FADD expression and caspase activation in B-cell lymphomas resistant to Fas-mediated apoptosis

British Journal of Haematology

Volumn 106, Issue 3, 1999, Pages 652-661

  Xerri, Luc ^a,b   Devilard, Elisabeth ^a,b   Bouabdallah, Reda ^b   Stoppa, Anne Marie ^b   Hassoun, Jacques ^b   Birg, Françoise ^a  

^a INSERM   (France)

^b INSTITUT PAOLI CALMETTES   (France)

Author keywords

Caspase activation; FADD Mort1; Fas pathway; Non Hodgkin's lymphoma; PARP activation

Indexed keywords

CASPASE; FAS ANTIGEN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

APOPTOSIS; ARTICLE; B CELL LYMPHOMA; ENZYME ACTIVATION; FOLLICULAR LYMPHOMA; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; LARGE CELL LYMPHOMA; LYMPHOCYTOMA; MANTLE CELL LYMPHOMA; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTIGENS, CD40; APOPTOSIS; BLOTTING, WESTERN; CARRIER PROTEINS; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; FAS LIGAND PROTEIN; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; HUMANS; LYMPHOMA, B-CELL; MEMBRANE GLYCOPROTEINS; POLY(ADP-RIBOSE) POLYMERASES;

EID: 0032877846     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1999.01586.x     Document Type: Article

References (44)

