Role of caspases in the regulation of apoptotic pancreatic islet beta-cells death

Journal of Cellular Physiology

Volumn 200, Issue 2, 2004, Pages 177-200

  Hui, Hongxiang ^a,b   Dotta, Francesco ^c   Di Mario, Umberto ^c   Perfetti, Riccardo ^a,b  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE;

APOPTOSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SPECIFICITY; CELL STRUCTURE; DIABETES MELLITUS; ENZYME ACTIVATION; HOMEOSTASIS; HUMAN; INNER CELL MASS; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CASPASES; DIABETES MELLITUS; ENZYME ACTIVATION; HUMANS; ISLETS OF LANGERHANS; MODELS, BIOLOGICAL; PANCREAS;

EID: 3042771527     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.20021     Document Type: Review

References (252)

1. Alheim K, Bartfai T. 1998. The interleukin-1 system: Receptors, ligands, and ICE in the brain and their involvement in the fever response. Ann NY Acad Sci 840:51-58.
2. Allison J, Thomas H, Beck D, Brady JL, Lew AM, Elefanty A, Kosaka H, Kay TW, Huang DC, Strasser A. 2000. Transgenic overexpression of human Bcl-2 in islet beta-cells inhibits apoptosis but does not prevent autoimmune destruction. Int Immunol 12:9-17.
3. Ambrosini G, Adida C, Altieri DC. 1997. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med 3:917-921.
4. Aschoff AP, Gunther E, Jirikowski GF. 2000. Tissue transglutaminase in the small intestine of the mouse as a marker for apoptotic cells. Colocalization with DNA fragmentation. Histochem Cell Biol 113: 313-317.
5. Augstein P, Elefanty AG, Allison J, Harrison LC. 1998. Apoptosis and beta-cell destruction in pancreatic islets of NOD mice with spontaneous and cyclophosphamide-accelerated diabetes. Diabetologia 41:1381-1388.
6. Augstein P, Dunger A, Salzsieder C, Heinke P, Kubernath R, Bahr J, Fischer U, Rettig R, Salzsieder E. 2002. Cell surface trafficking of Fas in NIT-1 cells and dissection of surface and total Fas expression. Biochem Biophys Res Commun 290:443-451.
7. Bai JZ, Saafi EL, Zhang S, Cooper GJ. 1999. Role of Ca2+ in apoptosis evoked by human amylin in pancreatic islet beta-cells. Biochem J 343:53-61.
8. Bailly C. 2000. Topoisomerase I poisons and suppressors as anticancer drugs. Curr Med Chem 7:39-58.
9. Baker MS, Chen X, Cao XC, Kaufman DB. 2001. Expression of a dominant negative inhibitor of NF-kappaB protects MIN6 beta-cells from cytokine-induced apoptosis. J Surg Res 97:117-122.
10. Barry M, Heibein JA, Pinkoski MJ, Lee SF, Moyer RW, Green DR, Bleackley RC. 2000. Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving bid. Mol Cell Biol 20:3781-3794.
11. Beil M, Leser J, Lutz MP, Gukovskaya A, Seufferlein T, Lynch G, Pandol SJ, Adler G. 2002. Caspase 8-mediated cleavage of plectin precedes F-actin breakdown in acinar cells during pancreatitis. Am J Physiol Gastrointest Liver Physiol 282:G450-G460.
12. Biarnes M, Montolio M, Nacher V, Raurell M, Soler J, Montanya E. 2002. Beta-cell death and mass in syngeneically transplanted islets exposed to short- and long-term hyperglycemia. Diabetes 51: 66-72.
13. Boldin MP, Goncharov TM, Goltsev YV, Wallach D. 1996. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell 85:803-815.
14. Boulares AH, Yakovlev AG, Ivanova V, Stoica BA, Wang G, Iyer S, Smulson M. 1999. Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells. J Biol Chem 274:22932-22940.
15. Budihardjo I, Oliver H, Lutter M, Luo X, Wang X. 1999. Biochemical pathways of caspase activation during apoptosis. Ann Rev Cell Dev Biol 15:269-290.
16. Bungay PJ, Owen RA, Coutts IC, Griffin M. 1986. A role for transglutaminase in glucose-stimulated insulin release from the pancreatic beta-cell. Biochem J 235:269-278.
17. Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, Reed JC. 1998. Regulation of cell death protease caspase-9 by phosphorylation. Science 282:1318-1321.
18. Cecconi F. 1999. Apaf1 and the apoptotic machinery. Cell Death Differ 6:1087-1098.
19. Cerasi E, Kaiser N, Leibowitz G. 2000. Type 2 diabetes and beta-cells apoptosis. Diabetes Metab 26(Suppl 3):13-16.
20. Chang HY, Yang X. 2000. Proteases for cell suicide: Functions and regulation of caspases. Microbiol Mol Biol Rev 64:821-846.
21. Chao DT, Korsmeyer SJ. 1998. BCL-2 family: Regulators of cell death. Annu Rev Immunol 16:395-419.
22. Chen M, Wang J. 2002. Initiator caspases in apoptosis signaling pathways. Apoptosis 7:313-319.
23. Chen CY, Juo P, Liou JS, Li CQ, Yu Q, Blenis J, Faller DV. 2001. The recruitment of Fas-associated death domain/caspase-8 in Ras-induced apoptosis. Cell Growth Differ 12:297-306.
24. Chinnaiyan AM, O'Rourke K, Tewari M, Dixit VM. 1995. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81:505-512.
25. Chou JJ, Matsuo H, Duan H, Wagner G. 1998. Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. Cell 94:171-180.
26. Cohen GM. 1997. Caspases: The executioners of apoptosis. Biochem J 326:1-16.
27. Contreras JL, Bilbao G, Smyth C, Eckhoff DE, Xiang XL, Jenkins S, Cartner S, Curiel DT, Thomas FT, Thomas JM. 2001a. Gene transfer of the Bcl-2 gene confers cytoprotection to isolated adult porcine pancreatic islets exposed to xenoreactive antibodies and complement. Surgery 130:166-174.
28. Contreras JL, Bilbao G, Smyth CA, Jiang XL, Eckhoff DE, Jenkins SM, Thomas FT, Curiel DT, Thomas JM. 2001b. Cytoprotection of pancreatic islets before and soon after transplantation by gene transfer of the anti-apoptotic Bcl-2 gene. Transplantation 71:1015-1023.
29. Contreras JL, Smyth CA, Bilbao G, Young CJ, Thompson JA, Eckhoff DE. 2002a. 17beta-Estradiol protects isolated human pancreatic islets against proinflammatory cytokine-induced cell death: Molecular mechanisms and islet functionality. Transplantation 74:1252-1259.
30. Contreras JL, Smyth CA, Bilbao G, Young CJ, Thompson JA, Eckhoff DE. 2002b. Simvastatin induces activation of the serine-threonine protein kinase AKT and increases survival of isolated human pancreatic islets. Transplantation 74:1063-1069.
