Two distinct pathways leading to nuclear apoptosis

Journal of Experimental Medicine

Volumn 192, Issue 4, 2000, Pages 571-579

  Susin, Santos A ^a   Daugas, Eric ^a,b   Ravagnan, Luigi ^a   Samejima, Kumiko ^c   Zamzami, Naoufal ^a   Loeffler, Markus ^a   Costantini, Paola ^a   Ferri, Karine F ^a   Irinopoulou, Theano ^d   Prévost, Marie Christine ^e   Brothers, Greg ^f   Mak, Tak W ^f   Penninger, Josef ^f   Earnshaw, William C ^c   Kroemer, Guido ^a,g  

^a CNRS   (France)

^b HÔPITAL TENON   (France)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d HÔPITAL BROUSSAIS   (France)

^e Unité d'Oncologie Virale   (France)

^f UNIVERSITY OF TORONTO   (Canada)

^g INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

Apaf 1; Apoptosis inducing factor; Caspase activated DNase; Caspases; Chromatin condensation

Indexed keywords

CASPASE; CELL PROTEIN; DEOXYRIBONUCLEASE; DNA FRAGMENT; ENZYME ACTIVATOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL FREE SYSTEM; CELL NUCLEUS; CHROMATIN CONDENSATION; CONTROLLED STUDY; DNA CLEAVAGE; EMBRYO; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; MITOCHONDRION; MOUSE; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; PROTEIN TRANSPORT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS INDUCING FACTOR; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; ARSENITES; CASPASE 3; CASPASES; CELL NUCLEUS; CELLS, CULTURED; CISPLATIN; CYTOCHROME C GROUP; DEOXYRIBONUCLEASES; DNA FRAGMENTATION; ETOPOSIDE; FIBROBLASTS; FLAVOPROTEINS; FLUORESCENT DYES; HELA CELLS; HUMANS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MICROINJECTIONS; MITOCHONDRIA; PROTEINS; RECOMBINANT PROTEINS;

EID: 0034698733     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.4.571     Document Type: Article

References (28)

1. DFF, a heterodimeric protein that functions downstream of caspase 3 to trigger DNA fragmentation during apoptosis
2. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
3. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
4. Transition from caspase-dependent to caspase-independent mechanisms at the onset of apoptotic execution
5. Acinus, a caspase-3 activated protein required for apoptosis chromatin condensation
6. Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo
7. Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes
8. Apaf1 is required for mitochondrial pathways of apoptosis and brain development
9. The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis
10. Caspase-independent cell death induced by anti-CD2 or staurosporine in activated human peripheral T lymphocytes
11. - cells
12. PML induces a novel caspase-independent death process
13. The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death
14. Molecular characterization of mitochondrial apoptosis-inducing factor
15. Mitochondrio-nuclear redistribution of AIF in apoptosis and necrosis
16. Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis
17. The Ced-3/interleukin 1 beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2 alpha are substrates for the apoptotic mediator CPP32
18. In situ immuno-detection of activated caspase-3 in apoptotic neurons in the developing nervous system
19. + T cells in mice tolerant to Staphylococcus aureus enterotoxin B
20. Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation
21. Mitochondrial release of caspases-2 and -9 during the apoptotic process
22. Bcl-2 inhibits the mitochondrial release of an apoptogenic protease
23. The central executioner of apoptosis. Multiple links between protease activation and mitochondria in Fas/Apo-1/CD95- and ceramide-induced apoptosis
24. Apaf-1, a human protein homologous to C. elegans Ced-4, participates in cytochrome c-dependent activation of caspase-3
25. Apoptotic death in epithelial cells: Cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation
26. Formation of 50 kbp chromatin fragments in isolated liver nuclei is mediated by protease and endonuclease activation
27. Large-scale fragmentation of mammalian DNA in the course of apoptosis proceeds via excision of chromosomal DNA loops and their oligomers
28. Apoptotic nuclear morphological change without DNA fragmentation