Gene transfection and expression of transforming growth factor-β1 in nonobese diabetic mouse islets protects β-cells in syngeneic islet grafts from autoimmune destruction

Cell Transplantation

Volumn 11, Issue 6, 2002, Pages 519-528

  Suarez Pinzon, W L ^a   Marcoux, Y ^a   Ghahary, A ^a   Rabinovitch, A ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Gene therapy; Islets; NOD mice; TGF 1; Type I diabetes

Indexed keywords

INSULIN; TRANSFORMING GROWTH FACTOR BETA1;

ADENOVIRUS; ADOLESCENT; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNITY; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; GENE OVEREXPRESSION; GENE THERAPY; GENETIC TRANSFECTION; IMMUNOHISTOCHEMISTRY; INSULIN DEPENDENT DIABETES MELLITUS; ISOGRAFT; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; RECURRENT DISEASE; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANIMALIA; SUIDAE; VECTORS;

EID: 0036408818     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/000000002783985503     Document Type: Article

References (32)

1. Allan, R.; Forsythe, P.; Stafford, S.; Fukada, Y. Transforming growth factor β abrogates effects of hematopoietins in eosinophils and induces their apoptosis. J. Exp. Med. 179:1041-1045; 1994.
2. Bright, J. J.; Kerr, L. D.; Sriram, S. TGF-β inhibits IL-2-induced tyrosine phosphorylation and activation of Jak-1 and Stat 5 in T lymphocytes. J. Immunol. 159:175-183; 1997.
3. Carel, J. C.; Schreiber, R. D.; Falqui, L.; Lacy, P. E. Transforming growth factor β decreases the immunogenicity of rat islet xenografts (rat to mouse) and prevents rejection in association with treatment of the recipient with a monoclonal antibody to interferon-gamma. Proc. Natl. Acad. Sci. USA 87:1591-1595; 1990.
4. Deng, S.; Ketchum, R. J.; Kucher, T.; Weber, M.; Shaked, A.; Naji, A.; Brayman, K. L. IL-10 and TGF-beta gene transfer for xenogeneic islet transplantation: Comparison of effect in concordant vs. discordant combination. Transplant. Proc. 29:2204-2205; 1997.
5. Gainer, A. L.; Suarez-Pinzon W. L.; Min, W. P.; Swiston, J. R.; Hancock-Friesen, C.; Korbutt, G. S.; Nagata, S.; Rajotte, R. V.; Warnock, G. L.; Elliot, J. F. Improved survival of biobalistically transfected mouse islet allografts expressing CTLA4-Ig or soluble Fas ligand. Transplantation 66:194-199; 1998.
6. Gallichan, W. S.; Kafri, T.; Krahl, T.; Verma, I. M.; Sarvetnick, N. Lentivirus-mediated transduction of islet grafts with interleukin 4 results in sustained gene expression and protection from insulitis. Hum. Gene Ther. 9:2717-2726; 1998.
7. Ghahary, A.; Marcoux, Y.; Karimi-Busheri, F.; Tredget, E. E. Keratinocyte differentiation inversely regulates the expression of involucrin and transforming growth factor β1. J. Cell. Biochem. 83:239-248; 2001.
8. Giannoukakis, N.; Rudert, W. A.; Robbins, P. D.; Trucco, M. Targeting autoimmune diabetes with gene therapy. Diabetes 48:2107-2121; 1999.
9. Giannoukakis, N.; Mi, Z.; Gambotto, A.; Eramo, A.; Ricordi, C.; Trucco, M.; Robbins, P. D. Infection of intact human islets by a lentiviral vector. Gene Ther. 6:1545-1551; 1999.
10. Gill, R. G. Transforming growth factor β prevents islet allograft rejection. Transplant. Proc. 23:747-748; 1991.
11. Gojo, S.; Cooper, D. K C.; Iacomini, J.; LeGuern, C. Gene therapy and transplantation. Transplantation 69:1995-1999; 2000.
12. Gotoh, M.; Maki, J.; Kiyoizumi, T.; Satomi, S.; Monaco, A. P. An improved method for isolation of mouse pancreatic islets. Transplantation 40:437-438; 1985.
13. Kenyon, N. S.; Harlan, D. M.; Alejandro, R.; Ricordi, C.; Mintz, D. H. Islet cell transplantation. In: LeRoith, D.; Taylor, S. I.; Olefsky, J. M., eds. Diabetes Mellitus. A Fundamental and Clinical Text. Philadelphia; PA: Lippincott Williams & Wilkins; 2000:507-517.
14. King, C.; Davies, J.; Mueller, R.; Lee, M-S.; Krahl, T.; Yeung, B.; O'Connor, E.; Sarvetnick, N. TGF-β1 alters APC preference, polarizing islet antigen responses toward a Th2 phenotype. Immunity 80:601-613; 1998.