31. Cottet S, Dupraz P, Hamburger F, Dolci W, Jaquet M, Thorens B. 2002. cFLIP protein prevents tumor necrosis factor-alpha-mediated induction of caspase-8-dependent apoptosis in insulin-secreting betaTc-Tet cells. Diabetes 51:1805-1814.
32. Darby IA, Bisucci T, Hewitson TD, MacLellan DG. 1997. Apoptosis is increased in a model of diabetes-impaired wound healing in genetically diabetic mice. Int J Biochem Cell Biol 29:191-200.
33. Degenhardt K, Sundararajan R, Lindsten T, Thompson C, White E. 2002. Bax and Bak independently promote cytochrome C release from mitochondria. J Biol Chem 277:14127-14134.
34. Deschesnes RG, Huot J, Valerie K, Landry J. 2001. Involvement of p38 in apoptosis-associated membrane blebbing and nuclear condensation. Mol Biol Cell 12:1569-1582.
35. Deveraux QL, Roy N, Stennicke HR, Van Arsdale T, Zhou Q, Srinivasula SM, Alnemri ES, Salvesen GS, Reed JC. 1998. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J 17:2215-2223.
36. Dharnidharka VR, Van Patten Y, Bahjat FR, Clare-Salzler M. 2002. Fas stimulation results in selective islet infiltrate apoptosis in situ and reversal of diabetes. Ann NY Acad Sci 958:160-162.
37. Dobrucki J, Darzynkiewicz Z. 2001. Chromatin condensation and sensitivity of DNA in situ to denaturation during cell cycle and apoptosis - A confocal microscopy study. Micron 32:645-652.
38. Donath MY, Gross DJ, Cerasi E, Kaiser N. 1999. Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes. Diabetes 48:738-744.
39. Drachenberg CB, Klassen DK, Weir MR, Wiland A, Fink JC, Bartlett ST, Cangro CB, Blahut S, Papadimitriou JC. 1999. Islet cell damage associated with tacrolimus and cyclosporine: Morphological features in pancreas allograft biopsies and clinical correlation. Transplantation 68:396-402.
40. Duchen MR. 2000. Mitochondria and calcium: From cell signalling to cell death. J Physiol 529:57-68.
41. Dvorcakova M, Macejova D, Pallet V, Higueret P, Vasson MP, Rock E, Brtko J. 2002. Transglutamines and endocrine system (minireview). Endocr Regul 36:31-36.
42. Eizirik DL, Mandrup-Poulsen T. 2001. A choice of death-The signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 44:2115-2133.
43. Emoto K, Toyama-Sorimachi N, Karasuyama H, Inoue K, Umeda M. 1997. Exposure of phosphatidylethanolamine on the surface of apoptotic cells. Exp Cell Res 232:430-434.
44. Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S. 1998. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391:43-50.
45. Fabisiak JP, Tyurina YY, Tyurin VA, Lazo JS, Kagan VE. 1998. Random versus selective membrane phospholipid oxidation in apoptosis: Role of phosphatidylserine. Biochemistry 37:13781-13790.
46. Fantuzzi G, Dinarello CA. 1996. The inflammatory response in interleukin-1 beta-deficient mice: Comparison with other cytokine-related knock-out mice. J Leukoc Biol 59:489-493.
47. Farilla L, Hui H, Perfetti R. 2002. GLP-1 promoter growth and inhibit apoptosis of beta-cell in Zucker diabetic rat. Endocrinology 143: 4397-4408.
48. Fattman CL, Delach SM, Dou QP, Johnson DE. 2001. Sequential two-step cleavage of the retinoblastoma protein by caspase-3/-7 during etoposide-induced apoptosis. Oncogene 20:2918-2926.
49. Federici M, Hribal M, Perego L, Ranalli M, Caradonna Z, Perego C, Usellini L, Nano R, Bonini P, Bertuzzi F, Marlier LN, Davalli AM, Carandente O, Pontiroli AE, Melino G, Marchetti P, Lauro R, Sesti G, Folli F. 2001. High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: A potential role for regulation of specific Bcl family genes toward an apoptotic cell death program. Diabetes 50:1290-1301.
50. Fernandes-Alnemri T, Litwack G, Alnemri ES. 1994. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. J Biol Chem 269:30761-30764.
51. Fujita E, Egashira J, Urase K, Kuida K, Momoi T. 2001. Caspase-9 processing by caspase-3 via a feedback amplification loop in vivo. Cell Death Differ 8:335-344.
52. Fukagawa NK, Li M, Timblin CR, Mossman BT. 2001. Modulation of cell injury and survival by high glucose and advancing age. Free Radic Biol Med 31:1560-1569.
53. Garratt KN, Brady PA, Hassinger NL, Grill DE, Terzic A, Holmes DR. 1999. Sulfonylurea drugs increase early mortality in patients with diabetes mellitus after direct angioplasty for acute myocardial infarction. J Am Coll Cardiol 33:119-124.
54. George M, Ayuso E, Casellas A, Costa C, Devedjian JC, Bosch F. 2002. Beta-cells expression of IGF-I leads to recovery from type 1 diabetes. J Clin Invest 109:1153-1163.
55. Giannoukakis N, Rudert WA, Trucco M, Robbins PD. 2000a. Protection of human islets from the effects of interleukin-1beta by adenoviral gene transfer of an Ikappa B repressor. J Biol Chem 275:36509-36513.
56. Giannoukakis N, Mi Z, Rudert WA, Gambotto A, Trucco M, Robbins P. 2000b. Prevention of beta-cells dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor I. Gene Ther 7:2015-2022.
57. Gochuico BR, Zhang J, Ma BY, Marshak-Rothstein A, Fine A. 2000. TRAIL expression in vascular smooth muscle. Am J Physiol Lung Cell Mol Physiol 278:L1045-L1050.
58. Gomez-Angelats M, Cidlowski JA. 2001. Protein kinase C regulates FADD recruitment and death-inducing signaling complex formation in Fas/CD95-induced apoptosis. J Biol Chem 276:44944-54492.
59. Gomis R, Arbos MA, Sener A, Malaisse WJ. 1986. Glucose-induced activation of transglutaminase in pancreatic islets. Diabetes Res 3:115-117.
60. Goping IS, Gross A, Lavoie JN, Nguyen M, Jemmerson R, Roth K, Korsmeyer SJ, Shore GC. 1998. Regulated targeting of BAX to mitochondria. J Cell Biol 143:207-215.
61. Gottlieb PA, Hayward AR. 2002. Cytokine and immunosuppressive therapies of type 1 diabetes mellitus. Endocrinol Metab Clin North Am 31:477-495 (Review).
