Differential requirement for Caspase 9 in apoptotic pathways in vivo

Cell

Volumn 94, Issue 3, 1998, Pages 339-352

  Hakem, Razqallah ^a,b   Hakem, Anne ^a,b   Duncan, Gordon S ^a,b   Henderson, Jeffrey T ^c   Woo, Minna ^a,b   Soengas, Maria S ^d   Elia, Andrew ^a,b   De La Pompa, José Luis ^a,b   Kagi, David ^a,b   Khoo, Wilson ^a,b   Potter, Julia ^a,b   Yoshida, Ritsuko ^a,b   Kaufman, Stephen A ^e   Lowe, Scott W ^d   Penninger, Josef M ^a,b   Mak, Tak W ^a,b  

^a AMGEN INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MOUNT SINAI HOSPITAL   (Canada)

^d Watson School of Biological Sciences   (United States)

^e AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C; DEXAMETHASONE; INTERLEUKIN 1BETA CONVERTING ENZYME;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN DEVELOPMENT; BRAIN MALFORMATION; CELL DEATH; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVATION; FIBROBLAST CULTURE; FLOW CYTOMETRY; GAMMA IRRADIATION; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; THYMOCYTE;

ANIMALIA; MAMMALIA;

EID: 0032493870     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81477-4     Document Type: Article

References (42)

