-
1
-
-
0035093737
-
DNA double-strand breaks: Signaling, repair and the cancer connection
-
Khanna K.K., Jackson S.P. DNA double-strand breaks: signaling, repair and the cancer connection. Nat. Genet. 27:2001;247-254
-
(2001)
Nat. Genet.
, vol.27
, pp. 247-254
-
-
Khanna, K.K.1
Jackson, S.P.2
-
2
-
-
0033560796
-
The DNA-dependent protein kinase
-
Smith G.C., Jackson S.P. The DNA-dependent protein kinase. Genes Dev. 13:1999;916-934
-
(1999)
Genes Dev.
, vol.13
, pp. 916-934
-
-
Smith, G.C.1
Jackson, S.P.2
-
3
-
-
0037365789
-
ATM and related protein kinases: Safeguarding genome integrity
-
Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer. 3:2003;155-168
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
-
4
-
-
0035856495
-
DNA repair: How Ku makes ends meet?
-
Doherty A.J., Jackson S.P. DNA repair: how Ku makes ends meet? Curr. Biol. 11:2001;R920-924
-
(2001)
Curr. Biol.
, vol.11
, pp. 920-924
-
-
Doherty, A.J.1
Jackson, S.P.2
-
5
-
-
0033006852
-
A DNA repair protein with multiple cellular functions?
-
Featherstone C., Jackson Ku S.P. A DNA repair protein with multiple cellular functions? Mutat. Res. 434:1999;3-15
-
(1999)
Mutat. Res.
, vol.434
, pp. 3-15
-
-
Featherstone, C.1
Jackson Ku, S.P.2
-
6
-
-
0032509097
-
Cryo-EM imaging of the catalytic subunit of the DNA-dependent protein kinase
-
Chiu C.Y., Cary R.B., Chen D.J., Peterson S.R., Stewart P.L. Cryo-EM imaging of the catalytic subunit of the DNA-dependent protein kinase. J. Mol. Biol. 284:1998;1075-1081
-
(1998)
J. Mol. Biol.
, vol.284
, pp. 1075-1081
-
-
Chiu, C.Y.1
Cary, R.B.2
Chen, D.J.3
Peterson, S.R.4
Stewart, P.L.5
-
7
-
-
0033104498
-
Structure of DNA-dependent protein kinase: Implications for its regulation by DNA
-
Leuther K.K., Hammarsten O., Kornberg R.D., Chu G. Structure of DNA-dependent protein kinase: implications for its regulation by DNA. Embo. J. 18:1999;1114-1123
-
(1999)
Embo. J.
, vol.18
, pp. 1114-1123
-
-
Leuther, K.K.1
Hammarsten, O.2
Kornberg, R.D.3
Chu, G.4
-
8
-
-
0035833552
-
Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
-
Walker J.R., Corpina R.A., Goldberg J. Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature. 412:2001;607-614
-
(2001)
Nature
, vol.412
, pp. 607-614
-
-
Walker, J.R.1
Corpina, R.A.2
Goldberg, J.3
-
9
-
-
0033198709
-
Mapping of protein-protein interactions within the DNA-dependent protein kinase complex
-
Gell D., Jackson S.P. Mapping of protein-protein interactions within the DNA-dependent protein kinase complex. Nucleic Acids Res. 27:1999;3494-3502
-
(1999)
Nucleic Acids Res.
, vol.27
, pp. 3494-3502
-
-
Gell, D.1
Jackson, S.P.2
-
10
-
-
0032933430
-
The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit
-
Singleton B.K., Torres-Arzayus M.I., Rottinghaus S.T., Taccioli G.E., Jeggo P.A. The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit. Mol. Cell Biol. 19:1999;3267-3277
-
(1999)
Mol. Cell Biol.
, vol.19
, pp. 3267-3277
-
-
Singleton, B.K.1
Torres-Arzayus, M.I.2
Rottinghaus, S.T.3
Taccioli, G.E.4
Jeggo, P.A.5
-
11
-
-
0031930488
-
DNA-dependent protein kinase: DNA binding and activation in the absence of Ku
-
Hammarsten O., Chu G. DNA-dependent protein kinase: DNA binding and activation in the absence of Ku. Proc. Natl. Acad. Sci. U.S.A. 95:1998;525-530
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 525-530
-
-
Hammarsten, O.1
Chu, G.2
-
12
-
-
0033572709
-
Geometry of a complex formed by double strand break repair proteins at a single DNA end: Recruitment of DNA-PKcs induces inward translocation of Ku protein
-
Yoo S., Dynan W.S. Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA-PKcs induces inward translocation of Ku protein. Nucleic Acids Res. 27:1999;4679-4686
-
(1999)
Nucleic Acids Res.
, vol.27
, pp. 4679-4686
-
-
Yoo, S.1
Dynan, W.S.2
-
13
-
-
0030903145
-
DNA looping by Ku and the DNA-dependent protein kinase
-
Cary R.B., Peterson S.R., Wang J., Bear D.G., Bradbury E.M., Chen D.J. DNA looping by Ku and the DNA-dependent protein kinase. Proc. Natl. Acad. Sci. U.S.A. 94:1997;4267-4272
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 4267-4272
-
-
Cary, R.B.1
Peterson, S.R.2
Wang, J.3
Bear, D.G.4
Bradbury, E.M.5
Chen, D.J.6
-
15
-
-
0037187199
-
Defining interactions between DNA-PK and ligase IV/XRCC4
-
Hsu H.L., Yannone S.M., Chen D.J. Defining interactions between DNA-PK and ligase IV/XRCC4. DNA Repair (Amst.). 1:2002;225-235
-
(2002)
DNA Repair (Amst.)