62. Gozani O, Boyce M, Yoo L, Karuman P, Yuan J. 2002. Life and death in paradise. Nat Cell Biol 4:E159-E162.
63. Greenberg AH. 1996. Granzyme B-induced apoptosis. Adv Exp Med Biol 406:219-228.
64. Grewal IS, Grewal KD, Wong FS, Wang H, Picarella DE, Janeway CA, Jr., Flavell RA. 2002. Expression of transgene encoded TGF-beta in islets prevents autoimmune diabetes in NOD mice by a local mechanism. J Autoimmun 19:9-22.
65. Grimm S, Stanger BZ, Leder P. 1996. RIP and FADD: Two "death domain"-containing proteins can induce apoptosis by convergent, but dissociable, pathways. Proc Natl Acad Sci USA 93:10923-10927.
66. Grzanka A. 2001. Actin distribution patterns in HL-60 leukemia cells treated with etoposide. Acta Histochem 103:453-464.
67. Guerra S, Mosca F, Boggi U, Purrello F, Navalesi R, Marchetti P. 2001. Th2 cytokines have a partial, direct protective effect on the function and survival of isolated human islets exposed to combined proinflammatory and Th1 cytokines. J Clin Endocrinol Metab 86: 4974-4978.
68. Gukovskaya AS, Gukovsky I, Jung Y, Mouria M, Pandol SJ. 2002. Cholecystokinin induces caspase activation and mitochondrial dysfunction in pancreatic acinar cells. Roles in cell injury processes of pancreatitis. J Biol Chem 277:22595-22604.
69. Gunther L, Berberat PO, Haga M, Brouard S, Smith RN, Soares MP, Bach FH, Tobiasch E. 2002. Carbon monoxide protects pancreatic beta-cells from apoptosis and improves islet function/survival after transplantation. Diabetes 51:994-999.
70. Gupta S. 2001. Molecular steps of tumor necrosis factor receptor-mediated apoptosis. Curr Mol Med 1:317-324.
71. Ha HC, Woster PM, Yager JD, Casero RA. 1997. The role of polyamine catabolism in polyamine analogue-induced programmed cell death. Proc Natl Acad Sci USA 94:11557-11562.
72. Hadjivassiliou V, Green MH, James RF, Swift SM, Clayton HA, Green IC. 1998. Insulin secretion, DNA damage, and apoptosis in human and rat islets of Langerhans following exposure to nitric oxide, peroxynitrite, and cytokines. Nitric Oxide 2:429-441.
73. Hakem R, Hakem A, Duncan GS, Henderson JT, Woo M, Soengas MS, Elia A, de la Pompa JL, Kagi D, Khoo W, Potter J, Yoshida R, Kaufman SA, Lowe SW, Penninger JM, Mak TW. 1998. Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell 94: 339-352.
74. Hanke J. 2000. Apoptosis and occurrence of Bcl-2, Bak, Bax, Fas and FasL in the developing and adult rat endocrine pancreas. Anat Embryol (Berl) 202:303-312.
75. Harris MH, Thompson CB. 2000. The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability. Cell Death Differ 7:1182-1191.
76. Harrison M, Dunger AM, Berg S, Mabley J, John N, Green MH, Green IC. 1998. Growth factor protection against cytokine-induced apoptosis in neonatal rat islets of Langerhans: Role of Fas. FEBS Lett 435:207-210.
77. Harrison DC, Davis RP, Bond BC, Campbell CA, James MF, Parsons AA, Philpott KL. 2001. Caspase mRNA expression in a rat model of focal cerebral ischemia. Brain Res Mol Brain Res 89: 133-146.
78. Heitmeier MR, Arnush M, Scarim AL, Corbett JA. 2001. Pancreatic beta-cell damage mediated by beta-cell production of interleukin-1. A novel mechanism for virus-induced diabetes. J Biol Chem 276: 11151-11158.
79. Held W, MacDonald HR, Weissman IL, Hess MW, Mueller C. 1990. Genes encoding tumor necrosis factor alpha and granzyme A are expressed during development of autoimmune diabetes. Proc Natl Acad Sci USA 87:2239-2243.
80. Hennino A, Berard M, Casamayor-Palleja M, Krammer PH, Defrance T. 2000. Regulation of the Fas death pathway by CASPASE 8-inhibitory protein in primary human B cells. J Immunol 165:3023-3030.
81. Henshall DC, Bonislawski DP, Skradski SL, Araki T, Lan JQ, Schindler CK, Meller R, Simon RP. 2001. Formation of the Apaf-1/cytochrome c complex precedes activation of caspase-9 during seizure-induced neuronal death. Cell Death Differ 8:1169-1181.
82. Hill DJ, Strutt B, Arany E, Zaina S, Coukell S, Graham CF. 2000. Increased and persistent circulating insulin-like growth factor II in neonatal transgenic mice suppresses developmental apoptosis in the pancreatic islets. Endocrinology 141:1151-1157.
83. Hofmann TG, Moller A, Hehner SP, Welsch D, Droge W, Schmitz ML. 2001. CD95-induced JNK activation signals are transmitted by the death-inducing signaling complex (DISC), but not by Daxx. Int J Cancer 93:185-191.
84. Holcik M, Korneluk RG. 2001. XIAP, the guardian angel. Nat Rev Mol Cell Biol 2:550-556.
85. Hsu H, Shu HB, Pan MG, Goeddel DV. 1996. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 84:299-308.
86. Hu WH, Johnson H, Shu HB. 1999. Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways. J Biol Chem 274:30603-30610.
87. Hu WH, Johnson H, Shu HB. 2000. Activation of NF-kappaB by FADD, Casper, and caspase-8. J Biol Chem 275:10838-10844.
88. Hugues S, Mougneau E, Ferlin W, Jeske D, Hofman P, Homann D, Beaudoin L, Schrike C, Von Herrath M, Lehuen A, Glaichenhaus N. 2002. Tolerance to islet antigens and prevention from diabetes induced by limited apoptosis of pancreatic beta-cells. Immunity 16:169-181.
89. Hui H, Nourparvar A, Zhao X, Perfetti R. 2003. Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5′-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway. Endocrinology 144:1444-1455.
90. Huo J, Luo RH, Metz SA, Li G. 2002. Activation of caspase-2 mediates the apoptosis induced by GTP-depletion in insulin-secreting (HIT-T15) cells. Endocrinology 143:1695-1704.
91. Idriss HT, Naismith JH. 2000. TNF alpha and the TNF receptor superfamily: Structure-function relationship (s). Microsc Res Tech 50:184-195.
92. Ingelsson E, Saldeen J, Welsh N. 1998. Islet expression of perforin, Fas/Apo-1 and interleukin-1 converting enzyme (ICE) in non-obese diabetic (NOD) mice. Immunol Lett 63:125-129.
93. Ishizuka N, Yagui K, Tokuyama Y, Yamada K, Suzuki Y, Miyazaki J, Hashimoto N, Makino H, Saito Y, Kanatsuka A. 1999. Tumor necrosis factor alpha signaling pathway and apoptosis in pancreatic beta-cells. Metabolism 48:1485-1492.
