Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

Journal of Clinical Investigation

Volumn 110, Issue 6, 2002, Pages 851-860

  Maedler, Kathrin ^a   Sergeev, Pavel ^a   Ris, Frédéric ^b,c   Oberholzer, José ^c   Joller Jemelka, Helen I ^a   Spinas, Giatgen A ^a   Kaiser, Nurit ^d   Halban, Philippe A ^b   Donath, Marc Y ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^d HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

DNA FRAGMENT; FAS ANTIGEN; GAMMA INTERFERON; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FEMALE; GERBIL; HUMAN; HUMAN TISSUE; IN VIVO STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TOXICITY;

ADULT; AGED; ANIMALS; ANTIOXIDANTS; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; FEMALE; GERBILLINAE; GLUCOSE; HUMANS; HYPERGLYCEMIA; INTERLEUKIN-1; ISLETS OF LANGERHANS; MALE; MIDDLE AGED; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PROLINE; RECEPTORS, INTERLEUKIN-1; THIOCARBAMATES;

EID: 0036738398     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200215318     Document Type: Article

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