, vol.1
, pp. 225-235
-
-
Hsu, H.L.1
Yannone, S.M.2
Chen, D.J.3
-
16
-
-
0037423743
-
Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment
-
Calsou P., Delteil C., Frit P., Drouet J., Salles B. Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment. J. Mol. Biol. 326:2003;93-103
-
(2003)
J. Mol. Biol.
, vol.326
, pp. 93-103
-
-
Calsou, P.1
Delteil, C.2
Frit, P.3
Drouet, J.4
Salles, B.5
-
17
-
-
0034714199
-
Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase
-
Chen L., Trujillo K., Sung P., Tomkinson A.E. Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase. J. Biol. Chem. 275:2000;26196-26205
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 26196-26205
-
-
Chen, L.1
Trujillo, K.2
Sung, P.3
Tomkinson, A.E.4
-
18
-
-
0037224429
-
Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro
-
Lee J.W., Yannone S.M., Chen D.J., Povirk L.F. Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro. Cancer Res. 63:2003;22-24
-
(2003)
Cancer Res.
, vol.63
, pp. 22-24
-
-
Lee, J.W.1
Yannone, S.M.2
Chen, D.J.3
Povirk, L.F.4
-
19
-
-
0031939411
-
The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase
-
Leber R., Wise T.W., Mizuta R., Meek K. The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase. J. Biol. Chem. 273:1998;1794-1801
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 1794-1801
-
-
Leber, R.1
Wise, T.W.2
Mizuta, R.3
Meek, K.4
-
20
-
-
0034726003
-
Cleavage and phosphorylation of XRCC4 protein induced by X-irradiation
-
Matsumoto Y., Suzuki N., Namba N., Umeda N., Ma X.J., Morita A., Tomita M., Enomoto A., Serizawa S., Hirano K., Sakaia K., Yasuda H., Hosoi Y. Cleavage and phosphorylation of XRCC4 protein induced by X-irradiation. FEBS Lett. 478:2000;67-71
-
(2000)
FEBS Lett.
, vol.478
, pp. 67-71
-
-
Matsumoto, Y.1
Suzuki, N.2
Namba, N.3
Umeda, N.4
Ma, X.J.5
Morita, A.6
Tomita, M.7
Enomoto, A.8
Serizawa, S.9
Hirano, K.10
Sakaia, K.11
Yasuda, H.12
Hosoi, Y.13
-
21
-
-
0033574001
-
Catalytic subunit of DNA-dependent protein kinase: Impact on lymphocyte development and tumorigenesis
-
Kurimasa A., Ouyang H., Dong L.J., Wang S., Li X., Cordon-Cardo C., Chen D.J., Li G.C. Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis. Proc. Natl. Acad. Sci. U.S.A. 96:1999;1403-1408
-
(1999)
Proc. Natl. Acad. Sci. U.S.A.
, vol.96
, pp. 1403-1408
-
-
Kurimasa, A.1
Ouyang, H.2
Dong, L.J.3
Wang, S.4
Li, X.5
Cordon-Cardo, C.6
Chen, D.J.7
Li, G.C.8
-
22
-
-
0030885974
-
Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination in vivo
-
Ouyang H., Nussenzweig A., Kurimasa A., Soares V.C., Li X., Cordon-Cardo C., Li W., Cheong N., Nussenzweig M., Iliakis G., Chen D.J., Li G.C. Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo. J. Exp. Med. 186:1997;921-929
-
(1997)
J. Exp. Med.
, vol.186
, pp. 921-929
-
-
Ouyang, H.1
Nussenzweig, A.2
Kurimasa, A.3
Soares, V.C.4
Li, X.5
Cordon-Cardo, C.6
Li, W.7
Cheong, N.8
Nussenzweig, M.9
Iliakis, G.10
Chen, D.J.11
Li, G.C.12
-
23
-
-
0029778191
-
Requirement for Ku80 in growth and immunoglobulin V(D)J recombination
-
Nussenzweig A., Chen C., da Costa Soares V., Sanchez M., Sokol K., Nussenzweig M.C., Li G.C. Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature. 382:1996;551-555
-
(1996)
Nature
, vol.382
, pp. 551-555
-
-
Nussenzweig, A.1
Chen, C.2
Da Costa Soares, V.3
Sanchez, M.4
Sokol, K.5
Nussenzweig, M.C.6
Li, G.C.7
-
24
-
-
0032417640
-
A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis
-
Gao Y., Sun Y., Frank K.M., Dikkes P., Fujiwara Y., Seidl K.J., Sekiguchi J.M., Rathbun G.A., Swat W., Wang J., Bronson R.T., Malynn B.A., Bryans M., Zhu C., Chaudhuri J., Davidson L., Ferrini R., Stamato T., Orkin S.H., Greenberg M.E., Alt F.W. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell. 95:1998;891-902
-
(1998)
Cell
, vol.95
, pp. 891-902
-
-
Gao, Y.1
Sun, Y.2
Frank, K.M.3
Dikkes, P.4
Fujiwara, Y.5
Seidl, K.J.6
Sekiguchi, J.M.7
Rathbun, G.A.8
Swat, W.9
Wang, J.10
Bronson, R.T.11
Malynn, B.A.12
Bryans, M.13
Zhu, C.14
Chaudhuri, J.15
Davidson, L.16
Ferrini, R.17
Stamato, T.18
Orkin, S.H.19
Greenberg, M.E.20
Alt, F.W.21
more..