94. Iwahashi H, Hanafusa T, Eguchi Y, Nakajima H, Miyagawa J, Itoh N, Tomita K, Namba M, Kuwajima M, Noguchi T, Tsujimoto Y, Matsuzawa Y. 1996. Cytokine-induced apoptotic cell death in a mouse pancreatic beta-cell line: Inhibition by Bcl-2. Diabetologia 39:530-536.
95. Jonas JC, Laybutt DR, Steil GM, Trivedi N, Pertusa JG, Van de Casteele M, Weir GC, Henquin JC. 2001. High glucose stimulates early response gene c-Myc expression in rat pancreatic beta-cells. J Biol Chem 276:35375-35381.
96. Juo P, Kuo CJ, Yuan J, Blenis J. 1998. Essential requirement for caspase-8/CASPASE 8 in the initiation of the Fas-induced apoptotic cascade. Curr Biol 8:1001-1018.
97. Juo P, Woo MS, Kuo CJ, Signorelli P, Biemann HP, Hannun YA, Blenis J. 1999. FADD is required for multiple signaling events downstream of the receptor Fas. Cell Growth Differ 10:797-804.
98. Kaplowitz N. 2000. Mechanisms of liver cell injury. J Hepatol 32: 39-47.
99. Kawakami A, Tian Q, Duan X, Streuli M, Schlossman SF, Anderson P. 1992. Identification and functional characterization of a TIA-1-related nucleolysin. Proc Natl Acad Sci USA 89:8681-8685.
100. Keramaris E, Stefanis L, MacLaurin J, Harada N, Takaku K, Ishikawa T, Taketo MM, Robertson GS, Nicholson DW, Slack RS, Park DS. 2000. Involvement of caspase 3 in apoptotic death of cortical neurons evoked by DNA damage. Mol Cell Neurosci 15: 368-379.
101. Kim S, Kim KA, Yagita H, Kayagaki N, Kim KW, Lee MS. 1999. Apoptosis of pancreatic beta-cells detected in accelerated diabetes of NOD mice: No role of Fas-Fas ligand interaction in autoimmune diabetes. Eur J Immunol 29:455-465.
102. Kischkel FC, Lawrence DA, Chuntharapai A, Schow P, Kim KJ, Ashkenazi A. 2000. Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5. Immunity 12:611-620.
103. Klein D, Ricordi C, Pugliese A, Pastori RL. 2000. Inhibition of Fas-mediated apoptosis in mouse insulinoma betaTC-3 cells via an anti-Fas ribozyme. Hum Gene Ther 11:1033-1045.
104. Kolb H, Burkart V. 1999. Nicotinamide in type 1 diabetes. Mechanism of action revisited. Diabetes Care 22:B16-B20 (Review).
105. Kothakota S, Azuma T, Reinhard C, Klippel A, Tang J, Chu K, McGarry TJ, Kirschner MW, Koths K, Kwiatkowski DJ, Williams LT. 1997. Caspase-3-generated fragment of gelsolin: Effector of morphological change in apoptosis. Science 278:294-298.
106. Kowluru A. 2000. Evidence for the carboxyl methylation of nuclear lamin-B in the pancreatic beta-cells. Biochem Biophys Res Commun 268:249-254.
107. Kreuwel HT, Sherman LA. 2001. The role of Fas-FasL in CD8+ T-cell-mediated insulin-dependent diabetes mellitus (IDDM). J Clin Immunol 21:15-18.
108. Kristal BS, Brown AM. 1999. Apoptogenic ganglioside GD3 directly induces the mitochondrial permeability transition. J Biol Chem 274:23169-23175.
109. Kruidering M, Evan GI. 2000. Caspase-8 in apoptosis: The beginning of "the end"? IUBMB Life 50:85-90.
110. Ku NO, Omary MB. 2000. Keratins turn over by ubiquitination in a phosporylation-modulated fashion. J Cell Biol 149:547-552.
111. Kuida K, Haydar TF, Kuan CY, Gu Y, Taya C, Karasuyama H, Su MS, Rakic P, Flavell RA. 1998. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94:325-337.
112. Kumar S. 1999. Mechanisms mediating caspase activation in cell death. Cell Death Differ 6:1060-1066.
113. Lally FJ, Ratcliff H, Bone AJ. 2001. Apoptosis and disease progression in the spontaneously diabetic BB/S rat. Diabetologia 44:320-324.
114. Lamkanfi M, Declercq W, Kalai M, Saelens X, Vandenabeele P. 2002. Alice in caspase land. A phylogenetic analysis of caspases from worm to man. Cell Death Differ 9:358-361.
115. Larsen CM, Wadt KA, Juhl LF, Andersen HU, Karlsen AE, Su MS, Seedorf K, Shapiro L, Dinarello CA, Mandrup-Poulsen T. 1998. Interleukin-1beta-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases. J Biol Chem 273:15294-15300.
116. Laybutt DR, Kaneto H, Hasenkamp W, Grey S, Jonas JC, Sgroi DC, Groff A, Ferran C, Bonner-Weir S, Sharma A, Weir GC. 2002. Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia. Diabetes 51:413-443.
117. Leibowitz G, Yuli M, Donath MY, Nesher R, Melloul D, Cerasi E, Gross DJ, Kaiser N. 2001. Beta-cell glucotoxicity in the Psammomys obesus model of type 2 diabetes. Diabetes 50(Suppl 1):S113-S117.
118. Liu X, Zou H, Slaughter C, Wang X. 1997. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 89:175-184.
119. Liu D, Pavlovic D, Chen MC, Flodstrom M, Sandler S, Eizirik DL. 2000. Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-). Diabetes 49:1116-1122.
120. Liu D, Cardozo AK, Darville MI, Eizirik DL. 2002. Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: Potential mechanisms for viral-induced insulitis and beta-cell death in type 1 diabetes mellitus. Endocrinology 143:1225-1234.
121. Lorenzo A, Razzaboni B, Weir GC, Yankner BA. 1994. Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus. Nature 368:756-760.
122. Loweth AC, Williams GT, James RF, Scarpello JH, Morgan NG. 1998. Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1beta and Fas ligation. Diabetes 47:727-732.
123. Lupi R, Dotta F, Marselli L, Del Guerra S, Masini M, Santangelo C, Patane G, Boggi U, Piro S, Anello M, Bergamini E, Mosca F, Di Mario U, Del Prato S, Marchetti P. 2002. Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: Evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 51:1437-1442.
124. Mabley JG, Belin V, John N, Green IC. 1997. Insulin-like growth factor I reverses interleukin-1beta inhibition of insulin secretion, induction of nitric oxide synthase and cytokine-mediated apoptosis in rat islets of Langerhans. FEBS Lett 417:235-238.
125. Mabley JG, Suarez-Pinzon WL, Hasko G, Salzman AL, Rabinovitch A, Kun E, Szabo C. 2001. Inhibition of poly (ADP-ribose) synthetase by gene disruption or inhibition with 5-iodo-6-amino-1,2-benzopyrone protects mice from multiple-low-dose-streptozotocin-induced diabetes. Br J Pharmacol 133:909-919.
