Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: Evidence that β-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated

Diabetes

Volumn 51, Issue 5, 2002, Pages 1437-1442

  Lupi, Roberte ^a   Dotta, Francesco ^b   Marselli, Lorella ^a   Del Guerra, Silvia ^a   Masini, Matilde ^a   Santangelo, Carmela ^b   Patané, Giovanni ^c   Boggi, Ugo ^a   Piro, Salvatore ^c   Anello, Marcello ^c   Bergamini, Ettore ^a   Mosca, Franco ^a   Di Mario, Umberto ^b   Del Prato, Stefane ^a   Marchetti, Piero ^a,d  

^a UNIVERSITY OF PISA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF CATANIA   (Italy)

^d CISANELLO HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CERAMIDE; FATTY ACID; GLUCOSE; NITRIC OXIDE; PALMITIC ACID; PROTEIN BCL 2; SERINE PROTEINASE;

ADULT; AGED; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; CELL ISOLATION; CELL STRUCTURE; CELL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOSTASIS; CYTOTOXICITY; ENZYME ACTIVITY; FEMALE; GENE CONTROL; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; INSULIN RELEASE; MALE; OXIDATION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0036315888     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.5.1437     Document Type: Article

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