-
25
-
-
0032511976
-
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV
-
Frank K.M., Sekiguchi J.M., Seidl K.J., Swat W., Rathbun G.A., Cheng H.L., Davidson L., Kangaloo L., Alt F.W. Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature. 396:1998;173-177
-
(1998)
Nature
, vol.396
, pp. 173-177
-
-
Frank, K.M.1
Sekiguchi, J.M.2
Seidl, K.J.3
Swat, W.4
Rathbun, G.A.5
Cheng, H.L.6
Davidson, L.7
Kangaloo, L.8
Alt, F.W.9
-
27
-
-
0035851181
-
Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase
-
Yannone S.M., Roy S., Chan D.W., Murphy M.B., Huang S., Campisi J., Chen D.J. Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase. J. Biol. Chem. 276:2001;38242-38248
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38242-38248
-
-
Yannone, S.M.1
Roy, S.2
Chan, D.W.3
Murphy, M.B.4
Huang, S.5
Campisi, J.6
Chen, D.J.7
-
28
-
-
0037166306
-
Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation
-
Karmakar P., Piotrowski J., Brosh R.M. Jr., Sommers J.A., Miller S.P., Cheng W.H., Snowden C.M., Ramsden D.A., Bohr V.A. Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation. J. Biol. Chem. 277:2002;18291-18302
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 18291-18302
-
-
Karmakar, P.1
Piotrowski, J.2
Brosh Jr., R.M.3
Sommers, J.A.4
Miller, S.P.5
Cheng, W.H.6
Snowden, C.M.7
Ramsden, D.A.8
Bohr, V.A.9
-
29
-
-
0037155703
-
Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination
-
Ma Y., Pannicke U., Schwarz K., Lieber M.R. Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell. 108:2002;781-794
-
(2002)
Cell
, vol.108
, pp. 781-794
-
-
Ma, Y.1
Pannicke, U.2
Schwarz, K.3
Lieber, M.R.4
-
30
-
-
3242879122
-
The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination
-
M. Lieber, The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination, DNA Repair 3 (2004) 817-826.
-
(2004)
DNA Repair
, vol.3
, pp. 817-826
-
-
Lieber, M.1
-
31
-
-
0032938747
-
Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining
-
Kurimasa A., Kumano S., Boubnov N.V., Story M.D., Tung C.S., Peterson S.R., Chen D.J. Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining. Mol. Cell Biol. 19:1999;3877-3884
-
(1999)
Mol. Cell Biol.
, vol.19
, pp. 3877-3884
-
-
Kurimasa, A.1
Kumano, S.2
Boubnov, N.V.3
Story, M.D.4
Tung, C.S.5
Peterson, S.R.6
Chen, D.J.7
-
33
-
-
0030009738
-
The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit
-
Chan D.W., Lees-Miller S.P. The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit. J. Biol. Chem. 271:1996;8936-8941
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 8936-8941
-
-
Chan, D.W.1
Lees-Miller, S.P.2
-
34
-
-
0037106180
-
Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks
-
Chan D.W., Chen B.P., Prithivirajsingh S., Kurimasa A., Story M.D., Qin J., Chen D.J. Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes Dev. 16:2002;2333-2338
-
(2002)
Genes Dev.
, vol.16
, pp. 2333-2338
-
-
Chan, D.W.1
Chen, B.P.2
Prithivirajsingh, S.3
Kurimasa, A.4
Story, M.D.5
Qin, J.6
Chen, D.J.7
-
35
-
-
2242484657
-
Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase
-
Douglas P., Sapkota G.P., Morrice N., Yu Y., Goodarzi A.A., Merkle D., Meek K., Alessi D.R., Lees-Miller S.P. Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase. Biochem. J. 368:2002;243-251
-
(2002)
Biochem. J.
, vol.368
, pp. 243-251
-
-
Douglas, P.1
Sapkota, G.P.2
Morrice, N.3
Yu, Y.4
Goodarzi, A.A.5
Merkle, D.6
Meek, K.7
Alessi, D.R.8
Lees-Miller, S.P.9
-
36
-
-
0037444375
-
Threonines 2638/2647 in DNA-PK are essential for cellular resistance to ionizing radiation
-
Soubeyrand S., Pope L., Pakuts B., Hache R.J. Threonines 2638/2647 in DNA-PK are essential for cellular resistance to ionizing radiation. Cancer Res. 63:2003;1198-1201
-
(2003)
Cancer Res.
, vol.63
, pp. 1198-1201
-
-
Soubeyrand, S.1
Pope, L.2
Pakuts, B.3
Hache, R.J.4
-
37
-
-
0033621392
-
Substrate specificities and identification of putative substrates of ATM kinase family members
-
Kim S.T., Lim D.S., Canman C.E., Kastan M.B. Substrate specificities and identification of putative substrates of ATM kinase family members. J. Biol. Chem. 274:1999;37538-37543
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 37538-37543
-
-
Kim, S.T.1
Lim, D.S.2
Canman, C.E.3
Kastan, M.B.4
-
38
-
-
0043133778
-
Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair
-
Ding Q., Reddy Y.V., Wang W., Woods T., Douglas P., Ramsden D.A., Lees-Miller S.P., Meek K. Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair. Mol. Cell Biol. 23:2003;5836-5848
-
(2003)
Mol. Cell Biol.
, vol.23
, pp. 5836-5848
-
-
Ding, Q.1
Reddy, Y.V.2
Wang, W.3
Woods, T.4
Douglas, P.5
Ramsden, D.A.6
Lees-Miller, S.P.7
Meek, K.8
-
39
-
-
0032574750
-
Homology-directed repair is a major double-strand break repair pathway in mammalian cells
-
Liang F., Han M., Romanienko P.J., Jasin M. Homology-directed repair is a major double-strand break repair pathway in mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 95:1998;5172-5177
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 5172-5177
-
-
Liang, F.1
Han, M.2
Romanienko, P.J.3
Jasin, M.4
-
40
-
-
0000391880
-
Evidence for DNA-PK-dependent and -independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle
-
Lee S.E., Mitchell R.A., Cheng A., Hendrickson E.A. Evidence for DNA-PK-dependent and -independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle. Mol. Cell Biol. 17:1997;1425-1433
-
(1997)
Mol. Cell Biol.
, vol.17
, pp. 1425-1433
-
-
Lee, S.E.1
Mitchell, R.A.2
Cheng, A.3
Hendrickson, E.A.4
-
41
-
-
0037133699
-
DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination
-
Allen C., Kurimasa A., Brenneman M.A., Chen D.J., Nickoloff J.A. DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination. Proc. Natl. Acad. Sci. U.S.A. 99:2002;3758-3763
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 3758-3763
-
-
Allen, C.1
Kurimasa, A.2
Brenneman, M.A.3
Chen, D.J.4
Nickoloff, J.A.5
-
42
-
-
0035977007
-
Genetic analysis of the DNA-dependent protein kinase reveals an inhibitory role of Ku in late S/G2 phase DNA double-strand break repair
-
Fukushima T., Takata M., Morrison C., Araki R., Fujimori A., Abe M., Tatsumi K., Jasin M., Dhar P.K., Sonoda E., Chiba T., Takeda S. Genetic analysis of the DNA-dependent protein kinase reveals an inhibitory role of Ku in late S/G2 phase DNA double-strand break repair. J. Biol. Chem. 276:2001;44413-44418
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 44413-44418
-
-
Fukushima, T.1
Takata, M.2
Morrison, C.3
Araki, R.4
Fujimori, A.5
Abe, M.6
Tatsumi, K.7
Jasin, M.8
Dhar, P.K.9
Sonoda, E.10
Chiba, T.11
Takeda, S.12
-
43
-
-
0038820065
-
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes
-
Furuta T., Takemura H., Liao Z.Y., Aune G.J., Redon C., Sedelnikova O.A., Pilch D.R., Rogakou E.P., Celeste A., Chen H.T., Nussenzweig A., Aladjem M.I., Bonner W.M., Pommier Y. Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes. J. Biol. Chem. 278:2003;20303-20312
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 20303-20312
-
-
Furuta, T.1
Takemura, H.2
Liao, Z.Y.3
Aune, G.J.4
Redon, C.5
Sedelnikova, O.A.6
Pilch, D.R.7
Rogakou, E.P.8
Celeste, A.9
Chen, H.T.10
Nussenzweig, A.11
Aladjem, M.I.12
Bonner, W.M.13
Pommier, Y.14
-
44
-
-
0033104517
-
Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes
-
Shao R.G., Cao C.X., Zhang H., Kohn K.W., Wold M.S., Pommier Y. Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes. Embo. J. 18:1999;1397-1406
-
(1999)
Embo. J.
, vol.18
, pp. 1397-1406
-
-
Shao, R.G.1
Cao, C.X.2
Zhang, H.3
Kohn, K.W.4
Wold, M.S.5
Pommier, Y.6
-
45
-
-
0035577796
-
Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase
-
Wang H., Guan J., Perrault A.R., Wang Y., Iliakis G. Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase. Cancer Res. 61:2001;8554-8563
-
(2001)
Cancer Res.
, vol.61
, pp. 8554-8563
-
-
Wang, H.1
Guan, J.2
Perrault, A.R.3
Wang, Y.4
Iliakis, G.5
-
46
-
-
0035374588
-
Protein phosphatases regulate DNA-dependent protein kinase activity
-
Douglas P., Moorhead G.B., Ye R., Lees-Miller S.P. Protein phosphatases regulate DNA-dependent protein kinase activity. J. Biol. Chem. 276:2001;18992-18998
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 18992-18998
-
-
Douglas, P.1
Moorhead, G.B.2
Ye, R.3
Lees-Miller, S.P.4
-
47
-
-
0842320995
-
DNA-PKcs function regulated specifically by protein phosphatases 5
-
Wechsler T., Chen B.P.C., Harper R., Marotomi-Yano K., Huang B.C.B., Meek K., Chen D.J., Wable M. DNA-PKcs function regulated specifically by protein phosphatases 5. Proc. Natl. Acad. Sci. U.S.A. 101:2004;1247-1252
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 1247-1252
-
-
Wechsler, T.1
Chen, B.P.C.2
Harper, R.3
Marotomi-Yano, K.4
Huang, B.C.B.5
Meek, K.6
Chen, D.J.7
Wable, M.8
-
48
-
-
0037159220
-
The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation
-
Merkle D., Douglas P., Moorhead G.B., Leonenko Z., Yu Y., Cramb D., Bazett-Jones D.P., Lees-Miller S.P. The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation. Biochemistry. 41:2002;12706-12714
-
(2002)
Biochemistry
, vol.41
, pp. 12706-12714
-
-
Merkle, D.1
Douglas, P.2
Moorhead, G.B.3
Leonenko, Z.4
Yu, Y.5
Cramb, D.6
Bazett-Jones, D.P.7
Lees-Miller, S.P.8
-
49
-
-
0142240342
-
BRCT repeats as phosphopeptide-binding modules involved in protein targeting
-
Manke I.A., Lowery D.M., Nguyen A., Yaffe M.B. BRCT repeats as phosphopeptide-binding modules involved in protein targeting. Science. 302:2003;636-639
-
(2003)
Science
, vol.302
, pp. 636-639
-
-
Manke, I.A.1
Lowery, D.M.2
Nguyen, A.3
Yaffe, M.B.4
-
50
-
-
0346101743
-
Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains
-
Rodriguez M., Yu X., Chen J., Songyang Z. Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains. J. Biol. Chem. 278:2003;52914-52918
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 52914-52918
-
-
Rodriguez, M.1
Yu, X.2
Chen, J.3
Songyang, Z.4
-
51
-
-
0142147272
-
The BRCT domain is a phospho-protein binding domain
-
Yu X., Chini C.C., He M., Mer G., Chen J. The BRCT domain is a phospho-protein binding domain. Science. 302:2003;639-642
-
(2003)
Science
, vol.302
, pp. 639-642
-
-
Yu, X.1
Chini, C.C.2
He, M.3
Mer, G.4
Chen, J.5
-
52
-
-
0034597794
-
Telomere states and cell fates
-
Blackburn E.H. Telomere states and cell fates. Nature. 408:2000;53-56
-
(2000)
Nature
, vol.408
, pp. 53-56
-
-
Blackburn, E.H.1
-
54
-
-
0032536861
-
Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing
-
Boulton S.J., Jackson S.P. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. Embo. J. 17:1998;1819-1828
-
(1998)
Embo. J.
