Interleukin-1β-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen- activated protein kinases

Journal of Biological Chemistry

Volumn 273, Issue 24, 1998, Pages 15294-15300

  Larsen, Claus M ^a   Wadt, Karin A W ^a   Juhl, Lone F ^b   Andersen, Henrik U ^a,e   Karlsen, Allan E ^a   Su, Michael S S ^c   Seedorf, Klaus ^b   Shapiro, Leland ^d   Dinarello, Charles A ^d   Mandrup Poulsen, Thomas ^a  

^a STENO DIABETES CENTER   (Denmark)

^b HAGEDORN RESEARCH INSTITUTE   (Denmark)

^c VERTEX PHARMACEUTICALS   (United States)

^d UNIVERSITY OF COLORADO   (United States)

^e Juvenile Diabet Found Intl ^*

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; GLUCOSE; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE SYNTHASE; NOS2 PROTEIN, RAT; PROTEIN KINASE (CALCIUM,CALMODULIN);

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DESTRUCTION; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; DNA DAMAGE; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; METABOLISM; OSMOLARITY; PANCREAS; PANCREAS ISLET; PHOSPHORYLATION; PHYSIOLOGY; RAT STRAIN;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOSE; INSULIN; INTERLEUKIN-1; ISLETS OF LANGERHANS; MITOGEN-ACTIVATED PROTEIN KINASES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OSMOLAR CONCENTRATION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PANCREAS; PHOSPHORYLATION; RATS; RATS, INBRED STRAINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0032510838     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.24.15294     Document Type: Article

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