126. MacEwan DJ. 2002. TNF receptor subtype signalling: Differences and cellular consequences. Cell Signal 14:477-492.
127. Maedler K, Spinas GA, Lehmann R, Sergeev P, Weber M, Fontana A, Kaiser N, Donath MY. 2001. Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets. Diabetes 50:1683-1690.
128. Maedler K, Fontana A, Ris F, Sergeev P, Toso C, Oberholzer J, Lehmann R, Bachmann F, Tasinato A, Spinas GA, Halban PA, Donath MY. 2002a. FLIP switches Fas-mediated glucose signaling in human pancreatic beta-cells from apoptosis to cell replication. Proc Natl Acad Sci USA 99:8236-8241.
129. Maedler K, Sergeev P, Ris F, Oberholzer J, Joller-Jemelka HI, Spinas GA, Kaiser N, Halban PA, Donath MY. 2002b. Glucose-induced beta-cells production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J Clin Invest 110:851-860.
130. Major CD, Gao ZY, Wolf BA. 2000. Activation of the sphingomielynase/ ceramide signal transduction pathway in insulin-secreting beta-cells. Diabetes 48:1372-1380.
131. Mandrup-Poulsen T. 2001. Beta-cell apoptosis: Stimuli and signaling. Diabetes 50(Suppl 1):S58-S63.
132. Martin SJ. 2001. Dealing the CARDs between life and death. Trends Cell Biol 11:188-189.
133. Martin SJ, O-Brien GA, Nishioka WK, McGahon AJ, Mahboubi A, Saido TC, Green DR. 1995. Proteolysis of fodrin (non-erythroid spectrin) during apoptosis. J Biol Chem 270:6425-6428.
134. Masters SC, Fu H. 2001. 14-3-3 proteins mediate an essential anti-apoptotic signal. J Biol Chem 276:45193-45200.
135. Mathis D, Vence L, Benoist C. 2001. Beta-cell death during progression to diabetes. Nature 414:792-798.
136. Melino G, Piacentini M. 1998. 'Tissue' transglutaminase in cell death: A downstream or a multifunctional upstream effector? FEBS Lett 430:59-63.
137. Middelkoop E, Coppens A, Llanillo M, Van der Hoek EE, Slotboom AJ, Lubin BH, Op den Kamp JA, Van Deenen LL, Roelofsen B. 1989. Aminophospholipid translocase in the plasma membrane of Friend erythroleukemic cells can induce an asymmetric topology for phosphatidylserine but not for phosphatidylethanolamine. Biochim Biophys Acta 978:241-248.
138. Mikhailov VM, Komarov SA, Nilova VK, Shtein GI, Baranov VS. 2001. Ultrastructural and morphometrical analysis of apoptosis stages in cardiomyocytes of MDX mice. Tsitologiia 43:729-737.
139. Mills JC, Stone NL, Erhardt J, Pittman RN. 1998. Apoptotic membrane blebbing is regulated by myosin light chain phosphorylation. J Cell Biol 140:627-636.
140. Motyka B, Korbutt G, Pinkoski MJ, Heibein JA, Caputo A, Hobman M, Barry M, Shostak I, Sawchuk T, Holmes CF, Gauldie J, Bleackley RC. 2000. Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis. Cell 103:491-500.
141. Nakata M, Uto N, Maruyama I, Yada T. 1999. Nitric oxide induces apoptosis via Ca2+-dependent processes in the pancreatic beta-cell line MIN6. Cell Struct Funct 24:451-455.
142. Nakayama M, Nagata M, Yasuda H, Arisawa K, Kotani R, Yamada K, Chowdhury SA, Chakrabarty S, Jin ZZ, Yagita H, Yokono K, Kasuga M. 2002. Fas/Fas ligand interactions play an essential role in the initiation of murine autoimmune diabetes. Diabetes 51:1391-1397.
143. Nargi-Aizenman JL, Simbulan-Rosenthal CM, Kelly TA, Smulson ME, Griffin DE. 2002. Rapid activation of poly-(ADP-ribose) polymerase contributes to Sindbis virus and staurosporine-induced apoptotic cell death. Virology 293:164-171.
144. Nunez G, Benedict MA, Hu Y, Inohara N. 1998. Caspases: The proteases of the apoptotic pathway. Oncogene 17:3237-3245.
145. O'Brien BA, Harmon BV, Cameron DP, Allan DJA. 1997. Apoptosis is the mode of beta-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse. Diabetes 46:750-757.
146. Okuya S, Tanabe K, Tanizawa Y, Oka Y. 2001. Leptin increases the viability of isolated rat pancreatic islets by suppressing apoptosis. Endocrinology 142:4827-4830.
147. Oleana VH, Salehi A, Swaab DF. 1998. Increased expression of the TIAR protein in the hippocampus of Alzheimer patients. Neuroreport 9:1451-1454.
148. Omary MB, Ku NO, Liao J, Price D. 1998. Keratin modifications and solubility properties in epithelial cells and in vitro. Subcell Biochem 31:105-140.
149. Ou D, Metzger DL, Wang X, Huang J, Pozzilli P, Tingle AJ. 2002. TNF-related apoptosis-inducing ligand death pathway-mediated human beta-cell destruction. Diabetologia 45:1678-1688.
150. Owen RA, Bungay PJ, Hussain M, Griffin M. 1988. Transglutaminase- catalysed cross-linking of proteins phosphorylated in the intact glucose-stimulated pancreatic beta-cell. Biochim Biophys Acta 968:220-230.
151. Papaccio G, Nicoletti F, Pisanti FA, Galdieri M, Bendtzen K. 2002. An imidazoline compound completely counteracts interleukin-1 [beta] toxic effects to rat pancreatic islet [beta] cells. Mol Med 8:536-545.
152. Paraskevas S, Maysinger D, Wang R, Duguid TP, Rosenberg L. 2000. Cell loss in isolated human islets occurs by apoptosis. Pancreas 20:270-276.
153. Payne CM, Bernstein C, Bernstein H. 1995. Apoptosis overview emphasizing the role of oxidative stress, DNA damage and signal-transduction pathways. Leuk Lymphoma 19:43-93.
154. Perkins CL, Fang G, Kim CN, Bhalla KN. 2000. The role of Apaf-1, caspase-9, and bid proteins in etoposide- or paclitaxel-induced mitochondrial events during apoptosis. Cancer Res 60:1645-1653.
155. Petrovsky N, Silva D, Socha L, Slattery R, Charlton B. 2002. The role of Fas ligand in beta-cells destruction in autoimmune diabetes of NOD mice. Ann NY Acad Sci 958:204-208.
156. Pham CT, Ley TJ. 1997. The role of granzyme B cluster proteases in cell-mediated cytotoxicity. Semin Immunol 9:127-133.
157. Pick A, Clark J, Kubstrup C, Levisetti M, Pugh W, Bonner-Weir S, Polonsky KS. 1998. Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat. Diabetes 47:358-364.
