The role of Apaf-1, caspase-9, and Bid proteins in etoposide- or paclitaxel-induced mitochondrial events during apoptosis

Cancer Research

Volumn 60, Issue 6, 2000, Pages 1645-1653

  Perkins, Charles L ^a   Fang, Guofu ^a   Kim, Caryn Nae ^a   Bhalla, Kapil N ^a  

^a UNIVERSITY OF MIAMI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 9; CASPASE INHIBITOR; CYTOCHROME C OXIDASE; ETOPOSIDE; PACLITAXEL; PROTEIN; PROTEIN BID; PROTEIN PRECURSOR; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL MEMBRANE POTENTIAL; CELL STRAIN HL 60; FIBROBLAST; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CARRIER PROTEINS; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; CYTOCHROME C GROUP; CYTOSOL; ENZYME PRECURSORS; ETOPOSIDE; FIBROBLASTS; GENE EXPRESSION REGULATION; HL-60 CELLS; HUMANS; INTRACELLULAR MEMBRANES; MEMBRANE POTENTIALS; MICE; MITOCHONDRIA; PACLITAXEL; PROTEINS; RECOMBINANT FUSION PROTEINS;

EID: 0034654517     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Salvesen, G., and Dixit, V. Caspases: intracellular signaling by proteolysis. Cell, 91: 433-446, 1997.
2. Thronberry, N., and Lazebnik, Y. Caspases: enemies within. Science (Washington DC), 28: 1312-1316, 1998.
3. Ashkenazi, A., and Dixit, V. Death receptors: signaling and modulation. Science (Washington DC), 281: 1305-1308, 1998.
4. Li, H., Zhu, H., Xu, C., and Yuan, J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell, 94: 491-501, 1998.
5. Lou, X., Budihardjo, I., Zou, H., Slaughter, C., and Wang, X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell, 94: 481-490, 1998.
6. L prevents this release but not tumor necrosis factor-R1/Fas death. J. Biol. Chem., 274: 1156-1163, 1999.
7. McDonnell, J., Fushman, D., Milliman, C., Korsmeyer, S., and Cowburn, D. Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists. Cell, 96: 625-634, 1999.
8. Chinnaiyan, A. M., O'Rourke, K., Tewari, M., and Dixit, V. M. FADD, a novel death-domain-containing protein, interacts with the death domain of Fas and initiales apoptosis. Cell, 81: 505-512, 1995.
9. Ahmad, M., Srinivasula, S. M., Wang, L., Talanian, R. V., Litwack, G., Fernandes-Alnemri, T., and Alnemri, E. S. CRADD, a novel human apoptotic adaptor molecule for caspase-2 and Fas/TNF receptor interacting protein RIP. Cancer Res., 57: 615-619, 1997.
10. Wolf, B., and Green, D. Suicidal tendencies: apoptotic cell death by caspase family porteinases. J. Biol. Chem., 274: 20049-20052, 1999.
11. Zou, W., Henzel, W. J., Liu, X., Lutschg, A., and Wang, X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell, 90: 405-413, 1997.
12. Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S., Ahmad, M., Alnemri, E., and Wang, X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell, 91: 479-489, 1997.
13. Srinivasula, S. M., Ahmad, M., Fernandes-Almenri, T., and Almenri, E. S. Autoactivation of procaspase-9 by apaf-1 mediated oligomerization. Mol. Cell, 1: 949-957, 1998.
14. Zou, H., Li, Y., Liu, X., and Wang, X. An Apaf-1 cytochrome c mutlimeric complex is a functional apoptosome thai activates procaspase-9. J. Biol. Chem., 274: 11549-11556, 1999.
15. Saleh, A., Srinivasula, S. M., Acharya, S., Fishel, R., and Alnemri, E. S. Cytochrome and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation. J. Biol. Chem., 274: 17941-17945, 1999.
16. Hu, Y., Ding, L., Spencer, D. M., and Nunez, G. WD-40 repeat region regulates Apaf-1 self association and procaspase-9 activation. J. Biol. Chem., 273: 33489-33494, 1998.
17. Hu, Y., Benedict, M., Ding, L., and Nunez, G. Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis. EMBO J., 18: 3586-3595, 1999.
18. Srinivasula, S. M., Ahmad, M., Guo, Y., Zhan, Y., Lazebnik, Y., Fernandes-Alnemri, T., and Alnemri, E. S. Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis. Cancer Res., 59: 999-1002, 1999.
19. Seol, D., and Biliar, T. R. A caspase-9 variant missing that catalytic site is an endogenous inhibitor of apoptosis. J. Biol. Chem., 274: 2072-2076, 1999.
20. Yoshida, H., Kong, Y., Yoshida, R., Elia, A. J., Hakem, A., Hakem, R., Penninger, J. M., and Mak, T. W. Apaf-1 is required for mitochondrial pathways of apoptosis and brain development. Cell, 94: 739-750, 1998.
21. Cecconi, F., Alvarez-Bolado, G., Meyer, B. I., Roth, K. A., and Gruss, P. Apaf-1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell, 94: 727-737, 1998.
22. Hakem, R., Hakem, A., Duncan, G. S., Henderson, J. T., Woo, M., Soengas, M. S., Elia, A., de la Pompa, J. L., Kagi, D., Khoo, W., Potter, J., Yoshida, R., Kaufman, S. A., Lowe, S. W., Penninger, J. M., and Mak, T. W. Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell, 94: 339-352, 1998.
