-104
    • Petersen-Mahrt, S.K.1    Harris, R.S.2    Neuberger, M.S.3
  • 9
    • 0037452080 scopus 로고    scopus 로고
    • Transcription-targeted DNA deamination by the AID antibody diversification enzyme
    • Chaudhuri, J., M. Tian, C. Khuong, K. Chua, E. Pinaud, and F.W. Alt. 2003. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature. 422:726-730.
    • (2003) Nature , vol.422 , pp. 726-730
    • Chaudhuri, J.1    Tian, M.2    Khuong, C.3    Chua, K.4    Pinaud, E.5    Alt, F.W.6
  • 10
    • 0037561998 scopus 로고    scopus 로고
    • AID mediates hypermutation by deaminating single stranded DNA
    • Dickerson, S.K., E. Market, E. Besmer, and F.N. Papavasiliou. 2003. AID mediates hypermutation by deaminating single stranded DNA. J. Exp. Med. 197:1291-1296.
    • (2003) J. Exp. Med. , vol.197 , pp. 1291-1296
    • Dickerson, S.K.1    Market, E.2    Besmer, E.3    Papavasiliou, F.N.4
  • 11
    • 0037926476 scopus 로고    scopus 로고
    • Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation
    • Pham, P., R. Bransteitter, J. Petruska, and M.F. Goodman. 2003. Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation. Nature. 424:103-107.
    • (2003) Nature , vol.424 , pp. 103-107
    • Pham, P.1    Bransteitter, R.2    Petruska, J.3    Goodman, M.F.4
  • 12
    • 0037901850 scopus 로고    scopus 로고
    • Human activation-induced cytidine deaminase causes transcription- dependent, strand-biased C to U deaminations
    • Sohail, A., J. Klapacz, M. Samaranayake, A. Ullah, and A.S. Bhagwat. 2003. Human activation-induced cytidine deaminase causes transcription- dependent, strand-biased C to U deaminations. Nucleic Acids Res. 31:2990-2994.
    • (2003) Nucleic Acids Res. , vol.31 , pp. 2990-2994
    • Sohail, A.1    Klapacz, J.2    Samaranayake, M.3    Ullah, A.4    Bhagwat, A.S.5
  • 13
    • 0037108463 scopus 로고    scopus 로고
    • Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
    • Rada, C., G.T. Williams, H. Nilsen, D.E. Barnes, T. Lindahl, and M.S. Neuberger. 2002. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr. Biol. 12:1748-1755.
    • (2002) Curr. Biol. , vol.12 , pp. 1748-1755
    • Rada, C.1    Williams, G.T.2    Nilsen, H.3    Barnes, D.E.4    Lindahl, T.5    Neuberger, M.S.6
  • 17
    • 0027417869 scopus 로고
    • Shutdown of class switch recombination by deletion of a switch region control element
    • Jung, S., K. Rajewsky, and A. Radbruch. 1993. Shutdown of class switch recombination by deletion of a switch region control element. Science. 259:984-987.
    • (1993) Science , vol.259 , pp. 984-987
    • Jung, S.1    Rajewsky, K.2    Radbruch, A.3
  • 18
    • 3142765336 scopus 로고    scopus 로고
    • Class-switch recombination: Interplay of transcription, DNA deamination and DNA repair
    • Chaudhuri, J., and F.W. Alt. 2004. Class-switch recombination: interplay of transcription, DNA deamination and DNA repair. Nat. Rev. Immunol. 4:541-552.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 541-552
    • Chaudhuri, J.1    Alt, F.W.2
  • 19
    • 0038293484 scopus 로고    scopus 로고
    • Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand
    • Ramiro, A.R., P. Stavropoulos, M. Jankovic, and M.C. Nussenzweig. 2003. Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nat. Immunol. 4:452-456.
    • (2003) Nat. Immunol. , vol.4 , pp. 452-456
    • Ramiro, A.R.1    Stavropoulos, P.2    Jankovic, M.3    Nussenzweig, M.C.4
  • 20
    • 0029598833 scopus 로고
    • RNA:DNA complex formation upon transcription of immunoglobulin switch regions: Implications for the mechanism and regulation of class switch recombination
    • Daniels, G.A., and M.R. Lieber. 1995. RNA:DNA complex formation upon transcription of immunoglobulin switch regions: implications for the mechanism and regulation of class switch recombination. Nucleic Acids Res. 23:5006-5011.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 5006-5011
    • Daniels, G.A.1    Lieber, M.R.2
  • 21
    • 0034604622 scopus 로고    scopus 로고
    • Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro
    • Tian, M., and F.W. Alt. 2000. Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro. J. Biol. Chem. 275:24163-24172.