1. Armitage, R.J. (1994) Tumor necrosis factor receptor superfamily members and their ligands. Current Biology, 6, 407-413.
2. Bakhshi, A., Jensen, J.P., Goldman, P., Wright, J.J., McBride, O.W., Epstein, A.L. & Korsmeyer, S.J. (1985) Cloning the chromosomal breakpoint of t(14;18) in human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell, 41, 899-906.
3. Bellosilo, B., Dalmau, M., Colomer, D. & Gil, J. (1997) Involvement of CED-3/ICE proteases in the apoptosis of B-chronic lymphocytic leukemia cells. Blood, 89, 3378-3384.
4. Boldin, M.P., Goncharov, T.M., Goltsev, Y.V. & Wallach, D. (1996) Involvement of MACH, a novel MORTI/FADD-interacting protease, in Fas/APO-I-and TNF receptor-induced cell death. Cell, 85, 803-815.
5. Brancolini, C., Benedetti, M. & Schneider, C. (1995) Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases. EMBO Journal, 14, 5179-5190.
6. Casciola-Rosen, L., Nicholson, D.W., Cong, T., Rowan, K.R., Thornberry, N.A, Miller, D.K. & Rosen, A. (1996) Apopain/ CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death. Journal of Experimental Medicine, 183, 1957-1964.
7. Chinnaiyan, A.M., O'Rourke, K., Tewari, M. & Dixit, V.M. (1995) FADD, a novel death containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell, 85, 505-512.
8. Chinnaiyan, A.M., Tepper, C.G., Seldin, M.F., O'Rourke, K., Kischkel, F.C., Hellbardt, S., Krammer, P.H., Peter, M.E. & Dixit, V.M. (1996) FADD/MORTI is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis. Journal of Biological Chemistry, 271, 4961-4965.
9. Cleary, M.L., Smith, S.D. & Sklar, J. (1986) Cloning and structural analysis of cDNAs for bcl-2 and hybrid bcl-2 immunoglobulin transcript resulting from the t(14:18) translocation. Cell, 47, 19-28.
10. Duriez, P.J., Desnoyers, S., Hoflack, J.C., Shah, G.M., Morelle, B., Bourassa, S., Poirier, G.G. & Talbot, B. (1997) Characterization of anti-peptide antibodies directed towards the automodification domain and apoptotic fragment of poly (ADP-ribose) polymerase, Biophysica et Biochimica Acta, 1334, 65-72.
11. Enari, M., Talanian, R.V., Wong, W.W. & Nagata, S. (1996) Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature, 380, 723-726.
12. Fernandes-Alnemri, T., Litwach, G. & Alnemri, E.S. (1994) CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1b-converting enzyme. Journal of Biological Chemistry, 269, 30761-30764.
13. Friesen, C., Herr, I., Krammer, P.H. & Debatin, K.M. (1996) Involvement of CD 95 (Apo-1/Fas) receptor/ligand system in drug induced apoptosis in leukaemia cells. Nature Medicine, 5, 574-577.
14. Ghiotto-Ragueneau, M., Battifora, M., Truneh, A., Waterfield, M.D., Olive, D. (1996) Comparison of CD28-B7.1 and B7.2 functional interaction in resting human T cells: phosphatidylinositol 3-kinase association to CD28 and cytokine production. European Journal of Immunology, 26, 34-41.
15. Gronback, K., Straten, P., Ralfkiaer, E., Ahrenkiel, V., Andersen, M.K., Hansen, N.E., Zeuthen, J., Hou-Jensen, K. & Guldberg, P. (1998) Somatic Fas mutations in non-Hodgkin's lymphoma: association with extranodal disease and autoimmunity. Blood, 92, 3018-3024.
16. Harris, N., Jaffe, E.S., Stein, H., Banks, P.M., Chan, J.K.C., Cleary, M.L., Delsol, G., De Wolf-Peeters, C., Falini, B., Gatter, K.C., Grogan, TM., Isaacson, P.G., Knowles, D., Mason, D.Y., Muller-Hermelink, H.K., Pileri, S.A., Piris, M.A., Ralfkiaer, E. & Warnke, R.A. (1994) A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood, 84, 1361-1392.
17. Irmler, M., Thome, M., Hahne, M., Schneider, P., Hofmann, K., Steiner, V., Bodmer, J.L., Schroter, M., Burns, K., Mattmann, C., Rimoldi, D., French, L.E. & Tschopp, J. (1997) Inhibition of death receptor signals by cellular FLIP. Nature, 388, 190-195.
18. Itoh, N., Yonehara, S., Ishii, A., Yonehara, M., Mizushima, S., Sameshima, M., Hase, A., Seto, Y. & Nagata, S. (1991) The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell, 66, 233-243.
19. King, D., Pringle, J.H., Hutchinson, M. & Cohen, G.M. (1998) Processing/activation of caspases-3 and -7 and -8 but not caspase-2, in the induction of apoptosis in B-chronic lymphocytic leukemia cells. Leukemia, 12, 1553-1560.
20. Krajewski, S., Gascoyne, R., Zapata, J., Krajewska, M., Kitada, S., Chhanabhai, M., Horsman, D., Berean, K., Piro, L.D., Fugier-Vivier, I., Liu, Y.J., Wang, H.G. & Reed, J.C. (1997) Immunolocalization of the ICE/ced-3 family protease CPP32 (Caspase-3) in non-Hodgkin's lymphomas, chronic lymphocytic leukemias and reactive lymph nodes. Blood, 89, 3817-3825.
21. Landowski, T.H., Gleason-Guzman, M. & Dalton, S. (1997) Selection for drug resistance results in resistance to Fas-mediated apoptosis. Blood, 89, 1854-1861.
22. Lazebnik, Y.A., Kaufmann, S.H., Desnoyers, S., Poirier, G.G. & Earnshaw, W.C. (1994) Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature, 371, 346-347.
