An early oxygen-dependent step is required for dexamethasone-induced apoptosis of immature mouse thymocytes

Journal of Immunology

Volumn 165, Issue 9, 2000, Pages 4822-4830

  Torres Roca, J F ^a   Tung, J W ^a   Greenwald, D R ^a   Brown, J M ^a   Herzenberg, L A ^a,a   Katsikis, P D ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; DEXAMETHASONE; FAS ANTIGEN; OXYGEN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL HYPOXIA; CONTROLLED STUDY; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THYMOCYTE;

EID: 0034327754     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.9.4822     Document Type: Article

References (56)

1. Apoptosis
2. Mitochondrial control of apoptosis
3. Oxidative stress as a mediator of apoptosis
4. Tumour cell killing by tumour necrosis factor: Inhibition by anaerobic conditions, free-radical scavengers and inhibitors of arachidonate metabolism
5. Cytotoxic mechanism of tumor necrosis factor-α
6. Role of free radicals and catalytic metal ions in human disease: An overview
7. Inhibition of activation-induced death in T cell hybridomas by thiol antioxidants: Oxidative stress as a mediator of apoptosis
8. The early production of a reactive oxygen intermediate mediates apoptosis in dexamethasone-treated thymocytes
9. Spermine prevents endonuclease activation and apoptosis in thymocytes
10. Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis
11. Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli
12. Programmed cell death and Bcl-2 protection in very low oxygen
13. Induction of apoptosis at different oxygen tensions: Evidence that oxygen radicals do not mediate apoptotic signaling
14. The role of oxygen in thymocyte apoptosis
15. Modulation of the mitochondrial permeability transition pore by pyridine nucleotides and dithiol oxidation at two separate sites
16. Redox regulation of apoptosis: Impact of thiol oxidation status on mitochondrial function
17. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
18. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
19. Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals
20. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo
21. Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis
22. Data analysis in flow cytometry
23. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
24. A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death
25. Mitochondrial permeability transition is a central coordinating event of apoptosis
26. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death
27. Unifying theory of hypoxia tolerance: Molecular/metabolic defense and rescue mechanisms for surviving oxygen lack
28. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
29. Bcl-2 inhibits the mitochondrial release of an apoptogenic protease
30. Specific activation of the cysteine protease CPP32 during the negative selection of T cells in the thymus
31. Neuroprotective action of cycloheximide involves induction of bcl-2 and antioxidant pathways
32. Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
33. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
34. Cytochrome c and dATP-dependent formation of Apaf-1/ caspase-9 complex initiates an apoptotic protease cascade
35. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
36. Differential requirement for caspase 9 in apoptotic pathways in vivo
37. Apaf1 is required for mitochondriai pathways of apoptosis and brain development
38. ATP depletion inhibits glucocorticoid-induced thymocyte apoptosis
39. Differential regulation and ATP requirement for caspase-8 and caspase-3 activation during CD95- and anticancer drag-induced apoptosis
40. Metabolic depletion of ATP by fructose inversely controls CD95- and tumor necrosis factor receptor 1-mediated hepatic apoptosis
41. Aponecrosis: Morphological and biochemical exploration of a syncretic process of cell death sharing apoptosis and necrosis
42. 150-kDa oxygen-regulated protein (ORP150) suppresses hypoxia-induced apoptotic cell death
43. Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH
44. Changes in intramitochondrial and cytosolic pH: Early events that modulate caspase activation during apoptosis
45. - exchanger in spontaneous thymocyte apoptosis
46. Intracellular alkalinization in dexamethasone-induced thymocyte apoptosis
47. Bax-deficient mice with lymphoid hyperplasia and male germ cell death
48. Reperfusion injury induces apoptosis in rabbit cardiomyocytes
49. Apoptosis in the pathogenesis and treatment of disease
50. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
51. Mechanisms of neuronal degeneration: A final common pathway?
52. Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway
53. Developmental switches in the immune system
54. Thymus-derived glucocorticoids set the thresholds for thymocyte selection by inhibiting TCR-mediated thymocyte activation
55. Thymocyte resistance to glucocorticoids leads to antigen-specific unresponsiveness due to holes in the T cell repertoire