158. Piganelli JD, Flores SC, Cruz C, Koepp J, Batinic-Haberle I, Crapo J, Day B, Kachadourian R, Young R, Bradley B, Haskins K. 2002. A metalloporphyrin- based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone. Diabetes 51:347-355.
159. Pileggi A, Molano RD, Berney T, Cattan P, Vizzardelli C, Oliver R, Fraker C, Ricordi C, Pastori RL, Bach FH, Inverardi L. 2001. Heme oxygenase-1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation. Diabetes 50:1983-1991.
160. Pinkoski MJ, Heibein JA, Waterhouse NJ, Wolf BB, Kuwana T, Goldstein JC, Newmeyer DD, Bleackley RC, Green DR. 2001. Granzyme B-mediated apoptosis proceeds predmominantly through a Bcl-2-inhibitable mitochondrial pathway. J Biol Chem 276:12060-12067.
161. Prasad S, Soldatenkov VA, Srinivasarao G, Dritschilo A. 1998. Identification of keratins 18, 19 and heat-shock protein 90 beta as candidate substrates of proteolysis during ionizing radiation-induced apoptosis of estrogen-receptor negative breast tumor cells. Int J Oncol 13:757-764.
162. Prasad S, Soldatenkov VA, Srinivasarao G, Dritschilo A. 1999. Intermediate filament proteins during carcinogenesis and apoptosis (Review). Int J Oncol 14:563-570.
163. Rabinovitch A. 1998. An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus. Diabetes Metab Rev 14:129-151.
164. Rabinovitch A, Suarez-Pinzon WL, Sooy K, Strynadka K, Christakos S. 2001. Expression of calbindin-D(28k) in a pancreatic islet beta-cell line protects against cytokine-induced apoptosis and necrosis. Endocrinology 142:3649-3655.
165. Riachy R, Vandewalle B, Kerr Conte J, Moerman E, Sacchetti P, Lukowiak B, Gmyr V, Bouckenooghe T, Dubois M, Pattou F. 2002. 1,25-dihydroxyvitamin D3
166. Rice GE. 1998. Secretory phospholipases and membrane polishing. Placenta 19:13-20.
167. Rosenberg L, Wang R, Paraskevas S, Maysinger D. 1999. Structural and functional changes resulting from islet isolation lead to islet cell death. Surgery 126:393-398.
168. Rotonda J, Garcia-Calvo M, Bull HG, Geissler WM, McKeever BM, Willoughby CA, Thornberry NA, Becker JW. 2001. The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1. Chem Biol 8:357-368.
169. Roucou X, Rostovtseva T, Montessuit S, Martinou JC, Antonsson B. 2002. Bid induces cytochrome c-impermeable Bax channels in liposomes. Biochem J 363:547-552.
170. Saafi EL, Konarkowska B, Zhang S, Kistler J, Cooper GJ. 2001. Ultrastructural evidence that apoptosis is the mechanism by which human amylin evokes death in RINm5F pancreatic islet beta-cells. Cell Biol Int 25:339-350.
171. Sakahira H, Enari M, Nagata S. 1998. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature 391:96-99.
172. Saldeen J, Welsh N. 1998. Nicotinamide-induced apoptosis in insulin producing cells is associated with cleavage of poly-(ADP-ribose) polymerase. Mol Cell Endocrinol 139:99-107.
173. Saldeen J, Lee JC, Welsh N. 2001. Role of p38 mitogen-activated protein kinase (p38 MAPK) in cytokine-induced rat islet cell apoptosis. Biochem Pharmacol 61:1561-1569.
174. Salvesen GS, Dixit VM. 1999. Caspase activation: The induced-proximity model. Proc Natl Acad Sci USA 96:10964-10967.
175. Samejima K, Svingen PA, Basi GS, Kottke T, Mesner PW, Stewart L, Durrieu F, Poirier GG, Alnemri ES, Champoux JJ, Kaufmann SH, Earnshaw WC. 1999. Caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosis. J Biol Chem 274:4335-4340.
176. Sanna MG, da Silva Correia J, Ducrey O, Lee J, Nomoto K, Schrantz N, Deveraux QL, Ulevitch RJ. 2002. IAP suppression of apoptosis involves distinct mechanisms: The TAK1/JNK1 signaling cascade and caspase inhibition. Mol Cell Biol 22:1754-1766.
177. Saraste A, Pulkki K. 2000. Morphologic and biochemical hallmarks of apoptosis. Cardiovasc Res 45:528-537.
178. Satoh K, Shimosegawa T, Masamune A, Hirota M, Koizumi M, Toyota T. 1999. Fas ligand is frequently expressed in human pancreatic duct cell carcinoma. Pancreas 19:339-345.
179. Scaffidi C, Fulda S, Srinivasan A, Friesen C, Li F, Tomaselli KJ, Debatin KM, Krammer PH, Peter ME. 1998. Two CD95 (APO-1/Fas) signaling pathways. EMBO J 17:1675-1687.
180. Schickling O, Stegh AH, Byrd J, Peter ME. 2001. Nuclear localization of DEDD leads to caspase-6 activation through its death effector domain and inhibition of RNA polymerase I dependent transcription. Cell Death Differ 8:1157-1168.
181. Schneider P, Bodmer JL, Thome M, Hofmann K, Holler N, Tschopp J. 1997. Characterization of two receptors for TRAIL. FEBS Lett 416:329-334.
182. Schwingshackl A, Blasko I, Steiner E, Pozzilli P, Cavallo MG, Berger P, Grubeck-Loebenstein B. 1998. Sex steroids do not prevent amylin-induced apoptosis in human cells. Exp Cell Res 241: 265-268.
183. Seol DW, Li J, Seol MH, Park SY, Talanian RV, Billiar TR. 2001. Signaling events triggered by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL): Caspase-8 is required for TRAIL-induced apoptosis. Cancer Res 61:1138-1143.
184. Sharma K, Wang RX, Zhang LY, Yin DL, Luo XY, Solomon JC, Jiang RF, Markos K, Davidson W, Scott DW, Shi YF. 2000. Death the Fas way: Regulation and pathophysiology of CD95 and its ligand. Pharmacol Ther 88:333-347.
185. Shimabukuro M, Zhou YT, Levi M, Unger RH. 1998. Fatty acid-induced beta-cells apoptosis: A link between obesity and diabetes. Proc Natl Acad Sci USA 95:2498-2502.
186. Shimizu S, Eguchi Y, Kamiike W, Funahashi Y, Mignon A, Lacronique V, Matsuda H, Tsujimoto Y. 1998. Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux. Proc Natl Acad Sci USA 95:1455-1459.
187. Shiozaki EN, Chai J, Shi Y. 2002. Oligomerization and activation of caspase-9, induced by Apaf-1 CARD. Proc Natl Acad Sci USA 99: 4197-4202.