1. Bakhshi, A., Jensen, J.P., Goldman, P., Wright, J.J., McBride, O.W., Epstein, A.L., and Korsmeyer, S.J. (1985). Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell 41, 899-906.
2. Bergeron, L., Perez, G.I., Macdonald, G., Shi, L., Sun, Y., Jurisicova, A., Varmuza, S., Latham, K.E., Flaws, J.A., Salter, J.C., et al. (1998). Defects in regulation of apoptosis in caspase-2-deficient mice. Genes Dev. 12, 1304-1314.
3. Bossy, W.E., Newmeyer, D.D., and Green, D.R. (1998). Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial trans-membrane depolarization. EMBO J. 17, 37-49.
4. Cheng, E.H., Kirsch, D.G., Clem, R.J., Ravi, R., Kastan, M.B., Bedi, A., Ueno, K., and Hardwick, J.M. (1997). Conversion of Bcl-2 to a Bax-like death effector by caspases. Science 278, 1966-1968.
5. Clem, R.J., Cheng, E.H., Karp, C.L., Kirsch, D.G., Ueno, K., Takahashi, A., Kastan, M.B., Griffin, D.E., Earnshaw, W.C., Veliuona M.A., et al. (1998). Modulation of cell death by Bcl-XL through caspase interaction. Proc. Natl. Acad. Sci. USA 95, 554-559.
6. Cohen, G.M. (1997). Caspases: the executioners of apoptosis. Biochem. J. 326, 1-16.
7. Deckwerth, T.L., Elliott, J.L., Knudson, C.M., Johnson, E.M., Jr., Snider, W.D., and Korsmeyer, S.J. (1996). BAX is required for neuronal death aftertrophic factor deprivation and during development. Neuron 17, 401-411.
8. Deveraux, Q.L., Roy, N., Stennicke, H.R., Van Arsdale, T., Zhou, Q., Srinivasula, S.M., Alnemri, E.S., Salvesen, G.S., and Reed, J.C. (1998). IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J. 17, 2215-2223.
9. Donehower, L.A. (1996). The p53-deficient mouse: a model for basic and applied cancer studies. Semin. Cancer Biol. 7, 269-278.
10. Duan, H., Orth, K., Chinnaiyan, A.M., Poirier, G.G., Froelich, C.J., He, W.W., and Dixit, V.M. (1996). ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J. Biol. Chem. 271, 16720-16724.
11. Green, D.R., and Martin, S.J. (1995). The killer and the executioner: how apoptosis controls malignancy. Curr. Opin. Immunol. 7, 694-703.
12. Hakem, R., de la Pompa, J.L., Sirard, C., Mo, R., Woo, M., Hakem, A., Wakeham, A., Potter, J., Reitmair, A., Billia, F., et al. (1996). The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell 85, 1009-1023.
13. Hengartner, M.O. (1996). Programmed cell death in invertebrates. Curr. Opin. Genet. Dev. 6, 34-38.
14. Hu, Y., Benedict, M.A., Wu, D., Inohara, N., and Nunez, G. (1998). Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. Proc. Natl. Acad. Sci. USA 95, 4386-4391.
15. Kharbanda, S., Pandey, P., Schofield, L., Israels, S., Roncinske, R., Yoshida, K., Bharti, A., Yuan, Z.M., Saxena, S., Weichselbaum, R., et al. (1997). Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis. Proc. Natl. Acad. Sci. USA 94, 6939-6942.
16. Kluck, R.M., Bossy, W.E., Green, D.R., and Newmeyer, D.D (1997). The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275, 1132-1136.
17. Knudson, C.M., Tung, K.S., Tourtellotte, W.G., Brown, G.A., and Korsmeyer, S.J. (1995). Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270, 96-99.
18. Kuida, K., Lippke, J.A., Ku, G., Harding, M.W., Livingston, D.J., Su, M.S.-S., and Flavell, R.A. (1995). Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 267, 2000-2003.
19. Kuida, K., Zheng, T.S., Na, S., Kuan, C.K., Yang, D., Karasuyama, H., Rakic, P., and Flavell, R.A. (1996). Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384, 368-372.
20. Li, F., Srinivasan, A., Wang, Y., Armstrong, R.C., Tomaselli, K.J., and Fritz, L.C. (1997a). Cell-specific induction of apoptosis by microinjection of cytochrome c. Bcl-xL has activity independent of cytochrome c release. J. Biol. Chem. 272, 30299-30305.
21. Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S.M., Ahmad, M., Alnemri, E.S., and Wang, X., (1997b). Cytochrome c and dATP-dependent formation of Apaf-1/Caspase-9 complex initiates an apoptotic protease cascade. Cell 91, 479-489.
22. Liston, P., Roy, N., Tamai, K., Lefebvre, C., Baird, S., Cherton-Horvat, G., Farahani, R., McLean, M., Ikeda, J.E., MacKenzie, A., et al. (1996). Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. Nature 379, 349-353.
23. Lowe, S.W., Schmitt, E.M., Smith, S.W., Osborne, B.A., and Jacks, T. (1993). p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362, 847-849.
24. Mignotte, B., and Vayssiere, J.L. (1998). Mitochondria and apoptosis. Eur. J. Biochem. 252, 1-15.
25. Mishina, Y., Suzuki, A., Ueno, N., and Behringer, R.R. (1995). Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis. Genes Dev. 9, 3027-3037.
26. Motoyama, N., Wang, F., Roth, K.A., Sawa, H., Nakayama, K., Nakayama, K., Negishi, I., Senju, S., Zhang, Q., Fujii, S., et al. (1995). Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 267, 1506-1510.
27. Nagata, S. (1997). Apoptosis by death factor. Cell 88, 355-365.
28. Pan, G., O'Rourke, K., and Dixit, V.M. (1998). Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex. J. Biol. Chem. 273, 5841-5845.
29. Reed, J.C. (1994). Bcl-2 and the regulation of programmed cell death. J. Cell. Biol. 124, 1-6.
30. Roy, N., Deveraux, Q.L., Takahashi, R., Salvesen, G.S., and Reed, J.C. (1997). The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J. 16, 6914-6925.
31. Salvesen, G.S., and Dixit, V.M. (1997). Caspases: intracellular signaling by proteolysis. Cell 91, 443-446.
32. Sentman, C.L., Shutter, J.R., Hockenbery, D., Kanagawa, O., and Korsmeyer, S.J. (1991). bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67, 879-888.
33. Srinivasula, S.M., Fernandes-Alnemri, T., Zangrilli, J., Robertson, N., Armstrong, R.C., Wang, L., Trapani, J.A., Tomaselli, K.J., Litwack, G., and Alnemri, E.S. (1996). The Ced-3/interleukin 1 beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32. J. Biol. Chem. 271, 27099-27106.
34. Steller, H. (1995). Mechanisms and genes of cellular suicide. Science 267, 1445-1449.
35. Thompson, C.B. (1995). Apoptosis in the pathogenesis and treatment of disease. Science 267, 1456-1462.
36. Tsujimoto, Y., Gorham, J., Cossman, J., Jaffe, E., and Croce, C.M. (1985). The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science 229, 1390-1393.
37. Wang, S., Miura, M., Jung, Y.-K., Zhu, H., Li, E., and Yuan, J. (1998). Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell 92, 501-509.
38. White, E. (1993). Death-defying acts: a meeting review on apoptosis. Genes Dev. 7, 2277-2284.
39. Woo, M., Hakem, R., Soengas, M.S., Duncan, G.S., Shahinian, A., Kagi, D., Hakem, A., McCurrach, M., Khoo, W., Kaufman, S.A., et al. (1998). Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev. 12, 806-819.
40. Yang, J., Liu, X., Bhalla, K., Kim, C.N., Ibrado, A.M., Cai, J., Peng, T.I., Jones, D.P., and Wang, X. (1997). Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275, 1129-1132.
41. Zhivotovsky, B., Orrenius, S., Brustugun, O.T., and Doskeland, S.O. (1998). Injected cytochrome c induces apoptosis. Nature 391, 449-450.
42. Zou, H., Henzel, W., Liu, X., Lutschg, A., and Wang, X. (1997). Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90, 405-413.