Ultrastructural evidence that apoptosis is the mechanism by which human amylin evokes death in RINm5F pancreatic islet β-cells

Cell Biology International

Volumn 25, Issue 4, 2001, Pages 339-350

  Saafi, Etuate L ^a   Konarkowska, Barbara ^a   Zhang, Shaoping ^a   Kistler, Joerg ^b   Cooper, Garth J S ^a,c  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Amylin; Apoptosis; Cellular morphology; Islet amyloid; RINm5F islet cells; Scanning electron microscopy; Transmission electron microscopy; Type 2 diabetes; Ultrastructure

Indexed keywords

AMYLIN; DNA;

APOPTOSIS; ARTICLE; CELL DEATH; CELL ULTRASTRUCTURE; DIABETES MELLITUS; ELECTRON MICROSCOPY; HUMAN; HUMAN CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL;

EID: 0034823116     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1006/cbir.2000.0643     Document Type: Article

References (42)

1. Transgenic over-expression of human islet amyloid polypeptide inhibits insulin secretion and glucose elimination after gastric glucose gavage in mice
2. Role of calcium in apoptosis evoked by human amylin in pancreatic islet β-cells
3. Hyalinization of the islets of Langerhans in diabetes mellitus
4. Hyalinization of the islets of Langerhans in non-diabetic individuals
5. Apoptosis and disease
6. Islet amyloid formed from diabetes-associated peptide may be pathogenic in type-2 diabetes
7. Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation
8. Cell death: Current difficulties in discriminating apoptosis from necrosis in the context of pathological processes in vivo
9. Amylin compared with calcitonin gene-related peptide: Structure, biology, and relevance to metabolic disease
10. Amylin and the amylin gene: Structure, function and relationships to islet amyloid and to diabetes mellitus
11. Amylin found in amyloid deposits in human type 2 diabetes mellitus may be a hormone that regulates glycogen metabolism in skeletal muscle
12. Purification and characterisation of a peptide from amyloid-rich pancreases of type 2 diabetic patients
13. Amylin hormone
14. Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide
15. Death of cells by apoptosis following attachment of specifically allergized lymphocytes in vitro
16. Apoptosis: Lessons from in vitro systems
17. Amyloidosis of the islet of Langerhans
18. Apoptosis of HL-60 cells induced by Harringtonine: Membrane blebs, nucleus blebs and chromatin condensation
19. Polymorphic fibrillar assembly of human amylin
20. Watching amyloid fibrils grow by time lapse atomic force microscopy
21. Coated pits, coated vesicles, and receptor-mediated endocytosis
22. Intracellular amyloidogenesis by human islet amyloid polypeptide induces apoptosis in COS-1 cells
23. Newly identified pancreatic protein islet amyloid polypeptide. What is its relationship to diabetes?
24. Definition and incidence of apoptosis: An historical perspective
25. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
26. Pancreatic amylin and calcitonin gene-peptide cause resistance to insulin in skeletal muscle in vitro
27. Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus
28. Apoptosis, oncosis, and necrosis: An overview of cell death
29. Dicing with death: Dissecting the components of the apoptosis machinery
30. Induction of insulin resistance in vivo by amylin and calcitonin gene-related peptide
31. Co-secretion of amylin and insulin from cultured islet beta-cells: Modulation by nutrient secretagogues, islet hormones and hypoglycaemic agents
32. Induction of apoptosis in cultured hepatocytes and in the regressing liver by transforming growth factor-beta 1 occurs without activation of an endonuclease
33. Amylin secretion from the rat pancreas and its selective loss after streptozotocin treatment
34. On the relation of chronic interstitial pancreatitis to the islands of Langerhans and to diabetes mellitus
35. Morphological aspects of glucocorticoid-induced cell death in human lymphoblastoid cells
36. The mechanism of T cell mediated cytotoxicity. II. Morphological studies of cell death by time-lapse microcinematography
37. Ultrastructural analysis of β-amyloid-induced apoptosis in cultured hippocampal neurons
38. Islet amyloid polypeptide: Pin-pointing amino acid residues linked to amyloid fibril formation
39. A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas
40. Islet amyloid in type 2 (non-insulin dependent) diabetes is related to insulin
41. Cell death: The significance of apoptosis
42. WAF1/CIP1