, vol.17
, pp. 1819-1828
-
-
Boulton, S.J.1
Jackson, S.P.2
-
55
-
-
0033597820
-
Ku binds telomeric DNA in vitro
-
Bianchi A., de Lange T. Ku binds telomeric DNA in vitro. J. Biol. Chem. 274:1999;21223-21227
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 21223-21227
-
-
Bianchi, A.1
De Lange, T.2
-
57
-
-
0035822641
-
Effects of DNA non-homologous end-joining factors on telomere length and chromosomal stability in mammalian cells
-
d'Adda di Fagagna F., Hande M.P., Tong W.M., Roth D., Lansdorp P.M., Wang Z.Q., Jackson S.P. Effects of DNA non-homologous end-joining factors on telomere length and chromosomal stability in mammalian cells. Curr. Biol. 11:2001;1192-1196
-
(2001)
Curr. Biol.
, vol.11
, pp. 1192-1196
-
-
D'Adda Di Fagagna, F.1
Hande, M.P.2
Tong, W.M.3
Roth, D.4
Lansdorp, P.M.5
Wang, Z.Q.6
Jackson, S.P.7
-
58
-
-
0034669104
-
Ku acts in a unique way at the mammalian telomere to prevent end joining
-
Hsu H.L., Gilley D., Galande S.A., Hande M.P., Allen B., Kim S.H., Li G.C., Campisi J., Kohwi-Shigematsu T., Chen D.J. Ku acts in a unique way at the mammalian telomere to prevent end joining. Genes Dev. 14:2000;2807-2812
-
(2000)
Genes Dev.
, vol.14
, pp. 2807-2812
-
-
Hsu, H.L.1
Gilley, D.2
Galande, S.A.3
Hande, M.P.4
Allen, B.5
Kim, S.H.6
Li, G.C.7
Campisi, J.8
Kohwi-Shigematsu, T.9
Chen, D.J.10
-
59
-
-
0033592950
-
DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes
-
Bailey S.M., Meyne J., Chen D.J., Kurimasa A., Li G.C., Lehnert B.E., Goodwin E.H. DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes. Proc. Natl. Acad. Sci. U.S.A. 96:1999;14899-14904
-
(1999)
Proc. Natl. Acad. Sci. U.S.A.
, vol.96
, pp. 14899-14904
-
-
Bailey, S.M.1
Meyne, J.2
Chen, D.J.3
Kurimasa, A.4
Li, G.C.5
Lehnert, B.E.6
Goodwin, E.H.7
-
60
-
-
0034280093
-
Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang
-
Samper E., Goytisolo F.A., Slijepcevic P., van Buul P.P., Blasco M.A. Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang. EMBO Rep. 1:2000;244-252
-
(2000)
EMBO Rep.
, vol.1
, pp. 244-252
-
-
Samper, E.1
Goytisolo, F.A.2
Slijepcevic, P.3
Van Buul, P.P.4
Blasco, M.A.5
-
61
-
-
0035909929
-
DNA-PKcs is critical for telomere capping
-
Gilley D., Tanaka H., Hande M.P., Kurimasa A., Li G.C., Oshimura M., Chen D.J. DNA-PKcs is critical for telomere capping. Proc. Natl. Acad. Sci. U.S.A. 98:2001;15084-15088
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 15084-15088
-
-
Gilley, D.1
Tanaka, H.2
Hande, M.P.3
Kurimasa, A.4
Li, G.C.5
Oshimura, M.6
Chen, D.J.7
-
63
-
-
0035023139
-
The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang
-
Goytisolo F.A., Samper E., Edmonson S., Taccioli G.E., Blasco M.A. The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang. Mol. Cell Biol. 21:2001;3642-3651
-
(2001)
Mol. Cell Biol.
, vol.21
, pp. 3642-3651
-
-
Goytisolo, F.A.1
Samper, E.2
Edmonson, S.3
Taccioli, G.E.4
Blasco, M.A.5
-
64
-
-
0037112834
-
Functional interaction between DNA-PKcs and telomerase in telomere length maintenance
-
Espejel S., Franco S., Sgura A., Gae D., Bailey S.M., Taccioli G.E., Blasco M.A. Functional interaction between DNA-PKcs and telomerase in telomere length maintenance. Embo. J. 21:2002;6275-6287
-
(2002)
Embo. J.
, vol.21
, pp. 6275-6287
-
-
Espejel, S.1
Franco, S.2
Sgura, A.3
Gae, D.4
Bailey, S.M.5
Taccioli, G.E.6
Blasco, M.A.7
-
65
-
-
0036566036
-
Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres
-
Espejel S., Franco S., Rodriguez-Perales S., Bouffler S.D., Cigudosa J.C., Blasco M.A. Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres. Embo. J. 21:2002;2207-2219
-
(2002)
Embo. J.
, vol.21
, pp. 2207-2219
-
-
Espejel, S.1
Franco, S.2
Rodriguez-Perales, S.3
Bouffler, S.D.4
Cigudosa, J.C.5
Blasco, M.A.6
-
66
-
-
0029972806
-
P53: Puzzle and paradigm
-
Ko L.J., Prives C. p53: puzzle and paradigm. Genes. Dev. 10:1996;1054-1072
-
(1996)
Genes. Dev.
, vol.10
, pp. 1054-1072
-
-
Ko, L.J.1
Prives, C.2
-
67
-
-
0032508608
-
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
-
Canman C.E., Lim D.S., Cimprich K.A., Taya Y., Tamai K., Sakaguchi K., Appella E., Kastan M.B., Siliciano J.D. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science. 281:1998;1677-1679
-
(1998)
Science
, vol.281
, pp. 1677-1679
-
-
Canman, C.E.1
Lim, D.S.2
Cimprich, K.A.3
Taya, Y.4
Tamai, K.5
Sakaguchi, K.6
Appella, E.7
Kastan, M.B.8
Siliciano, J.D.9
-
68
-
-
0032508504
-
Enhanced phosphorylation of p53 by ATM in response to DNA damage
-
Banin S., Moyal L., Shieh S., Taya Y., Anderson C.W., Chessa L., Smorodinsky N.I., Prives C., Reiss Y., Shiloh Y., Ziv Y. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science. 281:1998;1674-1677
-
(1998)
Science
, vol.281
, pp. 1674-1677
-
-
Banin, S.1
Moyal, L.2
Shieh, S.3
Taya, Y.4
Anderson, C.W.5
Chessa, L.6
Smorodinsky, N.I.7
Prives, C.8
Reiss, Y.9
Shiloh, Y.10
Ziv, Y.11
-
69
-
-
0026523766
-
Phosphorylation sites in the amino-terminal region of mouse p53
-
Wang Y., Eckhart W. Phosphorylation sites in the amino-terminal region of mouse p53. Proc. Natl. Acad. Sci. U.S.A. 89:1992;4231-4235
-
(1992)
Proc. Natl. Acad. Sci. U.S.A.
, vol.89
, pp. 4231-4235
-
-
Wang, Y.1
Eckhart, W.2
-
70
-
-
0026687883
-
Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53
-
Lees-Miller S.P., Sakaguchi K., Ullrich S.J., Appella E., Anderson C.W. Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol. Cell Biol. 12:1992;5041-5049
-
(1992)
Mol. Cell Biol.
, vol.12
, pp. 5041-5049
-
-
Lees-Miller, S.P.1
Sakaguchi, K.2
Ullrich, S.J.3
Appella, E.4
Anderson, C.W.5
-
71
-
-
0029858143
-
V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors
-
Guidos C.J., Williams C.J., Grandal I., Knowles G., Huang M.T., Danska J.S. V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors. Genes Dev. 10:1996;2038-2054
-
(1996)
Genes Dev.
, vol.10
, pp. 2038-2054
-
-
Guidos, C.J.1
Williams, C.J.2
Grandal, I.3
Knowles, G.4
Huang, M.T.5
Danska, J.S.6
-
72
-
-
0030446964
-
P53 induction, cell cycle checkpoints, and apoptosis in DNAPK-deficient scid mice
-
Gurley K.E., Kemp C.J. p53 induction, cell cycle checkpoints, and apoptosis in DNAPK-deficient scid mice. Carcinogenesis. 17:1996;2537-2542
-
(1996)
Carcinogenesis
, vol.17
, pp. 2537-2542
-
-
Gurley, K.E.1
Kemp, C.J.2
-
73
-
-
0029941651
-
P53-Dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts
-
Huang L.C., Clarkin K.C., Wahl G.M. p53-Dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts. Cancer Res. 56:1996;2940-2944
-
(1996)
Cancer Res.
, vol.56
, pp. 2940-2944
-
-
Huang, L.C.1
Clarkin, K.C.2
Wahl, G.M.3
-
74
-
-
0031025079
-
DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage
-
Rathmell W.K., Kaufmann W.K., Hurt J.C., Byrd L.L., Chu G. DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage. Cancer Res. 57:1997;68-74
-
(1997)
Cancer Res.
, vol.57
, pp. 68-74
-
-
Rathmell, W.K.1
Kaufmann, W.K.2
Hurt, J.C.3
Byrd, L.L.4
Chu, G.5
-
75
-
-
0032514485
-
DNA-dependent protein kinase acts upstream of p53 in response to DNA damage
-
Woo R.A., McLure K.G., Lees-Miller S.P., Rancourt D.E., Lee P.W. DNA-dependent protein kinase acts upstream of p53 in response to DNA damage. Nature. 394:1998;700-704
-
(1998)
Nature
, vol.394
, pp. 700-704
-
-
Woo, R.A.1
McLure, K.G.2
Lees-Miller, S.P.3
Rancourt, D.E.4
Lee, P.W.5
-
76
-
-
0033532174
-
The ability of p53 to activate downstream genes p21(WAF1/cip1) and MDM2, and cell cycle arrest following DNA damage is delayed and attenuated in scid cells deficient in the DNA-dependent protein kinase
-
Kachnic L.A., Wu B., Wunsch H., Mekeel K.L., DeFrank J.S., Tang W., Powell S.N. The ability of p53 to activate downstream genes p21(WAF1/cip1) and MDM2, and cell cycle arrest following DNA damage is delayed and attenuated in scid cells deficient in the DNA-dependent protein kinase. J. Biol. Chem. 274:1999;13111-13117
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 13111-13117
-
-
Kachnic, L.A.1
Wu, B.2
Wunsch, H.3
Mekeel, K.L.4
Defrank, J.S.5
Tang, W.6
Powell, S.N.7
-
77
-
-
17444370101
-
Enhanced phosphorylation of p53 serine 18 following DNA damage in DNA-dependent protein kinase catalytic subunit-deficient cells
-
Araki R., Fukumura R., Fujimori A., Taya Y., Shiloh Y., Kurimasa A., Burma S., Li G.C., Chen D.J., Sato K., Hoki Y., Tatsumi K., Abe M. Enhanced phosphorylation of p53 serine 18 following DNA damage in DNA-dependent protein kinase catalytic subunit-deficient cells. Cancer Res. 59:1999;3543-3546
-
(1999)
Cancer Res.