23. Kuida, K., Haydar, T. F., Kuan, C-Y., Gu, Y., Taya, C., Karasuyama, H., Su, M. S-S., Rakic, P., and Flavel, R. A. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase-9. Cell, 94: 325-337, 1998.
24. Soengas, M. S., Alarcon, R. M., Yoshida, H., Giaccia, A. J., Hakem, R., Mak, T. W., and Lowe, S. W. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science (Washington DC), 284: 156-159, 1999.
25. Perkins, C., Kim, C., Fang, G., and Bhalla, K. Overexpression of apaf-1 promotes apoptosis of untreated and paclitaxel-or etoposide-treated HL-60 cells. Cancer Res., 58: 4561-4566, 1998.
26. Ray, S., Ponnathpur, V., Huang, Y., Tang, C., Mahoney, M. E., Ibrado, A. M., Bullock, G., and Bhalla, K. 1-β-D-Arabinofuranosylcytosine-, mitoxantrone-and paclitaxel-induced apoptosis in HL-60 cells: improved method for detection of internucleosomal DNA fragmentation. Cancer Chemother. Pharmacol., 34: 365-371, 1994.
27. Fang, G., Chang, B. S., Kim, C. N., Perkins, C., Thompson, C. B., and Bhalla, K. Loop domain is necessary for Taxol-induced mobility shift and phosphorylation of Bcl-2 as well as for inhibiting Taxol-induced cytosolic accumulation of cytochrome c (cyt c) and apoptosis. Cancer Res., 58: 3202-3208, 1998.
28. L overexpression inhibits Taxol-induced Yama protease activity and apoptosis. Cell Growth Differ., 7: 1087-1094, 1996.
29. Liu, X., Kim, C. N., Yang, J., Jemmerson, R.,and Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell, 86: 147-157, 1996.
30. Koopman, G., Reutelingsperger, C. P. M., Kuijten, G. A. M., Keehnen, R. M. J., Pals, S. T., and van Oers, M. H. J. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood, 84: 1415-1420, 1994.
31. L inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations and activate the molecular cascade of apoptosis. Cancer Res., 57: 3115-3120, 1997.
32. Amarante-Mendez, G., Kim, C. N., Liu, L., Huang, Y., Perkins, C., Green, D., and Bhalla, K. Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome c and activation of caspase-3. Blood, 91: 1700-1705, 1998.
33. Liu, X., Zhou, H., Widlak, P., Garrard, W., and Wang, X. Activation of apoptotic endonuclease DFF40 (caspase-activation DNase or nuclease). J. Biol. Chem., 274: 13836-13840, 1999.
34. Gu, J., Dong, R-P., Zhang, C., McLaughlin, D., Wu, M., and Schlossman, S. Functional interaction of DFF35 and DFF45 with caspase-activated DNA fragmentation nuclease DFF40. J. Biol. Chem., 274: 20759-20762, 1999.
35. Deveraux, Q. L., Takahashi, R., Salvesen, G. S., and Reed, J. C. X-linked IAP is a direct inhibitor of cell-death proteases. Nature (Lond.), 338: 300-304, 1997.
36. Deveraux, Q., Roy, N., Stennicke, H. R., Van Arsdale, T., Zhou, Q., Srinivasula, S. M., Alnemri, E. S., Salvesen, G. S., and Reed, J. C. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J., 17: 2215-2223, 1998.
37. Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., and Gentz, R. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95(Fas/APO-1) death-inducing signaling complex. Cell, 85: 817-827, 1996.
38. Stennicke, H. R., Deveraux, Q. L., Humke, E. W., Reed, J. C., Dixit, V. M., and Salvesen, G. S. Caspase-9 can be activated without proteolytic processing. J. Biol. Chem., 274: 8359-8362, 1999.
39. Sheridan, J., Marsters, S., Pitti, R., Gurney, A., Skubatch, M., Baldwin, D., Ramakrishnan, L., Gray, C., Baker, K., Wood, W., Goddard, A., Godowski, P., and Ashkenazi, A. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science (Washington DC), 277: 818-821, 1997.
40. French, L., and Tschopp, J. The TRAIL to selective tumor death. Nat. Med., 5: 146-147, 1999.
41. Bossy-Wetzel, E., and Green, D. R. Caspase induce cytochrome c release from mitochondria by activating cytosolic factors. J. Biol. Chem., 274: 17484-17490, 1999.
42. L, and Apaf-1 form a ternary complex, J. Biol. Chem., 571: 5841-5845, 1998.
43. L interacts with Apaf-1 and inhibits Apaf-1 dependent caspase-9 activation. Proc. Natl. Acad. Sci. USA, 95: 4386-4391, 1998.
44. Inohara, N., Gourley, T. S., Carrio, R., Muniz, M., Merion, J., Garcia, I., Koseki, T., Hu, Y., Chen, S., and Nunez, G. Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death. J. Biol. Chem., 273: 32479-32486, 1998.
45. Song, Q., Kuang, Y., Dixit, V. M., and Vincenz, C. Boo, a novel negative regulator of cell death, interacts with Apaf-1. EMBO J., 18: 167-178, 1999.
46. Cardone, M. H., Roy, N., Stennicke, H. R., Salvesen, G. S., Franke, T. F., Stanbridge, E., Frisch, S., and Reed, J. C. Regulation of cell death protease caspase-9 by phosphorylation. Science (Washington DC), 282: 1318-1321, 1998.
47. Alnemri, E. Hidden powers of the mitochondria. Nat. Cell Biol., 1: 40-42, 1999.