    • (2000) J. Biol. Chem. , vol.275 , pp. 24163-24172
    • Tian, M.1    Alt, F.W.2
  • 22
    • 0037650190 scopus 로고    scopus 로고
    • R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells
    • Yu, K., F. Chedin, C.L. Hsieh, T.E. Wilson, and M.R. Lieber. 2003. R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells. Nat. Immunol. 4:442-451.
    • (2003) Nat. Immunol. , vol.4 , pp. 442-451
    • Yu, K.1    Chedin, F.2    Hsieh, C.L.3    Wilson, T.E.4    Lieber, M.R.5
  • 23
    • 4444239054 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled
    • Shen, H.M., and U. Storb. 2004. Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled. Proc. Natl. Acad. Sci. USA.. 101:12997-13002.
    • (2004) Proc. Natl. Acad. Sci. USA. , vol.101 , pp. 12997-13002
    • Shen, H.M.1    Storb, U.2
  • 24
    • 4344593754 scopus 로고    scopus 로고
    • Single-strand DNA breaks adjacent to cytosines occur during immunoglobulin class switch recombination
    • Arudchandran, A., R.M. Bernstein, and E.E. Max. 2004. Single-strand DNA breaks adjacent to cytosines occur during immunoglobulin class switch recombination. J. Immunol. 173:3223-3229.
    • (2004) J. Immunol. , vol.173 , pp. 3223-3229
    • Arudchandran, A.1    Bernstein, R.M.2    Max, E.E.3
  • 25
    • 0031278299 scopus 로고    scopus 로고
    • Ig Sg3 DNA-specific double strand breaks are induced in mitogen-activated B cells and are implicated in switch recombination
    • Wuerffel, R.A., J. Du, R.J. Thompson, and A.L. Kenter. 1997. Ig Sg3 DNA-specific double strand breaks are induced in mitogen-activated B cells and are implicated in switch recombination. J. Immunol. 159:4139-4144.
    • (1997) J. Immunol. , vol.159 , pp. 4139-4144
    • Wuerffel, R.A.1    Du, J.2    Thompson, R.J.3    Kenter, A.L.4
  • 26
    • 1342282983 scopus 로고    scopus 로고
    • DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine
    • Yu, K., F.T. Huang, and M.R. Lieber. 2004. DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine. J. Biol. Chem. 279:6496-6500.
    • (2004) J. Biol. Chem. , vol.279 , pp. 6496-6500
    • Yu, K.1    Huang, F.T.2    Lieber, M.R.3
  • 27
    • 1542619234 scopus 로고    scopus 로고
    • Cutting edge: DGYW/WRCH is a better predictor of mutability at G:C bases in Ig hypermutation than the widely accepted RGYW/WRCY motif and probably reflects a two-step activation-induced cytidine deaminase-triggered process
    • Rogozin, I.B., and M. Diaz. 2004. Cutting edge: DGYW/WRCH is a better predictor of mutability at G:C bases in Ig hypermutation than the widely accepted RGYW/WRCY motif and probably reflects a two-step activation-induced cytidine deaminase-triggered process. J. Immunol. 172:3382-3384.
    • (2004) J. Immunol. , vol.172 , pp. 3382-3384
    • Rogozin, I.B.1    Diaz, M.2
  • 28
    • 10944223445 scopus 로고    scopus 로고
    • Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase
    • Bransteitter, R., P. Pham, P. Calabrese, and M.F. Goodman. 2004. Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase. J. Biol. Chem. 279:51612-51621.
    • (2004) J. Biol. Chem. , vol.279 , pp. 51612-51621
    • Bransteitter, R.1    Pham, P.2    Calabrese, P.3    Goodman, M.F.4
  • 31
    • 0036499127 scopus 로고    scopus 로고
    • Evolution of Ig DNA sequence to target specific base positions within codons for somatic hypermutation
    • Shapiro, G.S., K. Aviszus, J. Murphy, and L.J. Wysocki. 2002. Evolution of Ig DNA sequence to target specific base positions within codons for somatic hypermutation. J. Immunol. 168:2302-2306.