, vol.59
, pp. 3543-3546
-
-
Araki, R.1
Fukumura, R.2
Fujimori, A.3
Taya, Y.4
Shiloh, Y.5
Kurimasa, A.6
Burma, S.7
Li, G.C.8
Chen, D.J.9
Sato, K.10
Hoki, Y.11
Tatsumi, K.12
Abe, M.13
-
78
-
-
0033546182
-
DNA-dependent protein kinase-independent activation of p53 in response to DNA damage
-
Burma S., Kurimasa A., Xie G., Taya Y., Araki R., Abe M., Crissman H.A., Ouyang H., Li G.C., Chen D.J. DNA-dependent protein kinase-independent activation of p53 in response to DNA damage. J. Biol. Chem. 274:1999;17139-17143
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 17139-17143
-
-
Burma, S.1
Kurimasa, A.2
Xie, G.3
Taya, Y.4
Araki, R.5
Abe, M.6
Crissman, H.A.7
Ouyang, H.8
Li, G.C.9
Chen, D.J.10
-
79
-
-
0033167979
-
DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage
-
Jimenez G.S., Bryntesson F., Torres-Arzayus M.I., Priestley A., Beeche M., Saito S., Sakaguchi K., Appella E., Jeggo P.A., Taccioli G.E., Wahl G.M., Hubank M. DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage. Nature. 400:1999;81-83
-
(1999)
Nature
, vol.400
, pp. 81-83
-
-
Jimenez, G.S.1
Bryntesson, F.2
Torres-Arzayus, M.I.3
Priestley, A.4
Beeche, M.5
Saito, S.6
Sakaguchi, K.7
Appella, E.8
Jeggo, P.A.9
Taccioli, G.E.10
Wahl, G.M.11
Hubank, M.12
-
80
-
-
0036270993
-
DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: Fail-safe protection against carcinogenesis
-
Bernstein C., Bernstein H., Payne C.M., Garewal H. DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis. Mutat. Res. 511:2002;145-178
-
(2002)
Mutat. Res.
, vol.511
, pp. 145-178
-
-
Bernstein, C.1
Bernstein, H.2
Payne, C.M.3
Garewal, H.4
-
81
-
-
0031795922
-
Inactivation of DNA-dependent protein kinase by protein kinase Cdelta: Implications for apoptosis
-
Bharti A., Kraeft S.K., Gounder M., Pandey P., Jin S., Yuan Z.M., Lees-Miller S.P., Weichselbaum R., Weaver D., Chen L.B., Kufe D., Kharbanda S. Inactivation of DNA-dependent protein kinase by protein kinase Cdelta: implications for apoptosis. Mol. Cell Biol. 18:1998;6719-6728
-
(1998)
Mol. Cell Biol.
, vol.18
, pp. 6719-6728
-
-
Bharti, A.1
Kraeft, S.K.2
Gounder, M.3
Pandey, P.4
Jin, S.5
Yuan, Z.M.6
Lees-Miller, S.P.7
Weichselbaum, R.8
Weaver, D.9
Chen, L.B.10
Kufe, D.11
Kharbanda, S.12
-
82
-
-
12944316615
-
The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest
-
Wang S., Guo M., Ouyang H., Li X., Cordon-Cardo C., Kurimasa A., Chen D.J., Fuks Z., Ling C.C., Li G.C. The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest. Proc. Natl. Acad. Sci. U.S.A. 97:2000;1584-1588
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 1584-1588
-
-
Wang, S.1
Guo, M.2
Ouyang, H.3
Li, X.4
Cordon-Cardo, C.5
Kurimasa, A.6
Chen, D.J.7
Fuks, Z.8
Ling, C.C.9
Li, G.C.10
-
83
-
-
0037124322
-
DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53
-
Woo R.A., Jack M.T., Xu Y., Burma S., Chen D.J., Lee P.W. DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53. Embo. J. 21:2002;3000-3008
-
(2002)
Embo. J.
, vol.21
, pp. 3000-3008
-
-
Woo, R.A.1
Jack, M.T.2
Xu, Y.3
Burma, S.4
Chen, D.J.5
Lee, P.W.6
-
84
-
-
0028131554
-
Transcriptional activation by p53 correlates with suppression of growth but not transformation
-
Crook T., Marston N.J., Sara E.A., Vousden K.H. Transcriptional activation by p53 correlates with suppression of growth but not transformation. Cell. 79:1994;817-827
-
(1994)
Cell
, vol.79
, pp. 817-827
-
-
Crook, T.1
Marston, N.J.2
Sara, E.A.3
Vousden, K.H.4
-
85
-
-
0032499210
-
Essential role of mouse telomerase in highly proliferative organs
-
Lee H.W., Blasco M.A., Gottlieb G.J., Horner J.W., 2nd C.W., Greider R.A., DePinho Essential role of mouse telomerase in highly proliferative organs. Nature. 392:1998;569-574
-
(1998)
Nature
, vol.392
, pp. 569-574
-
-
Lee, H.W.1
Blasco, M.A.2
Gottlieb, G.J.3
Horner, J.W.4
II, C.W.5
Greider, R.A.6
Depinho7
-
86
-
-
0034025078
-
The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinase
-
Jhappan C., Yusufzai T.M., Anderson S., Anver M.R., Merlino G. The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinase. Mol. Cell Biol. 20:2000;4075-4083
-
(2000)
Mol. Cell Biol.
