Signaling events triggered by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL): Caspase-8 is required for TRAIL-induced apoptosis

Cancer Research

Volumn 61, Issue 3, 2001, Pages 1138-1143

  Seol, Dai Wu ^a   Li, Jianrong ^a   Seol, Mi Hyang ^a   Park, Sang Youel ^a   Talanian, Robert V ^b   Billiar, Timothy R ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b BASF Bioresearch Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE; CASPASE 3; CASPASE 8; CASPASE INHIBITOR; CYTOCHROME C; DNA FRAGMENT; FAS ANTIBODY; FAS LIGAND; INTERLEUKIN 1BETA CONVERTING ENZYME; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA CLEAVAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME RELEASE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CASPASE 8; CASPASE 9; CASPASES; CYSTEINE PROTEINASE INHIBITORS; ENZYME ACTIVATION; ENZYME PRECURSORS; HELA CELLS; HUMANS; JURKAT CELLS; MEMBRANE GLYCOPROTEINS; OLIGOPEPTIDES; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035117460     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (65)

1. Death receptors: Signaling and modulation
2. Apoptosis by death factor
3. Caspases: Intracellular signaling by proteolysis
4. The TNF receptor 1-associated protein TRADD signals cell death and NF-ΚB activation
5. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
6. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex
7. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1-and TNF receptor-induced cell death
8. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
9. Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE- like cysteine proteases
10. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-ΚB activation prevents cell death
11. The death domain kinase RIP mediates the TNF-induced NF-ΚB signal
12. The involvement of NF-ΚB in β-interferon gene regulation reveals its role as widely inducible mediator of signal transduction
13. Activation of interleukin-6 gene expression through the NF-ΚB transcription factor
14. Targeted disruption of the p50 subunit of NF-ΚB leads to multifocal defects in immune responses
15. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
16. An essential role for NF-ΚB in preventing TNF-α-induced cell death
17. TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-ΚB
18. Suppression of TNF-α-induced apoptosis by NF-ΚB
19. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain
20. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
21. FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis
22. Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade
23. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
24. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
25. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
26. Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex
27. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
28. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
29. The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis
30. 2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity
31. Triggering cell death: The crystal structure of Apo2L/TRAIL in a complex with death receptor 5
32. The receptor for the cytotoxic ligand TRAIL
33. An antagonist decoy receptor and a death domain-containing receptor for TRAIL
34. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors
35. Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL
36. A novel receptor for Apo2L/TRAIL contains a truncated death domain
37. Identification and characterization of a new member of the TNF family that induces apoptosis
38. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family
39. Lethal effect of the anti-Fas antibody in mice
40. Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage
41. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
42. Safety and antitumor activity of recombinant soluble Apo2 ligand
43. TRAIL/Apc-2-ligand-induced apoptosis in human T cells
44. Caspase-independent cell killing by Fas-associated protein with death domain
45. A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis
46. Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylation
47. Regulation of the c-met proto-oncogene promoter by p53
48. Nitric oxide suppression of apoptosis occurs in association with an inhibition of Bcl-2 cleavage and cytochrome c release
49. Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells
50. Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death
51. Fas-associated death domain protein interleukin-1β-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue is proximally involved in CD95- and p55-mediated death signaling
52. Molecular cloning and characterization of two novel pro-apoptotic isoforms of caspase-10
53. Inherited human caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II
54. Involvement of an ICE-like protease in Fas-mediated apoptosis
55. C1mA, a poxvirus-encoded serpin, inhibits cytotoxic T-lymphocyte-mediated apoptosi
56. Granule-mediated killing: Pathways for granzyme B-initiated apoptosis
57. Activation of apoptosis by APO-2 ligand is independent of FADD but blocked by CrmA
58. TRAIL-R2: A novel apoptosis-mediating receptor for TRAIL
59. Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-ΚB pathway
60. TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-ΚB
61. Dominant-negative FADD inhibits TNFR60-, Fas/Apo1-, and TRAIL-R/Apo2-mediated cell death but not gene induction
62. FADD: Essential for embryo development and signaling from some, but not all, inducers of apoptosis
63. Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand
64. Fas and Fas ligand in embryos and adult mice: Ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover
65. Multiple pathways of Fas-induced apoptosis in primary culture of hepatocytes