Evidence that β cell death in the nonobese diabetic mouse is Fas independent

Journal of Immunology

Volumn 163, Issue 3, 1999, Pages 1562-1569

  Thomas, Helen E ^b   Darwiche, Rima ^b   Corbett, John A ^a   Kay, Thomas W H ^b  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; FAS LIGAND; NITRITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CELL DEATH; DIABETOGENESIS; FEMALE; FLOW CYTOMETRY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MOUSE; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; CELL DEATH; CELLS, CULTURED; CYTOKINES; DIABETES MELLITUS, TYPE 1; FAS LIGAND PROTEIN; FEMALE; ISLETS OF LANGERHANS; LIGANDS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED MRL LPR; MICE, INBRED NOD; NITRIC OXIDE; STAINING AND LABELING; UP-REGULATION;

EID: 0033178741     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Nagata, S., and P. Golstein. 1995. The Fas death factor. Science 267:1449.
2. Ashkenazi, A., and V. M. Dixit. 1998. Death receptors: signaling and modulation. Science 281:1305.
3. O'Brien, B. A., B. V. Harmon, D. P. Cameron, and D. J. Allan. 1997. Apoptosis is the mode of β-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse. Diabetes 46:750.
4. Kurrer, M. O., S. V. Pakala, H. L. Hanson, and J. D. Katz. 1997. β cell apoptosis in T cell-mediated autoimmune diabetes. Proc. Natl. Acad. Sci. USA 94:213.
5. Augstein, P., A. G. Elefanty, J. Allison, and L. C. Harrison. 1998. Apoptosis and β-cell destruction in pancreatic islets on NOD mice with spontaneous and cyclophosphamide-accelerated diabetes. Diabetologia 41:1381.
6. Yamada, K., N. Takane-Gyotoku, X. Yuan, F. Ichikawa, C. Inada, and K. Nonaka. 1996. Mouse islet cell lysis mediated by interleukin-1-induced Fas. Diabetologia 39:1306.
7. Stassi, G., M. Todaro, P. Richiusa, M. Giordano, A. Mattina, M. S. Sbriglia, A. Lo Monte, G. Buscemi, A. Galluzzo, and C. Giordano. 1995. Expression of apoptosis-inducing CD95 (Fas/Apo-1) on human β-cells sorted by flow-cytometry and cultured in vitro. Transpl. Proc. 27:3271.
8. Loweth, A. C., G. T. Williams, R. F. James, J. H. Scarpello, and N. G. Morgan. 1998. Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1β and Fas ligation. Diabetes 47:727.
9. Corbett, J. A., M. A. Sweetland, J. L. Wang, J. Lancaster, Jr., and M. L. McDaniel. 1993. Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. Proc. Natl. Acad. Sci. USA 90: 1731.
10. Eizirik, D. L., M. Flodstrom, A. E. Karlsen, and N. Welsh. 1996. The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic β cells. Diabetologia 39:875.
11. Stassi, G., R. D. Maria, G. Trucco, W. Rudert, R. Testi, A. Galluzzo, C. Giordano, and M. Trucco. 1997. Nitric oxide primes pancreatic beta cells for Fas-mediated destruction in insulin-dependent diabetes mellitus. J. Exp. Med. 186:1193.
12. Cohen, P. L., and R. A. Eisenberg. 1991. Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9:243.
13. Chervonsky, A. V., Y. Wang, F. S. Wong, I. Visintin, R. A. Flavell, C. Janeway, Jr., and L. A. Matis. 1997. The role of Fas in autoimmune diabetes. Cell 89:17.
14. Itoh, N., A. Imagawa, T. Hanafusa, M. Waguri, K. Yamamoto, H. Iwahashi, M. Moriwaki, H. Nakajima, J. Miyagawa, M. Namba, S. Makino, S. Nagata, N. Kono, and Y. Matsuzawa. 1997. Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice. J. Exp. Med. 186:613.
15. Allison, J., and A. Strasser. 1998. Mechanisms of β cell death in diabetes: a minor role for CD95. Proc. Natl. Acad Sci. USA 95:13818.