, vol.20
, pp. 4075-4083
-
-
Jhappan, C.1
Yusufzai, T.M.2
Anderson, S.3
Anver, M.R.4
Merlino, G.5
-
87
-
-
8944241298
-
DNA-dependent protein kinase catalytic subunit: A target for an ICE-like protease in apoptosis
-
Song Q., Lees-Miller S.P., Kumar S., Zhang Z., Chan D.W., Smith G.C., Jackson S.P., Alnemri E.S., Litwack G., Khanna K.K., Lavin M.F. DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis. Embo. J. 15:1996;3238-3246
-
(1996)
Embo. J.
, vol.15
, pp. 3238-3246
-
-
Song, Q.1
Lees-Miller, S.P.2
Kumar, S.3
Zhang, Z.4
Chan, D.W.5
Smith, G.C.6
Jackson, S.P.7
Alnemri, E.S.8
Litwack, G.9
Khanna, K.K.10
Lavin, M.F.11
-
88
-
-
0031093496
-
The DNA-dependent protein kinase catalytic subunit (p460) is cleaved during Fas-mediated apoptosis in Jurkat cells
-
McConnell K.R., Dynan W.S., Hardin J.A. The DNA-dependent protein kinase catalytic subunit (p460) is cleaved during Fas-mediated apoptosis in Jurkat cells. J. Immunol. 158:1997;2083-2089
-
(1997)
J. Immunol.
, vol.158
, pp. 2083-2089
-
-
McConnell, K.R.1
Dynan, W.S.2
Hardin, J.A.3
-
89
-
-
0030666222
-
Innate immunity: The virtues of a non-clonal system of recognition
-
Medzhitov R., Janeway C.A. Jr. Innate immunity: the virtues of a non-clonal system of recognition. Cell. 91:1997;295-298
-
(1997)
Cell
, vol.91
, pp. 295-298
-
-
Medzhitov, R.1
Janeway Jr., C.A.2
-
90
-
-
0031050034
-
Innate immunity: Impact on the adaptive immune response
-
Medzhitov R., Janeway C.A. Jr. Innate immunity: impact on the adaptive immune response. Curr. Opin. Immunol. 9:1997;4-9
-
(1997)
Curr. Opin. Immunol.
, vol.9
, pp. 4-9
-
-
Medzhitov, R.1
Janeway Jr., C.A.2
-
91
-
-
0029984358
-
CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma
-
Klinman D.M., Yi A.K., Beaucage S.L., Conover J., Krieg A.M. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proc. Natl. Acad. Sci. U.S.A. 93:1996;2879-2883
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 2879-2883
-
-
Klinman, D.M.1
Yi, A.K.2
Beaucage, S.L.3
Conover, J.4
Krieg, A.M.5
-
92
-
-
0032995849
-
Bacterial CpG DNA activates immune cells to signal infectious danger
-
Wagner H. Bacterial CpG DNA activates immune cells to signal infectious danger. Adv. Immunol. 73:1999;329-368
-
(1999)
Adv. Immunol.
, vol.73
, pp. 329-368
-
-
Wagner, H.1
-
93
-
-
0033637315
-
DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA
-
Chu W., Gong X., Li Z., Takabayashi K., Ouyang H., Chen Y., Lois A., Chen D.J., Li G.C., Karin M., Raz E. DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA. Cell. 103:2000;909-918
-
(2000)
Cell
, vol.103
, pp. 909-918
-
-
Chu, W.1
Gong, X.2
Li, Z.3
Takabayashi, K.4
Ouyang, H.5
Chen, Y.6
Lois, A.7
Chen, D.J.8
Li, G.C.9
Karin, M.10
Raz, E.11
-
94
-
-
0037099629
-
Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation
-
Ishii K.J., Takeshita F., Gursel I., Gursel M., Conover J., Nussenzweig A., Klinman D.M. Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation. J. Exp. Med. 196:2002;269-274
-
(2002)
J. Exp. Med.
, vol.196
, pp. 269-274
-
-
Ishii, K.J.1
Takeshita, F.2
Gursel, I.3
Gursel, M.4
Conover, J.5
Nussenzweig, A.6
Klinman, D.M.7
-
95
-
-
0037022639
-
Interferon regulatory factor-3 is an in vivo target of DNA-PK
-
Karpova A.Y., Trost M., Murray J.M., Cantley L.C., Howley P.M. Interferon regulatory factor-3 is an in vivo target of DNA-PK. Proc. Natl. Acad. Sci. U.S.A. 99:2002;2818-2823
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 2818-2823
-
-
Karpova, A.Y.1
Trost, M.2
Murray, J.M.3
Cantley, L.C.4
Howley, P.M.5
-
96
-
-
0032015647
-
Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo
-
Wathelet M.G., Lin C.H., Parekh B.S., Ronco L.V., Howley P.M., Maniatis T. Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo. Mol. Cell. 1:1998;507-518
-
(1998)
Mol. Cell
, vol.1
, pp. 507-518
-
-
Wathelet, M.G.1
Lin, C.H.2
Parekh, B.S.3
Ronco, L.V.4
Howley, P.M.5
Maniatis, T.6
-
97
-
-
0032861343
-
Megabase chromatin domains involved in DNA double-strand breaks in vivo
-
Rogakou E.P., Boon C., Redon C., Bonner W.M. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J. Cell Biol. 146:1999;905-916
-
(1999)
J. Cell Biol.
, vol.146
, pp. 905-916
-
-
Rogakou, E.P.1
Boon, C.2
Redon, C.3
Bonner, W.M.4
-
98
-
-
0035972194
-
Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways
-
Rappold I., Iwabuchi K., Date T., Chen J. Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways. J. Cell Biol. 153:2001;613-620
-
(2001)
J. Cell Biol.
, vol.153
, pp. 613-620
-
-
Rappold, I.1
Iwabuchi, K.2
Date, T.3
Chen, J.4
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