A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone

Diabetes

Volumn 51, Issue 2, 2002, Pages 347-355

  Piganelli, Jon D ^a,e   Flores, Sonia C ^b   Cruz, Coral ^b   Koepp, Jeffrey ^b   Batinic Haberle, Ines ^c   Crapo, James ^d   Day, Brian ^d   Kachadourian, Remy ^d   Young, Rebekah ^a   Bradley, Brenda ^a   Haskins, Kathryn ^a  

^a UNIVERSITY OF COLORADO DENVER   (United States)

^b Webb Waring Inst for Biomed Res   (United States)

^c DUKE UNIVERSITY   (United States)

^d NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^e CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOXAN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; METALLOPORPHYRIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN RECOGNITION; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CELL DESTRUCTION; CELL INFILTRATION; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE RELEASE; DIABETES MELLITUS; INSULINOMA; LYMPHOCYTE CLONE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; RESPIRATORY BURST; SCID MOUSE; T LYMPHOCYTE;

EID: 0036061614     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.2.347     Document Type: Article

References (74)

1. Inducible nitric oxide synthase (iNOS) in pancreatic islets of nonobese diabetic mice: Identification of iNOS-expressing cells and relationships to cytokines expressed in the islets
2. The role of interleukin-1 in the pathogenesis of IDDM
3. The harmony of the spheres: Inducible nitric oxide synthase and related genes in pancreatic beta cells
4. Cytokines and the endocrine system. II. Roles in substrate metabolism, modulation of thyroidal and pancreatic endocrine cell functions and autoimmune endocrine diseases
5. Superoxide dismutase, catalase and scavengers of hydroxyl radical protect against the toxic action of alloxan on pancreatic islet cells in vitro
6. Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation
7. Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans: Evidence for the beta-cell as a source and site of action of nitric oxide
8. Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes
9. Beta cell apoptosis in T cell-mediated autoimmune diabetes
10. Apoptosis is the mode of beta-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse
11. The role of Fas in autoimmune diabetes
12. Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice
13. Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells
14. Distinction between interleukin-1-induced necrosis and apoptosis of islet cells
15. CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse
16. Determinants of the selective toxicity of alloxan to the pancreatic B cell
17. Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues
18. Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells
19. Adenovirus-mediated catalase gene transfer reduces oxidant stress in human, porcine and rat pancreatic islets
20. Complementary action of antioxidant enzymes in the protection of bioengineered insulin-producing RINm 5F cells against the toxicity of reactive oxygen species
21. Protection against the co-operative toxicity of nitric oxide and oxygen free radicals by overexpression of antioxidant enzymes in bioengineered insulin-producing RINm 5F cells
22. Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta-induced cytotoxicity and reduces nitric oxide production
23. Transgenic copper/zinc superoxide dismutase modulates susceptibility to type I diabetes
24. Targeted overexpression of Cu/Zn superoxide dismutase protects pancreatic beta-cells against oxidative stress
25. Pancreatic beta cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and streptozotocin-induced diabetes
26. Superoxide dismutases: An adaptation to a paramagnetic gas
27. Catalysis of the disproportion of superoxide by metalloporphyrins. III
28. Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo
29. The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium-2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic
30. Metalloporphyrin class of therapeutic catalytic antioxidants
31. Manganese(III) biliverdin IX dimethyl ester: A powerful catalytic scavenger of superoxide employing the Mn(III)/Mn(IV) couple
32. Relationship among redox potentials, proton dissociation constants of pyrrolic nitrogens, and in vivo and in vitro superoxide dismutating activities of manganese(III) and iron(III) water-soluble porphyrins
33. Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury
34. Catalytic scavenging of peroxynitrite by isomeric Mn(III) n-methylpyridylporphyrins in the presence of reductants
35. Nitrosylation of manganese (II) tetrakis(N-ethylpyridinium-2-yl)porphyrin: A simple and sensitive spectrophotometric assay for nitric oxide
36. Metalloporphyrins are potent inhibitors of lipid peroxidation
37. The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock
38. Requirement for superoxide in excitotoxic cell death
39. Inhibition of neuronal apoptosis by a metalloporphyrin superoxide dismutase mimic
40. Manganese-porphyrin reactions with lipids and lipoproteins
41. A catalytic antioxidant metalloporphyrin blocks hydrogen peroxide-induced mitochondrial DNA damage
42. A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase
43. T-lymphocyte clone specific for pancreatic islet antigen
44. Pancreatic islet-specific T-cell clones from nonobese diabetic mice
45. Comparison of a T cell clone and of T cells from a TCR transgenic mouse: TCR transgenic T cells specific for self-antigen are atypical
46. Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T cell clone
47. NIT-1, a pancreatic beta-cell line established from a transgenic NOD/Lt mouse
48. Selective induction of apoptosis in mouse and human lung epithelial cell lines by the tert-butyl hydroxylated metabolite of butylated hydroxytoluene: A proposed role in tumor promotion
49. An accessory cell-derived costimulatory signal acts independently of protein kinase C activation to allow T cell proliferation and prevent the induction of unresponsiveness
50. Clonal expansion versus functional clonal inactivation: A costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy
51. T-cell clonal anergy
52. The B7 and CD28 receptor families
53. Requirement for an Ia-bearing accessory cell in Con A-induced T cell proliferation
54. The role of accessory cells in polyclonal T cell activation. I. Both induction of interleukin 2 production and of interleukin 2 responsiveness by concanavalin A are accessory cell dependent
55. The role of accessory cells in polyclonal T cell activation. II. Induction of interleukin 2 responsiveness requires cell-cell contact
56. The role of accessory cells in polyclonal T cell activation. III. No requirement for recognition of H-2-encoded antigens on accessory cells
57. Accessory cell function in the Con A response: Role of Ia-positive and Ia-negative accessory cells
58. T cell triggering by lectins. I. Requirements for interleukin 2 production; lectin concentration determines the accessory cell dependency
59. Conditional requirement for accessory cells in the response of T cells to Con A
60. Following a diabetogenic T cell from genesis through pathogenesis
61. Macrophage activation for tumor cytotoxicity: Characterization of priming and trigger signals during lymphokine activation
62. Peroxynitrite activates the phosphoinositide 3-kinase/Akt pathway in human skin primary fibroblasts
63. p21ras as a common signaling target of reactive free radicals and cellular redox stress
64. Importance of MEK in neutrophil microbicidal responsiveness
65. Activation of mitogen-activated protein kinase cascades during priming of human neutrophils by TNF-alpha and GM-CSF
66. Biphasic regulation of leukocyte superoxide generation by nitric oxide and peroxynitrite
67. Endogenous oxygen radicals modulate protein tyrosine phosphorylation and JNK-1 activation in lectin-stimulated thymocytes
68. IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase
69. IkappaB kinases serve as a target of CD28 signaling
70. Analysis of leukocytes recruited to the pancreas by diabetogenic T cell clones
71. Gene therapy made difficult
72. A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats