Regulation of the Fas death pathway by FLICE-inhibitory protein in primary human B cells

Journal of Immunology

Volumn 165, Issue 6, 2000, Pages 3023-3030

  Hennino, A ^a   Berard, M ^a   Casamayor Palleja, M ^a   Krammer, P H ^a   Defrance, T ^a  

^a Institut National de la Sante   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; ENZYME PRECURSOR; FAS ANTIGEN; FAS LIGAND; GLYCOPROTEIN GP 39; INTERLEUKIN 1BETA CONVERTING ENZYME;

APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL DEATH; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PHAGOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM;

EID: 0034665308     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.6.3023     Document Type: Article

References (55)

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3. A novel protein that interacts with the death domain of Fas/ APO1 contains a sequence motif related to the death domain
4. FLICE, a novel FADD-homologous 1CE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
5. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
6. Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases
7. Cytotoxicity-dependent APO-1(Fas/CD95)-association proteins form a death-inducing signaling complex (DISC) with the receptor
8. Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1
9. A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes
10. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally
11. Two CD95 (APO-1/Fas) signaling pathways
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14. Casper is a FADD- and caspase-related inducer of apoptosis
15. CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis
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27. FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b
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35. Resistance of cultured peripheral T cells towards activation-induced cell death involves a lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death-inducing signaling complex
36. Differential regulation and ATP requirement for caspase-8 and caspase-3 activation during CD95- and anticancer drug-induced apoptosis
37. The caspase-3 precursor has a cytosolic and mitochondrial distribution: Implications for apoptotic signaling
38. Mitochondrial release of caspase-2 and -9 during the apoptotic process
39. Molecular characterization of mitochondrial apoptosis-inducing factor
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41. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
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55. Expression and release of chemokines associated with apoptotic cell death in human promonocytic U937 cells and peripheral blood mononuclear cells