15. Koevary, S. B. Effects of transforming growth factor β (TGF-β1) on the lymphocyte- and cytokine-mediated destruction of islet cells in the BB/Wor rat. Lymphokine Cytokine Res. 10:337-342; 1991.
16. Letterio, J. L.; Roberts, A. B. Regulation of immune responses by TGF-β. Annu. Rev. Immunol. 16:137-162; 1998.
17. + T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today 16:34-38; 1995.
18. Ma, L.; Tamarina, N.; Wang, Y.; Kuznetsov, A.; Patel, N.; Kending, C.; Hering, B. J.; Philipson, L. H. Baculovirus-mediated gene transfer into pancreatic islet cells. Diabetes 49:1986-1991; 2000.
19. Mabley, J. G.; Cunningham, J. M.; John, N.; DiMatteo, M. A.; Green, I. C. Transforming growth factor β1 prevents cytokine-mediated inhibitory effects and induction of nitric oxide synthase in the RINm5F insulin-containing β-cell line. J. Endocrinol. 155:567-575; 1997.
20. Mortani, M.; Yoshimoto, K.; Wong, S. F.; Tanaka, C.; Yamaoka, T.; Sano, T.; Komagata, Y.; Miyazaki, J-I.; Kikutani, M.; Itakura, M. Abrogation of autoimmune diabetes in nonobese diabetic mice and protection against effector lymphocytes by transgenic paracrine TGF-β1. J. Clin. Invest. 102:499-506; 1998.
21. Ohno, K.; Ammann, P.; Fasciati, R.; Maier, P. Transforming growth factor β1 preferentially induces apoptotic cell death in rat hepatocytes cultured under pericentral-equivalent conditions. Toxicol. Appl. Pharmacol. 132:227-236; 1995.
22. Picirillo, C. A.; Chang, Y.; Prud'homme, G. J. TGF-β1 somatic gene therapy prevents autoimmune disease in nonobese diabetic mice. J. Immunol. 161:3950-3956; 1998.
23. Prud'homme, G. J.; Piccirillo, C. A. The inhibitory effects of transforming growth factor-beta-1 (TGF-β1) in autoimmune diseases. J. Autoimmun. 14:23-42; 2000.
24. Rabinovitch, A.; Suarez-Pinzon, W. L.; Strynadka, K.; Ju, Q.; Edelstein D.; Brownlee, M.; Korbutt, G. S. Rajotte, R. V. Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects β-cells from cytokine-induced destruction. Diabetes 48:1223-1229; 1999.
25. Ryan, E. A.; Lakey, J. R. T.; Rajotte, R. V.; Korbutt, G. S.; Kin, T.; Imes, S.; Rabinovitch, A.; Elliot, J. F.; Bigam, D.; Kneteman, N. M.; Warnock, G. L.; Larsen, I.; Shapiro, A. J. M. Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol. Diabetes 50:710-719; 2001.
26. Shapiro, A. M. J.; Lakey, J. R. T.; Ryan, E. A.; Korbutt, G. S.; Toth, E. L.; Warnock, G. L.; Kneteman, N. M.; Rajotte, R. V. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N. Engl. J. Med. 343:230-238; 2000.
27. Sime, P. J.; Xing, Z.; Graham, F. L.; Csaky, K. G.; Gauldie, J. Adenovector-mediated gene transfer of active transforming growth factor-β1 induces prolonged severe fibrosis in rat lung. J. Clin. Invest. 100:768-776; 1997.
28. Suarez-Pinzon, W. L.; Rabinovitch, A. Approaches to type 1 diabetes prevention by intervention in cytokine immunoregulatory circuits. Int. J. Exp. Diabetes Res. 2:3-17; 2001.
29. Sutherland, D. E. R.; Gruessner, R. W. G.; Mauer, S. M.; Gruessner, A. Pancreas transplantation. In: LeRoith, D.; Taylor, S. I.; Olefsky, J. M., eds. Diabetes Mellitus. A Fundamental and Clinical Text. Philadelphia PA: Lippincott Williams & Wilkins; 2000:518-525.
30. Wallick, S. C.; Figari, I. S.; Morris, R. E.; Levison, A. D.; Palladino, M. A. Immunoregulatory role of transforming growth factor β (TGFβ) in development of killer cells: Comparison of active and latent TGF-β1. J. Exp. Med. 172:1777-1784; 1990.
31. Wang, T.; Singh, B.; Warnock, G.; Rajotte, R. V. Prevention of recurrence of IDDM in islet-transplanted diabetic NOD mice by adjuvant immunotherapy. Diabetes 41:114-117; 1992.
32. Yasuda, H.; Nagata, M.; Arisawa, K.; Yoshida, R.; Fujihira, K.; Okamoto, N.; Moriyama, H.; Miki, M.; Saito, I.; Hamada, H.; Yokono, K.; Kasuga, M. Local expression of immunoregulatory IL-12 p40 gene prolonged syngeneic islet graft survival in diabetic NOD mice. J. Clin. Invest. 102:1807-1814; 1998.