16. Kim, Y.-H., S. Kim, K.-A. Kim, H. Yagita, N. Kayagaki, K.-W. Kim, and M.-S. Lee. 1999. Apoptosis of pancreatic β cells detected in accelerated diabetes of NOD mice: no role of Fas-Fas ligand interaction in autoimmune diabetes. Eur. J. Immunol. 29:455.
17. Suarez-Pinzon, W., O. Sorensen, R. C. Bleackley, J. F. Elliott, R. V. Rajotte, and A. Rabinovitch. 1999. β-cell destruction in NOD mice correlates with Fas (CD95) expression on β-cells and proinflammatory cytokine expression in islets. Diabetes 48:21.
18. Benoist, C., and D. Mathis. 1997. Cell death mediators in autoimmune diabetes: no shortage of suspects. Cell 89:1.
19. Chu, J. L., P. Ramos, A. Rosendorff, J. Nikolic-Zugic, E. Lacy, A. Matsuzawa, and K. B. Elkon. 1995. Massive upregulation of the Fas ligand in lpr and gld mice: implications for Fas regulation and the graft-versus-host disease-like wasting syndrome. J. Exp. Med. 181:393.
20. Stokes, T. A., M. Rymaszewski, P. L. Arscott, S. H. Wang, J. D. Bretz, J. Barton, and J. R. J. Baker. 1998. Constitutive expression of FasL in thyrocytes. Science 279:2015.
21. Lake, S. P., J. Anderson, J. Chamberlain, S. J. Gardner, P. R. Bell, and R. F. James. 1987. Bovine serum albumin density gradient isolation of rat pancreatic islets. Transplantation 43:805.
22. Thomas, H. E., J. L. Parker, R. D. Schreiber, and T. W. Kay. 1998. IFN-γ action on pancreatic β cells causes class 1 MHC upregulation but not diabetes. J. Clin. Invest. 102:1249.
23. Pipeleers, D. G., P. A. in't Veld, M. Van de Winkel, E. Maes, F. C. Schuit, and W. Gepts. 1985. A new in vitro model for the study of pancreatic A and B cells. Endocrinology 117:806.
24. Eisenbarth, G. S., F. S. Walsh, and M. Nirenberg. 1979. Monoclonal antibody to a plasma membrane antigen of neurons. Proc. Natl. Acad Sci. USA 76:4913.
25. Nicoletti, I., G. Migliorati, M. C. Pagliacci, F. Grignani, and C. Riccardi. 1991. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods 139:271.
26. 15N]nitrate in biological fluids. Anal. Biochem. 126:131.
27. Schneider, P., J. L. Bodmer, N. Holler, C. Mattmann, P. Scuderi, A. Terskikh, M. C. Peitsch, and J. Tschopp. 1997. Characterization of Fas (Apo-1, CD95)-Fas ligand interaction. J. biol. Chem. 272:18827.
28. Signore, A., A. Annovazzi, E. Procaccini, P. E. Beales, J. Spencer, R. Testi, and G. Ruberti. 1997. CD95 and CD95-ligand expression in endocrine pancreas of NOD, NOR and BALB/c mice. Diabetologia 40:1476.
29. Kayagaki, N., N. Yamaguchi, F. Nagao, S. Matsuo, H. Maeda, K. Okumura, and H. Yagita. 1997. Polymorphism of murine Fas ligand that affects the biological activity. Proc. Nail. Acad. Sci. USA 94:3914.
30. Allison, J., H. M. Georgiou, A. Strasser, and D. L. Vaux. 1997. Transgenic expression of CD95 ligand on islet β cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts. Proc. Natl. Acad. Sci. USA 94:3943.
31. Gazda, L. S., B. Charlton, and K. J. Lafferty. 1997. Diabetes results from a late change in the autoimmune response of NOD mice. J. Autoimmun. 10:261.
32. Kagi, D., B. Odermatt, P. Seiler, R. M. Zinkernagel, T. W. Mak, and H. Hengartner. 1997. Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice. J. Exp. Med 186:989.
33. 2-microglobulin null nonobese diabetic mice. J. Immunol. 157:3688.
34. Kay. T., H. L. Chaplin, J. L. Parker, L. A. Stephens, and H. E. Thomas. 1997. CD4(+) and CD8(+) T lymphocytes: clarification of their pathogenic roles in diabetes in the NOD mouse. Res. Immunol. 148:320.
35. Rabinovitch, A., W. L. Suarez-Pinzon, O. Sorensen, R. C. Bleackley, and R. F. Power. 1995. IFN-γ gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice. J. Immunol. 154:4874.
36. Welsh, M., N. Welsh, K. Bendtzen, J. Mares, E. Strandell, C. Oberg, and S. Sandler. 1995. Comparison of mRNA contents of interleukin-1β and nitric oxide synthase in pancreatic islets isolated from female and male nonobese diabetic mice. Diabetologia 38:153.
37. Corbett, J. A., and M. L. McDaniel. 1995. Intraislet release of interleukin 1 inhibits β cell function by inducing β cell expression of inducible nitric oxide synthase. J. Exp. Med. 181:559.
38. Mandrup-Poulsen, T. 1996. The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia 39:1005.
39. Fisher, G. H., F. J. Rosenberg, S. E. Straus, J. K. Dale, L. A. Middleton, A. Y. Lin, W. Strober, M. J. Lenardo, and J. M. Puck. 1995. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell 81:935.
40. Vaishnaw, A. K., J. R. Orlinick, J. Chu, P. H. Krammer, M. V. Chao, and K. B. Elkon. 1999. The molecular basis for apoptotic defects in patients with CD95 (Fas/Apo-1) mutations. J. Clin. Invest. 103:355.
41. + T cells. Nature 376:181.
42. Kumar, A., M. Commane, T. W. Flickinger, C. M. Horvath, and G. R. Stark. 1997. Defective TNF-α-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases. Science 278:1630.
43. Chin, Y. E., M. Kitagawa, K. Kuida, R. A. Flavell, and X. Y. Fu. 1997. Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis. Mol. Cell. Biol. 17:5328.
44. Fukuo, K., S. Hata, T. Suhara, T. Nakahashi, Y. Shinto, Y. Tsujimoto, S. Morimoto, and T. Ogihara. 1996. Nitric oxide induces upregulation of Fas and apoptosis in vascular smooth muscle. Hypertension 27:823.
45. Andrew, P. J., H. Harant, and I. J. Lindley. 1995. Nitric oxide regulates IL-8 expression in melanoma cells at the transcriptional level. Biochem. Biophys. Res. Commun. 214:949.
46. Sano, H., M. Hirai, H. Saito, I. Nakashima, and K. I. Isobe. 1997. A nitric oxide-releasing reagent, 5-nitroso-N-acetylpenicillamine, enhances the expression of Superoxide dismutases mRNA in the murine macrophage cell line RAW264-7. Immunology 92:118.
47. Dimmeler, S., J. Haendeler, A. Sause, and A. M. Zeiher. 1998. Nitric oxide inhibits APO-1/Fas-mediated cell death. Cell Growth Differ. 9:415.
48. Kim, Y. M., R. V. Talanian, and T. R. Billiar. 1997. Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms. J. Biol. Chem. 272:31138.
49. Mannick, J. B., X. Q. Miao, and J. S. Stamler. 1997. Nitric oxide inhibits Fas-induced apoptosis. J. Biol. Chem. 272:24125.
50. Kolb, H., and V. Kolb-Bachofen 1998. Nitric oxide in autoimmune disease: cytotoxic or regulatory mediator? Immunol. Today 19:556.
51. Takamura, T., I. Kato, N. Kimura, T. Nakazawa, H. Yonekura, S. Takasawa, and H. Okamoto. 1998. Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic β cells develop insulin-dependent diabetes without insulitis. J. Biol. Chem. 273:2493.
52. Kagi, D., A. Ho, B. Odermatt, A. Zakavian, P. S. Ohashi, and T. W. Mak. 1999. TNF-receptor 1-deficient β cell toxicity as an effector pathway in autoimmune diabetes. J. Immunol. 162:4598.