Heme oxygenase-1 protects pancreatic β cells from apoptosis caused by various stimuli

Journal of Investigative Medicine

Volumn 49, Issue 6, 2001, Pages 566-571

  Tobiasch, E ^a   Gunther L ^a   Bach, F H ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Apoptosis; Beta cells; Diabetes mellitus; Heme oxygenase 1; p38 mitogen activated protein kinase

Indexed keywords

HEME OXYGENASE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; HEME OXYGENASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; TUMOR NECROSIS FACTOR;

ANIMAL CELL; APOPTOSIS; CELL PROTECTION; CONFERENCE PAPER; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; SIGNAL TRANSDUCTION; ALLOTRANSPLANTATION; CELL STRESS; COMPARATIVE STUDY; DIABETES MELLITUS; ENZYME ACTIVATION; ENZYME ACTIVITY; EXPRESSION VECTOR; GENE OVEREXPRESSION; GRAFT REJECTION; IN VITRO STUDY; MONOCYTE; NATURAL KILLER CELL; PROMOTER REGION; TRANSIENT TRANSFECTION; UPREGULATION;

ANIMALIA;

EID: 0035179294     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: 10.2310/6650.2001.33721     Document Type: Conference Paper

References (47)

1. Autoimmunity and diabetes
2. Pancreatic beta cells in insulin-dependent diabetes
3. The beta cell in autoimmune diabetes: Many mechanisms and pathways of loss
4. The role of interleukin-1 in the pathogenesis of IDDM
5. Is there a role for nitric oxide in beta-cell dysfunction and damage in IDDM?
6. An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus
7. Interleukin-1 beta-induced nitric oxide synthase expression by rat pancreatic beta-cells: Evidence for the involvement of nuclear factor kappa B in the signaling mechanism
8. Cytokines activate the nuclear factor kappa B (NF-kappa B) and induce nitric oxide production in human pancreatic islets
9. Inducible nitric oxide synthase (iNOS) in pancreatic islets of nonobese diabetic mice: Identification of iNOS-expressing cells and relationships to cytokines expressed in the islets
10. Nitric oxide production and Fas surface expression mediate two independent pathways of cytokine-induced murine beta-cell damage
11. Apoptosis and the pathogenesis of IDDM: A question of life and death
12. Nitric oxide primes pancreatic beta cells for Fas-mediated destruction in insulin-dependent diabetes mellitus
13. Fas and Fas ligand expression in inflamed islets in pancreas sections of patients with recent-onset Type I diabetes mellitus
14. Islet transplantation in seven patients with Type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
15. Vulnerability of islets in the immediate posttransplantation period. Dynamic changes in structure and function
16. Apoptosis occurs in freshly isolated human islets under standard culture conditions
17. Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells
18. Nicotinamide protects human beta cells against chemically-induced necrosis, but not against cytokine-induced apoptosis
19. The role of interferon regulatory factor-1 in cytokine-induced mRNA expression and cell death in murine pancreatic beta-cells
20. Activation of extracellular signal-regulated kinase (ERK)1/2 contributes to cytokine-induced apoptosis in purified rat pancreatic beta-cells
21. Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-)
22. The p38 signal transduction pathway: Activation and function
23. Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family
24. Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase
25. Early activation of c-Jun N-terminal kinase and p38 kinase regulate cell survival in response to tumor necrosis factor alpha
26. An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia
27. Heme oxygenase-1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation
28. Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays
29. Solubilization and partial purification of heme oxygenase from rat liver
30. The heme oxygenase system: A regulator of second messenger gases
31. Ferritin: A cytoprotective antioxidant strategem of endothelium
32. Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis
33. Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene
34. Adenovirus-mediated expression of a dominant negative mutant of p65/RelA inhibits proinflammatory gene expression in endothelial cells without sensitizing to apoptosis
35. Bcl-2 and Bcl-XL serve an anti-inflammatory function in endothelial cells through inhibition of NF-kappaB
36. Expression of heme oxygenase-1 can determine cardiac xenograft survival
37. Kinetic mechanism for p38 MAP kinase
38. The role of antiapoptotic Bcl-2 family members in endothelial apoptosis elucidated with antisense oligonucleotides
39. Reversal of HO-1 related cytoprotection with increased expression is due to reactive iron
40. Dual control mechanism for heme oxygenase: Tin(IV)-protoporphyrin potently inhibits enzyme activity while markedly increasing content of enzyme protein in liver
41. Specificity and mechanism of action of some commonly used protein kinase inhibitors
42. Haem oxygenase-1 prevents cell death by regulating cellular iron
43. Oxidants, oxidative stress and the biology of ageing
44. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress
45. Role of heme oxygenase-1 in the regulation of manganese superoxide dismutase gene expression in oxidatively-challenged astroglia
46. Carbon monoxide has anti-inflammatory effects involving the mitogen- activated protein kinase pathway
47. Caspase-dependent cleavage and inactivation of the Vav1 proto-oncogene product during apoptosis prevents IL-2 transcription