    • (2002) J. Immunol. , vol.168 , pp. 2302-2306
    • Shapiro, G.S.1    Aviszus, K.2    Murphy, J.3    Wysocki, L.J.4
  • 32
    • 0027190015 scopus 로고
    • DNA sequences at immunoglobulin switch region recombination sites
    • Dunnick, W., G.Z. Hertz, L. Scappino, and C. Gritzmacher. 1993. DNA sequences at immunoglobulin switch region recombination sites. Nucleic Acids Res. 21:365-372.
    • (1993) Nucleic Acids Res. , vol.21 , pp. 365-372
    • Dunnick, W.1    Hertz, G.Z.2    Scappino, L.3    Gritzmacher, C.4
  • 34
    • 3543124198 scopus 로고    scopus 로고
    • Deletion of the nucleotide excision repair gene Ercc1 reduces Ig class switching and alters mutations near switch recombination junctions
    • Schrader, C.E., J. Vardo, E. Linehan, M.Z. Twarog, L.J. Niedernhofer, J.H. Hoeijmakers, and J. Stavnezer. 2004. Deletion of the nucleotide excision repair gene Ercc1 reduces Ig class switching and alters mutations near switch recombination junctions. J. Exp. Med. 200:321-330.
    • (2004) J. Exp. Med. , vol.200 , pp. 321-330
    • Schrader, C.E.1    Vardo, J.2    Linehan, E.3    Twarog, M.Z.4    Niedernhofer, L.J.5    Hoeijmakers, J.H.6    Stavnezer, J.7
  • 35
    • 0037442190 scopus 로고    scopus 로고
    • Cutting edge: The G-U mismatch glycosylase methyl- CpG binding domain 4 is dispensable for somatic hypermutation and class switch recombination
    • Bardwell, P.D., A. Martin, E. Wong, Z. Li, W. Edelmann, and M.D. Scharff. 2003. Cutting edge: the G-U mismatch glycosylase methyl- CpG binding domain 4 is dispensable for somatic hypermutation and class switch recombination. J. Immunol. 170:1620-1624.
    • (2003) J. Immunol. , vol.170 , pp. 1620-1624
    • Bardwell, P.D.1    Martin, A.2    Wong, E.3    Li, Z.4    Edelmann, W.5    Scharff, M.D.6
  • 36
    • 6344256944 scopus 로고    scopus 로고
    • Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation
    • Rada, C., J.M. Di Noia, and M.S. Neuberger. 2004. Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation. Mol. Cell. 16:163-171.
    • (2004) Mol. Cell. , vol.16 , pp. 163-171
    • Rada, C.1    Di Noia, J.M.2    Neuberger, M.S.3
  • 37
    • 1842366037 scopus 로고    scopus 로고
    • Two pathways for removal of nonhomologous DNA ends during double-strand break repair in Saccharomyces cerevisiae
    • Paques, F., and J.E. Haber. 1997. Two pathways for removal of nonhomologous DNA ends during double-strand break repair in Saccharomyces cerevisiae. Mol. Cell. Biol. 17:6765-6771.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 6765-6771
    • Paques, F.1    Haber, J.E.2
  • 38
    • 3142663166 scopus 로고    scopus 로고
    • A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination
    • Martomo, S.A., W.W. Yang, and P.J. Gearhart. 2004. A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination. J. Exp. Med. 200:61-68.
    • (2004) J. Exp. Med. , vol.200 , pp. 61-68
    • Martomo, S.A.1    Yang, W.W.2    Gearhart, P.J.3
  • 40
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • Hoeijmakers, J.H. 2001. Genome maintenance mechanisms for preventing cancer. Nature. 411:366-374.
    • (2001) Nature , vol.411 , pp. 366-374
    • Hoeijmakers, J.H.1
  • 41
    • 0029664798 scopus 로고    scopus 로고
    • Activation of NF-κB/Rel by CD40 engagement induces the mouse germline immunoglobulin Cγ1 promoter
    • Lin, S.C., and J. Stavnezer. 1996. Activation of NF-κB/Rel by CD40 engagement induces the mouse germline immunoglobulin Cγ1 promoter. Mol. Cell. Biol. 16:4591-4603.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4591-4603
    • Lin, S.C.1    Stavnezer, J.2
  • 42
    • 0034626802 scopus 로고    scopus 로고
    • Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes
    • Papavasiliou, F.N., and D.G. Schatz. 2000. Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes. Nature. 408:216-221.
    • (2000) Nature , vol.408 , pp. 216-221
    • Papavasiliou, F.N.1    Schatz, D.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.