Expression of transgene encoded TGF-β in islets prevents autoimmune diabetes in NOD mice by a local mechanism

Journal of Autoimmunity

Volumn 19, Issue 1-2, 2002, Pages 9-22

  Grewal, Iqbal S ^a,b,c   Grewal, Kate D ^a,c   Wong, F Susan ^a,c   Wang, Hua ^b,c   Picarella, Dominic E ^a,c   Janeway Jr , Charles A ^a,c   Flavell, Richard A ^a,c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GENENTECH INC   (United States)

^c MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

Autoimmunity; Cytokines; Immune regulation; Pancreas; Suppression

Indexed keywords

GLUCOSE; INULIN; TRANSFORMING GROWTH FACTOR BETA; INSULIN;

ADOPTIVE TRANSFER; AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CELL INVASION; CONTROLLED STUDY; CYSTIC FIBROSIS; EFFECTOR CELL; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; IMMUNE RESPONSE; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; LYMPHOCYTE CLONE; LYMPHOCYTIC INFILTRATION; MONONUCLEAR CELL; MOUSE; NICK END LABELING; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SPLEEN; TRANSGENIC MOUSE; WILD TYPE; ANIMAL; BIOSYNTHESIS; GENETICS; IMMUNOLOGICAL TOLERANCE; METABOLISM; NONOBESE DIABETIC MOUSE; PANCREAS; PANCREAS ISLET; PATHOLOGY; PHYSIOLOGY;

ANIMALS; APOPTOSIS; DIABETES MELLITUS, TYPE 1; IMMUNE TOLERANCE; INSULIN; ISLETS OF LANGERHANS; LEUKOCYTES, MONONUCLEAR; MICE; MICE, INBRED NOD; MICE, TRANSGENIC; PANCREAS; PROMOTER REGIONS (GENETICS); TRANSFORMING GROWTH FACTOR BETA;

EID: 0036700341     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.2002.0599     Document Type: Article

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