23. Los, M., Van de Craen, M., Penning, L.C., Schenk, H., Westendorp, M., Baeuerle, P.A., Dröge, W., Krammer, P.H., Fiers, W. & Schulze-Osthoff, K. (1995) Requirement of an ICE/CED-3 protease for Fas/ APO-1-mediated apoptosis. Nature, 375, 81-83.
24. Medema, J.P., Scaffidi, C., Kischkel, E.C., Shevchenko, A., Mann, M., Krammer, P.H. & Peter, M.E. (1997) FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO Journal, 16, 2794-2804.
25. Medema, J.P., Scaffidi, C., Krammer, P.H. & Peter, M.E. (1998) Bcl-xl, acts downstream of caspase-8 activation by the CD95 death-inducing signaling complex. Journal of Biological Chemistry, 273, 3388-3393.
26. Möller, P., Henne, C., Leithäuser, F., Eichelman, A., Schmidt, A., Brüderlein, S., Dhein, J. & Krammer, P.H. (1993) Coregulation of the APO-1 antigen with intercellular adhesion molecule-1 (CD54) in tonsillar B cells and coordinate expression in follicular center B cells and in follicle center and mediastinal B-cell lymphomas. Blood, 81, 2067-2075.
27. Muzio, M., Chinnaiyan, A.M., Kischkel, F.C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J.D., Zhang, M., Gentz, R., Mann, M., Krammer, P.H., Peter, M.E. & Dixit, V.M. (1996) FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell, 85, 817-827.
28. Nicholson, D.W., Ali, A., Thornberry, N.A., Vaillancourt, J.P., Ding, C.K., Gallant, M., Gareau, Y., Griffin, P.R., Labelle, M., Lazebnik, Y.A., Munday, N.A., Raju, S.M., Smulson, M.E., Yamin, T.T., Yu, V.L. & Miller, D.K. (1995) Identification and inhibition of the ICE/ CED-3 protease necessary for mammalian apoptosis. Nature, 376, 37-43.
29. Nicholson, D.W. & Thornberry, N.A. (1997) Caspases: killer proteases. Trends in Biochemical Sciences, 22, 299-306.
30. Oehm, A., Berhmann, I., Falk, W., Pawlita, M., Maier, G., Klas, C., Li-Weber, M., Richards, S., Dhein, J., Trauth, B.C., Ponsting, H. & Krammer, P. (1992) Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Journal of Biological Chemistry, 267, 10709-10715.
31. Pagès, F., Ragueneau, M., Rottapel, R., Truneh, A., Nunes, J., Imbert, J. & Olive, D. (1994) Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling. Nature, 369, 327-329.
32. Peter, M.E., Kischkel, F.C., Scheuerpflug, C.G., Medema, J.P., Debatin, K.M. & Krammer, P.H. (1997) Resistance of cultured peripheral T-cells towards activation-induced cell death involves a lack of recruitment of FLICE (MACH/caspase-8) to the CD95 death inducing signaling complex. European Journal of Immunology, 27, 1207-1212.
33. Plumas, J., Jacob, M.C., Chaperot, L., Molens, J.P., Sotto, J.J. & Bensa, J.C. (1998) Tumor B cells from non-Hodgkin's lymphoma are resistant to CD95 (Fas/Apo-1)-mediated apoptosis. Blood, 91, 2875-2885.
34. Sakahira, H., Enari, M. & Nagata, S. (1998) Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature, 391, 96-99.
35. Scaffidi, C., Medema, J.P., Krammer, P.H. & Peter, M.E. (1997) FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b. Journal of Biological Chemistry, 272, 26953-26958.
36. Tewari, M., Quan, L.T., O'Rourke, K., Desnoyers, S., Zeng, Z., Beidler, D.R., Poirier, G.G., Salvesen, G.S. & Dixit, V.M. (1995) Yama/ CPP32b, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell, 81, 801-809.
37. Wang, D., Freeman, G.J., Levine, H., Ritz, J. & Robertson, M.J. (1997) Role ofthe CD40 and CD95 (APO-1/FAS) antigens in the apoptosis of human B-cell malignancies. British Journal of Haematology, 97, 409-417.
38. Xerri, L., Bouabdallah, R., Devilard, E., Hassoun, J., Stoppa, A.M. & Birg, F. (1998) Sensitivity to Fas-mediated apoptosis is null or weak in B-cell non-Hodgkin's lymphomas and is moderately increased by CD40 ligation. British Journal of Cancer, 78, 225-232.
39. Xerri, L., Carbuccia, N., Parc, P. & Birg, F. (1995a) Search for rearrangements and/or allelic loss of the Fas-APO1 gene in 101 human lymphomas. American Journal of Clinical Pathology, 104, 424-430.
40. Xerri, L., Carbuccia, N., Parc, P., Hassoun, J. & Birg, F. (1995b) Frequent expression of FAS/APO-1 in Hodgkin's disease and anaplastic large cell lymphomas. Histopathology, 27, 235-241.
41. Xerri, L., Devilard, E., Ayello, C., Brousset, P., Reed, J.C., Emile, J.F., Hassoun, J., Parmentier, S. & Birg, F. (1997a) Cysteine protease CPP32, but not Ich1-L, is expressed in germinal center B cells and their neoplastic counterparts. Human Pathology, 28, 912-921.
42. Xerri, L., Devilard, E., Parc, P., Hassoun, J., Haddad, P. & Birg, F. (1997b) Malignant and reactive cells from human lymphomas frequently express the Fas Ligand but display a different sensitivity to Fas-mediated apoptosis. Leukemia, 11, 1868-1877.
43. Yasuhara, N., Sahara, S., Kamada, S., Eguchi, Y. & Tsujimoto, Y. (1997) Evidence against a functional site for Bcl-2 downstream of caspase cascade in preventing apoptosis. Oncogene, 15, 1921-1928.
44. Zhang, C., Ao, Z., Seth, A. & Schlossman, S.E. (1996) A mitochondrial membrane protein defined by a novel monoclonal antibody is preferentially detected in apoptotic cells. Journal of Immunology, 157, 3980-3987.