188. Shu HB, Halpin DR, Goeddel DV. 1997. Casper is a FADD- and caspase-related inducer of apoptosis. Immunity 6:751-763.
189. Sjoholm A. 1998. Aspects of the involvement of interleukin-1 and nitric oxide in the pathogenesis of insulin-dependent diabetes mellitus. Cell Death Differ 5:461-468.
190. Sjoholm A, Berggren PO, Cooney RV. 2000. Gamma-tocopherol partially protects insulin-secreting cells against functional inhibition by nitric oxide. Biochem Biophys Res Commun 277:334-340.
191. Sjoholm A, Arkhammar P, Berggren PO, Andersson A. 2001. Polyamines in pancreatic islets of obese-hyperglycemic (ob/ob) mice of different ages. Am J Physiol Cell Physiol 280:C317-C323.
192. Slee EA, Adrain C, Martin SJ. 1999a. Serial killers: Ordering caspase activation events in apoptosis. Cell Death Differ 6:1067-1074.
193. Slee EA, Harte MT, Kluck RM, Wolf BB, Casiano CA, Newmeyer DD, Wang HG, Reed JC, Nicholson DW, Alnemri ES, Green DR, Martin SJ. 1999b. Ordering the cytochrome c-initiated caspase cascade: Hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol 144:281-292.
194. Slee EA, Adrain C, Martin SJ. 2001. Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis. J Biol Chem 276:7320-7326.
195. Sobel DO, Han J, Williams J, Yoon JW, Jun HS, Ahvazi B. 2002. Gamma interferon paradoxically inhibits the development of diabetes in the NOD mouse. J Autoimmun 19:129-137.
196. Soriano FG, Virag L, Szabo C. 2001. Diabetic endothelial dysfunction: Role of reactive oxygen and nitrogen species production and poly-(ADP-ribose) polymerase activation. J Mol Med 79:437-448.
197. Srinivasan S, Bernal-Mizrachi E, Ohsugi M, Permutt MA. 2002. Glucose promotes pancreatic islet beta-cell survival through a PI 3-kinase/Akt-signaling pathway. Am J Physiol Endocrinol Metab 283: E784-E793.
198. Stanger BZ. 1996. Looking beneath the surface: The cell death pathway of Fas/APO-1 (CD95). Mol Med 2:7-20.
199. Steen RL, Collas P. 2001. Mistargeting of B-type lamins at the end of mitosis: Implications on cell survival and regulation of lamins A/C expression. J Cell Biol 153:621-626.
200. Stennicke HR, Salvesen GS. 1997. Biochemical characteristics of caspases-3, -6, -7, and -8. J Biol Chem 272:25719-25723.
201. Stennicke HR, Jurgensmeier JM, Shin H, Deveraux Q, Wolf BB, Yang X, Zhou Q, Ellerby HM, Ellerby LM, Bredesen D, Green DR, Reed JC, Froelich CJ, Salvesen GS. 1998. Pro-caspase-3 is a major physiologic target of caspase-8. J Biol Chem 273:27084-27090.
202. Suarez-Pinzon WL, Marcoux Y, Ghahary A, Rabinovitch A. 2002. Gene transfection and expression of transforming growth factor-beta1 in nonobese diabetic mouse islets protects beta-cells in syngeneic islet grafts from autoimmune destruction. Cell Transplant 11:519-528.
203. Susin SA, Zamzami N, Castedo M, Daugas E, Wang HG, Geley S, Fassy F, Reed JC, Kroemer G. 1997. The central executioner of apoptosis: Multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis. J Exp Med 186:25-37.
204. Susin SA, Daugas E, Ravagnan L, Samejima K, Zamzami N, Loeffler M, Costantini P, Ferri KF, Irinopoulou T, Prevost MC, Brothers G, Mak TW, Penninger J, Earnshaw WC, Kroemer G. 2000. Two distinct pathways leading to nuclear apoptosis. J Exp Med 192:571-580.
205. Takahashi R, Deveraux Q, Tamm I, Welsh K, Assa-Munt N, Salvesen GS, Reed JC. 1998. A single BIR domain of XIAP sufficient for inhibiting caspases. J Biol Chem 273:7787-7790.
206. Talanian RV, Dang LC, Ferenz CR, Hackett MC, Mankovich JA, Welch JP, Wong WW, Brady KD. 1996. Stability and oligomeric equilibria of refolded interleukin-1beta converting enzyme. J Biol Chem 271:21853-21858.
207. Talanian RV, Yang X, Turbov J, Seth P, Ghayur T, Casiano CA, Orth K, Froelich CJ. 1997a. Granule-mediated killing: Pathways for granzyme B-initiated apoptosis. J Exp Med 186:1323-1331.
208. Talanian RV, Quinlan C, Trautz S, Hackett MC, Mankovich JA, Banach D, Ghayur T, Brady KD, Wong WW. 1997b. Substrate specificities of caspase family proteases. J Biol Chem 272:9677-9682.
209. Taupin JL, Tian Q, Kedersha N, Robertson M, Anderson P. 1995. The RNA-binding protein TIAR is translocated from the nucleus to the cytoplasm during Fas-mediated apoptotic cell death. Proc Natl Acad Sci USA 92:1629-1633.
210. Thomas HE, Darwiche R, Corbett JA, Kay TW. 1999. Evidence that beta-cells death in the nonobese diabetic mouse is Fas independent. J Immunol 163:1562-1569.
211. Thomas F, Wu J, Contreras JL, Smyth C, Bilbao G, He J, Thomas J. 2001. A tripartite anoikis-like mechanism causes early isolated islet apoptosis. Surgery 130:333-338.
212. Thomas D, Yang H, Boffa DJ, Ding R, Sharma VK, Lagman M, Li B, Hering B, Mohanakumar T, Lakey J, Kapur S, Hancock WW, Suthanthiran M. 2002. Proapoptotic bax is hyperexpressed in isolated human islets compared with antiapoptotic bcl-2. Transplantation 74:1489-1496.
213. Thornberry NA. 1997. The caspase family of cysteine proteases. Br Med Bull 53:478-490.
214. Tian J, Zekzer D, Hanssen L, Lu Y, Olcott A, Kaufman DL. 2001. Lipopolysaccharide-activated B cells down-regulate Thl immunity and prevent autoimmune diabetes in nonobese diabetic mice. J Immunol 167:1081-1089.
215. Tobiasch E, Gunther L, Bach FH. 2001. Heme oxygenase-1 protects pancreatic beta-cells from apoptosis caused by various stimuli. J Investig Med 49:566-571.
216. Tong WM, Cortes U, Wang ZQ. 2001. Poly-(ADP-ribose) polymerase: A guardian angel protecting the genome and suppressing tumorigenesis. Biochim Biophys Acta 1552:27-37.
217. Torres-Roca JF, Tung JW, Greenwald DR, Brown JM, Herzenberg LA, Herzenberg LA, Katsikis PD. 2000. An early oxygen-dependent step is required for dexamethasone-induced apoptosis of immature mouse thymocytes. J Immunol 165:4822-4830.
218. Trincavelli ML, Marselli L, Falleni A, Gremigni V, Ragge E, Dotta F, Santangelo C, Marchetti P, Lucacchini A, Martini C. 2002. Upregulation of mitochondrial peripheral benzodiazepine receptor expression by cytokine-induced damage of human pancreatic islets. J Cell Biochem 84:636-644.
219. Tschopp J, Irmler M, Thome M. 1998. Inhibition of fas death signals by FLIPs. Curr Opin Immunol 10:552-558.
220. Tucholski J, Johnson GV. 2002. Tissue transglutaminase differentially modulates apoptosis in a stimuli-dependent manner. J Neurochem 81:780-791.
221. Uchida M, Hanai S, Uematsu N, Sawamoto K, Okano H, Miwa M, Uchida K. 2001. Genetic and functional analysis of PARP, a DNA strand break-binding enzyme. Mutat Res 477:89-96.
222. Unger RH, Zhou YT. 2001. Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover. Diabetes 50(Suppl 1):S118-S121.
223. Verhoven B, Krahling S, Schlegel RA, Williamson P. 1999. Regulation of phosphatidylserine exposure and phagocytosis of apoptotic T lymphocytes. Cell Death Differ 6:262-270.
224. Villunger A, Huang DC, Holler N, Tschopp J, Strasser A. 2000. Fas ligand-induced c-Jun kinase activation in lymphoid cells requires extensive receptor aggregation but is independent of DAXX, and Fas-mediated cell death does not involve DAXX, RIP, or RAIDD. J Immunol 165:1337-1343.
225. Wajant H, Scheurich P. 2001. Tumor necrosis factor receptor-associated factor (TRAF) 2 and its role in TNF signaling. Int J Biochem Cell Biol 33:19-32.
226. Wakabayashi T, Karbowski M. 2001. Structural changes of mitochondria related to apoptosis. Biol Signals Recept 10:26-56.
227. Walczak H, Degli-Esposti MA, Johnson RS, Smolak PJ, Waugh JY, Boiani N, Timour MS, Gerhart MJ, Schooley KA, Smith CA, Goodwin RG, Rauch CT. 1997. TRAIL-R2: A novel apoptosis-mediating receptor for TRAIL. EMBO J 16:5386-5397.
228. Walker NP, Talanian RV, Brady KD, Dang LC, Bump NJ, Ferenz CR, Franklin S, Ghayur T, Hackett MC, Hammill LD. 1994. Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: A (p20/p10)2 homodimer. Cell 78:343-352.
229. Wang Y, Gu X. 2001. Functional divergence in the caspase gene family and altered functional constraints: Statistical analysis and prediction. Genetics 158:1311-1320.
230. Wang TH, Wang HS. 1999. Apoptosis: (2) Characteristics of apoptosis. J Formos Med Assoc Aug 98:531-542.
231. Warner HR. 1997. Aging and regulation of apoptosis. Curr Top Cell Regul 35:107-121.
232. Weber CH, Vincenz C. 2001. The death domain superfamily: A tale of two interfaces? Trends Biochem Sci 26:475-481.
233. Wride MA. 2000. Minireview: Apoptosis as seen through a lens. Apoptosis 5:203-209.
234. Wyllie A. 1998. Apoptosis. An endonuclease at last. Nature 391:20-21.
235. Xerri L, Devilard E, Bouabdallah R, Stoppa AM, Hassoun J, Birg F. 1999. FADD expression and caspase activation in B-cell lymphomas resistant to Fas-mediated apoptosis. Br J Haematol 106: 652-661.
236. Xiao C, Yang BF, Asadi N, Beguinot F, Hao C. 2002. Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells. J Biol Chem 277:25020-25025.
237. Yagihashi S. 1996. Pathology of diabetes mellitus. Nippon Naika Gakkai Zasshi 85:568-572.
238. Yamada K, Takane-Gyotoku N, Yuan X, Ichikawa F, Inada C, Nonaka K. 1996. Mouse islet cell lysis mediated by interleukin-1-induced Fas. Diabetologia 39:1306-1312.
239. Yamada K, Ichikawa F, Ishiyama-Shigemoto S, Yuan X, Nonaka K. 1999. Essential role of caspase-3 in apoptosis of mouse beta-cells transfected with human Fas. Diabetes 48:478-483.
240. Yang YL, Li XM. 2000. The IAP family: Endogenous caspase inhibitors with multiple biological activities. Cell Res 10:169-177.
241. Yang X, Khosravi-Far R, Chang HY, Baltimore D. 1997. Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell 89: 1067-1076.
242. Yang X, Chang HY, Baltimore D. 1998a. Autoproteolytic activation of pro-caspases by oligomerization. Mol Cell 1:319-325.
243. Yang X, Stennicke HR, Wang B, Green DR, Janicke RU, Srinivasan A, Seth P, Salvesen GS, Froelich CJ. 1998b. Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7. J Biol Chem 273:34278-34283.
244. Yoshii T, Fukumori T, Honjo Y, Inohara H, Kim HR, Raz A. 2002. Galectin-3 phosphorylation is required for its anti-apoptotic function and cell cycle arrest. J Biol Chem 277:6852-6857.
245. Yu PW, Huang BC, Shen M, Quast J, Chan E, Xu X, Nolan GP, Payan DG, Luo Y. 1999. Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB. Curr Biol 9:539-542.
246. Zapata JM, Takahashi R, Salvesen GS, Reed JC. 1998. Granzyme release and caspase activation in activated human T-lymphocytes. J Biol Chem 273:6916-6920.
247. Zhang S, Liu J, MacGibbon G, Dragunow M, Cooper GJ. 2002. Increased expression and activation of c-Jun contributes to human amylin-induced apoptosis in pancreatic islet beta-cells. J Mol Biol 324:271-285.
248. Zheng TS, Hunot S, Kuida K, Momoi T, Srinivasan A, Nicholson DW, Lazebnik Y, Flavell RA. 2000. Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation. Nat Med 6:1241-1247.
249. Zhou Q, Snipas S, Orth K, Muzio M, Dixit VM, Salvesen GS. 1997. Target protease specificity of the viral serpin CrmA. Analysis of five caspases. J Biol Chem 272:7797-7800.
250. Zhou YP, Pena JC, Roe MW, Mittal A, Levisetti M, Baldwin AC, Pugh W, Ostrega D, Ahmed N, Bindokas VP, Philipson LH, Hanahan D, Thompson CB, Polonsky KS. 2000. Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion. Am J Physiol Endocrinol Metab 278: E340-E351.
251. Zimmermann KC, Bonzon C, Green DR. 2001. The machinery of programmed cell death. Pharmacol Ther 92:57-70.
252. Zumsteg U, Frigerio S, Hollander GA. 2000. Nitric oxide production and Fas surface expression mediate two indipendent pathways of cytokine-induced murine beta-cell damage. Diabetes 49: 39-47.